Click here to switch to the map view.

The map label for this gene is crp [C]

Identifier: 45656142

GI number: 45656142

Start: 272901

End: 274118

Strand: Direct

Name: crp [C]

Synonym: LIC10237

Alternate gene names: 45656142

Gene position: 272901-274118 (Clockwise)

Preceding gene: 45656141

Following gene: 45656143

Centisome position: 6.38

GC content: 38.1

Gene sequence:

>1218_bases
ATGTCCACAGGGATCTTCCAAATCGTTAATTTCCAAAAAGGCTCCTACATTATCGTAGAAGGTAAAAAGGATTCCCCTAG
TTTTTTTATTATTCGAGAAGGAAAGGTAAAAATAGGCAGAGAAAATCCGGTTGTTGGCGAAGATCCGAATTCGGTTCAAG
GTCCAGGGGATTTTTTCGGAGTTGTCGCCGCTATGAGCCAACACGCTCAAATTGAGTCTGCAGTTGCGTTGACCGATGTT
TCGGTAATCGAGGTAAGTTACGATCAATTCGGAACTCTCATTCAAAGAAACACTCCGGTTGCAATGAAAATCATTCGTTA
TTTTTCCATGAAACTACGTCAGTTTGATCAGACGATTACTCGTCTTACGTTTCGTTCTGCGGTAGAAGAAGATCCGAATG
AACTCTACAACATCGGGGAGAATTATTTTAATCAGAAGAATAATCACCACGCTGCTTACGCTTTCCAAAAATATCTTCAA
TATCTTCCAAACGGGCCGTTCGCTACTCAGGCTAAACTAAAGTTGCAAACGATGAATCAACCGATGCAGTCTCCTGTAAT
TGATCTCACTAAATTCAATCGTATGTATGCGGATAATGAAATGATCTTTTGCGAACACGAACCCGGCAGAGAATTGTATA
TCATTCAAAACGGAAAAGTGAAGATCACTAAGATAGTAGATAAAAACGAAGTATTACTAGCGGTTCTTCAGAACGGAGAT
ATTTTTGGTGAGATGGCTCTTTTAGATAACAAACCTAGATCTGCTTCGGCGATTGCATGGGGCCACGTTCAACTTCTCGC
GATCAACAAAGCCAACTTTGAAGGTATGGTTAAGGCACAACCTCAACTTGCAACTCGTTTGATCACACTTCTTTCTGAAA
GAATTTGGACCGCTTACAAACAACTTGCGAATTTGATGATCAATGATCCGCAGGGTAGAATTGCAGACACTCTGTTAACT
CTTGTTGAAAAAAATAGAATTAAAATTACTCCGAAAGTTTTATATAACTTTGAAATAGGTACGAAGGACTTGATAAAAAT
GGTAGGTCTTTCTTATCCAAAAGACGAAAACTTAGTTTTGGATCTTTTAACTAAAAACAAATGGATCAAACTGGATCAGG
GTAAATTGAGTTGTACCGATTTAGTAGAACTAGAAAAGTTAGTCCATGTTTATAGAAAAAAATCTCAGATGGAAAACAAA
CTCAAAAAAAGAGTATAA

Upstream 100 bases:

>100_bases
TGCGCAGAAAAGTAGCTCTTTTTTTAGAGATTGGATTCTTGAAAGCCGATAATGAAAACAGTTGAACTCTGATTTTCAAA
AAAAATATTAACATTACAGC

Downstream 100 bases:

>100_bases
CAACACTTTCTTGAGTTTGAATGTCTTCTCCAAATTCTTCCCAATCGACTAATTTTAAAAAACGTTCTTCTAACGTTTTG
GAAAATAGAGAAGTTCGTCT

Product: cyclic nucleotide binding protein

Products: NA

Alternate protein names: Crp/Fnr Family Transcriptional Regulator; Crp/FNR Family Transcriptional Regulator; Transcriptional Regulator; CRP/FNR Family Transcriptional Regulator; Crp Family Transcriptional Regulator; Catabolite Gene Activator; Transcriptional Regulatory Protein; CRP Family Transcriptional Regulator; Transcription Regulator; Transcriptional Regulator Crp/Fnr Family Protein; Cyclic AMP Receptor Protein; Transcriptional Regulator MrpC; CAMP-Dependent Protein Kinase; Transcriptional Regulator Crp

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MSTGIFQIVNFQKGSYIIVEGKKDSPSFFIIREGKVKIGRENPVVGEDPNSVQGPGDFFGVVAAMSQHAQIESAVALTDV
SVIEVSYDQFGTLIQRNTPVAMKIIRYFSMKLRQFDQTITRLTFRSAVEEDPNELYNIGENYFNQKNNHHAAYAFQKYLQ
YLPNGPFATQAKLKLQTMNQPMQSPVIDLTKFNRMYADNEMIFCEHEPGRELYIIQNGKVKITKIVDKNEVLLAVLQNGD
IFGEMALLDNKPRSASAIAWGHVQLLAINKANFEGMVKAQPQLATRLITLLSERIWTAYKQLANLMINDPQGRIADTLLT
LVEKNRIKITPKVLYNFEIGTKDLIKMVGLSYPKDENLVLDLLTKNKWIKLDQGKLSCTDLVELEKLVHVYRKKSQMENK
LKKRV

Sequences:

>Translated_405_residues
MSTGIFQIVNFQKGSYIIVEGKKDSPSFFIIREGKVKIGRENPVVGEDPNSVQGPGDFFGVVAAMSQHAQIESAVALTDV
SVIEVSYDQFGTLIQRNTPVAMKIIRYFSMKLRQFDQTITRLTFRSAVEEDPNELYNIGENYFNQKNNHHAAYAFQKYLQ
YLPNGPFATQAKLKLQTMNQPMQSPVIDLTKFNRMYADNEMIFCEHEPGRELYIIQNGKVKITKIVDKNEVLLAVLQNGD
IFGEMALLDNKPRSASAIAWGHVQLLAINKANFEGMVKAQPQLATRLITLLSERIWTAYKQLANLMINDPQGRIADTLLT
LVEKNRIKITPKVLYNFEIGTKDLIKMVGLSYPKDENLVLDLLTKNKWIKLDQGKLSCTDLVELEKLVHVYRKKSQMENK
LKKRV
>Mature_404_residues
STGIFQIVNFQKGSYIIVEGKKDSPSFFIIREGKVKIGRENPVVGEDPNSVQGPGDFFGVVAAMSQHAQIESAVALTDVS
VIEVSYDQFGTLIQRNTPVAMKIIRYFSMKLRQFDQTITRLTFRSAVEEDPNELYNIGENYFNQKNNHHAAYAFQKYLQY
LPNGPFATQAKLKLQTMNQPMQSPVIDLTKFNRMYADNEMIFCEHEPGRELYIIQNGKVKITKIVDKNEVLLAVLQNGDI
FGEMALLDNKPRSASAIAWGHVQLLAINKANFEGMVKAQPQLATRLITLLSERIWTAYKQLANLMINDPQGRIADTLLTL
VEKNRIKITPKVLYNFEIGTKDLIKMVGLSYPKDENLVLDLLTKNKWIKLDQGKLSCTDLVELEKLVHVYRKKSQMENKL
KKRV

Specific function: This Protein Complexes With Cyclic AMP And Binds To Specific DNA Sites Near The Promoter To Regulate The Transcription Of Several Catabolite-Sensitive Operons. The Protein Induces A Severe Bend In The DNA. Acts As A Negative Regulator Of Its Own Synthesi

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 46126; Mature: 45995

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00889 CNMP_BINDING_2 ; PS50042 CNMP_BINDING_3 ; PS50005 TPR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTGIFQIVNFQKGSYIIVEGKKDSPSFFIIREGKVKIGRENPVVGEDPNSVQGPGDFFG
CCCCEEEEEEECCCCEEEEECCCCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCHHHHH
VVAAMSQHAQIESAVALTDVSVIEVSYDQFGTLIQRNTPVAMKIIRYFSMKLRQFDQTIT
HHHHHHHHHHHHHHHEEECEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
RLTFRSAVEEDPNELYNIGENYFNQKNNHHAAYAFQKYLQYLPNGPFATQAKLKLQTMNQ
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHEEEEEHHCC
PMQSPVIDLTKFNRMYADNEMIFCEHEPGRELYIIQNGKVKITKIVDKNEVLLAVLQNGD
CCCCCCHHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCEEEEEEECCCCEEEEEEECCC
IFGEMALLDNKPRSASAIAWGHVQLLAINKANFEGMVKAQPQLATRLITLLSERIWTAYK
CEEEEEEECCCCCCCCEEEECCEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHH
QLANLMINDPQGRIADTLLTLVEKNRIKITPKVLYNFEIGTKDLIKMVGLSYPKDENLVL
HHHHHEECCCCCHHHHHHHHHHHCCCEEEEEEEEEEEECCHHHHHHHHCCCCCCCCCEEE
DLLTKNKWIKLDQGKLSCTDLVELEKLVHVYRKKSQMENKLKKRV
EEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STGIFQIVNFQKGSYIIVEGKKDSPSFFIIREGKVKIGRENPVVGEDPNSVQGPGDFFG
CCCEEEEEEECCCCEEEEECCCCCCCEEEEECCEEEECCCCCCCCCCCCCCCCCHHHHH
VVAAMSQHAQIESAVALTDVSVIEVSYDQFGTLIQRNTPVAMKIIRYFSMKLRQFDQTIT
HHHHHHHHHHHHHHHEEECEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
RLTFRSAVEEDPNELYNIGENYFNQKNNHHAAYAFQKYLQYLPNGPFATQAKLKLQTMNQ
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHEEEEEHHCC
PMQSPVIDLTKFNRMYADNEMIFCEHEPGRELYIIQNGKVKITKIVDKNEVLLAVLQNGD
CCCCCCHHHHHHHHHCCCCCEEEEECCCCCEEEEEECCCEEEEEEECCCCEEEEEEECCC
IFGEMALLDNKPRSASAIAWGHVQLLAINKANFEGMVKAQPQLATRLITLLSERIWTAYK
CEEEEEEECCCCCCCCEEEECCEEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHH
QLANLMINDPQGRIADTLLTLVEKNRIKITPKVLYNFEIGTKDLIKMVGLSYPKDENLVL
HHHHHEECCCCCHHHHHHHHHHHCCCEEEEEEEEEEEECCHHHHHHHHCCCCCCCCCEEE
DLLTKNKWIKLDQGKLSCTDLVELEKLVHVYRKKSQMENKLKKRV
EEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA