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The map label for this gene is yfjP [H]

Identifier: 45656143

GI number: 45656143

Start: 274139

End: 274825

Strand: Direct

Name: yfjP [H]

Synonym: LIC10238

Alternate gene names: 45656143

Gene position: 274139-274825 (Clockwise)

Preceding gene: 45656142

Following gene: 45656144

Centisome position: 6.41

GC content: 35.66

Gene sequence:

>687_bases
ATGTCTTCTCCAAATTCTTCCCAATCGACTAATTTTAAAAAACGTTCTTCTAACGTTTTGGAAAATAGAGAAGTTCGTCT
TAAAAAGGCATCTAGTTGGCTTCGTAAAAAAGACCCGATTACAAAAAAATTGATCGATTCTATTGGTCTTTGTAAATTAA
AAACCATTGGAACCCCTTATCAAGTTTTAATTAAATCCGTTTTAGGACAACAGCTTTCCGTTAAAGTTGCACTGACTTTT
GAACGTAGATTGATTTCTTTGGTTGGAAGCAAAAAAATTCCTTCGCCCGAACAGATTTTGAAAATACCGAACGATGAGAT
GAGAAAGATCGGAGTTTCTCAAGCCAAGACGGAAACGATCAAACGTATCGCTGAGGCCTACTTAAAACGGAGTATCACTG
ATTCTAAACTTCACAAATTAGAAGATTCTGATGTTCTAAAACTTCTTTGTTCTATTAAAGGTGTGGGGCCTTGGACCGCG
GAAATGGTGTTGATTTTTGCTTTGGATCGTTGGGATCATTTCTCCATTAATGATCTCATACTTAGAAAATCAGTCGAAAA
ACACTATGGAATTTCTAAAGATAATAAAAAGGAAATTCAACTTTTTTTAAATACGTATTCTCCTTATAGAACAATTCTTT
CCTGGTATCTTTGGGCAGATATTGACGGTGGAGAGGGTTGGGGGTAA

Upstream 100 bases:

>100_bases
ATTTAGTAGAACTAGAAAAGTTAGTCCATGTTTATAGAAAAAAATCTCAGATGGAAAACAAACTCAAAAAAAGAGTATAA
CAACACTTTCTTGAGTTTGA

Downstream 100 bases:

>100_bases
TATTAGAGTTTTTGAATGATTCTATAGTGAAGATTCGTAAAACTGTTTCGATTATCCATTTCAATACAACAAAAACGGAT
CAAGAATTAATTTTTTAACA

Product: 3-methyladenine DNA glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MSSPNSSQSTNFKKRSSNVLENREVRLKKASSWLRKKDPITKKLIDSIGLCKLKTIGTPYQVLIKSVLGQQLSVKVALTF
ERRLISLVGSKKIPSPEQILKIPNDEMRKIGVSQAKTETIKRIAEAYLKRSITDSKLHKLEDSDVLKLLCSIKGVGPWTA
EMVLIFALDRWDHFSINDLILRKSVEKHYGISKDNKKEIQLFLNTYSPYRTILSWYLWADIDGGEGWG

Sequences:

>Translated_228_residues
MSSPNSSQSTNFKKRSSNVLENREVRLKKASSWLRKKDPITKKLIDSIGLCKLKTIGTPYQVLIKSVLGQQLSVKVALTF
ERRLISLVGSKKIPSPEQILKIPNDEMRKIGVSQAKTETIKRIAEAYLKRSITDSKLHKLEDSDVLKLLCSIKGVGPWTA
EMVLIFALDRWDHFSINDLILRKSVEKHYGISKDNKKEIQLFLNTYSPYRTILSWYLWADIDGGEGWG
>Mature_227_residues
SSPNSSQSTNFKKRSSNVLENREVRLKKASSWLRKKDPITKKLIDSIGLCKLKTIGTPYQVLIKSVLGQQLSVKVALTFE
RRLISLVGSKKIPSPEQILKIPNDEMRKIGVSQAKTETIKRIAEAYLKRSITDSKLHKLEDSDVLKLLCSIKGVGPWTAE
MVLIFALDRWDHFSINDLILRKSVEKHYGISKDNKKEIQLFLNTYSPYRTILSWYLWADIDGGEGWG

Specific function: Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, 3-methylguanine, 7-methylguanine, O2- methylthymine, and O2-methylcytosine from the damaged DNA polymer formed by alkylation lesions [H]

COG id: COG0122

COG function: function code L; 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alkylbase DNA glycosidase alkA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003265
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: =3.2.2.21 [H]

Molecular weight: Translated: 26006; Mature: 25874

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPNSSQSTNFKKRSSNVLENREVRLKKASSWLRKKDPITKKLIDSIGLCKLKTIGTPY
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEECCCCH
QVLIKSVLGQQLSVKVALTFERRLISLVGSKKIPSPEQILKIPNDEMRKIGVSQAKTETI
HHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHCCHHHHHHHH
KRIAEAYLKRSITDSKLHKLEDSDVLKLLCSIKGVGPWTAEMVLIFALDRWDHFSINDLI
HHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHH
LRKSVEKHYGISKDNKKEIQLFLNTYSPYRTILSWYLWADIDGGEGWG
HHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCC
>Mature Secondary Structure 
SSPNSSQSTNFKKRSSNVLENREVRLKKASSWLRKKDPITKKLIDSIGLCKLKTIGTPY
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEECCCCH
QVLIKSVLGQQLSVKVALTFERRLISLVGSKKIPSPEQILKIPNDEMRKIGVSQAKTETI
HHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHCCHHHHHHHH
KRIAEAYLKRSITDSKLHKLEDSDVLKLLCSIKGVGPWTAEMVLIFALDRWDHFSINDLI
HHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHH
LRKSVEKHYGISKDNKKEIQLFLNTYSPYRTILSWYLWADIDGGEGWG
HHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969503; 9384377 [H]