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The map label for this gene is acdA [H]

Identifier: 45656481

GI number: 45656481

Start: 709204

End: 710517

Strand: Reverse

Name: acdA [H]

Synonym: LIC10583

Alternate gene names: 45656481

Gene position: 710517-709204 (Counterclockwise)

Preceding gene: 45656483

Following gene: 45656480

Centisome position: 16.61

GC content: 43.61

Gene sequence:

>1314_bases
TTGACGGTAGAAGATTCTCTTCGAATCCTGCATACAGAGCTTTGTCCCAAAACCGATTTCGAGGCCGAACCGGAAAACCA
AATCCAGTCCATCGGCAATCCAGGCGGGATGTCTGGGACCGTTCAATTTCGACCAAGGTGTACTATAAAAATGGAATTCG
CTCTTTCCAGTGAACAAAAAGAATTACGTGATCTCGCCAGAAAATTTGCCAAAGAGGAAATTCGCCCAAAAGCAGAGCAT
CACGATCATACGGGGGAATACCCACTTGCAGTCTTAAAAAAAGCCTGGGAAATCGGATTGATGAATATTCATATCGAACC
CAGATTTAACGGTGCGGGGATGCAAGAATTAGACGATGTAATCATCGGAGAAGAACTTTTCTGGGGATGTTCCGCTATGG
CAACCGCCATTCTTGCAAATAACTTAGCATTAGCACCGGTTCTTTTAGGAGCAAACGATCGAATCAAAAAAGAATTCGTT
CAACCTATGACCGAAGAATTTAAGCTCGCGGCATATGCAGTGACCGAACCAGGCGCTGGATCAGACGTGGCCGCCATTCG
CACTTCCGCAAAAAAAGTTGGAGACGAATATATCCTCAATGGATCTAAAATGTGGATTACTAACGCCGGTTATGCGGATT
GGTTTTTCGTACTTACTAAAACAGATCCATCAGCAGGTCATAAAGGAATCACCGGATTTATCGTAGATTCAAAAACTCCC
GGAATTATCATGGGAAAGAAAGAAATCAATATGGGACAGAAATGTTCCGACACGCGTGGAATCACATTTGAAGACGTGAA
AGTTCCTGCTTGGCAAATGATCGGACGAGAAGGAGAAGGTTTTAAAATCGCCATGGGTGCCTTCGATCATACACGCCCAG
GAGTTGCAATTGGAGCAGTAGGAGTTGCACGCGCCGCGATGGAACATTCTATCCAATACGCAAATACTCGTAATACTTTC
GGTCGCCCGATTATGGAAAATCAGGGAATCTCCTTTATGATCGCTGAAATGGCTAGAGATATAGAAGCAGGAAGACTTCT
CTGTTATCAAGCTGCTTGGATGATTGATAATGGATTTAGAAATACATACCAAGCCTCGATCGCCAAAATGTTTTGTGCGG
ATATGTGTATGAGAGTTTGTACAGATGCAGTTCAAGTTTTAGGAGGATATGGGTTTAACACCGAATATCCGGTTGAAAAA
TTAATGAGAGACGCGAAAATTTTCCAAATTTACGAAGGTACTTCTCAAATCCAAAGAATGATCGTTTCTCGTTTCCTCGC
AGACGGAAAGGGAATCGAGGGGCCGAACTTCTGA

Upstream 100 bases:

>100_bases
AAAAAGCAAAAAAAGTTCCAGTTGGAATCAGGATCGATTGAGCAACAGACGGAAAAAATTACTTCTTTAAAGAGCACTTG
CATTTCACTTTCGTACCTTC

Downstream 100 bases:

>100_bases
AAGAATTCTCACTCACATTCGAAGAATTTTCCGTTCAAGCAGAACGTGGAAATTTAATTCCTATCTTCAAACAGATCTTT
TTAGATATGGAAACTCCAGT

Product: acyl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTVEDSLRILHTELCPKTDFEAEPENQIQSIGNPGGMSGTVQFRPRCTIKMEFALSSEQKELRDLARKFAKEEIRPKAEH
HDHTGEYPLAVLKKAWEIGLMNIHIEPRFNGAGMQELDDVIIGEELFWGCSAMATAILANNLALAPVLLGANDRIKKEFV
QPMTEEFKLAAYAVTEPGAGSDVAAIRTSAKKVGDEYILNGSKMWITNAGYADWFFVLTKTDPSAGHKGITGFIVDSKTP
GIIMGKKEINMGQKCSDTRGITFEDVKVPAWQMIGREGEGFKIAMGAFDHTRPGVAIGAVGVARAAMEHSIQYANTRNTF
GRPIMENQGISFMIAEMARDIEAGRLLCYQAAWMIDNGFRNTYQASIAKMFCADMCMRVCTDAVQVLGGYGFNTEYPVEK
LMRDAKIFQIYEGTSQIQRMIVSRFLADGKGIEGPNF

Sequences:

>Translated_437_residues
MTVEDSLRILHTELCPKTDFEAEPENQIQSIGNPGGMSGTVQFRPRCTIKMEFALSSEQKELRDLARKFAKEEIRPKAEH
HDHTGEYPLAVLKKAWEIGLMNIHIEPRFNGAGMQELDDVIIGEELFWGCSAMATAILANNLALAPVLLGANDRIKKEFV
QPMTEEFKLAAYAVTEPGAGSDVAAIRTSAKKVGDEYILNGSKMWITNAGYADWFFVLTKTDPSAGHKGITGFIVDSKTP
GIIMGKKEINMGQKCSDTRGITFEDVKVPAWQMIGREGEGFKIAMGAFDHTRPGVAIGAVGVARAAMEHSIQYANTRNTF
GRPIMENQGISFMIAEMARDIEAGRLLCYQAAWMIDNGFRNTYQASIAKMFCADMCMRVCTDAVQVLGGYGFNTEYPVEK
LMRDAKIFQIYEGTSQIQRMIVSRFLADGKGIEGPNF
>Mature_436_residues
TVEDSLRILHTELCPKTDFEAEPENQIQSIGNPGGMSGTVQFRPRCTIKMEFALSSEQKELRDLARKFAKEEIRPKAEHH
DHTGEYPLAVLKKAWEIGLMNIHIEPRFNGAGMQELDDVIIGEELFWGCSAMATAILANNLALAPVLLGANDRIKKEFVQ
PMTEEFKLAAYAVTEPGAGSDVAAIRTSAKKVGDEYILNGSKMWITNAGYADWFFVLTKTDPSAGHKGITGFIVDSKTPG
IIMGKKEINMGQKCSDTRGITFEDVKVPAWQMIGREGEGFKIAMGAFDHTRPGVAIGAVGVARAAMEHSIQYANTRNTFG
RPIMENQGISFMIAEMARDIEAGRLLCYQAAWMIDNGFRNTYQASIAKMFCADMCMRVCTDAVQVLGGYGFNTEYPVEKL
MRDAKIFQIYEGTSQIQRMIVSRFLADGKGIEGPNF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557231, Length=375, Percent_Identity=57.0666666666667, Blast_Score=449, Evalue=1e-126,
Organism=Homo sapiens, GI187960098, Length=375, Percent_Identity=57.0666666666667, Blast_Score=448, Evalue=1e-126,
Organism=Homo sapiens, GI4557233, Length=385, Percent_Identity=37.6623376623377, Blast_Score=266, Evalue=4e-71,
Organism=Homo sapiens, GI7656849, Length=397, Percent_Identity=36.0201511335013, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI4501859, Length=386, Percent_Identity=34.4559585492228, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI226958412, Length=403, Percent_Identity=32.0099255583127, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI226958414, Length=340, Percent_Identity=32.3529411764706, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI21361497, Length=365, Percent_Identity=32.0547945205479, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=31.8181818181818, Blast_Score=185, Evalue=9e-47,
Organism=Homo sapiens, GI4557235, Length=340, Percent_Identity=32.0588235294118, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI76496475, Length=340, Percent_Identity=32.0588235294118, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI4503943, Length=378, Percent_Identity=24.3386243386243, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI7669494, Length=365, Percent_Identity=23.2876712328767, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI48976061, Length=280, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI211971008, Length=280, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI38505218, Length=325, Percent_Identity=25.2307692307692, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1786223, Length=252, Percent_Identity=35.3174603174603, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87081958, Length=381, Percent_Identity=30.7086614173228, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI87082384, Length=289, Percent_Identity=24.9134948096886, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=54.353562005277, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17569725, Length=400, Percent_Identity=49.5, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17534899, Length=380, Percent_Identity=51.8421052631579, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17508101, Length=394, Percent_Identity=34.7715736040609, Blast_Score=251, Evalue=6e-67,
Organism=Caenorhabditis elegans, GI17533517, Length=374, Percent_Identity=36.3636363636364, Blast_Score=247, Evalue=8e-66,
Organism=Caenorhabditis elegans, GI17506239, Length=364, Percent_Identity=32.967032967033, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=32.8912466843501, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI71985184, Length=357, Percent_Identity=31.6526610644258, Blast_Score=195, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI71990804, Length=292, Percent_Identity=34.2465753424658, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71982178, Length=304, Percent_Identity=30.2631578947368, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI17551932, Length=362, Percent_Identity=29.8342541436464, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17505929, Length=362, Percent_Identity=29.8342541436464, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71985192, Length=317, Percent_Identity=29.6529968454259, Blast_Score=151, Evalue=8e-37,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=33.6099585062241, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17534353, Length=374, Percent_Identity=26.4705882352941, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI32563615, Length=240, Percent_Identity=30, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17562446, Length=281, Percent_Identity=26.3345195729537, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17531913, Length=177, Percent_Identity=28.2485875706215, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24660351, Length=375, Percent_Identity=54.1333333333333, Blast_Score=421, Evalue=1e-118,
Organism=Drosophila melanogaster, GI24646207, Length=377, Percent_Identity=38.4615384615385, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=38.2749326145553, Blast_Score=261, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24666513, Length=391, Percent_Identity=34.0153452685422, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=32.9815303430079, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI281363737, Length=387, Percent_Identity=31.0077519379845, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=26.7716535433071, Blast_Score=134, Evalue=9e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 48346; Mature: 48215

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVEDSLRILHTELCPKTDFEAEPENQIQSIGNPGGMSGTVQFRPRCTIKMEFALSSEQK
CCCCHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCEEEECCEEEEEEEEECCCHHH
ELRDLARKFAKEEIRPKAEHHDHTGEYPLAVLKKAWEIGLMNIHIEPRFNGAGMQELDDV
HHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHEEEEEEEEECCCCCCCHHHHHHH
IIGEELFWGCSAMATAILANNLALAPVLLGANDRIKKEFVQPMTEEFKLAAYAVTEPGAG
HHCHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHEEEEEEEECCCCC
SDVAAIRTSAKKVGDEYILNGSKMWITNAGYADWFFVLTKTDPSAGHKGITGFIVDSKTP
CCHHHHHHHHHHCCHHHEECCCEEEEEECCCCEEEEEEEECCCCCCCCCCEEEEEECCCC
GIIMGKKEINMGQKCSDTRGITFEDVKVPAWQMIGREGEGFKIAMGAFDHTRPGVAIGAV
CEEECCHHCCCCCCCCCCCCCEEECCCCCHHHHHCCCCCCEEEEECCCCCCCCCEEEHHH
GVARAAMEHSIQYANTRNTFGRPIMENQGISFMIAEMARDIEAGRLLCYQAAWMIDNGFR
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEHHHHHHCCCCC
NTYQASIAKMFCADMCMRVCTDAVQVLGGYGFNTEYPVEKLMRDAKIFQIYEGTSQIQRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECCHHHHHHH
IVSRFLADGKGIEGPNF
HHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TVEDSLRILHTELCPKTDFEAEPENQIQSIGNPGGMSGTVQFRPRCTIKMEFALSSEQK
CCCHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCCEEEECCEEEEEEEEECCCHHH
ELRDLARKFAKEEIRPKAEHHDHTGEYPLAVLKKAWEIGLMNIHIEPRFNGAGMQELDDV
HHHHHHHHHHHHHCCCCHHCCCCCCCCHHHHHHHHHHEEEEEEEEECCCCCCCHHHHHHH
IIGEELFWGCSAMATAILANNLALAPVLLGANDRIKKEFVQPMTEEFKLAAYAVTEPGAG
HHCHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHEEEEEEEECCCCC
SDVAAIRTSAKKVGDEYILNGSKMWITNAGYADWFFVLTKTDPSAGHKGITGFIVDSKTP
CCHHHHHHHHHHCCHHHEECCCEEEEEECCCCEEEEEEEECCCCCCCCCCEEEEEECCCC
GIIMGKKEINMGQKCSDTRGITFEDVKVPAWQMIGREGEGFKIAMGAFDHTRPGVAIGAV
CEEECCHHCCCCCCCCCCCCCEEECCCCCHHHHHCCCCCCEEEEECCCCCCCCCEEEHHH
GVARAAMEHSIQYANTRNTFGRPIMENQGISFMIAEMARDIEAGRLLCYQAAWMIDNGFR
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEHHHHHHCCCCC
NTYQASIAKMFCADMCMRVCTDAVQVLGGYGFNTEYPVEKLMRDAKIFQIYEGTSQIQRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHEEEECCHHHHHHH
IVSRFLADGKGIEGPNF
HHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]