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The map label for this gene is putP [H]

Identifier: 45357784

GI number: 45357784

Start: 229031

End: 230509

Strand: Direct

Name: putP [H]

Synonym: MMP0221

Alternate gene names: 45357784

Gene position: 229031-230509 (Clockwise)

Preceding gene: 45357783

Following gene: 45357785

Centisome position: 13.79

GC content: 39.15

Gene sequence:

>1479_bases
ATGATATCAGAAAATTTGAGTATCGTTTTGGTATTCATACTCTATTTGCTCGTGGTAATGGGCGTAGGTATGTATTTTTA
CAGGCGAAACGAAACGATAAGCGATTATGTGCTTGGTGGCAGAAAATTAAATAGTTGGGTTGCAGCGTTAAGTGCGCAAG
CTTCAGACATGAGCGGTTGGCTTCTTATGGGGCTTCCTGGCGTTGCATATCTTTCAGGAATGAGTGAAATATGGATTGGA
GTTGGTCTTGCAATAGGAACTTATCTAAACTGGAAGTTCGTTGCAGAAAGGCTTAGAAGATACACAGAAATTGCAAAAGA
TTCTATTACAATACCCGTTTACTTAGAAAATAGGTTTAGAGATCAGTCTAAATTGTTAAGAATTGTTTCAGCGTTTTTTA
TTATGCTATTTTTCTTATTGTACACATCTTCAGGATTAGTTGCAGGCGGAAAGTTGTTCAATCTTGTATTCGGGGTAGAT
TATACTCTAGCAGTTACAATCGGTGCTTTAGTAATTATTGGTTATACATTCCTCGGCGGTTTCCTTGCAGTTAGCTGGAC
TGACTTTATACAAGGTTCACTCATGTTTATTGCGATATTTTTAATTCCTATCATGGGGATTTCACAGGTGGGTGGAATTG
ATGCTACAATGAATGCATGGAATTCAATAAGTCCAGATTACCTAAATCCATTTACCAACCTAGATGGAGAATCCCTAGGT
ATAATGGGACTTGCATCAGCTCTTGCATGGGGTCTTGGATACTTTGGAATGCCACACATCCTTGTAAGGTTTATGGCAAT
CAAATCAGCTGATAAAGTTCCAAAAGCAAGAAAAATTGCAACTACTTGGGTTGTAATCAGCCTTTTCATGGCAGTACTTG
TTGGAATGGTCGGTGCAGTGGCTCTTGGAGCACCACTTGATGATCCGGAGCATGTATTCATGGCAATGGCACAAGGGTTA
TTCCCAAGTCTTATTGCAGGGTTATTTTTGGCAGGTGTTTTAGCAGCTATCATGAGTACTGCAGATTCACAGCTTTTAGT
GACCGCTTCAGCAATTACTGAAGATATTTATGCATTATTAAATAAAAATGCAAGTCAAAAAGAGCTTTTATGGATAAGCA
GGTTTGCGGTAATTGTTGTGGCGGCAATAGCTTATTACTTTGCAATAGTTCCTGGAAGCAGCGTTATGGGTCTTGTTTCA
TACGCATGGGCAGGATTTGGTGGCGCATTTGGTCCAGTAATATTGCTTTCACTGTACTGGAAGAGAATGACAAGAAATGG
TGCTCTTGCAGGACTGTTATCTGGTGGATTTATGGTAATTCTCTGGAAAAACTTGAGCGGTGGAATTTTCGACCTTTACG
AAATTGTTCCTGCATTTTTGCTTGCATCAGTAATGATTACGGTTGTAAGTTTAATGGATAAAGAACCGTCATTAGAAATT
CAAGAAGAGTTTGACAGGGCAGTTTCTGAAATGAAATAG

Upstream 100 bases:

>100_bases
CGTATTCAAAATTTGTATATATTATTATCAAGATATTTGGTTGAGTATTACCAAATAGGATTTTCACATTGCGGTGTGAT
TTTCCAATGGAGTTGAAGTT

Downstream 100 bases:

>100_bases
AAAATCTAAGAAAAAACTAAGAAATAAATATGATAAGTACCAATCATATTTAAAATAATTTTTTTATTTTGGGGTACTAT
GCATTATTCAATGATTAAAC

Product: sodium/proline symporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MISENLSIVLVFILYLLVVMGVGMYFYRRNETISDYVLGGRKLNSWVAALSAQASDMSGWLLMGLPGVAYLSGMSEIWIG
VGLAIGTYLNWKFVAERLRRYTEIAKDSITIPVYLENRFRDQSKLLRIVSAFFIMLFFLLYTSSGLVAGGKLFNLVFGVD
YTLAVTIGALVIIGYTFLGGFLAVSWTDFIQGSLMFIAIFLIPIMGISQVGGIDATMNAWNSISPDYLNPFTNLDGESLG
IMGLASALAWGLGYFGMPHILVRFMAIKSADKVPKARKIATTWVVISLFMAVLVGMVGAVALGAPLDDPEHVFMAMAQGL
FPSLIAGLFLAGVLAAIMSTADSQLLVTASAITEDIYALLNKNASQKELLWISRFAVIVVAAIAYYFAIVPGSSVMGLVS
YAWAGFGGAFGPVILLSLYWKRMTRNGALAGLLSGGFMVILWKNLSGGIFDLYEIVPAFLLASVMITVVSLMDKEPSLEI
QEEFDRAVSEMK

Sequences:

>Translated_492_residues
MISENLSIVLVFILYLLVVMGVGMYFYRRNETISDYVLGGRKLNSWVAALSAQASDMSGWLLMGLPGVAYLSGMSEIWIG
VGLAIGTYLNWKFVAERLRRYTEIAKDSITIPVYLENRFRDQSKLLRIVSAFFIMLFFLLYTSSGLVAGGKLFNLVFGVD
YTLAVTIGALVIIGYTFLGGFLAVSWTDFIQGSLMFIAIFLIPIMGISQVGGIDATMNAWNSISPDYLNPFTNLDGESLG
IMGLASALAWGLGYFGMPHILVRFMAIKSADKVPKARKIATTWVVISLFMAVLVGMVGAVALGAPLDDPEHVFMAMAQGL
FPSLIAGLFLAGVLAAIMSTADSQLLVTASAITEDIYALLNKNASQKELLWISRFAVIVVAAIAYYFAIVPGSSVMGLVS
YAWAGFGGAFGPVILLSLYWKRMTRNGALAGLLSGGFMVILWKNLSGGIFDLYEIVPAFLLASVMITVVSLMDKEPSLEI
QEEFDRAVSEMK
>Mature_492_residues
MISENLSIVLVFILYLLVVMGVGMYFYRRNETISDYVLGGRKLNSWVAALSAQASDMSGWLLMGLPGVAYLSGMSEIWIG
VGLAIGTYLNWKFVAERLRRYTEIAKDSITIPVYLENRFRDQSKLLRIVSAFFIMLFFLLYTSSGLVAGGKLFNLVFGVD
YTLAVTIGALVIIGYTFLGGFLAVSWTDFIQGSLMFIAIFLIPIMGISQVGGIDATMNAWNSISPDYLNPFTNLDGESLG
IMGLASALAWGLGYFGMPHILVRFMAIKSADKVPKARKIATTWVVISLFMAVLVGMVGAVALGAPLDDPEHVFMAMAQGL
FPSLIAGLFLAGVLAAIMSTADSQLLVTASAITEDIYALLNKNASQKELLWISRFAVIVVAAIAYYFAIVPGSSVMGLVS
YAWAGFGGAFGPVILLSLYWKRMTRNGALAGLLSGGFMVILWKNLSGGIFDLYEIVPAFLLASVMITVVSLMDKEPSLEI
QEEFDRAVSEMK

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=487, Percent_Identity=47.0225872689938, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI14140236, Length=484, Percent_Identity=24.5867768595041, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI4507031, Length=479, Percent_Identity=24.2171189979123, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI110835708, Length=543, Percent_Identity=25.0460405156538, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI11141885, Length=455, Percent_Identity=25.4945054945055, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4507035, Length=417, Percent_Identity=25.1798561151079, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI167466278, Length=474, Percent_Identity=24.4725738396624, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI17941285, Length=460, Percent_Identity=24.5652173913043, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI157671931, Length=449, Percent_Identity=23.162583518931, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI206597483, Length=443, Percent_Identity=23.4762979683973, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI206597487, Length=383, Percent_Identity=22.976501305483, Blast_Score=67, Evalue=6e-11,
Organism=Homo sapiens, GI109659836, Length=469, Percent_Identity=21.1087420042644, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1787251, Length=488, Percent_Identity=48.3606557377049, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI87082237, Length=468, Percent_Identity=27.5641025641026, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1790503, Length=449, Percent_Identity=24.9443207126949, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1790113, Length=413, Percent_Identity=25.181598062954, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539284, Length=461, Percent_Identity=24.5119305856833, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI115533094, Length=356, Percent_Identity=27.5280898876405, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24645928, Length=395, Percent_Identity=26.3291139240506, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648033, Length=470, Percent_Identity=23.6170212765957, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21356865, Length=470, Percent_Identity=23.6170212765957, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI221459584, Length=391, Percent_Identity=24.8081841432225, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221459586, Length=445, Percent_Identity=26.7415730337079, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI221459588, Length=393, Percent_Identity=26.7175572519084, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281362918, Length=212, Percent_Identity=29.2452830188679, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24651739, Length=217, Percent_Identity=27.1889400921659, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24651741, Length=210, Percent_Identity=26.6666666666667, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640370, Length=219, Percent_Identity=28.7671232876712, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 53468; Mature: 53468

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISENLSIVLVFILYLLVVMGVGMYFYRRNETISDYVLGGRKLNSWVAALSAQASDMSGW
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCE
LLMGLPGVAYLSGMSEIWIGVGLAIGTYLNWKFVAERLRRYTEIAKDSITIPVYLENRFR
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHC
DQSKLLRIVSAFFIMLFFLLYTSSGLVAGGKLFNLVFGVDYTLAVTIGALVIIGYTFLGG
CHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FLAVSWTDFIQGSLMFIAIFLIPIMGISQVGGIDATMNAWNSISPDYLNPFTNLDGESLG
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCHHHHHCCCCCCHHCCCCCCCCCCCHH
IMGLASALAWGLGYFGMPHILVRFMAIKSADKVPKARKIATTWVVISLFMAVLVGMVGAV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALGAPLDDPEHVFMAMAQGLFPSLIAGLFLAGVLAAIMSTADSQLLVTASAITEDIYALL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHH
NKNASQKELLWISRFAVIVVAAIAYYFAIVPGSSVMGLVSYAWAGFGGAFGPVILLSLYW
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
KRMTRNGALAGLLSGGFMVILWKNLSGGIFDLYEIVPAFLLASVMITVVSLMDKEPSLEI
HHHHCCCCHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
QEEFDRAVSEMK
HHHHHHHHHHCC
>Mature Secondary Structure
MISENLSIVLVFILYLLVVMGVGMYFYRRNETISDYVLGGRKLNSWVAALSAQASDMSGW
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHCCCCCCCE
LLMGLPGVAYLSGMSEIWIGVGLAIGTYLNWKFVAERLRRYTEIAKDSITIPVYLENRFR
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHC
DQSKLLRIVSAFFIMLFFLLYTSSGLVAGGKLFNLVFGVDYTLAVTIGALVIIGYTFLGG
CHHHHHHHHHHHHHHHHHHHHCCCCCEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FLAVSWTDFIQGSLMFIAIFLIPIMGISQVGGIDATMNAWNSISPDYLNPFTNLDGESLG
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCHHHHHCCCCCCHHCCCCCCCCCCCHH
IMGLASALAWGLGYFGMPHILVRFMAIKSADKVPKARKIATTWVVISLFMAVLVGMVGAV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALGAPLDDPEHVFMAMAQGLFPSLIAGLFLAGVLAAIMSTADSQLLVTASAITEDIYALL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHH
NKNASQKELLWISRFAVIVVAAIAYYFAIVPGSSVMGLVSYAWAGFGGAFGPVILLSLYW
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
KRMTRNGALAGLLSGGFMVILWKNLSGGIFDLYEIVPAFLLASVMITVVSLMDKEPSLEI
HHHHCCCCHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
QEEFDRAVSEMK
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]