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The map label for this gene is gyrA

Identifier: 45655920

GI number: 45655920

Start: 8624

End: 11128

Strand: Direct

Name: gyrA

Synonym: LIC10006

Alternate gene names: 45655920

Gene position: 8624-11128 (Clockwise)

Preceding gene: 45655919

Following gene: 45655921

Centisome position: 0.2

GC content: 36.33

Gene sequence:

>2505_bases
ATGAGTCAAGAAATGGAAAATGAAACCAAAGTCCTAAGCTATAATATTGCTGGAAAACCAGATATTGCAGATGCTCTTAA
AAACGGCGTAAGAGTTATTCCTGTAGAAATCGAAGATCAGATGAAAGAAGCGTATTTAGGATACGCTATGTCTGTGATCG
TTGGGCGTGCCCTTCCAGATGTAAGAGACGGATTAAAACCGGTTCATAGAAGAATCCTTCATGCTATGAACGAACGTGCA
TGGAGAAGTGATCGTCCTTATGTTAAATGTGCTAAAATTGTTGGGGAAGTAATCGGTAATTATCATCCTCACGGAGACGC
ATCTGTTTACGAAGCGCTTGTGAGAATGGTTCAGGAATTTTCCTTAAGAGTTCCTTTGATTGATGGACAGGGAAATTTCG
GTTCTATCGACGGAGATAACCCGGCGGCTTATCGATATACGGAAGCAAGGCTTGAAAAAGTTGCCGAAGAATTATTACGC
GACATCGAAAAAGAAACTGTTAGTTTTTCACCTAACTATGATGATACGAAAGAACAACCGGATGTTTTACCTGCAAATTT
TCCAAACTTACTTGTAAACGGTTCTTCTGGGATCGCGGTAGGAATGGCTACAAACATTCCTCCTCATAACCTTAGGGAAA
CTATTGATGCAGTAATCGCGGTCATTCGAAATCCGGAAATTACAATTCCAGAAATTCTAAAAATTATACCTGGTCCAGAT
TTTCCTACTTCCGGAATTATTATCGGAGGGGAGGGGCTGATCTCTGCTTATTCTACCGGAAAAGGTTCAATTCGAATTCG
TTCTAAAGTAGAAATAGAAGAAAAGAAAAATGGAAGAGAAGTAATCGTAGTCACAGAAATTCCATATCAAGTAAATAAAA
AAGTCCTTCTGGAAAAAATTGGAGATCTAGTTAACGAAAAACAAATCGAAGGAATTTCAGAAATTCTAGATCTTTCCGAT
CGAAAAGGAATTCGTGTAGAAATTCATATTAAAAAAGATGCAAATGCTCAAGTCATTCTAAACCAACTCTACAAGATGAC
TCAACTTCAGGTAAGTTACGGAATCACAATGCTTGCGATTTTAGATAACAAACCTAAAATTTTTAATATTAAAGAAATAT
TAACTGCTTACGCGGCCCATAGAAGGGAAGTTATCGTTAGGAGAACGCAGTTTGATTTAGATAAGGCGGAAAAAAGAGCT
CATATTTTAGAAGGTTTGAAAATCGCTTTAGAAAATATAGAAGATGTGATTAAAGTGATTCGTGCTTCTAAAAATCCTCC
AGAAGCAAAACAACAATTGATGATTCGATTTAGTTTATCTGAAGTTCAATCGGATGCGATTCTGGAGATGAGATTACAAA
GACTTACTTCTCTTGAGGTTCAGAAGATCATAGATGAATTGGAAGAAGTGAGAAAGCTTATCATCGATCTAAAGGATATT
CTCGCAAAACCTTCTCGTGTAAATGAAATTGTTTGTACAGAACTTCAAGAAGTTGGAGATAAATACGGGAATAAAAGAAA
AACAGAAATTTCTATTGAAACTATAGAGAGTTCTTCATTTAACGCAGAGGATTTAATCGCGGATGAAGAAATTGTAATTC
AAATTACTTATGATCAATTTATCAAGCGTCTTCCTATAGATACTTTTAAAAGACAAAAACGAGGTGGTAAAGGAATTCAG
GGTCTTTCTCAAAAACGAGATGATGTAATTAAGATCATGAAAGCTGCAATGACTCATGATAATATTATGTTTTTCTCTAA
TATAGGGAAAGTTTATGTAATGAAAGCCTACGAATTACCAATTGCTTCTAAAGAAGCAAGAGGAAAATCTCTCAAAGCAA
TCATCAACTTGAGAGAAGACGAATATATCTCTTCCGTTTTTACGTTTAGAGGAGAAGATATGGATAAAGATCTTCTTTTG
GTAACAAGGAAAGGATTTATTAAACGAATTCAATTAAAAGAGTTCGGAAATGTTAAAAAGTCTGGGATTATTGCAATCGG
ACTTAGAGAAGGAGACGAGTTAATCAAAGTAGAATCGATGACCGATAAAGACGAGGTTATGATCTTTTCTAAAAAAGGGT
TAGCTCTTCGAATTGAAGGTAACATCATTAGAGCCCAAGGAAGAACCGCTAGTGGTGTTACTGGGATGAGACTTGCAGAG
GACGATGCGATTGTAGGACTTAGCAAATATAAAGAAGGGGAAGATATATTTGTAGTTTCGGAAGAAGGTTATGGAAAACG
TCTTGGCTTTGAAGAATTTGCCGCAAAAGGTAGAGGCGGCAAAGGAATGGCCTATTTAAAGATAACCGAAAAGAACGGAT
TTTCCGTGGGAACAGGTTCTGTTGGAAGCGAAGACGAAATTATTCTAATCACTCAACAAGGGATGACAATCCGAATTAAT
GCATTCGATATTTCTAAATTAGGTAGAACTGCTGTAGGTGTTCGTATTGTGGATTTAAAAGACAACGATAAGGTTCAGGA
TTTTACAGTTCTAGGAGAAAATTGA

Upstream 100 bases:

>100_bases
TGTTCTTATGGGTGACGAAGTTCAACCTCGAAAACAATTCATAGAAGTAAATGCGGCTAAGGTAGCAAACTTAGATCTTT
GATCGAAAGGGGATTTTGAA

Downstream 100 bases:

>100_bases
TTTTATGATCCGGATCGGAAACGTAACGATTCCGGGGAAAATTTCTCTTTCTCCGATGGCGGGAATTTCAGATTCACCTA
CTCGTAGAATTTGTAGAAAA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 834; Mature: 833

Protein sequence:

>834_residues
MSQEMENETKVLSYNIAGKPDIADALKNGVRVIPVEIEDQMKEAYLGYAMSVIVGRALPDVRDGLKPVHRRILHAMNERA
WRSDRPYVKCAKIVGEVIGNYHPHGDASVYEALVRMVQEFSLRVPLIDGQGNFGSIDGDNPAAYRYTEARLEKVAEELLR
DIEKETVSFSPNYDDTKEQPDVLPANFPNLLVNGSSGIAVGMATNIPPHNLRETIDAVIAVIRNPEITIPEILKIIPGPD
FPTSGIIIGGEGLISAYSTGKGSIRIRSKVEIEEKKNGREVIVVTEIPYQVNKKVLLEKIGDLVNEKQIEGISEILDLSD
RKGIRVEIHIKKDANAQVILNQLYKMTQLQVSYGITMLAILDNKPKIFNIKEILTAYAAHRREVIVRRTQFDLDKAEKRA
HILEGLKIALENIEDVIKVIRASKNPPEAKQQLMIRFSLSEVQSDAILEMRLQRLTSLEVQKIIDELEEVRKLIIDLKDI
LAKPSRVNEIVCTELQEVGDKYGNKRKTEISIETIESSSFNAEDLIADEEIVIQITYDQFIKRLPIDTFKRQKRGGKGIQ
GLSQKRDDVIKIMKAAMTHDNIMFFSNIGKVYVMKAYELPIASKEARGKSLKAIINLREDEYISSVFTFRGEDMDKDLLL
VTRKGFIKRIQLKEFGNVKKSGIIAIGLREGDELIKVESMTDKDEVMIFSKKGLALRIEGNIIRAQGRTASGVTGMRLAE
DDAIVGLSKYKEGEDIFVVSEEGYGKRLGFEEFAAKGRGGKGMAYLKITEKNGFSVGTGSVGSEDEIILITQQGMTIRIN
AFDISKLGRTAVGVRIVDLKDNDKVQDFTVLGEN

Sequences:

>Translated_834_residues
MSQEMENETKVLSYNIAGKPDIADALKNGVRVIPVEIEDQMKEAYLGYAMSVIVGRALPDVRDGLKPVHRRILHAMNERA
WRSDRPYVKCAKIVGEVIGNYHPHGDASVYEALVRMVQEFSLRVPLIDGQGNFGSIDGDNPAAYRYTEARLEKVAEELLR
DIEKETVSFSPNYDDTKEQPDVLPANFPNLLVNGSSGIAVGMATNIPPHNLRETIDAVIAVIRNPEITIPEILKIIPGPD
FPTSGIIIGGEGLISAYSTGKGSIRIRSKVEIEEKKNGREVIVVTEIPYQVNKKVLLEKIGDLVNEKQIEGISEILDLSD
RKGIRVEIHIKKDANAQVILNQLYKMTQLQVSYGITMLAILDNKPKIFNIKEILTAYAAHRREVIVRRTQFDLDKAEKRA
HILEGLKIALENIEDVIKVIRASKNPPEAKQQLMIRFSLSEVQSDAILEMRLQRLTSLEVQKIIDELEEVRKLIIDLKDI
LAKPSRVNEIVCTELQEVGDKYGNKRKTEISIETIESSSFNAEDLIADEEIVIQITYDQFIKRLPIDTFKRQKRGGKGIQ
GLSQKRDDVIKIMKAAMTHDNIMFFSNIGKVYVMKAYELPIASKEARGKSLKAIINLREDEYISSVFTFRGEDMDKDLLL
VTRKGFIKRIQLKEFGNVKKSGIIAIGLREGDELIKVESMTDKDEVMIFSKKGLALRIEGNIIRAQGRTASGVTGMRLAE
DDAIVGLSKYKEGEDIFVVSEEGYGKRLGFEEFAAKGRGGKGMAYLKITEKNGFSVGTGSVGSEDEIILITQQGMTIRIN
AFDISKLGRTAVGVRIVDLKDNDKVQDFTVLGEN
>Mature_833_residues
SQEMENETKVLSYNIAGKPDIADALKNGVRVIPVEIEDQMKEAYLGYAMSVIVGRALPDVRDGLKPVHRRILHAMNERAW
RSDRPYVKCAKIVGEVIGNYHPHGDASVYEALVRMVQEFSLRVPLIDGQGNFGSIDGDNPAAYRYTEARLEKVAEELLRD
IEKETVSFSPNYDDTKEQPDVLPANFPNLLVNGSSGIAVGMATNIPPHNLRETIDAVIAVIRNPEITIPEILKIIPGPDF
PTSGIIIGGEGLISAYSTGKGSIRIRSKVEIEEKKNGREVIVVTEIPYQVNKKVLLEKIGDLVNEKQIEGISEILDLSDR
KGIRVEIHIKKDANAQVILNQLYKMTQLQVSYGITMLAILDNKPKIFNIKEILTAYAAHRREVIVRRTQFDLDKAEKRAH
ILEGLKIALENIEDVIKVIRASKNPPEAKQQLMIRFSLSEVQSDAILEMRLQRLTSLEVQKIIDELEEVRKLIIDLKDIL
AKPSRVNEIVCTELQEVGDKYGNKRKTEISIETIESSSFNAEDLIADEEIVIQITYDQFIKRLPIDTFKRQKRGGKGIQG
LSQKRDDVIKIMKAAMTHDNIMFFSNIGKVYVMKAYELPIASKEARGKSLKAIINLREDEYISSVFTFRGEDMDKDLLLV
TRKGFIKRIQLKEFGNVKKSGIIAIGLREGDELIKVESMTDKDEVMIFSKKGLALRIEGNIIRAQGRTASGVTGMRLAED
DAIVGLSKYKEGEDIFVVSEEGYGKRLGFEEFAAKGRGGKGMAYLKITEKNGFSVGTGSVGSEDEIILITQQGMTIRINA
FDISKLGRTAVGVRIVDLKDNDKVQDFTVLGEN

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=469, Percent_Identity=22.8144989339019, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI19913406, Length=319, Percent_Identity=24.1379310344828, Blast_Score=75, Evalue=3e-13,
Organism=Escherichia coli, GI1788562, Length=829, Percent_Identity=45.9589867310012, Blast_Score=739, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=612, Percent_Identity=37.0915032679739, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535065, Length=174, Percent_Identity=32.183908045977, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI212645657, Length=174, Percent_Identity=31.0344827586207, Blast_Score=74, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=500, Percent_Identity=22.8, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=176, Percent_Identity=29.5454545454545, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 93301; Mature: 93170

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQEMENETKVLSYNIAGKPDIADALKNGVRVIPVEIEDQMKEAYLGYAMSVIVGRALPD
CCCCCCCCCEEEEEECCCCCCHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCH
VRDGLKPVHRRILHAMNERAWRSDRPYVKCAKIVGEVIGNYHPHGDASVYEALVRMVQEF
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
SLRVPLIDGQGNFGSIDGDNPAAYRYTEARLEKVAEELLRDIEKETVSFSPNYDDTKEQP
CCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCC
DVLPANFPNLLVNGSSGIAVGMATNIPPHNLRETIDAVIAVIRNPEITIPEILKIIPGPD
CCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
FPTSGIIIGGEGLISAYSTGKGSIRIRSKVEIEEKKNGREVIVVTEIPYQVNKKVLLEKI
CCCCCEEECCCCEEEEECCCCCCEEEEEEEEEHHCCCCCEEEEEEECCCHHHHHHHHHHH
GDLVNEKQIEGISEILDLSDRKGIRVEIHIKKDANAQVILNQLYKMTQLQVSYGITMLAI
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEE
LDNKPKIFNIKEILTAYAAHRREVIVRRTQFDLDKAEKRAHILEGLKIALENIEDVIKVI
ECCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RASKNPPEAKQQLMIRFSLSEVQSDAILEMRLQRLTSLEVQKIIDELEEVRKLIIDLKDI
HCCCCCCHHHHHEEHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKPSRVNEIVCTELQEVGDKYGNKRKTEISIETIESSSFNAEDLIADEEIVIQITYDQF
HCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHCCCCCEEEEEEEHHHH
IKRLPIDTFKRQKRGGKGIQGLSQKRDDVIKIMKAAMTHDNIMFFSNIGKVYVMKAYELP
HHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEECC
IASKEARGKSLKAIINLREDEYISSVFTFRGEDMDKDLLLVTRKGFIKRIQLKEFGNVKK
CCCCCCCCCCEEHHEECCCHHHHHHHHHCCCCCCCCCEEEEECHHHHHEEHHHHHCCCCC
SGIIAIGLREGDELIKVESMTDKDEVMIFSKKGLALRIEGNIIRAQGRTASGVTGMRLAE
CCEEEEEECCCCCEEEEECCCCCCCEEEEECCCEEEEEECCEEEECCCCCCCCCCCEEEC
DDAIVGLSKYKEGEDIFVVSEEGYGKRLGFEEFAAKGRGGKGMAYLKITEKNGFSVGTGS
CCCEEEHHHCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCEEEEEEECCCCCEECCCC
VGSEDEIILITQQGMTIRINAFDISKLGRTAVGVRIVDLKDNDKVQDFTVLGEN
CCCCCCEEEEECCCCEEEEEEEEHHHCCCHHHCEEEEEECCCCCCEEEEEECCC
>Mature Secondary Structure 
SQEMENETKVLSYNIAGKPDIADALKNGVRVIPVEIEDQMKEAYLGYAMSVIVGRALPD
CCCCCCCCEEEEEECCCCCCHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCH
VRDGLKPVHRRILHAMNERAWRSDRPYVKCAKIVGEVIGNYHPHGDASVYEALVRMVQEF
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
SLRVPLIDGQGNFGSIDGDNPAAYRYTEARLEKVAEELLRDIEKETVSFSPNYDDTKEQP
CCEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCC
DVLPANFPNLLVNGSSGIAVGMATNIPPHNLRETIDAVIAVIRNPEITIPEILKIIPGPD
CCCCCCCCCEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
FPTSGIIIGGEGLISAYSTGKGSIRIRSKVEIEEKKNGREVIVVTEIPYQVNKKVLLEKI
CCCCCEEECCCCEEEEECCCCCCEEEEEEEEEHHCCCCCEEEEEEECCCHHHHHHHHHHH
GDLVNEKQIEGISEILDLSDRKGIRVEIHIKKDANAQVILNQLYKMTQLQVSYGITMLAI
HHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEE
LDNKPKIFNIKEILTAYAAHRREVIVRRTQFDLDKAEKRAHILEGLKIALENIEDVIKVI
ECCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RASKNPPEAKQQLMIRFSLSEVQSDAILEMRLQRLTSLEVQKIIDELEEVRKLIIDLKDI
HCCCCCCHHHHHEEHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAKPSRVNEIVCTELQEVGDKYGNKRKTEISIETIESSSFNAEDLIADEEIVIQITYDQF
HCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHCCCCCEEEEEEEHHHH
IKRLPIDTFKRQKRGGKGIQGLSQKRDDVIKIMKAAMTHDNIMFFSNIGKVYVMKAYELP
HHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEEEEEECC
IASKEARGKSLKAIINLREDEYISSVFTFRGEDMDKDLLLVTRKGFIKRIQLKEFGNVKK
CCCCCCCCCCEEHHEECCCHHHHHHHHHCCCCCCCCCEEEEECHHHHHEEHHHHHCCCCC
SGIIAIGLREGDELIKVESMTDKDEVMIFSKKGLALRIEGNIIRAQGRTASGVTGMRLAE
CCEEEEEECCCCCEEEEECCCCCCCEEEEECCCEEEEEECCEEEECCCCCCCCCCCEEEC
DDAIVGLSKYKEGEDIFVVSEEGYGKRLGFEEFAAKGRGGKGMAYLKITEKNGFSVGTGS
CCCEEEHHHCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCEEEEEEECCCCCEECCCC
VGSEDEIILITQQGMTIRINAFDISKLGRTAVGVRIVDLKDNDKVQDFTVLGEN
CCCCCCEEEEECCCCEEEEEEEEHHHCCCHHHCEEEEEECCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2987847; 7584024; 9384377 [H]