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The map label for this gene is deoA [C]

Identifier: 45357890

GI number: 45357890

Start: 324525

End: 326042

Strand: Direct

Name: deoA [C]

Synonym: MMP0327

Alternate gene names: 45357890

Gene position: 324525-326042 (Clockwise)

Preceding gene: 45357889

Following gene: 45357891

Centisome position: 19.54

GC content: 37.35

Gene sequence:

>1518_bases
ATGCTATTTTTAAATGCAAAATTTATAGACCTTGATCTGGGCGAAAATGCGGTAATTGTTAACGAAGACGATTTAAAAGG
AACTTCTTACTACCCGCAGGATAGGGTATTGATAGAGTCACACGCAGGTTCTGTCATTGGAAATATTTATTCTACAAAAA
CAATGGTCCAAAAAGGCGAAGTTGGAATGCTTGTCAGTGAACTTGCAGAAATTTCAATTTCAGAAGGGGAAGAAGTAAAA
TTAAGGCATGCAGAAAAGCCTGAATCGATTCCGTTTATAAAAAAGAAAATGGATGGTCAGGTTTTAAATCCGCATGAAAT
AAGAACGATAATTGATGAAATCGTATCTAAAAAACTTTCAAACATTGAATTATCCGCATTTGTTTCATCTACGTATATTA
ATGGAATGAATATGGATGAAATAGGCGAGATGACCAAGAGAATTGCAGAAACAGGGGACATGATTTCTTGGGAGAAAAAT
CTTGTTGTTGATATCCACAGTATTGGTGGAGTTCCTGGGAATAAATACGCTCTGCTTTCAATTCCAATACTTGCAGCAGC
GGGAATCACAATTCCAAAAACCTCATCAAGGGCGATAACTTCGCCTGCAGGAACTGCCGATGTAATGGAAGTGCTCACAA
ATGTTGAATTAAAGGAAGACGAGATAAAAAGAATAGTAAAAACCACAAACGGATGTCTTGTATGGGGTGGAGGAGTAAAT
TTGGCTCCTGCTGACGATATCATCATCAATGTGGAAAGACCAGTTTCAATAGACCCTCAGCCACAGCTTCTTGCAAGTGT
TATGGCAAAAAAGATTGCAACAGGAATTAAATACTCTGTAATCGATATTCCAGTTGGAAAAGGCGTAAAAATTAAAAATG
AGGCAGAAGGTGCAAAATTAGCGAGGAAATTTATTGAACTTGGGGAATTGTTAAATATTAAAGTAGAATGTGTCTTAACG
TATGGTGGACAGCCTCTTGGACGGGCAATTGGACCTGCACTCGAAGCAAAAGAAGCAATCGAAGCACTTCAAGATCCCAA
AAATGCTCCAAAAAGTTTAATTGAAAAAGCCTTATCTCTTGCAGGAATTCTTCTTGAACTTGGGGGAGCTGCACAAATTG
GTGAAGGGCAGAACTTAGCCTGGGAAATTTTAGAGTCTGGTAGGGCACTTGAAAAATTCAACCAGATCATAATTGAACAG
GGCGGAACTCCAAAAAAACCTGAAGAAATAGAACTTGGAGACTATATTGAAGAAATAATTGCTCCAATAGATGGCTACGT
TACAGATATAAATAATACTGGAATTACAAACGTAGTTAAAGAGGCTGGAGCTCCAAGGGATAAAAAAGCAGGACTTTTAC
TAAACTCAAAGATTGGAAACAAAGTTAAAAAAGGAGATGTGTTGTATACCATCTATTCTGGCTCTGAAGAAAGGCTTGTA
TCAGCAGTAAATCTTGCGAGAAGAGTTTATCCTGTAAAAGTTGAAGGAATGCTTATTGAAAGAATAAGTAAATTCTAA

Upstream 100 bases:

>100_bases
TTTTTTATAAAATTTTTTAAAAAAGTTTTTATTTTAAGTTAGATATAAACTGATTAGAGTTAATTTATTAATTTTAATAA
TAATCTGCGGGAGGGACATC

Downstream 100 bases:

>100_bases
CTTTTAATTTTTTAATATAGGTAGAATTAAATAGAATTATTCATAGTTATTTTTTACAAATGTTTACTGATTTAGTCTTA
TTTTATCTAGATTTAACTGC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MLFLNAKFIDLDLGENAVIVNEDDLKGTSYYPQDRVLIESHAGSVIGNIYSTKTMVQKGEVGMLVSELAEISISEGEEVK
LRHAEKPESIPFIKKKMDGQVLNPHEIRTIIDEIVSKKLSNIELSAFVSSTYINGMNMDEIGEMTKRIAETGDMISWEKN
LVVDIHSIGGVPGNKYALLSIPILAAAGITIPKTSSRAITSPAGTADVMEVLTNVELKEDEIKRIVKTTNGCLVWGGGVN
LAPADDIIINVERPVSIDPQPQLLASVMAKKIATGIKYSVIDIPVGKGVKIKNEAEGAKLARKFIELGELLNIKVECVLT
YGGQPLGRAIGPALEAKEAIEALQDPKNAPKSLIEKALSLAGILLELGGAAQIGEGQNLAWEILESGRALEKFNQIIIEQ
GGTPKKPEEIELGDYIEEIIAPIDGYVTDINNTGITNVVKEAGAPRDKKAGLLLNSKIGNKVKKGDVLYTIYSGSEERLV
SAVNLARRVYPVKVEGMLIERISKF

Sequences:

>Translated_505_residues
MLFLNAKFIDLDLGENAVIVNEDDLKGTSYYPQDRVLIESHAGSVIGNIYSTKTMVQKGEVGMLVSELAEISISEGEEVK
LRHAEKPESIPFIKKKMDGQVLNPHEIRTIIDEIVSKKLSNIELSAFVSSTYINGMNMDEIGEMTKRIAETGDMISWEKN
LVVDIHSIGGVPGNKYALLSIPILAAAGITIPKTSSRAITSPAGTADVMEVLTNVELKEDEIKRIVKTTNGCLVWGGGVN
LAPADDIIINVERPVSIDPQPQLLASVMAKKIATGIKYSVIDIPVGKGVKIKNEAEGAKLARKFIELGELLNIKVECVLT
YGGQPLGRAIGPALEAKEAIEALQDPKNAPKSLIEKALSLAGILLELGGAAQIGEGQNLAWEILESGRALEKFNQIIIEQ
GGTPKKPEEIELGDYIEEIIAPIDGYVTDINNTGITNVVKEAGAPRDKKAGLLLNSKIGNKVKKGDVLYTIYSGSEERLV
SAVNLARRVYPVKVEGMLIERISKF
>Mature_505_residues
MLFLNAKFIDLDLGENAVIVNEDDLKGTSYYPQDRVLIESHAGSVIGNIYSTKTMVQKGEVGMLVSELAEISISEGEEVK
LRHAEKPESIPFIKKKMDGQVLNPHEIRTIIDEIVSKKLSNIELSAFVSSTYINGMNMDEIGEMTKRIAETGDMISWEKN
LVVDIHSIGGVPGNKYALLSIPILAAAGITIPKTSSRAITSPAGTADVMEVLTNVELKEDEIKRIVKTTNGCLVWGGGVN
LAPADDIIINVERPVSIDPQPQLLASVMAKKIATGIKYSVIDIPVGKGVKIKNEAEGAKLARKFIELGELLNIKVECVLT
YGGQPLGRAIGPALEAKEAIEALQDPKNAPKSLIEKALSLAGILLELGGAAQIGEGQNLAWEILESGRALEKFNQIIIEQ
GGTPKKPEEIELGDYIEEIIAPIDGYVTDINNTGITNVVKEAGAPRDKKAGLLLNSKIGNKVKKGDVLYTIYSGSEERLV
SAVNLARRVYPVKVEGMLIERISKF

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=413, Percent_Identity=27.1186440677966, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI4503445, Length=413, Percent_Identity=27.1186440677966, Blast_Score=152, Evalue=7e-37,
Organism=Homo sapiens, GI166158922, Length=413, Percent_Identity=27.1186440677966, Blast_Score=152, Evalue=7e-37,
Organism=Escherichia coli, GI1790842, Length=404, Percent_Identity=26.2376237623762, Blast_Score=122, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017713
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 54598; Mature: 54598

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFLNAKFIDLDLGENAVIVNEDDLKGTSYYPQDRVLIESHAGSVIGNIYSTKTMVQKGE
CEEEEEEEEEEECCCCEEEECCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCC
VGMLVSELAEISISEGEEVKLRHAEKPESIPFIKKKMDGQVLNPHEIRTIIDEIVSKKLS
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHC
NIELSAFVSSTYINGMNMDEIGEMTKRIAETGDMISWEKNLVVDIHSIGGVPGNKYALLS
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCEEEEEHHCCCCCCCCEEEEE
IPILAAAGITIPKTSSRAITSPAGTADVMEVLTNVELKEDEIKRIVKTTNGCLVWGGGVN
EHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCC
LAPADDIIINVERPVSIDPQPQLLASVMAKKIATGIKYSVIDIPVGKGVKIKNEAEGAKL
CCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCHHHHH
ARKFIELGELLNIKVECVLTYGGQPLGRAIGPALEAKEAIEALQDPKNAPKSLIEKALSL
HHHHHHHHHHHCEEEEEEEEECCCHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AGILLELGGAAQIGEGQNLAWEILESGRALEKFNQIIIEQGGTPKKPEEIELGDYIEEII
HHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
APIDGYVTDINNTGITNVVKEAGAPRDKKAGLLLNSKIGNKVKKGDVLYTIYSGSEERLV
HCCCCEEEECCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCHHHHH
SAVNLARRVYPVKVEGMLIERISKF
HHHHHHHHCCEEEECHHHHHHHHCC
>Mature Secondary Structure
MLFLNAKFIDLDLGENAVIVNEDDLKGTSYYPQDRVLIESHAGSVIGNIYSTKTMVQKGE
CEEEEEEEEEEECCCCEEEECCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCC
VGMLVSELAEISISEGEEVKLRHAEKPESIPFIKKKMDGQVLNPHEIRTIIDEIVSKKLS
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHC
NIELSAFVSSTYINGMNMDEIGEMTKRIAETGDMISWEKNLVVDIHSIGGVPGNKYALLS
CCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCEEEEEHHCCCCCCCCEEEEE
IPILAAAGITIPKTSSRAITSPAGTADVMEVLTNVELKEDEIKRIVKTTNGCLVWGGGVN
EHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCC
LAPADDIIINVERPVSIDPQPQLLASVMAKKIATGIKYSVIDIPVGKGVKIKNEAEGAKL
CCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCHHHHH
ARKFIELGELLNIKVECVLTYGGQPLGRAIGPALEAKEAIEALQDPKNAPKSLIEKALSL
HHHHHHHHHHHCEEEEEEEEECCCHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
AGILLELGGAAQIGEGQNLAWEILESGRALEKFNQIIIEQGGTPKKPEEIELGDYIEEII
HHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
APIDGYVTDINNTGITNVVKEAGAPRDKKAGLLLNSKIGNKVKKGDVLYTIYSGSEERLV
HCCCCEEEECCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCHHHHH
SAVNLARRVYPVKVEGMLIERISKF
HHHHHHHHCCEEEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA