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The map label for this gene is glnA

Identifier: 45358769

GI number: 45358769

Start: 1192748

End: 1194088

Strand: Direct

Name: glnA

Synonym: MMP1206

Alternate gene names: 45358769

Gene position: 1192748-1194088 (Clockwise)

Preceding gene: 45358763

Following gene: 45358770

Centisome position: 71.8

GC content: 39.52

Gene sequence:

>1341_bases
ATGAATGCTGTTGAACAGGCTATGGAATACATTAAAACGAACAACGTTAAATTCATAAGATTCCAGTTTGTAGACATTCA
CGGGGAGCCAAAAAACATCGCTTACCCTGTAAAAGCAGGTGCTGCTGGTGAGGAAGAATTATACGACGTATTAGAAAAAG
GAGTATACTTCGATGGTTCATCAATTGAAGGATTTGTTTCAATTGAAAGTTCCGACATGATGTTAAAACCAGACTTAAAA
ACACTCTCAGTACTCCCATGGAGACCAACTGAAAAATCCGTCGCAAGAGTTATCTGTGATGTATACACTACAAACGGAAA
ACCATTCGAAGGAGATCCAAGAGGATGCTTAAAAAGAGTTTTAGCTAAGTTCGATGAAGAACTCGGAGGAGAATTCTTCG
TAGGCCCTGAACCAGAATTTTTCATCTTAAAAGAAGATGCATGCGGTTCATGGGTTCCAGCAGACGATGCAGGATACTTC
GACTTAGAACCTCTTGATGGAGGATGCGATATCAGAAGAAAAATCGTATTCGCTCTTGAAAACTTAGGTTTCCACGTAGA
AGCAAGCCACCACGAAGTTGCAGAAGGTCAGCACGAAGTTGACTTTAAATTCGCAGACGCAGTAAAAACTGCAGATAGCG
TTGTAACTTTCAAAACTACAATCAAAACACTCGCTGCACAAGACGGTTTAAAAGCTACATTCATGCCAAAACCATTCTTC
GGAATCAACGGAAGCGGTATGCACTGCCACCAGAGTATCTGGTTAAACGGTGAACCATCATTCTACGATGAAAGCGCACA
ATACCAATTAAGTGAAACCTGTATGAGCTATGTTGCAGGTATTTTAGACCACGCAAAATCAATTGTTGCTGTTACAAACC
CAACAGTAAACTCATACAAAAGATTAGTTCCAGGATACGAAGCACCTGTAAACATTGCATGGGCAAATTCAAACAGAAGT
GCAATTGTTAGAGTTCCAGCTCCAAGAGGAAAAGGAACAAGAATCGAATTCAGAGCACCTGACCCAGCATGCAACCCTTA
TTTAGCATTCACAGTAATGCTTGCAGCAGGTTTAGATGGTGTAAAAAGAAAATTAAGTGCAATAGAACCTGTTGAAAAGA
ACATCTTTGCAATGAGTGAAGCTCAGAAAAAAGCTGAAGGAATCGAATCAGTTCCTGCAAACTTAAAAGCTGCGCTTGAC
GAGTTAGAAAACAACTCAGTATTAAAAGATGCCTTAGGAAAACACATCTTTGAAAACTTCATTGAAATTAAAAACGCTGA
ATGGGATTCATTCAGAACCGCAGTTACAGACTGGGAAACAAAACAATACTTAAAAATCTAA

Upstream 100 bases:

>100_bases
TAATAAATATTGATTTAGATACATTTACGTACCGCAAAATATATATATTGAAAAAGCGGAAAGCTATTTCCTATATAGTA
ATGATTTCGGAGGCATGAAT

Downstream 100 bases:

>100_bases
TTACCTTTTTTTAAATATTTTTATTGTAATGTTTACCCCAAATTCTGTCGATTCTAATCGCTGTTGCTTTTTGCCAAAAA
CTATAAAAGTAATAAGTTAG

Product: glutamine synthetase

Products: NA

Alternate protein names: GS; Glutamate--ammonia ligase

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MNAVEQAMEYIKTNNVKFIRFQFVDIHGEPKNIAYPVKAGAAGEEELYDVLEKGVYFDGSSIEGFVSIESSDMMLKPDLK
TLSVLPWRPTEKSVARVICDVYTTNGKPFEGDPRGCLKRVLAKFDEELGGEFFVGPEPEFFILKEDACGSWVPADDAGYF
DLEPLDGGCDIRRKIVFALENLGFHVEASHHEVAEGQHEVDFKFADAVKTADSVVTFKTTIKTLAAQDGLKATFMPKPFF
GINGSGMHCHQSIWLNGEPSFYDESAQYQLSETCMSYVAGILDHAKSIVAVTNPTVNSYKRLVPGYEAPVNIAWANSNRS
AIVRVPAPRGKGTRIEFRAPDPACNPYLAFTVMLAAGLDGVKRKLSAIEPVEKNIFAMSEAQKKAEGIESVPANLKAALD
ELENNSVLKDALGKHIFENFIEIKNAEWDSFRTAVTDWETKQYLKI

Sequences:

>Translated_446_residues
MNAVEQAMEYIKTNNVKFIRFQFVDIHGEPKNIAYPVKAGAAGEEELYDVLEKGVYFDGSSIEGFVSIESSDMMLKPDLK
TLSVLPWRPTEKSVARVICDVYTTNGKPFEGDPRGCLKRVLAKFDEELGGEFFVGPEPEFFILKEDACGSWVPADDAGYF
DLEPLDGGCDIRRKIVFALENLGFHVEASHHEVAEGQHEVDFKFADAVKTADSVVTFKTTIKTLAAQDGLKATFMPKPFF
GINGSGMHCHQSIWLNGEPSFYDESAQYQLSETCMSYVAGILDHAKSIVAVTNPTVNSYKRLVPGYEAPVNIAWANSNRS
AIVRVPAPRGKGTRIEFRAPDPACNPYLAFTVMLAAGLDGVKRKLSAIEPVEKNIFAMSEAQKKAEGIESVPANLKAALD
ELENNSVLKDALGKHIFENFIEIKNAEWDSFRTAVTDWETKQYLKI
>Mature_446_residues
MNAVEQAMEYIKTNNVKFIRFQFVDIHGEPKNIAYPVKAGAAGEEELYDVLEKGVYFDGSSIEGFVSIESSDMMLKPDLK
TLSVLPWRPTEKSVARVICDVYTTNGKPFEGDPRGCLKRVLAKFDEELGGEFFVGPEPEFFILKEDACGSWVPADDAGYF
DLEPLDGGCDIRRKIVFALENLGFHVEASHHEVAEGQHEVDFKFADAVKTADSVVTFKTTIKTLAAQDGLKATFMPKPFF
GINGSGMHCHQSIWLNGEPSFYDESAQYQLSETCMSYVAGILDHAKSIVAVTNPTVNSYKRLVPGYEAPVNIAWANSNRS
AIVRVPAPRGKGTRIEFRAPDPACNPYLAFTVMLAAGLDGVKRKLSAIEPVEKNIFAMSEAQKKAEGIESVPANLKAALD
ELENNSVLKDALGKHIFENFIEIKNAEWDSFRTAVTDWETKQYLKI

Specific function: Unknown

COG id: COG0174

COG function: function code E; Glutamine synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamine synthetase family

Homologues:

Organism=Homo sapiens, GI221307485, Length=444, Percent_Identity=27.2522522522523, Blast_Score=128, Evalue=9e-30,
Organism=Escherichia coli, GI1790301, Length=481, Percent_Identity=36.1746361746362, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI87081870, Length=455, Percent_Identity=27.6923076923077, Blast_Score=138, Evalue=9e-34,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 15324 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal medi

Swissprot (AC and ID): GLNA_METMP (O59648)

Other databases:

- EMBL:   AF062391
- EMBL:   BX950229
- RefSeq:   NP_988326.1
- ProteinModelPortal:   O59648
- SMR:   O59648
- GeneID:   2761968
- GenomeReviews:   BX950229_GR
- KEGG:   mmp:MMP1206
- HOGENOM:   HBG553755
- OMA:   ALIRIPK
- ProtClustDB:   CLSK876540
- BioCyc:   MMAR267377:MMP1206-MONOMER
- BRENDA:   6.3.1.2
- GO:   GO:0005737
- InterPro:   IPR008147
- InterPro:   IPR014746
- InterPro:   IPR008146
- InterPro:   IPR004809
- Gene3D:   G3DSA:3.30.590.10
- TIGRFAMs:   TIGR00653

Pfam domain/function: PF00120 Gln-synt_C; PF03951 Gln-synt_N; SSF54368 Gln_synt_beta

EC number: =6.3.1.2

Molecular weight: Translated: 49421; Mature: 49421

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00180 GLNA_1; PS00181 GLNA_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVEQAMEYIKTNNVKFIRFQFVDIHGEPKNIAYPVKAGAAGEEELYDVLEKGVYFDGS
CCHHHHHHHHHHCCCEEEEEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHCCEEECCC
SIEGFVSIESSDMMLKPDLKTLSVLPWRPTEKSVARVICDVYTTNGKPFEGDPRGCLKRV
CCCEEEEECCCCEEECCCCCCEEEECCCCCHHHHHHHHHHHEECCCCCCCCCHHHHHHHH
LAKFDEELGGEFFVGPEPEFFILKEDACGSWVPADDAGYFDLEPLDGGCDIRRKIVFALE
HHHHHHHHCCEEEECCCCCEEEEEECCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHH
NLGFHVEASHHEVAEGQHEVDFKFADAVKTADSVVTFKTTIKTLAAQDGLKATFMPKPFF
HCCEEEECCCHHHHCCCCCCCEEHHHHHHHHCCEEEHHHHHHHHHHCCCCCEEECCCCCC
GINGSGMHCHQSIWLNGEPSFYDESAQYQLSETCMSYVAGILDHAKSIVAVTNPTVNSYK
CCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHH
RLVPGYEAPVNIAWANSNRSAIVRVPAPRGKGTRIEFRAPDPACNPYLAFTVMLAAGLDG
HHCCCCCCCEEEEEECCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCHH
VKRKLSAIEPVEKNIFAMSEAQKKAEGIESVPANLKAALDELENNSVLKDALGKHIFENF
HHHHHHHCCHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IEIKNAEWDSFRTAVTDWETKQYLKI
HHHCCCCCHHHHHHHCCCCCHHHHCC
>Mature Secondary Structure
MNAVEQAMEYIKTNNVKFIRFQFVDIHGEPKNIAYPVKAGAAGEEELYDVLEKGVYFDGS
CCHHHHHHHHHHCCCEEEEEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHCCEEECCC
SIEGFVSIESSDMMLKPDLKTLSVLPWRPTEKSVARVICDVYTTNGKPFEGDPRGCLKRV
CCCEEEEECCCCEEECCCCCCEEEECCCCCHHHHHHHHHHHEECCCCCCCCCHHHHHHHH
LAKFDEELGGEFFVGPEPEFFILKEDACGSWVPADDAGYFDLEPLDGGCDIRRKIVFALE
HHHHHHHHCCEEEECCCCCEEEEEECCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHH
NLGFHVEASHHEVAEGQHEVDFKFADAVKTADSVVTFKTTIKTLAAQDGLKATFMPKPFF
HCCEEEECCCHHHHCCCCCCCEEHHHHHHHHCCEEEHHHHHHHHHHCCCCCEEECCCCCC
GINGSGMHCHQSIWLNGEPSFYDESAQYQLSETCMSYVAGILDHAKSIVAVTNPTVNSYK
CCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHH
RLVPGYEAPVNIAWANSNRSAIVRVPAPRGKGTRIEFRAPDPACNPYLAFTVMLAAGLDG
HHCCCCCCCEEEEEECCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCHH
VKRKLSAIEPVEKNIFAMSEAQKKAEGIESVPANLKAALDELENNSVLKDALGKHIFENF
HHHHHHHCCHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
IEIKNAEWDSFRTAVTDWETKQYLKI
HHHCCCCCHHHHHHHCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9864338