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The map label for this gene is lolE

Identifier: 45656137

GI number: 45656137

Start: 267347

End: 268723

Strand: Direct

Name: lolE

Synonym: LIC10232

Alternate gene names: 45656137

Gene position: 267347-268723 (Clockwise)

Preceding gene: 45656133

Following gene: 45656138

Centisome position: 6.25

GC content: 36.82

Gene sequence:

>1377_bases
TTGATGAAGGTAAATTTGTTCCGAGGCTCTTTGATATTTCTGGTAACTTCTCGTTATATTCGAGGTTCACGAGTTGCTGG
TCTTCTCTCGTTAAAGTCTAGATTGTCGTTTATCGTTATGGCCGTTGGGGTTTCTCTTCTCATTGTGGTCTTATCCATAT
TCAACGGTTTTCAAAGACAAGTAAAAGAATCACTTTGGCAAGGTGGACCTCATATCACCGTAGAAAACAAATTTGATTCT
GGTGATATTAAAAATTATGAAAAGATAATTGCTTGGCTAAGTAGGAATCCTTATCTAAAAGATAGAATCGTTTCTATTGG
AGGAAGTATTACGAGTCACGGTTTGATTCAAAATACAAACTCGTTTATTCCTATTATGGTGCGTGCTCTTCCTGTTGAAA
ACATTCATGATCTCGTAGGAAATAAACTTACTAACTTTCCTAGAATCGTTCATCATAGCCGCGAAGAAATCGCAAGATAC
AACGTCGAAAATCAGGTTCTAATCGGAAAGGAAATGGCGGGTATCTACGACTTTGATTTAGGGGCAAATCTGACTATGGC
CGTTCCAGGAGGTAGGTTTTCTCTCGGAAAGGGAGTGGATGTTTCTATCAAAACATTTCGTACGGTGGGCTTTTTTAAAA
CTGGTTATTATAACTACGATACACATTACGTTTTTCTTTCGCTTCCGGTTGCACAAAAATTTTTTAATCTAAAAGATTCT
GTAAATCAAATCGCGATCAAAGTAAAATCTTTGGACGATTTACAAAATTGTAAAAAGGAAATTTTAAAAGAATTCAGAAA
TCCAGATTTTGAAAATGAGATCGGTTATTCCGCTTCTTTTAGCGTAAGAACGATTGCAGAAGAGCAAGAGAATTTTTTCA
CTGCTTTGAAGTTGGAAAAGACAATTATCTCTATTATAGTTTTCTTATTTATTATTCTCGCTGCATTAGGAATGGTTGCA
AGCGTTTATAGTTTAGTGAGGGCAAAAAGAAAATCGATCGGAGTTTTAAAAGCTCTTGGTTTACCTTCTTCCGGCGTTTT
ATTGATCTTTACTTTGAACGCTATGGTTGTCGGAGTTCTTGCTTCTCTTGTAGGAGGAGTTTCCGGAATTTTTATTGCGA
GTAATTTGGAAACGATTGTAAACGGACTTTCCGAGCTTATCAACATGGTGGGATATTATTTTTATCATTCCGAATGGACG
AATGTGGAGCTGGTTCCTAAAGACGTTTATTACTTTGATCATATTCCTGTGGATATTGATATTTCATTTATTTTTATGGT
TACTACTGCCGCTACGATTTTATCCGGAATTGCGGGTTATTTTCCTGCGAGATGGGCGGCTGGTCTCAATCCTGTGGATA
CGATAAGGAACGACTAA

Upstream 100 bases:

>100_bases
TTGTGCTTGAAAAACTTTCTTCTTTATTTTTGACATTCTGGTTCGGATTCAGAGAATTGTCAAACTAAGGAAGGATTTCC
CTTCTAATTTTAAGAGTTTT

Downstream 100 bases:

>100_bases
CGTGAGTCTGATCAAAGTAAGAAATTTAGTAAAAAATTATCATATTCTAGATAAAGAATTTAAGATTTTGGATCATTTAG
ATCTGGACGTTGAAGAAGGC

Product: lipoprotein releasing system transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MMKVNLFRGSLIFLVTSRYIRGSRVAGLLSLKSRLSFIVMAVGVSLLIVVLSIFNGFQRQVKESLWQGGPHITVENKFDS
GDIKNYEKIIAWLSRNPYLKDRIVSIGGSITSHGLIQNTNSFIPIMVRALPVENIHDLVGNKLTNFPRIVHHSREEIARY
NVENQVLIGKEMAGIYDFDLGANLTMAVPGGRFSLGKGVDVSIKTFRTVGFFKTGYYNYDTHYVFLSLPVAQKFFNLKDS
VNQIAIKVKSLDDLQNCKKEILKEFRNPDFENEIGYSASFSVRTIAEEQENFFTALKLEKTIISIIVFLFIILAALGMVA
SVYSLVRAKRKSIGVLKALGLPSSGVLLIFTLNAMVVGVLASLVGGVSGIFIASNLETIVNGLSELINMVGYYFYHSEWT
NVELVPKDVYYFDHIPVDIDISFIFMVTTAATILSGIAGYFPARWAAGLNPVDTIRND

Sequences:

>Translated_458_residues
MMKVNLFRGSLIFLVTSRYIRGSRVAGLLSLKSRLSFIVMAVGVSLLIVVLSIFNGFQRQVKESLWQGGPHITVENKFDS
GDIKNYEKIIAWLSRNPYLKDRIVSIGGSITSHGLIQNTNSFIPIMVRALPVENIHDLVGNKLTNFPRIVHHSREEIARY
NVENQVLIGKEMAGIYDFDLGANLTMAVPGGRFSLGKGVDVSIKTFRTVGFFKTGYYNYDTHYVFLSLPVAQKFFNLKDS
VNQIAIKVKSLDDLQNCKKEILKEFRNPDFENEIGYSASFSVRTIAEEQENFFTALKLEKTIISIIVFLFIILAALGMVA
SVYSLVRAKRKSIGVLKALGLPSSGVLLIFTLNAMVVGVLASLVGGVSGIFIASNLETIVNGLSELINMVGYYFYHSEWT
NVELVPKDVYYFDHIPVDIDISFIFMVTTAATILSGIAGYFPARWAAGLNPVDTIRND
>Mature_458_residues
MMKVNLFRGSLIFLVTSRYIRGSRVAGLLSLKSRLSFIVMAVGVSLLIVVLSIFNGFQRQVKESLWQGGPHITVENKFDS
GDIKNYEKIIAWLSRNPYLKDRIVSIGGSITSHGLIQNTNSFIPIMVRALPVENIHDLVGNKLTNFPRIVHHSREEIARY
NVENQVLIGKEMAGIYDFDLGANLTMAVPGGRFSLGKGVDVSIKTFRTVGFFKTGYYNYDTHYVFLSLPVAQKFFNLKDS
VNQIAIKVKSLDDLQNCKKEILKEFRNPDFENEIGYSASFSVRTIAEEQENFFTALKLEKTIISIIVFLFIILAALGMVA
SVYSLVRAKRKSIGVLKALGLPSSGVLLIFTLNAMVVGVLASLVGGVSGIFIASNLETIVNGLSELINMVGYYFYHSEWT
NVELVPKDVYYFDHIPVDIDISFIFMVTTAATILSGIAGYFPARWAAGLNPVDTIRND

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=441, Percent_Identity=23.8095238095238, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 50975; Mature: 50975

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKVNLFRGSLIFLVTSRYIRGSRVAGLLSLKSRLSFIVMAVGVSLLIVVLSIFNGFQRQ
CEEEEEECCHHEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKESLWQGGPHITVENKFDSGDIKNYEKIIAWLSRNPYLKDRIVSIGGSITSHGLIQNTN
HHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCHHCCCCCCCCC
SFIPIMVRALPVENIHDLVGNKLTNFPRIVHHSREEIARYNVENQVLIGKEMAGIYDFDL
CCHHHHHHHCCHHHHHHHHCCHHHCCHHHHHCCHHHHHHHCCCCCEEEEHHHCCEEEECC
GANLTMAVPGGRFSLGKGVDVSIKTFRTVGFFKTGYYNYDTHYVFLSLPVAQKFFNLKDS
CCCEEEECCCCCEECCCCCCEEHHHHHHHHEEECCEEECCCEEEEEECHHHHHHHHHHHH
VNQIAIKVKSLDDLQNCKKEILKEFRNPDFENEIGYSASFSVRTIAEEQENFFTALKLEK
HHHHEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TIISIIVFLFIILAALGMVASVYSLVRAKRKSIGVLKALGLPSSGVLLIFTLNAMVVGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEHHHHHHHHHH
ASLVGGVSGIFIASNLETIVNGLSELINMVGYYFYHSEWTNVELVPKDVYYFDHIPVDID
HHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCEEEECCCCEEEC
ISFIFMVTTAATILSGIAGYFPARWAAGLNPVDTIRND
HHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHCCCC
>Mature Secondary Structure
MMKVNLFRGSLIFLVTSRYIRGSRVAGLLSLKSRLSFIVMAVGVSLLIVVLSIFNGFQRQ
CEEEEEECCHHEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKESLWQGGPHITVENKFDSGDIKNYEKIIAWLSRNPYLKDRIVSIGGSITSHGLIQNTN
HHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCHHCCCCCCCCC
SFIPIMVRALPVENIHDLVGNKLTNFPRIVHHSREEIARYNVENQVLIGKEMAGIYDFDL
CCHHHHHHHCCHHHHHHHHCCHHHCCHHHHHCCHHHHHHHCCCCCEEEEHHHCCEEEECC
GANLTMAVPGGRFSLGKGVDVSIKTFRTVGFFKTGYYNYDTHYVFLSLPVAQKFFNLKDS
CCCEEEECCCCCEECCCCCCEEHHHHHHHHEEECCEEECCCEEEEEECHHHHHHHHHHHH
VNQIAIKVKSLDDLQNCKKEILKEFRNPDFENEIGYSASFSVRTIAEEQENFFTALKLEK
HHHHEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
TIISIIVFLFIILAALGMVASVYSLVRAKRKSIGVLKALGLPSSGVLLIFTLNAMVVGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCEEEEEHHHHHHHHHH
ASLVGGVSGIFIASNLETIVNGLSELINMVGYYFYHSEWTNVELVPKDVYYFDHIPVDID
HHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHEECCCCCEEEEECCEEEECCCCEEEC
ISFIFMVTTAATILSGIAGYFPARWAAGLNPVDTIRND
HHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]