| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is dnaN
Identifier: 45655916
GI number: 45655916
Start: 3279
End: 4400
Strand: Direct
Name: dnaN
Synonym: LIC10002
Alternate gene names: 45655916
Gene position: 3279-4400 (Clockwise)
Preceding gene: 45655915
Following gene: 45655917
Centisome position: 0.08
GC content: 32.35
Gene sequence:
>1122_bases TTGAAAATTAAAGTTAATACATCTGAATTCTTAAAAGCAATTCACGCCGTAGAAGGTGTAATTACTACAAGAGAGATTAA ATCTATATTATCAAATCTTAAAATAGAAGCCGAAGGAAAAGAAACCTTTCTCTCTGCTACCGATCTCGAAATTTCAATCA AAACATCTGTACCTGCTGACGTAACTCAAGAAGGGAATGTTTCTCTACCTGCAAAACAACTTTCTAGCTTTTTTAAAACA ATCCATTTTGAAGATACAAATTTGTCTTTAGAAGAATCGGATAGTAATTCTTCTATCGTTTACATTACCGATGCTTCTGG TAAAAACGATTATAAATCCAAAATCAGTGGAATGGATGCTGATGAAATTAAAACAATTTCAAAAATTGATTCTTCGCAAG TATCTTCTTTCCCTAGTACTTTGATAAATGACATGATTCGTAAGACTTCTTATGCAATTGCACATGAAGATCAGAGATTT ATATTTAACGGTCTTTATATGATTCCTAACGGAGATAAACTGATTTTTGTTGGAACGGATGGAAGAAGACTTTGCAAAAT TGAAAGAACCCTTCCTTCCCCATTACAGTTTAAAGATTCTATTATAGTTCCTGCAAAAGCGATCCGGGAAATTTCTAAAA TGATCGCAACTTCTGAAGTTGGAAATATAGGTTTAATTGACGGTCAAATTTATGTTTCTGCAAACAACATTGAACTATTA TGTAAATTGATTGAAGGAAATTTTCCAAACTACGAACAAGTCATTCCTAAAAATACTAAATTTTCTACGAGCATTTCTAA AGAAGAATTTCAAGTTTCCTTACGACAAGTTTTGACCGCTGCAGAAGAACCTTCCAGACAAGTAAGACTTACATTCAGTA AAAATAATTTAAATTTATTCGCTCAAACTCTTGGTGCTTCTGAGGCAAGTATTAACAAACCAATCGAATATTCTGGGGAT GAAGTCACGATTGCATTCAAAGGTGAATATCTCATGGATATTTTTAGATCGATTGACGACAACGAAGTTAAAATAGAATT TTCAGATGCAAACTCTCCGGTTATTTTTAAAGATCCTTCTGATCCTGAATTTATTTCTGTGATTATGCCTATGAAATTGT AA
Upstream 100 bases:
>100_bases CTTTAGGAATACAATTTTATGTACATATTTACAGGTACTACTCCTACAACTGTACAATAATAAGAACTTATTTAATTAAA AAGAAACTAGGAGAAAAAAA
Downstream 100 bases:
>100_bases TAGTATTATAATTTTATTATATAATATTAATTGCAAAAATGAAATTTTTATAACTAAGTTTGATTTTAAGGTTTGTATCT TTTAATTTAAAGCTCAGCCA
Product: DNA polymerase III subunit beta
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 373; Mature: 373
Protein sequence:
>373_residues MKIKVNTSEFLKAIHAVEGVITTREIKSILSNLKIEAEGKETFLSATDLEISIKTSVPADVTQEGNVSLPAKQLSSFFKT IHFEDTNLSLEESDSNSSIVYITDASGKNDYKSKISGMDADEIKTISKIDSSQVSSFPSTLINDMIRKTSYAIAHEDQRF IFNGLYMIPNGDKLIFVGTDGRRLCKIERTLPSPLQFKDSIIVPAKAIREISKMIATSEVGNIGLIDGQIYVSANNIELL CKLIEGNFPNYEQVIPKNTKFSTSISKEEFQVSLRQVLTAAEEPSRQVRLTFSKNNLNLFAQTLGASEASINKPIEYSGD EVTIAFKGEYLMDIFRSIDDNEVKIEFSDANSPVIFKDPSDPEFISVIMPMKL
Sequences:
>Translated_373_residues MKIKVNTSEFLKAIHAVEGVITTREIKSILSNLKIEAEGKETFLSATDLEISIKTSVPADVTQEGNVSLPAKQLSSFFKT IHFEDTNLSLEESDSNSSIVYITDASGKNDYKSKISGMDADEIKTISKIDSSQVSSFPSTLINDMIRKTSYAIAHEDQRF IFNGLYMIPNGDKLIFVGTDGRRLCKIERTLPSPLQFKDSIIVPAKAIREISKMIATSEVGNIGLIDGQIYVSANNIELL CKLIEGNFPNYEQVIPKNTKFSTSISKEEFQVSLRQVLTAAEEPSRQVRLTFSKNNLNLFAQTLGASEASINKPIEYSGD EVTIAFKGEYLMDIFRSIDDNEVKIEFSDANSPVIFKDPSDPEFISVIMPMKL >Mature_373_residues MKIKVNTSEFLKAIHAVEGVITTREIKSILSNLKIEAEGKETFLSATDLEISIKTSVPADVTQEGNVSLPAKQLSSFFKT IHFEDTNLSLEESDSNSSIVYITDASGKNDYKSKISGMDADEIKTISKIDSSQVSSFPSTLINDMIRKTSYAIAHEDQRF IFNGLYMIPNGDKLIFVGTDGRRLCKIERTLPSPLQFKDSIIVPAKAIREISKMIATSEVGNIGLIDGQIYVSANNIELL CKLIEGNFPNYEQVIPKNTKFSTSISKEEFQVSLRQVLTAAEEPSRQVRLTFSKNNLNLFAQTLGASEASINKPIEYSGD EVTIAFKGEYLMDIFRSIDDNEVKIEFSDANSPVIFKDPSDPEFISVIMPMKL
Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped
COG id: COG0592
COG function: function code L; DNA polymerase sliding clamp subunit (PCNA homolog)
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: NA
Homologues:
Organism=Escherichia coli, GI1790136, Length=385, Percent_Identity=26.2337662337662, Blast_Score=129, Evalue=4e-31,
Paralogues:
None
Copy number: 5954 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001001 - InterPro: IPR022635 - InterPro: IPR022637 - InterPro: IPR022634 [H]
Pfam domain/function: PF00712 DNA_pol3_beta; PF02767 DNA_pol3_beta_2; PF02768 DNA_pol3_beta_3 [H]
EC number: =2.7.7.7 [H]
Molecular weight: Translated: 41444; Mature: 41444
Theoretical pI: Translated: 4.76; Mature: 4.76
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.7 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.7 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKIKVNTSEFLKAIHAVEGVITTREIKSILSNLKIEAEGKETFLSATDLEISIKTSVPAD CEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEEEECEEEEEEECCCCC VTQEGNVSLPAKQLSSFFKTIHFEDTNLSLEESDSNSSIVYITDASGKNDYKSKISGMDA CCCCCCCCCCHHHHHHHHHEEEECCCCCEEECCCCCCEEEEEECCCCCCCHHHHHCCCCH DEIKTISKIDSSQVSSFPSTLINDMIRKTSYAIAHEDQRFIFNGLYMIPNGDKLIFVGTD HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECEEEEECCCEEEEEECC GRRLCKIERTLPSPLQFKDSIIVPAKAIREISKMIATSEVGNIGLIDGQIYVSANNIELL CCEEEEEECCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCEEEECCEEEEECCCHHHH CKLIEGNFPNYEQVIPKNTKFSTSISKEEFQVSLRQVLTAAEEPSRQVRLTFSKNNLNLF HHHHHCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEE AQTLGASEASINKPIEYSGDEVTIAFKGEYLMDIFRSIDDNEVKIEFSDANSPVIFKDPS EEHHCCCCCCCCCCCEECCCEEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCEEEECCC DPEFISVIMPMKL CCCEEEEEECCCC >Mature Secondary Structure MKIKVNTSEFLKAIHAVEGVITTREIKSILSNLKIEAEGKETFLSATDLEISIKTSVPAD CEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCEEEEEEECEEEEEEECCCCC VTQEGNVSLPAKQLSSFFKTIHFEDTNLSLEESDSNSSIVYITDASGKNDYKSKISGMDA CCCCCCCCCCHHHHHHHHHEEEECCCCCEEECCCCCCEEEEEECCCCCCCHHHHHCCCCH DEIKTISKIDSSQVSSFPSTLINDMIRKTSYAIAHEDQRFIFNGLYMIPNGDKLIFVGTD HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEEEEECEEEEECCCEEEEEECC GRRLCKIERTLPSPLQFKDSIIVPAKAIREISKMIATSEVGNIGLIDGQIYVSANNIELL CCEEEEEECCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCEEEECCEEEEECCCHHHH CKLIEGNFPNYEQVIPKNTKFSTSISKEEFQVSLRQVLTAAEEPSRQVRLTFSKNNLNLF HHHHHCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEE AQTLGASEASINKPIEYSGDEVTIAFKGEYLMDIFRSIDDNEVKIEFSDANSPVIFKDPS EEHHCCCCCCCCCCCEECCCEEEEEECCHHHHHHHHCCCCCEEEEEECCCCCCEEEECCC DPEFISVIMPMKL CCCEEEEEECCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10192388; 10684935; 10871362 [H]