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The map label for this gene is folP

Identifier: 45655965

GI number: 45655965

Start: 62561

End: 63403

Strand: Direct

Name: folP

Synonym: LIC10051

Alternate gene names: 45655965

Gene position: 62561-63403 (Clockwise)

Preceding gene: 45655960

Following gene: 45655968

Centisome position: 1.46

GC content: 32.62

Gene sequence:

>843_bases
ATGGAAAGTAAACAAGATTCGAATTCTTCAAGTTATTCTACAAAGATCTTTGGGGTATTGAATATTACCGAAGATTCATT
TTCCGATGGAGGAAAGTATCTTACTTTTAAATCTTCCTCTGAAAAAGCAAATTCTCTGTTAAACCAAGGCGCAGATGTAA
TTGATATAGGCGCTCAGTCTTCTAATATTCAAGCAAGTTTGATCGGTCCCGAAATCGAATGGATAAGAATGAAGGAGTTA
ATTTCCAATTTGGTTGCAAAAGGAGTTCGTATTTCCGTAGATTCTTTTCAACCTCAAGTAATTGCTAATTCTTTATCTGC
GGGTGTGGAATTTATTAATCATATCCGAGGCTTTGTAGATGAAGAATCTATTCGAGAGATTTCCAAATATGCCAGAACCA
ATCGAAAGTTTATTTTGATGTATTCTCATAATCATTCCAATCGTGCGGAAACAAAATCACATCTAACACCAAATAATGTA
ATTTTAGAAATTGTACGGTTTTTTCGTGAAAGAAAAAAAATTTTATTAAACGCGGGAATTGCACAAGAGCAATTGATCTT
TGATCCTGGAATGGGTTTTTTTCTCAGTTCTGATTTTCAGGTGAGTTTTGAAGTATTAAAAAAAATTAAAACTCTCCAGG
AAGAGTTTTCTCCGATGATGGTTTCGGTTACAAAAAAATCATTTTTAGGAAATGCGCTCGGAGGTTTGAAAGTAGAAGAA
AGAGAAATTCCTACCGTAATTGCCGAACTTTATTTATGTATTCAAAATGTAGAATATATCCGAACTCATGAACCTAAAAA
TTTAAAACAAGCTTTGAAAATTTGGAATTTAATGAATAAGTAA

Upstream 100 bases:

>100_bases
GACGCATGAACCCGCTCCGAAAAGAATATAAAGATTATTGTTTTTAGTTTAAATTCAGGATCTTACTTAGAGTATCGGTC
TTATATCTAAGTTTTTAAAG

Downstream 100 bases:

>100_bases
TTGTTATGGCAGGATCAAAATCCGTTCGGCTTCAATGAGGAAGCGAGACGTTTAGGTTATCCAGTTTACTACCCGACGTA
TAAAAACAGTATCGAAAATT

Product: 7,8-dihydropteroate synthase protein

Products: NA

Alternate protein names: Dihydropteroate pyrophosphorylase type I; Dihydropteroate synthase type I; DHPS [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MESKQDSNSSSYSTKIFGVLNITEDSFSDGGKYLTFKSSSEKANSLLNQGADVIDIGAQSSNIQASLIGPEIEWIRMKEL
ISNLVAKGVRISVDSFQPQVIANSLSAGVEFINHIRGFVDEESIREISKYARTNRKFILMYSHNHSNRAETKSHLTPNNV
ILEIVRFFRERKKILLNAGIAQEQLIFDPGMGFFLSSDFQVSFEVLKKIKTLQEEFSPMMVSVTKKSFLGNALGGLKVEE
REIPTVIAELYLCIQNVEYIRTHEPKNLKQALKIWNLMNK

Sequences:

>Translated_280_residues
MESKQDSNSSSYSTKIFGVLNITEDSFSDGGKYLTFKSSSEKANSLLNQGADVIDIGAQSSNIQASLIGPEIEWIRMKEL
ISNLVAKGVRISVDSFQPQVIANSLSAGVEFINHIRGFVDEESIREISKYARTNRKFILMYSHNHSNRAETKSHLTPNNV
ILEIVRFFRERKKILLNAGIAQEQLIFDPGMGFFLSSDFQVSFEVLKKIKTLQEEFSPMMVSVTKKSFLGNALGGLKVEE
REIPTVIAELYLCIQNVEYIRTHEPKNLKQALKIWNLMNK
>Mature_280_residues
MESKQDSNSSSYSTKIFGVLNITEDSFSDGGKYLTFKSSSEKANSLLNQGADVIDIGAQSSNIQASLIGPEIEWIRMKEL
ISNLVAKGVRISVDSFQPQVIANSLSAGVEFINHIRGFVDEESIREISKYARTNRKFILMYSHNHSNRAETKSHLTPNNV
ILEIVRFFRERKKILLNAGIAQEQLIFDPGMGFFLSSDFQVSFEVLKKIKTLQEEFSPMMVSVTKKSFLGNALGGLKVEE
REIPTVIAELYLCIQNVEYIRTHEPKNLKQALKIWNLMNK

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. The type II enzyme is stable whereas type I DHPS loses its activity rapidly. Implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=260, Percent_Identity=28.8461538461538, Blast_Score=116, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31648; Mature: 31648

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESKQDSNSSSYSTKIFGVLNITEDSFSDGGKYLTFKSSSEKANSLLNQGADVIDIGAQS
CCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCEEEEECCHHHHHHHHHCCCCEEEECCCC
SNIQASLIGPEIEWIRMKELISNLVAKGVRISVDSFQPQVIANSLSAGVEFINHIRGFVD
CCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
EESIREISKYARTNRKFILMYSHNHSNRAETKSHLTPNNVILEIVRFFRERKKILLNAGI
HHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
AQEQLIFDPGMGFFLSSDFQVSFEVLKKIKTLQEEFSPMMVSVTKKSFLGNALGGLKVEE
CHHHEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEECH
REIPTVIAELYLCIQNVEYIRTHEPKNLKQALKIWNLMNK
HHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MESKQDSNSSSYSTKIFGVLNITEDSFSDGGKYLTFKSSSEKANSLLNQGADVIDIGAQS
CCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCEEEEECCHHHHHHHHHCCCCEEEECCCC
SNIQASLIGPEIEWIRMKELISNLVAKGVRISVDSFQPQVIANSLSAGVEFINHIRGFVD
CCCEEEEECCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
EESIREISKYARTNRKFILMYSHNHSNRAETKSHLTPNNVILEIVRFFRERKKILLNAGI
HHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCC
AQEQLIFDPGMGFFLSSDFQVSFEVLKKIKTLQEEFSPMMVSVTKKSFLGNALGGLKVEE
CHHHEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCEECH
REIPTVIAELYLCIQNVEYIRTHEPKNLKQALKIWNLMNK
HHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2163027 [H]