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The map label for this gene is pepA

Identifier: 45656629

GI number: 45656629

Start: 893559

End: 895046

Strand: Direct

Name: pepA

Synonym: LIC10733

Alternate gene names: 45656629

Gene position: 893559-895046 (Clockwise)

Preceding gene: 45656628

Following gene: 45656630

Centisome position: 20.89

GC content: 39.11

Gene sequence:

>1488_bases
ATGAAACTGGATAAAAATAAAATCCAAATCTCGATCGGGAAAAATCCTTCTAAGACGTTTTATAAATTACAACTTCTTTT
AAAAGATCATTTTCCTGAGAATTTAAAGACGAAATTCTCTTTTCAAACTGCTTCTGGAATTTTTACGGGAGAAAACGGAC
AGATTTTTACAGATGAAGTCGAAAAAATCATTTATTTAGGGTTAGGCGAAACTTCCAAAATAAAAATCAGGGGAGTCGCA
CAACATTTTTTTCAATTTGGAGAGAAACTTAAAAAGTGGGAAGGTGTGGGTTTAGAAATTCATCTTCCAAAGGTTTTGAC
CAACTCGCTTTCAGCGGACTTAGTAGTTTATCAAATTGTAAACTCTTTAGAACAAGGAGCTTATGCGATTAACGTTTTGG
CAAAAGAATACAAAGAAAATTCCAAAAAAATAGGGAACGTATCTTTTATACTTCAAGACGCAGCAAAATTGAAAGAAGCA
GAAAAAGGACTCAAACGAGGAAAGATCGTTAGCCGTTATATCAACGGAGTTCGTCATATCGCTCATCTTCCTGCAAACCA
TTTTACTCCGGAAGAATTTGTCTCTAGATCTAAAGAAATCGCAAAAGACAACGGGCTTAAAATTACAGTCTTTGACGAAC
CTCAATTAAAAAAAGAAAAAATGGGGGGAATCCTTTCCGTTTGCGAAGGTTCTGATAAAAAAGCGAAAATGATTCTTTTG
GAATATACTCCAGTAAAACCAATTACGAAGAAAAAACTTGCGATCATCGGCAAGGGACTCACTTTTGATTCGGGTGGGAT
CAGCATTAAACCGGCTCAGGATATGCACGAAATGAAATACGATATGTGTGGAGCGGCTACGGCAATCCATGCGATCGGGG
CGATCGCCGAACTAGGATTAGGTGTTCCTGTAATTGCAGCGATTGGAGTTGCGGAAAATATGCCTGACGCCGCAGCTATC
AAACCGGGAGACGTATATACTGCATATAACGGAATTACTGTGGAAGTTCAAAATACGGACGCGGAAGGTCGTTTAGTTTT
GGGAGATGTACTCTCTTATGTAGGAAAAAAATTTAAACCGGATTACATGTTGGATCTTGCAACTTTAACTGGAGCGATTA
TCATTTCTTTAGGACACGAAGCTGCCGGTGTGATGAGTAACTCCGATGTTCTTACAAATCTATTAAAAGAAGCGTCTATT
TCTTCGGATGAAAGAATTTGGGAAATGCCTCTTTGGGAGGAATATTCAGAAGACTTAAAAAGTGACATTGCAGACATTCG
AAACGTGGCTGGAAGGGCCGGGGGTTCTTTGTCAGCGGCGAAGTTTTTGGAAAGATTTGTGGAACCCGGGATCGCTTGGG
CACATATTGATATTGCAGGAACTGCTTGGAGAAAAAAAACTTCTGGAACTCAAATTGGTAACGGGCCAACCGGATACGGG
GTTCGACTTTTAGTAGATTTGGTTGAAAAGATTGGCAAAAAGAAATAG

Upstream 100 bases:

>100_bases
TGATCGGAGCGGACGGAAAAATTCTCAAGGTATATCCCAAAGTCAGCGTGAAAGGACATGTAGATGAAATCCTTTCCGAC
ATTAAAACATTGGAGAAAAA

Downstream 100 bases:

>100_bases
AAGATACAGTCGTATATTAGATTTATATGTTTCTTTTGTAAAATGATTCTGCACTTTTTACATGAGACTATAAAGTTTTA
GTTTACAAATTGATAATTTT

Product: cytosol aminopeptidase protein

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MKLDKNKIQISIGKNPSKTFYKLQLLLKDHFPENLKTKFSFQTASGIFTGENGQIFTDEVEKIIYLGLGETSKIKIRGVA
QHFFQFGEKLKKWEGVGLEIHLPKVLTNSLSADLVVYQIVNSLEQGAYAINVLAKEYKENSKKIGNVSFILQDAAKLKEA
EKGLKRGKIVSRYINGVRHIAHLPANHFTPEEFVSRSKEIAKDNGLKITVFDEPQLKKEKMGGILSVCEGSDKKAKMILL
EYTPVKPITKKKLAIIGKGLTFDSGGISIKPAQDMHEMKYDMCGAATAIHAIGAIAELGLGVPVIAAIGVAENMPDAAAI
KPGDVYTAYNGITVEVQNTDAEGRLVLGDVLSYVGKKFKPDYMLDLATLTGAIIISLGHEAAGVMSNSDVLTNLLKEASI
SSDERIWEMPLWEEYSEDLKSDIADIRNVAGRAGGSLSAAKFLERFVEPGIAWAHIDIAGTAWRKKTSGTQIGNGPTGYG
VRLLVDLVEKIGKKK

Sequences:

>Translated_495_residues
MKLDKNKIQISIGKNPSKTFYKLQLLLKDHFPENLKTKFSFQTASGIFTGENGQIFTDEVEKIIYLGLGETSKIKIRGVA
QHFFQFGEKLKKWEGVGLEIHLPKVLTNSLSADLVVYQIVNSLEQGAYAINVLAKEYKENSKKIGNVSFILQDAAKLKEA
EKGLKRGKIVSRYINGVRHIAHLPANHFTPEEFVSRSKEIAKDNGLKITVFDEPQLKKEKMGGILSVCEGSDKKAKMILL
EYTPVKPITKKKLAIIGKGLTFDSGGISIKPAQDMHEMKYDMCGAATAIHAIGAIAELGLGVPVIAAIGVAENMPDAAAI
KPGDVYTAYNGITVEVQNTDAEGRLVLGDVLSYVGKKFKPDYMLDLATLTGAIIISLGHEAAGVMSNSDVLTNLLKEASI
SSDERIWEMPLWEEYSEDLKSDIADIRNVAGRAGGSLSAAKFLERFVEPGIAWAHIDIAGTAWRKKTSGTQIGNGPTGYG
VRLLVDLVEKIGKKK
>Mature_495_residues
MKLDKNKIQISIGKNPSKTFYKLQLLLKDHFPENLKTKFSFQTASGIFTGENGQIFTDEVEKIIYLGLGETSKIKIRGVA
QHFFQFGEKLKKWEGVGLEIHLPKVLTNSLSADLVVYQIVNSLEQGAYAINVLAKEYKENSKKIGNVSFILQDAAKLKEA
EKGLKRGKIVSRYINGVRHIAHLPANHFTPEEFVSRSKEIAKDNGLKITVFDEPQLKKEKMGGILSVCEGSDKKAKMILL
EYTPVKPITKKKLAIIGKGLTFDSGGISIKPAQDMHEMKYDMCGAATAIHAIGAIAELGLGVPVIAAIGVAENMPDAAAI
KPGDVYTAYNGITVEVQNTDAEGRLVLGDVLSYVGKKFKPDYMLDLATLTGAIIISLGHEAAGVMSNSDVLTNLLKEASI
SSDERIWEMPLWEEYSEDLKSDIADIRNVAGRAGGSLSAAKFLERFVEPGIAWAHIDIAGTAWRKKTSGTQIGNGPTGYG
VRLLVDLVEKIGKKK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=338, Percent_Identity=39.0532544378698, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI47155554, Length=331, Percent_Identity=32.3262839879154, Blast_Score=143, Evalue=4e-34,
Organism=Escherichia coli, GI1790710, Length=375, Percent_Identity=39.4666666666667, Blast_Score=266, Evalue=3e-72,
Organism=Escherichia coli, GI87082123, Length=325, Percent_Identity=35.3846153846154, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17556903, Length=325, Percent_Identity=33.5384615384615, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24661038, Length=318, Percent_Identity=31.4465408805031, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI21355725, Length=318, Percent_Identity=31.1320754716981, Blast_Score=169, Evalue=5e-42,
Organism=Drosophila melanogaster, GI20129969, Length=302, Percent_Identity=30.794701986755, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24662227, Length=301, Percent_Identity=29.2358803986711, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21357381, Length=358, Percent_Identity=30.1675977653631, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI221379063, Length=380, Percent_Identity=29.7368421052632, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI221379062, Length=380, Percent_Identity=29.7368421052632, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI20129963, Length=294, Percent_Identity=30.952380952381, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI161077148, Length=353, Percent_Identity=28.328611898017, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI20130057, Length=353, Percent_Identity=28.328611898017, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21355645, Length=297, Percent_Identity=28.6195286195286, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24662223, Length=297, Percent_Identity=28.6195286195286, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI19922386, Length=298, Percent_Identity=30.5369127516779, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24646701, Length=193, Percent_Identity=31.6062176165803, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24646703, Length=193, Percent_Identity=31.6062176165803, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21358201, Length=193, Percent_Identity=31.6062176165803, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_LEPIC (Q72UC6)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_000715.1
- ProteinModelPortal:   Q72UC6
- SMR:   Q72UC6
- GeneID:   2771497
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC10733
- NMPDR:   fig|267671.1.peg.715
- HOGENOM:   HBG742580
- OMA:   SISSDER
- ProtClustDB:   CLSK574839
- BioCyc:   LINT267671:LIC_10733-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 54049; Mature: 54049

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 270-270 ACT_SITE 344-344

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDKNKIQISIGKNPSKTFYKLQLLLKDHFPENLKTKFSFQTASGIFTGENGQIFTDEV
CCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEECCCCCEEHHHH
EKIIYLGLGETSKIKIRGVAQHFFQFGEKLKKWEGVGLEIHLPKVLTNSLSADLVVYQIV
CEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHCCHHHHHHHHHHH
NSLEQGAYAINVLAKEYKENSKKIGNVSFILQDAAKLKEAEKGLKRGKIVSRYINGVRHI
HHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHLPANHFTPEEFVSRSKEIAKDNGLKITVFDEPQLKKEKMGGILSVCEGSDKKAKMILL
HHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCEEEECCCCCCCEEEEEE
EYTPVKPITKKKLAIIGKGLTFDSGGISIKPAQDMHEMKYDMCGAATAIHAIGAIAELGL
EECCCCCCCHHHHHEEECCCEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GVPVIAAIGVAENMPDAAAIKPGDVYTAYNGITVEVQNTDAEGRLVLGDVLSYVGKKFKP
CHHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEECCCCCCCEEHHHHHHHHCCCCCC
DYMLDLATLTGAIIISLGHEAAGVMSNSDVLTNLLKEASISSDERIWEMPLWEEYSEDLK
CHHHHHHHHHCEEEEEECCHHHCCCCCHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHH
SDIADIRNVAGRAGGSLSAAKFLERFVEPGIAWAHIDIAGTAWRKKTSGTQIGNGPTGYG
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECCCHHCCCCCCCCCCCCCCCHH
VRLLVDLVEKIGKKK
HHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLDKNKIQISIGKNPSKTFYKLQLLLKDHFPENLKTKFSFQTASGIFTGENGQIFTDEV
CCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEECCCCCEEHHHH
EKIIYLGLGETSKIKIRGVAQHFFQFGEKLKKWEGVGLEIHLPKVLTNSLSADLVVYQIV
CEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHCCHHHHHHHHHHH
NSLEQGAYAINVLAKEYKENSKKIGNVSFILQDAAKLKEAEKGLKRGKIVSRYINGVRHI
HHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHLPANHFTPEEFVSRSKEIAKDNGLKITVFDEPQLKKEKMGGILSVCEGSDKKAKMILL
HHCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHCCCEEEECCCCCCCEEEEEE
EYTPVKPITKKKLAIIGKGLTFDSGGISIKPAQDMHEMKYDMCGAATAIHAIGAIAELGL
EECCCCCCCHHHHHEEECCCEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GVPVIAAIGVAENMPDAAAIKPGDVYTAYNGITVEVQNTDAEGRLVLGDVLSYVGKKFKP
CHHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEECCCCCCCEEHHHHHHHHCCCCCC
DYMLDLATLTGAIIISLGHEAAGVMSNSDVLTNLLKEASISSDERIWEMPLWEEYSEDLK
CHHHHHHHHHCEEEEEECCHHHCCCCCHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHH
SDIADIRNVAGRAGGSLSAAKFLERFVEPGIAWAHIDIAGTAWRKKTSGTQIGNGPTGYG
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECCCHHCCCCCCCCCCCCCCCHH
VRLLVDLVEKIGKKK
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA