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The map label for this gene is aIF2_gamma [H]

Identifier: 45358771

GI number: 45358771

Start: 1194834

End: 1196066

Strand: Direct

Name: aIF2_gamma [H]

Synonym: MMP1208

Alternate gene names: 45358771

Gene position: 1194834-1196066 (Clockwise)

Preceding gene: 45358770

Following gene: 45358772

Centisome position: 71.93

GC content: 38.28

Gene sequence:

>1233_bases
ATGGCAGCATCCAACCAATCAGAAGTTAATATCGGAATGGTAGGTCACGTAGACCACGGAAAAACGAGTTTAACAAGGAA
ATTAACCGGAGTATGGACTGACACACACAGTGAAGAGCTTAAAAGAGGAATTTCAATAAGACTCGGGTATGCAGACTGTG
AAATAAAAAAATGCGAAACATGCGATGAACCAGAATGCTATACTGTCGGTAAAAAATGCGACTCTTGTGGTGGCAAATTA
CAGACACTTAGAAAAATATCATTTGTTGATGCTCCAGGACACGAAACACTGATGGCTACCATGCTTTCAGGAGCTTCACT
TATGGATGGTGCAATTTTAGTTATTGCCGCAAGCGAAGAATGTCCGCAACCTCAAACAAAAGAGCACTTGATGGCACTTG
ATGCACTTGGTGTTGAAAAGATAATTATCGTTCAAAATAAAATCGACCTCGTATCTGAAGAAGCTGCGGTTGAAAACTAC
AACCAAATTAAAGAATTTACAAAAGGAACAGTTGCAGAAAATGCCCCAATTATCCCTGTTTCAGCACACCACGGTGCAAA
TTTAGATGTGCTTTTAAAAGCAATTCAGGACTTTATTCCAACTCCTGAAAGAGATGAAACTGTAAGTCCAAAATTATATG
TTGCAAGAAGTTTTGACGTAAATAAACCAGGTTCTGAAATAAAAGACCTAAAAGGTGGCGTTATCGGTGGAAGTATCATC
CAAGGTGCCTTAAAAGTTGGGGACGAACTTGAAATAAAACCGGGTATCAAAGTAACCGAAGGAAACAAAACTCACTGGGT
TCCAATAATAACTAAAATTATATCATTAGGTGTTGGCAGTAAAAAATTAAAAACCGCATACCCTGGTGGATTAATTGGTG
TTGGAACTGAACTCGATCCAAACTTGACAAAATCTGATGCACTAAGCGGTAGTTTAGCAGGAATTCCTGGAACACTTCCT
GAAACATTAGAAAAGATGGAAATAGAGCCACAACTTCTTGAAAGAGTCGTTGGATCACAAGATGAACTCGTAATCGAACC
ATTAAAAACGAACGAAGTTTTGATGTTAAATGTAGGAACATCCACAACAGTTGGAGTAACAGTTTCTGCAAGACCTGACA
GAGCAGAAATTAAATTAAAATTACCAGTATGTGCTGATAAAGGCGACAGAGTTGCAATAAGCAGAAAAATCGGATCAAGA
TGGAGATTGATCGGATACGGAATAATATTATAA

Upstream 100 bases:

>100_bases
AGTATTAGCCATAAAGTGATTATAGTTTTAACGTCATTTTTATATGGATTTTCAAGTATTCTTGTAATTTAAAAAACTAA
AAAATTGTGCGAGGGATAAA

Downstream 100 bases:

>100_bases
CTTTTTTATTATTTTTTTAACATTTGGGTGTATTTTATGGACTATTCAAAACTCCTCTCTAAAAAAGAGGATATATGTTC
TAAAATAAAAAATATCGATT

Product: translation initiation factor IF-2 subunit gamma

Products: NA

Alternate protein names: aIF2-gamma; eIF-2-gamma [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MAASNQSEVNIGMVGHVDHGKTSLTRKLTGVWTDTHSEELKRGISIRLGYADCEIKKCETCDEPECYTVGKKCDSCGGKL
QTLRKISFVDAPGHETLMATMLSGASLMDGAILVIAASEECPQPQTKEHLMALDALGVEKIIIVQNKIDLVSEEAAVENY
NQIKEFTKGTVAENAPIIPVSAHHGANLDVLLKAIQDFIPTPERDETVSPKLYVARSFDVNKPGSEIKDLKGGVIGGSII
QGALKVGDELEIKPGIKVTEGNKTHWVPIITKIISLGVGSKKLKTAYPGGLIGVGTELDPNLTKSDALSGSLAGIPGTLP
ETLEKMEIEPQLLERVVGSQDELVIEPLKTNEVLMLNVGTSTTVGVTVSARPDRAEIKLKLPVCADKGDRVAISRKIGSR
WRLIGYGIIL

Sequences:

>Translated_410_residues
MAASNQSEVNIGMVGHVDHGKTSLTRKLTGVWTDTHSEELKRGISIRLGYADCEIKKCETCDEPECYTVGKKCDSCGGKL
QTLRKISFVDAPGHETLMATMLSGASLMDGAILVIAASEECPQPQTKEHLMALDALGVEKIIIVQNKIDLVSEEAAVENY
NQIKEFTKGTVAENAPIIPVSAHHGANLDVLLKAIQDFIPTPERDETVSPKLYVARSFDVNKPGSEIKDLKGGVIGGSII
QGALKVGDELEIKPGIKVTEGNKTHWVPIITKIISLGVGSKKLKTAYPGGLIGVGTELDPNLTKSDALSGSLAGIPGTLP
ETLEKMEIEPQLLERVVGSQDELVIEPLKTNEVLMLNVGTSTTVGVTVSARPDRAEIKLKLPVCADKGDRVAISRKIGSR
WRLIGYGIIL
>Mature_409_residues
AASNQSEVNIGMVGHVDHGKTSLTRKLTGVWTDTHSEELKRGISIRLGYADCEIKKCETCDEPECYTVGKKCDSCGGKLQ
TLRKISFVDAPGHETLMATMLSGASLMDGAILVIAASEECPQPQTKEHLMALDALGVEKIIIVQNKIDLVSEEAAVENYN
QIKEFTKGTVAENAPIIPVSAHHGANLDVLLKAIQDFIPTPERDETVSPKLYVARSFDVNKPGSEIKDLKGGVIGGSIIQ
GALKVGDELEIKPGIKVTEGNKTHWVPIITKIISLGVGSKKLKTAYPGGLIGVGTELDPNLTKSDALSGSLAGIPGTLPE
TLEKMEIEPQLLERVVGSQDELVIEPLKTNEVLMLNVGTSTTVGVTVSARPDRAEIKLKLPVCADKGDRVAISRKIGSRW
RLIGYGIIL

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA [H]

COG id: COG5257

COG function: function code J; Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EIF2G subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503507, Length=430, Percent_Identity=46.9767441860465, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI34147630, Length=263, Percent_Identity=31.5589353612167, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI54607086, Length=405, Percent_Identity=25.1851851851852, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI46094014, Length=239, Percent_Identity=25.9414225941423, Blast_Score=66, Evalue=5e-11,
Organism=Homo sapiens, GI4503475, Length=201, Percent_Identity=27.8606965174129, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI2367247, Length=402, Percent_Identity=27.1144278606965, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790412, Length=435, Percent_Identity=26.8965517241379, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789737, Length=435, Percent_Identity=26.8965517241379, Blast_Score=98, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17509919, Length=423, Percent_Identity=43.7352245862884, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI25141371, Length=433, Percent_Identity=26.3279445727483, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17556456, Length=308, Percent_Identity=27.9220779220779, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17506081, Length=258, Percent_Identity=27.1317829457364, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115532067, Length=225, Percent_Identity=28.8888888888889, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115532065, Length=225, Percent_Identity=28.8888888888889, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17552884, Length=352, Percent_Identity=25.2840909090909, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17569207, Length=352, Percent_Identity=25.2840909090909, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320863, Length=423, Percent_Identity=46.3356973995272, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6324761, Length=346, Percent_Identity=30.3468208092486, Blast_Score=117, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6325337, Length=206, Percent_Identity=29.126213592233, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319594, Length=206, Percent_Identity=29.126213592233, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24647046, Length=425, Percent_Identity=46.5882352941176, Blast_Score=391, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24647048, Length=425, Percent_Identity=46.5882352941176, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI19921738, Length=250, Percent_Identity=33.2, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281363316, Length=256, Percent_Identity=30.46875, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17864358, Length=256, Percent_Identity=30.46875, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19922690, Length=253, Percent_Identity=27.6679841897233, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000795
- InterPro:   IPR022424
- InterPro:   IPR015256
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF09173 eIF2_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 43943; Mature: 43812

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAASNQSEVNIGMVGHVDHGKTSLTRKLTGVWTDTHSEELKRGISIRLGYADCEIKKCET
CCCCCCCCEEEEEEEECCCCCHHHHHHEEEEECCCCHHHHHCCCEEEEEECCCCCCCCCC
CDEPECYTVGKKCDSCGGKLQTLRKISFVDAPGHETLMATMLSGASLMDGAILVIAASEE
CCCCCEEECCCHHHHCCHHHHHHHHEEEECCCCHHHHHHHHHCCCCCCCCEEEEEECCCC
CPQPQTKEHLMALDALGVEKIIIVQNKIDLVSEEAAVENYNQIKEFTKGTVAENAPIIPV
CCCCCHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
SAHHGANLDVLLKAIQDFIPTPERDETVSPKLYVARSFDVNKPGSEIKDLKGGVIGGSII
ECCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHCCCEECHHHH
QGALKVGDELEIKPGIKVTEGNKTHWVPIITKIISLGVGSKKLKTAYPGGLIGVGTELDP
HHHHHCCCCEEECCCCEEECCCCEEHHHHHHHHHHCCCCCHHHHCCCCCCEEEECCCCCC
NLTKSDALSGSLAGIPGTLPETLEKMEIEPQLLERVVGSQDELVIEPLKTNEVLMLNVGT
CCCHHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCEEEEECCC
STTVGVTVSARPDRAEIKLKLPVCADKGDRVAISRKIGSRWRLIGYGIIL
CCEEEEEEECCCCCCEEEEEEEEECCCCCEEEEEECCCCCEEEEEEEEEC
>Mature Secondary Structure 
AASNQSEVNIGMVGHVDHGKTSLTRKLTGVWTDTHSEELKRGISIRLGYADCEIKKCET
CCCCCCCEEEEEEEECCCCCHHHHHHEEEEECCCCHHHHHCCCEEEEEECCCCCCCCCC
CDEPECYTVGKKCDSCGGKLQTLRKISFVDAPGHETLMATMLSGASLMDGAILVIAASEE
CCCCCEEECCCHHHHCCHHHHHHHHEEEECCCCHHHHHHHHHCCCCCCCCEEEEEECCCC
CPQPQTKEHLMALDALGVEKIIIVQNKIDLVSEEAAVENYNQIKEFTKGTVAENAPIIPV
CCCCCHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
SAHHGANLDVLLKAIQDFIPTPERDETVSPKLYVARSFDVNKPGSEIKDLKGGVIGGSII
ECCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHCCCEECHHHH
QGALKVGDELEIKPGIKVTEGNKTHWVPIITKIISLGVGSKKLKTAYPGGLIGVGTELDP
HHHHHCCCCEEECCCCEEECCCCEEHHHHHHHHHHCCCCCHHHHCCCCCCEEEECCCCCC
NLTKSDALSGSLAGIPGTLPETLEKMEIEPQLLERVVGSQDELVIEPLKTNEVLMLNVGT
CCCHHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCEEEEECCCCCEEEEECCC
STTVGVTVSARPDRAEIKLKLPVCADKGDRVAISRKIGSRWRLIGYGIIL
CCEEEEEEECCCCCCEEEEEEEEECCCCCEEEEEECCCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA