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The map label for this gene is moeA [C]

Identifier: 45359182

GI number: 45359182

Start: 1564401

End: 1565609

Strand: Direct

Name: moeA [C]

Synonym: MMP1619

Alternate gene names: 45359182

Gene position: 1564401-1565609 (Clockwise)

Preceding gene: 45359176

Following gene: 45359183

Centisome position: 94.18

GC content: 34.66

Gene sequence:

>1209_bases
ATGAAATTTGTAAAAGAACTGATTAGTCGCAGTGATGCTAAAAATAAGGTTTTTGAAAAATTTGAAGAAATGTTGGATGA
TAAATTTGAAAATATTGAAATAAATAAAGCATTTGGTAAAATCTGCTTTGAAGATGTTCATGCTCCCTGCAATATCCCGA
TGTTTAATCGTTCAGCAATGGATGGCTATGCAGTAATTGCAGAAGATACATTTGGAGCGTCTCAGACAAACCCGATTATC
TTAAATTTAGTTAAAACTGATTCAATAAACGAAGAAGAAATTTACAGGCTTTCAACGGGCATGAAACTTCCAGAAAATTC
AAATGCAGTTGTAATGAAAGAATATACTAAAGAATACGATTCTTTCGTTGAAATATATACTGGCGTCCACCCAAACGAAA
ATGTATCCCGAATCGGAGAAGACGTGAAAACTGGAGATCTTATTATTAAAAAAGGAGAATTAATTACGCCCTACCATGTT
GCCCTTATCTCATCACTTGGAATAAAAAAAATAAAGTGTTATTCTTTAAAAATTGGAGTTATTGCAACAGGGGACGAATT
ACTCGATATTGAAGACCTTGAAAGTGTCGAACAGCTTGAAAAAACTGCAATGATCGTTAATTCAAATTCCATGATGGTTT
CAGACCTTGTAAAAGAAACTGGTTTATCTCCCACAGCATATAGAAAAGTTCCTGACAACCGCGAAGAACTTGAAAAAGCG
ATCAAAAAAGCACTTTTAGAAAATGATATCGTAATTACAACAGGGGGAACGTCTGTAGGGGATAGAGACTACACAATTGA
AATAATTAAAAAAATTGGTAATATAATCTTTCATGGCGTTCAGATTAGGCCTGGACGTCCTGTTGGCTTTGCAGAAGCTG
AAATTGACGGTAAAAAGAAACTTTTATTCGTTCTTTCAGGATACCCCGTTGCGTCAGCAGTGCAGTTTGAACTGTTTATT
GCAAATTATTTCAAACCTCGAAAATCTGTTAAACTTCAGATAAATCGAAATATCGCATCTTCCCTTGGCAGAACTGATAT
TGTGAGGGTAAAACTTGTAGAACGTGAAGGCTTCACCAAAATTGAGCCGTTAAGAATAACTGGAAGCGGAGTTTTATCAT
CCATGACTAAAGCAGACGGATACTTAATGATAAAAGAAAATATTGAAGGATATGAAAAGGACGAATTCGTTGAAGTTTAC
TTGTTTTAA

Upstream 100 bases:

>100_bases
TTAACCTCAAATGAGTATTTAATTTATGCACTTTCGTTAAAATGTAAACTATTTAAGCACAGTTATTTAAAATTCCTCCA
GAATATCTCGGGTGAAGCAT

Downstream 100 bases:

>100_bases
TCAGGTGGTTTTATGAATTATCTGTTAATTCTTCTATTTTTTACAATCGGACTTTTTTCAGGATTTTATATAAAATCAAA
TAGGATTTACAGTACTTTTC

Product: molybdenum cofactor biosynthesis protein MoeA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MKFVKELISRSDAKNKVFEKFEEMLDDKFENIEINKAFGKICFEDVHAPCNIPMFNRSAMDGYAVIAEDTFGASQTNPII
LNLVKTDSINEEEIYRLSTGMKLPENSNAVVMKEYTKEYDSFVEIYTGVHPNENVSRIGEDVKTGDLIIKKGELITPYHV
ALISSLGIKKIKCYSLKIGVIATGDELLDIEDLESVEQLEKTAMIVNSNSMMVSDLVKETGLSPTAYRKVPDNREELEKA
IKKALLENDIVITTGGTSVGDRDYTIEIIKKIGNIIFHGVQIRPGRPVGFAEAEIDGKKKLLFVLSGYPVASAVQFELFI
ANYFKPRKSVKLQINRNIASSLGRTDIVRVKLVEREGFTKIEPLRITGSGVLSSMTKADGYLMIKENIEGYEKDEFVEVY
LF

Sequences:

>Translated_402_residues
MKFVKELISRSDAKNKVFEKFEEMLDDKFENIEINKAFGKICFEDVHAPCNIPMFNRSAMDGYAVIAEDTFGASQTNPII
LNLVKTDSINEEEIYRLSTGMKLPENSNAVVMKEYTKEYDSFVEIYTGVHPNENVSRIGEDVKTGDLIIKKGELITPYHV
ALISSLGIKKIKCYSLKIGVIATGDELLDIEDLESVEQLEKTAMIVNSNSMMVSDLVKETGLSPTAYRKVPDNREELEKA
IKKALLENDIVITTGGTSVGDRDYTIEIIKKIGNIIFHGVQIRPGRPVGFAEAEIDGKKKLLFVLSGYPVASAVQFELFI
ANYFKPRKSVKLQINRNIASSLGRTDIVRVKLVEREGFTKIEPLRITGSGVLSSMTKADGYLMIKENIEGYEKDEFVEVY
LF
>Mature_402_residues
MKFVKELISRSDAKNKVFEKFEEMLDDKFENIEINKAFGKICFEDVHAPCNIPMFNRSAMDGYAVIAEDTFGASQTNPII
LNLVKTDSINEEEIYRLSTGMKLPENSNAVVMKEYTKEYDSFVEIYTGVHPNENVSRIGEDVKTGDLIIKKGELITPYHV
ALISSLGIKKIKCYSLKIGVIATGDELLDIEDLESVEQLEKTAMIVNSNSMMVSDLVKETGLSPTAYRKVPDNREELEKA
IKKALLENDIVITTGGTSVGDRDYTIEIIKKIGNIIFHGVQIRPGRPVGFAEAEIDGKKKLLFVLSGYPVASAVQFELFI
ANYFKPRKSVKLQINRNIASSLGRTDIVRVKLVEREGFTKIEPLRITGSGVLSSMTKADGYLMIKENIEGYEKDEFVEVY
LF

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=406, Percent_Identity=29.5566502463054, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI10880983, Length=406, Percent_Identity=29.5566502463054, Blast_Score=143, Evalue=3e-34,
Organism=Escherichia coli, GI1787049, Length=354, Percent_Identity=27.9661016949153, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25147659, Length=317, Percent_Identity=29.3375394321767, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136978, Length=314, Percent_Identity=29.2993630573248, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24638841, Length=314, Percent_Identity=29.2993630573248, Blast_Score=104, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45102; Mature: 45102

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVKELISRSDAKNKVFEKFEEMLDDKFENIEINKAFGKICFEDVHAPCNIPMFNRSAM
CHHHHHHHHCCCCHHHHHHHHHHHHCCHHHCEEEEHHHHHHHHHHCCCCCCCCCCCCCCC
DGYAVIAEDTFGASQTNPIILNLVKTDSINEEEIYRLSTGMKLPENSNAVVMKEYTKEYD
CCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCEEEEHHHHHHHH
SFVEIYTGVHPNENVSRIGEDVKTGDLIIKKGELITPYHVALISSLGIKKIKCYSLKIGV
HHHHHHCCCCCCCCHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEEEEEE
IATGDELLDIEDLESVEQLEKTAMIVNSNSMMVSDLVKETGLSPTAYRKVPDNREELEKA
EECCCCEECHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHCCCCHHCCCCCCCHHHHHHH
IKKALLENDIVITTGGTSVGDRDYTIEIIKKIGNIIFHGVQIRPGRPVGFAEAEIDGKKK
HHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHEECEEECCCCCCCCEECCCCCCEE
LLFVLSGYPVASAVQFELFIANYFKPRKSVKLQINRNIASSLGRTDIVRVKLVEREGFTK
EEEEEECCCCHHHEEEEEEEHHHCCCCCCEEEEECCCHHHHCCCCEEEEEEEEECCCCCE
IEPLRITGSGVLSSMTKADGYLMIKENIEGYEKDEFVEVYLF
ECEEEEECCHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MKFVKELISRSDAKNKVFEKFEEMLDDKFENIEINKAFGKICFEDVHAPCNIPMFNRSAM
CHHHHHHHHCCCCHHHHHHHHHHHHCCHHHCEEEEHHHHHHHHHHCCCCCCCCCCCCCCC
DGYAVIAEDTFGASQTNPIILNLVKTDSINEEEIYRLSTGMKLPENSNAVVMKEYTKEYD
CCEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCCCCCCCEEEEHHHHHHHH
SFVEIYTGVHPNENVSRIGEDVKTGDLIIKKGELITPYHVALISSLGIKKIKCYSLKIGV
HHHHHHCCCCCCCCHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEEEEEE
IATGDELLDIEDLESVEQLEKTAMIVNSNSMMVSDLVKETGLSPTAYRKVPDNREELEKA
EECCCCEECHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHCCCCHHCCCCCCCHHHHHHH
IKKALLENDIVITTGGTSVGDRDYTIEIIKKIGNIIFHGVQIRPGRPVGFAEAEIDGKKK
HHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHEECEEECCCCCCCCEECCCCCCEE
LLFVLSGYPVASAVQFELFIANYFKPRKSVKLQINRNIASSLGRTDIVRVKLVEREGFTK
EEEEEECCCCHHHEEEEEEEHHHCCCCCCEEEEECCCHHHHCCCCEEEEEEEEECCCCCE
IEPLRITGSGVLSSMTKADGYLMIKENIEGYEKDEFVEVYLF
ECEEEEECCHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]