| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is lon
Identifier: 45656506
GI number: 45656506
Start: 743707
End: 746226
Strand: Reverse
Name: lon
Synonym: LIC10608
Alternate gene names: 45656506
Gene position: 746226-743707 (Counterclockwise)
Preceding gene: 45656510
Following gene: 45656505
Centisome position: 17.45
GC content: 38.06
Gene sequence:
>2520_bases TTGGAAGGAGGTCCTTTGGAACCTTTAGAGGATTTATCTGGAATTGAAGAAAATTCGATCATTCCATTGGATTCAATTTT GCCACCGGAATTATTTTTAATTCCGATTAAGTCTAGACCAGTATTTCCGGGTATTATCACACCTTTGATCGTTCCTAGCG GTAAGTTCGCAAAAGCCGTAGAAGAAACCGTCAAAGGAAACTCCTTTTTGGGTCTTGTTCTTTTAAAAGACGAAGAAAAC GAAAAAGAAACTTCCGAAAACATCTATCAGTACGGAGTTGTCGCTAAAATATTAAAAAAAGTGAATTTACCAGACAACGC CGTCAACATACTCGTCAACACAATCCGCCGTTTTAAAATCGAATCTTTCGTAAATAAAGATCCTTTGGTCGCAAGAGTTT CATATCCGGAAGAAGAACCTGGAGCTCCGAAAAACACCACTAAGGCAATGATGAGAACCTTACTCGTCATGACTAGAGAA CTCGCACAAAACAATCCTCTATTTACAGAAGAAATGAAACTTACCATGCTCAACGTAAATGAGCCTGGAAAGATGGCAGA CTTTGTATGTTCCATTCTCAATTTAGAAAAAGAAGAATACCAATCCGTAATCGAATCTAATATTCTCAAAACTAGAATTG AAAAGGTACTTCTCTTTCTAAAGAAAGAAATCGAACTAGTATCCATTCAAAGAGAAATTTCGGATCAGATCCAAGACAAA ATAGACAAACAACAAAGACAATTTTTTTTAAGAGAACAACTCAAAGCGATTCAAAATGAACTCGGTATTAAGGACGATAA GTTCGAAAAGAAATACGAAAAATTTTTAGAACGACTTAAAAACCTAAACGCAGACCCAGAAGTAATCGAAGAAGTGACCA GAGAACTGGATAAGTTTTCTTATGCGGACCCTAATACGGGAGATTATAACGTTATCCGAAATTATTTGGATATTTTAGAA TCTCTTCCTTGGGAGCCAGCGCCAGTTCGAGAAATCGATTTAGAAAAAGCTAAAAAGACTTTAGATAAAGATCACTATAA ACTCGAAGACGTTAAAGACAGAATTTTAGAATTCCTAGCAGTTAAAAAACTTAAAAACGATGAAAAAGGCACCATACTAC TATTAGTCGGACCTCCGGGCGTGGGGAAAACCTCAATCGCGAGATCGATCGCGGAAGCTATGGGAAGAAAATTTTTTCGA TTTTCAGTCGGAGGTATGAGGGACGAAGCCGAAATCAAAGGACACAGAAGAACTTACATCGGCTCAATGCCAGGCAAAAT CATTTCAGCACTTCGTATAACGAAAGAAAGAGACTGCGTCATTTTGTTAGACGAAATCGATAAACTTTCGATAGGCATTC AAGGTGATCCTGCTTCCGCCCTTTTGGAAGTTTTAGACCCGGAACAAAATAAAAATTTCAGAGATCATTATTTAGATCTT CCATTCGATATTTCTAATGTGTTTTTTATTGCTACTGCAAATACGTTAGATTCCATTTCCAGAATCCTTTTAGACAGAAT GGAAATCATCAATCTTTCCGGTTATATCACGGATGAGAAGGTTCAAATTTTTCAAAAATACCTTTGGAAAAAAGTCCTCT ATAAAAACGGAGTTACTCCCTACGGTATCGAGTTTGATAAAAAAGCGATCGTAGCTCTGATTGATTCTTACTCGAGAGAA TCAGGAGTAAGAGGTCTGGAAAAAGTGACCGATAAATTGGTTCGTAAGATTGCAATTAAAATCGTTCGTAAAGAATCGTT CCCTAAAATCATCCAAGAAAAAGATCTAGAAACTTTTTTAGGCGTTCCCAAATTTACGGACGAAAGAATGGTTCGCGCTT CTGTTCCTGGTACCGCCCTCGGTTTAGCCTGGACTTCGGTAGGAGGTGCGACCCTTCTCATAGAAGCACTTTTTGTCAAA GGGAAAGGTGGAATCCTTCTCACGGGAATGCTCGGTAAAACGATGGAAGAATCTTCTAACATCGCCTTGAGTTATATTAA AAATTTATTATATAAAGAAGAATTATTCAACAATCGAATGATTCATTTACACGTTCCGGATGGAGCAACTCCCAAGGACG GCCCTTCTGCCGGAATTACAATGGCCTCCGCGATTCTCTCTCTCGCTCTAAATACAAAAGTAAAGTCTGGTTTTGGAATG ACCGGAGAGCTCACTCTTACTGGAGAAGTGCTTGCGATCGGCGGTTTACGCGAAAAGATCGTAGCCGCCAAAAGAGTGGG AATTCATAAAATCATCTACCCAAAAGATAATCTTCAACATCTACAAGAGATTCCGGATTACGTAAAAAAGGGAATGTATT TTTTTCCGGTGAGTCGTTACGAGGAAGTCGCTTTATTATTGTTTGACGAAAAAGTTATTTCCAAGATCAACCCATCTTTT CGGGAAAATTTAAAATCAATTGTTAACCCGACCAGAAAACTTTCGCCTAAGAAAAAGACGACCCAAAAACAGAAACTGTC TCTTTCTAAACAAAAGGGAAACAATCAAAAAAAGAAGTAG
Upstream 100 bases:
>100_bases AAACCAACCTTTCGAAATTTTTTCGATCGAAAGCGGATCAGATTTGATTTGAGAATCTCTTCCACTGTAAGAACCTGGAC AAATTAAGAGATGTTTTCAG
Downstream 100 bases:
>100_bases TATTTTAGAGTATTCTTAAATATAAATTAACTCAGGAGAGCCAAATGGGCGTCCCATTTATAGACATTAAAAGATTTGAA CCTGGTTTACTGGAAGAATG
Product: ATP-dependent protease La
Products: NA
Alternate protein names: ATP-dependent protease La
Number of amino acids: Translated: 839; Mature: 839
Protein sequence:
>839_residues MEGGPLEPLEDLSGIEENSIIPLDSILPPELFLIPIKSRPVFPGIITPLIVPSGKFAKAVEETVKGNSFLGLVLLKDEEN EKETSENIYQYGVVAKILKKVNLPDNAVNILVNTIRRFKIESFVNKDPLVARVSYPEEEPGAPKNTTKAMMRTLLVMTRE LAQNNPLFTEEMKLTMLNVNEPGKMADFVCSILNLEKEEYQSVIESNILKTRIEKVLLFLKKEIELVSIQREISDQIQDK IDKQQRQFFLREQLKAIQNELGIKDDKFEKKYEKFLERLKNLNADPEVIEEVTRELDKFSYADPNTGDYNVIRNYLDILE SLPWEPAPVREIDLEKAKKTLDKDHYKLEDVKDRILEFLAVKKLKNDEKGTILLLVGPPGVGKTSIARSIAEAMGRKFFR FSVGGMRDEAEIKGHRRTYIGSMPGKIISALRITKERDCVILLDEIDKLSIGIQGDPASALLEVLDPEQNKNFRDHYLDL PFDISNVFFIATANTLDSISRILLDRMEIINLSGYITDEKVQIFQKYLWKKVLYKNGVTPYGIEFDKKAIVALIDSYSRE SGVRGLEKVTDKLVRKIAIKIVRKESFPKIIQEKDLETFLGVPKFTDERMVRASVPGTALGLAWTSVGGATLLIEALFVK GKGGILLTGMLGKTMEESSNIALSYIKNLLYKEELFNNRMIHLHVPDGATPKDGPSAGITMASAILSLALNTKVKSGFGM TGELTLTGEVLAIGGLREKIVAAKRVGIHKIIYPKDNLQHLQEIPDYVKKGMYFFPVSRYEEVALLLFDEKVISKINPSF RENLKSIVNPTRKLSPKKKTTQKQKLSLSKQKGNNQKKK
Sequences:
>Translated_839_residues MEGGPLEPLEDLSGIEENSIIPLDSILPPELFLIPIKSRPVFPGIITPLIVPSGKFAKAVEETVKGNSFLGLVLLKDEEN EKETSENIYQYGVVAKILKKVNLPDNAVNILVNTIRRFKIESFVNKDPLVARVSYPEEEPGAPKNTTKAMMRTLLVMTRE LAQNNPLFTEEMKLTMLNVNEPGKMADFVCSILNLEKEEYQSVIESNILKTRIEKVLLFLKKEIELVSIQREISDQIQDK IDKQQRQFFLREQLKAIQNELGIKDDKFEKKYEKFLERLKNLNADPEVIEEVTRELDKFSYADPNTGDYNVIRNYLDILE SLPWEPAPVREIDLEKAKKTLDKDHYKLEDVKDRILEFLAVKKLKNDEKGTILLLVGPPGVGKTSIARSIAEAMGRKFFR FSVGGMRDEAEIKGHRRTYIGSMPGKIISALRITKERDCVILLDEIDKLSIGIQGDPASALLEVLDPEQNKNFRDHYLDL PFDISNVFFIATANTLDSISRILLDRMEIINLSGYITDEKVQIFQKYLWKKVLYKNGVTPYGIEFDKKAIVALIDSYSRE SGVRGLEKVTDKLVRKIAIKIVRKESFPKIIQEKDLETFLGVPKFTDERMVRASVPGTALGLAWTSVGGATLLIEALFVK GKGGILLTGMLGKTMEESSNIALSYIKNLLYKEELFNNRMIHLHVPDGATPKDGPSAGITMASAILSLALNTKVKSGFGM TGELTLTGEVLAIGGLREKIVAAKRVGIHKIIYPKDNLQHLQEIPDYVKKGMYFFPVSRYEEVALLLFDEKVISKINPSF RENLKSIVNPTRKLSPKKKTTQKQKLSLSKQKGNNQKKK >Mature_839_residues MEGGPLEPLEDLSGIEENSIIPLDSILPPELFLIPIKSRPVFPGIITPLIVPSGKFAKAVEETVKGNSFLGLVLLKDEEN EKETSENIYQYGVVAKILKKVNLPDNAVNILVNTIRRFKIESFVNKDPLVARVSYPEEEPGAPKNTTKAMMRTLLVMTRE LAQNNPLFTEEMKLTMLNVNEPGKMADFVCSILNLEKEEYQSVIESNILKTRIEKVLLFLKKEIELVSIQREISDQIQDK IDKQQRQFFLREQLKAIQNELGIKDDKFEKKYEKFLERLKNLNADPEVIEEVTRELDKFSYADPNTGDYNVIRNYLDILE SLPWEPAPVREIDLEKAKKTLDKDHYKLEDVKDRILEFLAVKKLKNDEKGTILLLVGPPGVGKTSIARSIAEAMGRKFFR FSVGGMRDEAEIKGHRRTYIGSMPGKIISALRITKERDCVILLDEIDKLSIGIQGDPASALLEVLDPEQNKNFRDHYLDL PFDISNVFFIATANTLDSISRILLDRMEIINLSGYITDEKVQIFQKYLWKKVLYKNGVTPYGIEFDKKAIVALIDSYSRE SGVRGLEKVTDKLVRKIAIKIVRKESFPKIIQEKDLETFLGVPKFTDERMVRASVPGTALGLAWTSVGGATLLIEALFVK GKGGILLTGMLGKTMEESSNIALSYIKNLLYKEELFNNRMIHLHVPDGATPKDGPSAGITMASAILSLALNTKVKSGFGM TGELTLTGEVLAIGGLREKIVAAKRVGIHKIIYPKDNLQHLQEIPDYVKKGMYFFPVSRYEEVALLLFDEKVISKINPSF RENLKSIVNPTRKLSPKKKTTQKQKLSLSKQKGNNQKKK
Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced
COG id: COG0466
COG function: function code O; ATP-dependent Lon protease, bacterial type
Gene ontology:
Cell location: Cytoplasm
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Lon domain
Homologues:
Organism=Homo sapiens, GI21396489, Length=835, Percent_Identity=40, Blast_Score=575, Evalue=1e-164, Organism=Homo sapiens, GI31377667, Length=861, Percent_Identity=33.3333333333333, Blast_Score=452, Evalue=1e-127, Organism=Escherichia coli, GI1786643, Length=763, Percent_Identity=40.1048492791612, Blast_Score=555, Evalue=1e-159, Organism=Caenorhabditis elegans, GI17505831, Length=702, Percent_Identity=39.031339031339, Blast_Score=503, Evalue=1e-142, Organism=Caenorhabditis elegans, GI17556486, Length=666, Percent_Identity=35.5855855855856, Blast_Score=420, Evalue=1e-117, Organism=Saccharomyces cerevisiae, GI6319449, Length=725, Percent_Identity=42.4827586206897, Blast_Score=555, Evalue=1e-159, Organism=Drosophila melanogaster, GI221513036, Length=665, Percent_Identity=44.2105263157895, Blast_Score=554, Evalue=1e-158, Organism=Drosophila melanogaster, GI24666867, Length=665, Percent_Identity=44.2105263157895, Blast_Score=554, Evalue=1e-157,
Paralogues:
None
Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): LON_LEPIC (Q72UP9)
Other databases:
- EMBL: AE016823 - RefSeq: YP_000592.1 - ProteinModelPortal: Q72UP9 - SMR: Q72UP9 - MEROPS: S16.002 - GeneID: 2771277 - GenomeReviews: AE016823_GR - KEGG: lic:LIC10608 - NMPDR: fig|267671.1.peg.592 - HOGENOM: HBG566281 - OMA: DYRARIE - ProtClustDB: CLSK552898 - BioCyc: LINT267671:LIC_10608-MONOMER - GO: GO:0005737 - GO: GO:0006508 - InterPro: IPR003593 - InterPro: IPR003959 - InterPro: IPR008269 - InterPro: IPR004815 - InterPro: IPR003111 - InterPro: IPR008268 - InterPro: IPR001984 - InterPro: IPR015947 - InterPro: IPR020568 - PRINTS: PR00830 - SMART: SM00382 - SMART: SM00464 - TIGRFAMs: TIGR00763
Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold
EC number: =3.4.21.53
Molecular weight: Translated: 94788; Mature: 94788
Theoretical pI: Translated: 9.42; Mature: 9.42
Prosite motif: PS01046 LON_SER
Important sites: ACT_SITE 696-696 ACT_SITE 739-739
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.2 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.2 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MEGGPLEPLEDLSGIEENSIIPLDSILPPELFLIPIKSRPVFPGIITPLIVPSGKFAKAV CCCCCCCCHHHHCCCCCCCCCCHHCCCCCCEEEEEECCCCCCCHHHHHHCCCCCHHHHHH EETVKGNSFLGLVLLKDEENEKETSENIYQYGVVAKILKKVNLPDNAVNILVNTIRRFKI HHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH ESFVNKDPLVARVSYPEEEPGAPKNTTKAMMRTLLVMTRELAQNNPLFTEEMKLTMLNVN HHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEECCEEEEEEECC EPGKMADFVCSILNLEKEEYQSVIESNILKTRIEKVLLFLKKEIELVSIQREISDQIQDK CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH IDKQQRQFFLREQLKAIQNELGIKDDKFEKKYEKFLERLKNLNADPEVIEEVTRELDKFS HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC YADPNTGDYNVIRNYLDILESLPWEPAPVREIDLEKAKKTLDKDHYKLEDVKDRILEFLA CCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH VKKLKNDEKGTILLLVGPPGVGKTSIARSIAEAMGRKFFRFSVGGMRDEAEIKGHRRTYI HHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHEEHHHCCCCCCHHHHCCCHHHHC GSMPGKIISALRITKERDCVILLDEIDKLSIGIQGDPASALLEVLDPEQNKNFRDHYLDL CCCCHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHCCCCCCCHHHHHCCC PFDISNVFFIATANTLDSISRILLDRMEIINLSGYITDEKVQIFQKYLWKKVLYKNGVTP CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC YGIEFDKKAIVALIDSYSRESGVRGLEKVTDKLVRKIAIKIVRKESFPKIIQEKDLETFL CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH GVPKFTDERMVRASVPGTALGLAWTSVGGATLLIEALFVKGKGGILLTGMLGKTMEESSN CCCCCCCCCHHEECCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEHHCCHHHHCCC IALSYIKNLLYKEELFNNRMIHLHVPDGATPKDGPSAGITMASAILSLALNTKVKSGFGM HHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC TGELTLTGEVLAIGGLREKIVAAKRVGIHKIIYPKDNLQHLQEIPDYVKKGMYFFPVSRY CEEEEEECCEEEECCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCEEEEECCCH EEVALLLFDEKVISKINPSFRENLKSIVNPTRKLSPKKKTTQKQKLSLSKQKGNNQKKK HHHHHHHCCHHHHHHCCHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC >Mature Secondary Structure MEGGPLEPLEDLSGIEENSIIPLDSILPPELFLIPIKSRPVFPGIITPLIVPSGKFAKAV CCCCCCCCHHHHCCCCCCCCCCHHCCCCCCEEEEEECCCCCCCHHHHHHCCCCCHHHHHH EETVKGNSFLGLVLLKDEENEKETSENIYQYGVVAKILKKVNLPDNAVNILVNTIRRFKI HHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH ESFVNKDPLVARVSYPEEEPGAPKNTTKAMMRTLLVMTRELAQNNPLFTEEMKLTMLNVN HHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEECCEEEEEEECC EPGKMADFVCSILNLEKEEYQSVIESNILKTRIEKVLLFLKKEIELVSIQREISDQIQDK CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH IDKQQRQFFLREQLKAIQNELGIKDDKFEKKYEKFLERLKNLNADPEVIEEVTRELDKFS HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC YADPNTGDYNVIRNYLDILESLPWEPAPVREIDLEKAKKTLDKDHYKLEDVKDRILEFLA CCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH VKKLKNDEKGTILLLVGPPGVGKTSIARSIAEAMGRKFFRFSVGGMRDEAEIKGHRRTYI HHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHEEHHHCCCCCCHHHHCCCHHHHC GSMPGKIISALRITKERDCVILLDEIDKLSIGIQGDPASALLEVLDPEQNKNFRDHYLDL CCCCHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHCCCCCCCHHHHHCCC PFDISNVFFIATANTLDSISRILLDRMEIINLSGYITDEKVQIFQKYLWKKVLYKNGVTP CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC YGIEFDKKAIVALIDSYSRESGVRGLEKVTDKLVRKIAIKIVRKESFPKIIQEKDLETFL CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH GVPKFTDERMVRASVPGTALGLAWTSVGGATLLIEALFVKGKGGILLTGMLGKTMEESSN CCCCCCCCCHHEECCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEHHCCHHHHCCC IALSYIKNLLYKEELFNNRMIHLHVPDGATPKDGPSAGITMASAILSLALNTKVKSGFGM HHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC TGELTLTGEVLAIGGLREKIVAAKRVGIHKIIYPKDNLQHLQEIPDYVKKGMYFFPVSRY CEEEEEECCEEEECCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCEEEEECCCH EEVALLLFDEKVISKINPSFRENLKSIVNPTRKLSPKKKTTQKQKLSLSKQKGNNQKKK HHHHHHHCCHHHHHHCCHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA