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The map label for this gene is lysA [H]

Identifier: 45358763

GI number: 45358763

Start: 1186534

End: 1187844

Strand: Direct

Name: lysA [H]

Synonym: MMP1200

Alternate gene names: 45358763

Gene position: 1186534-1187844 (Clockwise)

Preceding gene: 45358762

Following gene: 45358769

Centisome position: 71.43

GC content: 35.39

Gene sequence:

>1311_bases
ATGGAATTCTTGGGGAACGAAATGATTACCGTTGACGGCGGAAACTTAAAAATTGACGGGCACGATGCAAGCAAACTTGC
TAGTACTTACGGAACGCCACTCTACGTTATGAGTGAAACCCAAACAGTTAAAAACTTTACAAGATACGTGGAATCATTTA
AAGAATACTCTGAAAAAACCGGAAAAGAATTCATAATCTCATTTGCATACAAAGCAAACACGAACCTTGCTGTAACAAGA
CTCCTATCAAAACTTGGATGCGGTGCAGACATTGTGAGTGCAGGGGAATTATACATTGCAAAACTTTCAGACGTTCCTTC
CGAAAAAATTGTATTTAATGGAAACTGTAAATTAAAAGAAGAAATTAAAATGGGAATTGAAGCTGAAATAAGAGCATTTA
ACGTTGACAGCATCAGCGAACTTGTTTTAATTAATGAAACTGCAAAAGAAATGGGAAAAATTGCAAATGTTGCATTTAGA
GTAAATCCAAATGTTGATGCAAAAACACACCCCAAAATTTCAACAGGAATGAAAAAGAACAAATTCGGGCTCGACATTGA
AAGCGGAATTGCACTTGAAACAATTAAAATGGCAGAAAAAATGGAAAACGTGAAAATTGTGGGAATTCACTGCCACATTG
GTTCACAATTAACATACATTAGCCCATTCGTTGAAGAAGCAAGAAAAATCATGGATTTCGTAGTTTTACTCAAAAACGAA
GGAATTAAAATAAGAGATGTAAACTTAGGTGGAGGCCTTGGAATTCCATACGATAAAAATACAAAAATTCCAGTTCAAAA
AGACCTCTCAAAAGCAGTTCTCGATGTAATTTATGAATATGAAGGAAAAATCGAACTTCCAAACCTTATTTTAGAACCAG
GAAGAAGTTTAGTTGCAACCGCAGGAGTTTTACTTGGAACTGTCGAACATGTTAAAGAAACCCCTGTTGCAAAATGGGTG
ATGATTGATGCTGGAATGAACGACATGATGAGACCTGCAATCTATGAATCATACCACGAAATTACACCTTGCACAATAAG
GGCTGAAAAAGAAGTTGTAAGCGTTGCAGGAGGACTTTGTGAAAGTTCTGATGTATTTGGAAAAGATAGAGAAATTTCAA
AAATGGAAGTAAAAGATACTGTCGCAATTTTAGATGTTGGAGCATATGGAATCAGTATGGCAAACAACTACAATTCAAGA
GGAAAACCTGCAATGATTCTTACAAACGAAAAAGAAGTTTCATTAATTAGAGCAAGAGAAACCCTTGCTGATTTGATTTC
AAAAGATATCGTTCCAAATCATCTTTTGTAA

Upstream 100 bases:

>100_bases
TAACGAGATATTAATTAAAGGATGAATTATATATCTTATTTTATCGACATATTTAAATAATATTACTGCTTATGATGAAA
AAACAACTTATGGTGAAACC

Downstream 100 bases:

>100_bases
ATTAAATTCTTTTTAAACTTTTTTAAAAAATAATAAAAATACAGAAAAATTAGTAAACTAGCCTAAGATACATAATATCG
TACAAAAAACTGTAGATAAT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MEFLGNEMITVDGGNLKIDGHDASKLASTYGTPLYVMSETQTVKNFTRYVESFKEYSEKTGKEFIISFAYKANTNLAVTR
LLSKLGCGADIVSAGELYIAKLSDVPSEKIVFNGNCKLKEEIKMGIEAEIRAFNVDSISELVLINETAKEMGKIANVAFR
VNPNVDAKTHPKISTGMKKNKFGLDIESGIALETIKMAEKMENVKIVGIHCHIGSQLTYISPFVEEARKIMDFVVLLKNE
GIKIRDVNLGGGLGIPYDKNTKIPVQKDLSKAVLDVIYEYEGKIELPNLILEPGRSLVATAGVLLGTVEHVKETPVAKWV
MIDAGMNDMMRPAIYESYHEITPCTIRAEKEVVSVAGGLCESSDVFGKDREISKMEVKDTVAILDVGAYGISMANNYNSR
GKPAMILTNEKEVSLIRARETLADLISKDIVPNHLL

Sequences:

>Translated_436_residues
MEFLGNEMITVDGGNLKIDGHDASKLASTYGTPLYVMSETQTVKNFTRYVESFKEYSEKTGKEFIISFAYKANTNLAVTR
LLSKLGCGADIVSAGELYIAKLSDVPSEKIVFNGNCKLKEEIKMGIEAEIRAFNVDSISELVLINETAKEMGKIANVAFR
VNPNVDAKTHPKISTGMKKNKFGLDIESGIALETIKMAEKMENVKIVGIHCHIGSQLTYISPFVEEARKIMDFVVLLKNE
GIKIRDVNLGGGLGIPYDKNTKIPVQKDLSKAVLDVIYEYEGKIELPNLILEPGRSLVATAGVLLGTVEHVKETPVAKWV
MIDAGMNDMMRPAIYESYHEITPCTIRAEKEVVSVAGGLCESSDVFGKDREISKMEVKDTVAILDVGAYGISMANNYNSR
GKPAMILTNEKEVSLIRARETLADLISKDIVPNHLL
>Mature_436_residues
MEFLGNEMITVDGGNLKIDGHDASKLASTYGTPLYVMSETQTVKNFTRYVESFKEYSEKTGKEFIISFAYKANTNLAVTR
LLSKLGCGADIVSAGELYIAKLSDVPSEKIVFNGNCKLKEEIKMGIEAEIRAFNVDSISELVLINETAKEMGKIANVAFR
VNPNVDAKTHPKISTGMKKNKFGLDIESGIALETIKMAEKMENVKIVGIHCHIGSQLTYISPFVEEARKIMDFVVLLKNE
GIKIRDVNLGGGLGIPYDKNTKIPVQKDLSKAVLDVIYEYEGKIELPNLILEPGRSLVATAGVLLGTVEHVKETPVAKWV
MIDAGMNDMMRPAIYESYHEITPCTIRAEKEVVSVAGGLCESSDVFGKDREISKMEVKDTVAILDVGAYGISMANNYNSR
GKPAMILTNEKEVSLIRARETLADLISKDIVPNHLL

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=363, Percent_Identity=23.1404958677686, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1789203, Length=429, Percent_Identity=29.8368298368298, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789307, Length=324, Percent_Identity=24.3827160493827, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17562780, Length=376, Percent_Identity=25.7978723404255, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24586472, Length=352, Percent_Identity=22.1590909090909, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47953; Mature: 47953

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFLGNEMITVDGGNLKIDGHDASKLASTYGTPLYVMSETQTVKNFTRYVESFKEYSEKT
CCCCCCEEEEEECCEEEECCCCHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHC
GKEFIISFAYKANTNLAVTRLLSKLGCGADIVSAGELYIAKLSDVPSEKIVFNGNCKLKE
CCEEEEEEEEECCCCHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCCCEEECCCCCCHH
EIKMGIEAEIRAFNVDSISELVLINETAKEMGKIANVAFRVNPNVDAKTHPKISTGMKKN
HHHCCCEEEEEEECCCCCCEEEEEEHHHHHHHHHEEEEEEECCCCCCCCCCCHHCCCCCC
KFGLDIESGIALETIKMAEKMENVKIVGIHCHIGSQLTYISPFVEEARKIMDFVVLLKNE
CCCCCCCCCCHHHHHHHHHHHCCEEEEEEEEEECCCEEEHHHHHHHHHHHHHHHHHEECC
GIKIRDVNLGGGLGIPYDKNTKIPVQKDLSKAVLDVIYEYEGKIELPNLILEPGRSLVAT
CEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCHHEECCCCHHHHH
AGVLLGTVEHVKETPVAKWVMIDAGMNDMMRPAIYESYHEITPCTIRAEKEVVSVAGGLC
HHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCC
ESSDVFGKDREISKMEVKDTVAILDVGAYGISMANNYNSRGKPAMILTNEKEVSLIRARE
CCCCCCCCCCCCCCEEHHHEEEEEEECCHHEEECCCCCCCCCCEEEEECCCHHHHHHHHH
TLADLISKDIVPNHLL
HHHHHHHHCCCCCCCC
>Mature Secondary Structure
MEFLGNEMITVDGGNLKIDGHDASKLASTYGTPLYVMSETQTVKNFTRYVESFKEYSEKT
CCCCCCEEEEEECCEEEECCCCHHHHHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHC
GKEFIISFAYKANTNLAVTRLLSKLGCGADIVSAGELYIAKLSDVPSEKIVFNGNCKLKE
CCEEEEEEEEECCCCHHHHHHHHHHCCCCCEECCCCEEEEEECCCCCCCEEECCCCCCHH
EIKMGIEAEIRAFNVDSISELVLINETAKEMGKIANVAFRVNPNVDAKTHPKISTGMKKN
HHHCCCEEEEEEECCCCCCEEEEEEHHHHHHHHHEEEEEEECCCCCCCCCCCHHCCCCCC
KFGLDIESGIALETIKMAEKMENVKIVGIHCHIGSQLTYISPFVEEARKIMDFVVLLKNE
CCCCCCCCCCHHHHHHHHHHHCCEEEEEEEEEECCCEEEHHHHHHHHHHHHHHHHHEECC
GIKIRDVNLGGGLGIPYDKNTKIPVQKDLSKAVLDVIYEYEGKIELPNLILEPGRSLVAT
CEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEECCHHEECCCCHHHHH
AGVLLGTVEHVKETPVAKWVMIDAGMNDMMRPAIYESYHEITPCTIRAEKEVVSVAGGLC
HHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHCCCC
ESSDVFGKDREISKMEVKDTVAILDVGAYGISMANNYNSRGKPAMILTNEKEVSLIRARE
CCCCCCCCCCCCCCEEHHHEEEEEEECCHHEEECCCCCCCCCCEEEEECCCHHHHHHHHH
TLADLISKDIVPNHLL
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]