| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is gcpE
Identifier: 45656843
GI number: 45656843
Start: 1151785
End: 1153776
Strand: Reverse
Name: gcpE
Synonym: LIC10955
Alternate gene names: 45656843
Gene position: 1153776-1151785 (Counterclockwise)
Preceding gene: 45656847
Following gene: 45656839
Centisome position: 26.98
GC content: 39.31
Gene sequence:
>1992_bases ATGAATTTTAGATACAATCAAACACCTTTCGGTTATCAAAGAAGAAAAACCAGAGAAGTCAAAGTAGGAGACGTCAAAGT AGGCGGTAATAATCCGATTGTCATCCAATCTATGATCAACAGTGATACCACGGATACACAAGGTTCCGTAAAACAAATTT TGGAATTAGAACGCGCCGGCTGTGAAATCGTAAGACTTACTGTTCCCTCTCAAGCGGACGCGGACAATCTTCCTTCCATT CGGCAAGAACTGAAAAAAGCGGGCAGTAAGGTTCCTCTCGTTGCGGATATTCATTTTACCCCTAGCGTCGCCATGAAAGC GGTCGAGTATGTAGAAAAGGTGAGAATCAACCCGGGTAATTTTGCAGATAAGAAAAAATTTGCGGTCAGAGATTATACAG ACTTGAAATATAACCAAGAATTGGAAAGAATTTCGGAAGTATTTTCCCCTCTTGTTTTACGTTGTAAAGAATTAGGAGTT TCGATGAGGATCGGAACCAATCACGGTTCTCTTTCCGATCGGATCATGAACCGATACGGCGACACTCCTCAGGGTATGGT TGAATCCGCACTCGAATTTATTCGTATTGCAGAAAGTTTAGGATATTATGATATTATTGTAAGTATGAAAGCTTCCAATC CTCAGGTTATGGTTCAAGCCTACAGGATGTTAGCTTCCAGATTTAACGAGCTAAAAATGGATTATCCCCTACATTTAGGA GTCACCGAAGCAGGAGACGGTAATGACGGAAGAATCAAATCTGCCATCGGTATTGGTTCTCTTTTAGAAGACGGTCTAGG AGATACAATCCGGGTTTCTCTTACGGAAGACCCAGTCTTAGAAGTGCCAGTTGCAAAACTTCTTGCAGACAAATTTAACA AAAAAATCTCGAACCTAAATTCCGTAAAAGGTTATTCCGAATTTAGAAATCCTTTCTCTTATAATCGATTTTATAGTAGT GAAATTAAGATCGTTCAATTCGAAGCGGGAGAAAACCATCCGGTTCGAGTGGAGACTATTTTACCTTTCGAAAATTCAAA CTCATTTTTAGAAAACGTTGCAAAACTTTATCAGTATGGAAAATCTCTTTCGATAGAACCGGAAAGCATTTTAGTAGATT CCCCCTTACCCGATCAATTGAAAGAAATTTCTGAAGCTGCTACGGCTTTGTCTATTCCGGTGGGGATCCTTCTTTCTAAA AACGTTTCTTTAAACGAAAAACTTCAAAAAGAACTTCTTAGTTTTCCTAAGATTGTATTTGATCCGTTTCTTCAATTTCA GGATGGAGAAAAGATGTTATCTTTTCTAAAAGAAAGACAAAACGCTGGGCTTTTTTCGGAAATTCATACGAGTGGTGATA AACTCGATTCTCTCAGAGGACTTCCAGATACGTTATCCGAAATAGGTATCAAAAACGTTTTATTTTCTCTGGATTCTAAA GAAATTCTATACGACTATAGAAAGTTAGGAAGCATTCTAAGCCGTTTTGAATTTCCGATTCTTCTTCACGGTTCTTTTTC CAACCCAGAAGAAGCTTTATATAATTCCGCAATCGGTATCGGTGGACTTTTGATAGACGGCATCGGAGATCTGATACGAA TCTCCACTTCTAAAATCAAAGACATCGAAGAAATATTCCAACTTTCTTATGATCTTTTACAAGGCACCAGACTTCGTTTA ACAAAAACGGAATATATATCTTGCCCTTCTTGCGGTAGAACTCTTTTTGATCTTCAAGAAACTACGGCCAGAATCAAATC CAGAACTGGTCATCTTAAGGGAGTTAAAATTGCGGTGATGGGTTGTATTGTAAACGGTCCTGGCGAAATGGCGGACGCGG ACTTTGGCTATGTGGGCGCCGGTCCTGGTAAAGTTCATCTTTATCGAGGAAAAGAAATCGTTCTGAAAAACGTCCCCAGC GAAATCGCGGATGAAAAGTTAGTCCAACTCATCAAAGACAACGAACTTTGGCAGGATCCTTCTAATGATTAA
Upstream 100 bases:
>100_bases CTTAGTTTTGGAATCGGTTTTACTCTGATAAAAAGGAGAATGACGAAGTTATAATTCTCTACAAAACTGTCTTAAGTAAG AGGGAGTATTCTAAACGAGA
Downstream 100 bases:
>100_bases AATTTCATAATTTTATGTTATTTGATCTGACGGCTTCTTTGTTTTTGATTTATCAAGACTTTATTTAAAACTTGGTCCGA CAAATTATTGAATGTGGGTT
Product: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Products: NA
Alternate protein names: 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Number of amino acids: Translated: 663; Mature: 663
Protein sequence:
>663_residues MNFRYNQTPFGYQRRKTREVKVGDVKVGGNNPIVIQSMINSDTTDTQGSVKQILELERAGCEIVRLTVPSQADADNLPSI RQELKKAGSKVPLVADIHFTPSVAMKAVEYVEKVRINPGNFADKKKFAVRDYTDLKYNQELERISEVFSPLVLRCKELGV SMRIGTNHGSLSDRIMNRYGDTPQGMVESALEFIRIAESLGYYDIIVSMKASNPQVMVQAYRMLASRFNELKMDYPLHLG VTEAGDGNDGRIKSAIGIGSLLEDGLGDTIRVSLTEDPVLEVPVAKLLADKFNKKISNLNSVKGYSEFRNPFSYNRFYSS EIKIVQFEAGENHPVRVETILPFENSNSFLENVAKLYQYGKSLSIEPESILVDSPLPDQLKEISEAATALSIPVGILLSK NVSLNEKLQKELLSFPKIVFDPFLQFQDGEKMLSFLKERQNAGLFSEIHTSGDKLDSLRGLPDTLSEIGIKNVLFSLDSK EILYDYRKLGSILSRFEFPILLHGSFSNPEEALYNSAIGIGGLLIDGIGDLIRISTSKIKDIEEIFQLSYDLLQGTRLRL TKTEYISCPSCGRTLFDLQETTARIKSRTGHLKGVKIAVMGCIVNGPGEMADADFGYVGAGPGKVHLYRGKEIVLKNVPS EIADEKLVQLIKDNELWQDPSND
Sequences:
>Translated_663_residues MNFRYNQTPFGYQRRKTREVKVGDVKVGGNNPIVIQSMINSDTTDTQGSVKQILELERAGCEIVRLTVPSQADADNLPSI RQELKKAGSKVPLVADIHFTPSVAMKAVEYVEKVRINPGNFADKKKFAVRDYTDLKYNQELERISEVFSPLVLRCKELGV SMRIGTNHGSLSDRIMNRYGDTPQGMVESALEFIRIAESLGYYDIIVSMKASNPQVMVQAYRMLASRFNELKMDYPLHLG VTEAGDGNDGRIKSAIGIGSLLEDGLGDTIRVSLTEDPVLEVPVAKLLADKFNKKISNLNSVKGYSEFRNPFSYNRFYSS EIKIVQFEAGENHPVRVETILPFENSNSFLENVAKLYQYGKSLSIEPESILVDSPLPDQLKEISEAATALSIPVGILLSK NVSLNEKLQKELLSFPKIVFDPFLQFQDGEKMLSFLKERQNAGLFSEIHTSGDKLDSLRGLPDTLSEIGIKNVLFSLDSK EILYDYRKLGSILSRFEFPILLHGSFSNPEEALYNSAIGIGGLLIDGIGDLIRISTSKIKDIEEIFQLSYDLLQGTRLRL TKTEYISCPSCGRTLFDLQETTARIKSRTGHLKGVKIAVMGCIVNGPGEMADADFGYVGAGPGKVHLYRGKEIVLKNVPS EIADEKLVQLIKDNELWQDPSND >Mature_663_residues MNFRYNQTPFGYQRRKTREVKVGDVKVGGNNPIVIQSMINSDTTDTQGSVKQILELERAGCEIVRLTVPSQADADNLPSI RQELKKAGSKVPLVADIHFTPSVAMKAVEYVEKVRINPGNFADKKKFAVRDYTDLKYNQELERISEVFSPLVLRCKELGV SMRIGTNHGSLSDRIMNRYGDTPQGMVESALEFIRIAESLGYYDIIVSMKASNPQVMVQAYRMLASRFNELKMDYPLHLG VTEAGDGNDGRIKSAIGIGSLLEDGLGDTIRVSLTEDPVLEVPVAKLLADKFNKKISNLNSVKGYSEFRNPFSYNRFYSS EIKIVQFEAGENHPVRVETILPFENSNSFLENVAKLYQYGKSLSIEPESILVDSPLPDQLKEISEAATALSIPVGILLSK NVSLNEKLQKELLSFPKIVFDPFLQFQDGEKMLSFLKERQNAGLFSEIHTSGDKLDSLRGLPDTLSEIGIKNVLFSLDSK EILYDYRKLGSILSRFEFPILLHGSFSNPEEALYNSAIGIGGLLIDGIGDLIRISTSKIKDIEEIFQLSYDLLQGTRLRL TKTEYISCPSCGRTLFDLQETTARIKSRTGHLKGVKIAVMGCIVNGPGEMADADFGYVGAGPGKVHLYRGKEIVLKNVPS EIADEKLVQLIKDNELWQDPSND
Specific function: Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
COG id: COG0821
COG function: function code I; Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the ispG family
Homologues:
Organism=Escherichia coli, GI1788863, Length=284, Percent_Identity=41.5492957746479, Blast_Score=200, Evalue=3e-52,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): ISPG_LEPIC (Q72TR2)
Other databases:
- EMBL: AE016823 - RefSeq: YP_000929.1 - ProteinModelPortal: Q72TR2 - GeneID: 2771632 - GenomeReviews: AE016823_GR - KEGG: lic:LIC10955 - NMPDR: fig|267671.1.peg.929 - HOGENOM: HBG335271 - OMA: SMRIGTN - ProtClustDB: CLSK574746 - BioCyc: LINT-130-01:LINT-130-01-000929-MONOMER - BioCyc: LINT267671:LIC_10955-MONOMER - HAMAP: MF_00159 - InterPro: IPR017178 - InterPro: IPR004588 - PIRSF: PIRSF037336 - TIGRFAMs: TIGR00612
Pfam domain/function: PF04551 GcpE
EC number: =1.17.7.1
Molecular weight: Translated: 73852; Mature: 73852
Theoretical pI: Translated: 5.82; Mature: 5.82
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNFRYNQTPFGYQRRKTREVKVGDVKVGGNNPIVIQSMINSDTTDTQGSVKQILELERAG CCCCCCCCCCCHHHCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCC CEIVRLTVPSQADADNLPSIRQELKKAGSKVPLVADIHFTPSVAMKAVEYVEKVRINPGN CEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCC FADKKKFAVRDYTDLKYNQELERISEVFSPLVLRCKELGVSMRIGTNHGSLSDRIMNRYG CCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCC DTPQGMVESALEFIRIAESLGYYDIIVSMKASNPQVMVQAYRMLASRFNELKMDYPLHLG CCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEE VTEAGDGNDGRIKSAIGIGSLLEDGLGDTIRVSLTEDPVLEVPVAKLLADKFNKKISNLN EECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH SVKGYSEFRNPFSYNRFYSSEIKIVQFEAGENHPVRVETILPFENSNSFLENVAKLYQYG HCCCHHHHCCCCCCCCEECCCEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHCC KSLSIEPESILVDSPLPDQLKEISEAATALSIPVGILLSKNVSLNEKLQKELLSFPKIVF CCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHCCHHHH DPFLQFQDGEKMLSFLKERQNAGLFSEIHTSGDKLDSLRGLPDTLSEIGIKNVLFSLDSK HHHHHCCCHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCH EILYDYRKLGSILSRFEFPILLHGSFSNPEEALYNSAIGIGGLLIDGIGDLIRISTSKIK HHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH DIEEIFQLSYDLLQGTRLRLTKTEYISCPSCGRTLFDLQETTARIKSRTGHLKGVKIAVM HHHHHHHHHHHHHCCCEEEEEECCEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEE GCIVNGPGEMADADFGYVGAGPGKVHLYRGKEIVLKNVPSEIADEKLVQLIKDNELWQDP EEEECCCCCCCCCCCCEECCCCCEEEEEECCEEEECCCCHHHHHHHHHHHHHCCCCCCCC SND CCC >Mature Secondary Structure MNFRYNQTPFGYQRRKTREVKVGDVKVGGNNPIVIQSMINSDTTDTQGSVKQILELERAG CCCCCCCCCCCHHHCCCCEEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCC CEIVRLTVPSQADADNLPSIRQELKKAGSKVPLVADIHFTPSVAMKAVEYVEKVRINPGN CEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHCCCCCC FADKKKFAVRDYTDLKYNQELERISEVFSPLVLRCKELGVSMRIGTNHGSLSDRIMNRYG CCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCC DTPQGMVESALEFIRIAESLGYYDIIVSMKASNPQVMVQAYRMLASRFNELKMDYPLHLG CCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEE VTEAGDGNDGRIKSAIGIGSLLEDGLGDTIRVSLTEDPVLEVPVAKLLADKFNKKISNLN EECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH SVKGYSEFRNPFSYNRFYSSEIKIVQFEAGENHPVRVETILPFENSNSFLENVAKLYQYG HCCCHHHHCCCCCCCCEECCCEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHHHHHHCC KSLSIEPESILVDSPLPDQLKEISEAATALSIPVGILLSKNVSLNEKLQKELLSFPKIVF CCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHCCHHHH DPFLQFQDGEKMLSFLKERQNAGLFSEIHTSGDKLDSLRGLPDTLSEIGIKNVLFSLDSK HHHHHCCCHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCH EILYDYRKLGSILSRFEFPILLHGSFSNPEEALYNSAIGIGGLLIDGIGDLIRISTSKIK HHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH DIEEIFQLSYDLLQGTRLRLTKTEYISCPSCGRTLFDLQETTARIKSRTGHLKGVKIAVM HHHHHHHHHHHHHCCCEEEEEECCEECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEE GCIVNGPGEMADADFGYVGAGPGKVHLYRGKEIVLKNVPSEIADEKLVQLIKDNELWQDP EEEECCCCCCCCCCCCEECCCCCEEEEEECCEEEECCCCHHHHHHHHHHHHHCCCCCCCC SND CCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA