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The map label for this gene is fdhA [H]

Identifier: 45357701

GI number: 45357701

Start: 145038

End: 147068

Strand: Direct

Name: fdhA [H]

Synonym: MMP0138

Alternate gene names: 45357701

Gene position: 145038-147068 (Clockwise)

Preceding gene: 45357700

Following gene: 45357702

Centisome position: 8.73

GC content: 38.5

Gene sequence:

>2031_bases
ATGACCGAATTTAAGGTTGTTCATACTATATGCCCCTACTGTGGAACGGGTTGCGGTATTGACCTCGTAGTTAAGGACGG
TAAAGTAGTAGATTCCCACCCTTTCAAAAGACACCCTGTAAACGAGGGTAAAGTCTGTATAAAAGGTAATTACTGTTATG
AATTCGTTCATAGCGAAGACAGGCTGACAAAACCCCTCATAAAAAAGAATGGGGAGTTTATTGAAGCCACATGGGATGAA
GCATTAGATCTTATCGCAGGAAAATTAAAACAATATTCTCCTGATGAAGTAGCATTCTTTTCATGTGCGAGAGGCACAAA
TGAAGAGAGCTATGCTTTGCAGAAATTTGCAAGAACTGTACTCAAAACGAACAACGTAGATCACTGTGCGAGGATATGAC
ACGCTCCAACAGTTGTAGGTCTCGGAGAATGTTTTGGTTCAGGTGCAATGACCAATTCAATCACTGATTTAGCACAAGCA
GATGTATTGCTTATCTACGGTTCCAATACTTTTGAAGCTCACCCTTTAATAGCAAGAAGTATTGTAAAGGCCAAAGAAAA
TGGTACTAAAATAATTGCAATCGATCCAAGAACAACACACACTGCAAAAATGGCAGATTTACATTTAAAGCTTATTCCTG
GATCAAATATTGATTTGATAAATACTATCACGAATATCATCATCCAAGAAGGAATGGCTGATGAAGAATTTATTAAAAAC
AGAACCGAAGGTTACGATGAACTAAAAGATGTAGTTTCAAAGTATACTCTCGAAAAAACAGCAGAACTTTCAGGAATACC
TGCAGAAACAATTCTTGAAGCAGCAAGAATGTACGGAAGTGCAGAAAACGCGTCTATAATGTATTGTTTAGGTGTTACTG
AATATACATTTGGTGTGGATAACGTTAAATCATGCTGTAACCTTGCAATGGTTACAGGAAACCTTGGAAGGCCTGGAACT
GGTGTAAACCCATTAAGAGGTCAGAATAACGTTCAAGGTGCATGTGACATGGGTGCACTTCCAAACGTATTCCCTGGATA
CCAGAAAGTTGGAGAAGCTTATGAAAGACTCGAAAACTTATGGGAAACAGCAGATTTAAACAGAGAAATTGGATTGACAA
GTCCTGAAGTTTTACACAAGGCTGGAGAACAGGTAAAATTCCTTCACATTGTTGGGGAAGACCCTATGGTTGCTGATGCA
GATATAAACCACGTTGAAAAAGCTTTGAAAAGTTTAGATTTCTTTGTAGTTCAAGATATCTTCTTAACTGAAACTGCAAA
ACTTGCAGATGTTGTACTTCCTGCAGCTTGCTGGGCTGAAAAAGACGGAACATTCACAAATTCTGAAAGAAGAGTACAAA
GAATCAGAAAAGCAGTTGACGCACCTGGAGACGCACTTCCAGACTGGCTTATTGTTCGAAAACTTGCTGAAAAAATGGGC
GCTGGCGAAAAACTCAATTTCGAAAGTGCATCAGAAATATTCGATGAAATGGCAAAAGTTATTCCACAATATGCAGGAAT
GTCTTTTGAACGACTCGGCATTGATGGACTTCAGTGGCCATGTAAAACTCCAGAAGACCCTGGAACTCCAATACTCCACA
AAGAAAAATTCTTAAGGCCAAACGGACTCGGTAAATTTACTCCAGTTGAACATAAAGATGCTGATGAGCTTATTGATGAA
GAATACCCACTCATACTTACTACGGGAAGAATAATCTTCCACTACAACTCTGGAACAATGACCAGAAGGTGTGACAGTAT
CACAAATGAGATTGATGAAAACTTCATTGAAATAAATACTGAAGATGCCAAAGAATTGGGAATAAAGCCTGGAGAAAAAG
TTAGAGTTTCCTCAAGAAGGGGAACTGTAAATGCAGATGCCCGAGTAACTGAAAACGTCATAAAAGGAGTAGTTTACATG
TCATTCCACTTTTTAGAGGAAGCAACAAACAAACTAACAAATTCCGCGTATGACCCAGTATCAAAAACCGCAGAACTAAA
AATATGTGCCGTTAAAGTTGAAAAAATTTAA

Upstream 100 bases:

>100_bases
TTTAACTTTGAATTTGTGACTTAACGGCTTTTAAATTTTTAATTTAGCCCGTATTTCCAATTCTTGGTTAAAAATAAGTA
TAAAATTAAAAGGTGGAATA

Downstream 100 bases:

>100_bases
TAATTATTTTTGAGGTGATTTAAATGAGCTATTATTTAGTTCAGTCAACGGACGAAGATATTTTAAAGCATGCGGAATGT
GGTGGGGCAGTTACTGCATT

Product: formate dehydrogenase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 676; Mature: 675

Protein sequence:

>676_residues
MTEFKVVHTICPYCGTGCGIDLVVKDGKVVDSHPFKRHPVNEGKVCIKGNYCYEFVHSEDRLTKPLIKKNGEFIEATWDE
ALDLIAGKLKQYSPDEVAFFSCARGTNEESYALQKFARTVLKTNNVDHCARIUHAPTVVGLGECFGSGAMTNSITDLAQA
DVLLIYGSNTFEAHPLIARSIVKAKENGTKIIAIDPRTTHTAKMADLHLKLIPGSNIDLINTITNIIIQEGMADEEFIKN
RTEGYDELKDVVSKYTLEKTAELSGIPAETILEAARMYGSAENASIMYCLGVTEYTFGVDNVKSCCNLAMVTGNLGRPGT
GVNPLRGQNNVQGACDMGALPNVFPGYQKVGEAYERLENLWETADLNREIGLTSPEVLHKAGEQVKFLHIVGEDPMVADA
DINHVEKALKSLDFFVVQDIFLTETAKLADVVLPAACWAEKDGTFTNSERRVQRIRKAVDAPGDALPDWLIVRKLAEKMG
AGEKLNFESASEIFDEMAKVIPQYAGMSFERLGIDGLQWPCKTPEDPGTPILHKEKFLRPNGLGKFTPVEHKDADELIDE
EYPLILTTGRIIFHYNSGTMTRRCDSITNEIDENFIEINTEDAKELGIKPGEKVRVSSRRGTVNADARVTENVIKGVVYM
SFHFLEEATNKLTNSAYDPVSKTAELKICAVKVEKI

Sequences:

>Translated_676_residues
MTEFKVVHTICPYCGTGCGIDLVVKDGKVVDSHPFKRHPVNEGKVCIKGNYCYEFVHSEDRLTKPLIKKNGEFIEATWDE
ALDLIAGKLKQYSPDEVAFFSCARGTNEESYALQKFARTVLKTNNVDHCARI*HAPTVVGLGECFGSGAMTNSITDLAQA
DVLLIYGSNTFEAHPLIARSIVKAKENGTKIIAIDPRTTHTAKMADLHLKLIPGSNIDLINTITNIIIQEGMADEEFIKN
RTEGYDELKDVVSKYTLEKTAELSGIPAETILEAARMYGSAENASIMYCLGVTEYTFGVDNVKSCCNLAMVTGNLGRPGT
GVNPLRGQNNVQGACDMGALPNVFPGYQKVGEAYERLENLWETADLNREIGLTSPEVLHKAGEQVKFLHIVGEDPMVADA
DINHVEKALKSLDFFVVQDIFLTETAKLADVVLPAACWAEKDGTFTNSERRVQRIRKAVDAPGDALPDWLIVRKLAEKMG
AGEKLNFESASEIFDEMAKVIPQYAGMSFERLGIDGLQWPCKTPEDPGTPILHKEKFLRPNGLGKFTPVEHKDADELIDE
EYPLILTTGRIIFHYNSGTMTRRCDSITNEIDENFIEINTEDAKELGIKPGEKVRVSSRRGTVNADARVTENVIKGVVYM
SFHFLEEATNKLTNSAYDPVSKTAELKICAVKVEKI
>Mature_675_residues
TEFKVVHTICPYCGTGCGIDLVVKDGKVVDSHPFKRHPVNEGKVCIKGNYCYEFVHSEDRLTKPLIKKNGEFIEATWDEA
LDLIAGKLKQYSPDEVAFFSCARGTNEESYALQKFARTVLKTNNVDHCARI*HAPTVVGLGECFGSGAMTNSITDLAQAD
VLLIYGSNTFEAHPLIARSIVKAKENGTKIIAIDPRTTHTAKMADLHLKLIPGSNIDLINTITNIIIQEGMADEEFIKNR
TEGYDELKDVVSKYTLEKTAELSGIPAETILEAARMYGSAENASIMYCLGVTEYTFGVDNVKSCCNLAMVTGNLGRPGTG
VNPLRGQNNVQGACDMGALPNVFPGYQKVGEAYERLENLWETADLNREIGLTSPEVLHKAGEQVKFLHIVGEDPMVADAD
INHVEKALKSLDFFVVQDIFLTETAKLADVVLPAACWAEKDGTFTNSERRVQRIRKAVDAPGDALPDWLIVRKLAEKMGA
GEKLNFESASEIFDEMAKVIPQYAGMSFERLGIDGLQWPCKTPEDPGTPILHKEKFLRPNGLGKFTPVEHKDADELIDEE
YPLILTTGRIIFHYNSGTMTRRCDSITNEIDENFIEINTEDAKELGIKPGEKVRVSSRRGTVNADARVTENVIKGVVYMS
FHFLEEATNKLTNSAYDPVSKTAELKICAVKVEKI

Specific function: Catalyzes the oxidation of formate [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=691, Percent_Identity=41.534008683068, Blast_Score=572, Evalue=1e-164,
Organism=Escherichia coli, GI1788534, Length=784, Percent_Identity=29.2091836734694, Blast_Score=291, Evalue=1e-79,
Organism=Escherichia coli, GI3868719, Length=750, Percent_Identity=25.6, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI3868720, Length=638, Percent_Identity=27.2727272727273, Blast_Score=198, Evalue=9e-52,
Organism=Escherichia coli, GI1787778, Length=304, Percent_Identity=30.5921052631579, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1787870, Length=786, Percent_Identity=24.1730279898219, Blast_Score=114, Evalue=3e-26,
Organism=Escherichia coli, GI145693196, Length=506, Percent_Identity=24.3083003952569, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI87081797, Length=485, Percent_Identity=22.680412371134, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI87081994, Length=544, Percent_Identity=24.0808823529412, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1787231, Length=725, Percent_Identity=23.0344827586207, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17565758, Length=120, Percent_Identity=38.3333333333333, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 74567; Mature: 74436

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFKVVHTICPYCGTGCGIDLVVKDGKVVDSHPFKRHPVNEGKVCIKGNYCYEFVHSED
CCCEEHHHHHHHHCCCCCCEEEEEECCEEECCCCCCCCCCCCCCEEEECCEEEEEECCCH
RLTKPLIKKNGEFIEATWDEALDLIAGKLKQYSPDEVAFFSCARGTNEESYALQKFARTV
HHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
LKTNNVDHCARIHAPTVVGLGECFGSGAMTNSITDLAQADVLLIYGSNTFEAHPLIARSI
HHCCCCHHHHHHCCCCEEEHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHH
VKAKENGTKIIAIDPRTTHTAKMADLHLKLIPGSNIDLINTITNIIIQEGMADEEFIKNR
HHHHCCCCEEEEECCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHH
TEGYDELKDVVSKYTLEKTAELSGIPAETILEAARMYGSAENASIMYCLGVTEYTFGVDN
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCHHHCCHHH
VKSCCNLAMVTGNLGRPGTGVNPLRGQNNVQGACDMGALPNVFPGYQKVGEAYERLENLW
HHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ETADLNREIGLTSPEVLHKAGEQVKFLHIVGEDPMVADADINHVEKALKSLDFFVVQDIF
HHHCCCCCCCCCCHHHHHHCCCCEEEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHH
LTETAKLADVVLPAACWAEKDGTFTNSERRVQRIRKAVDAPGDALPDWLIVRKLAEKMGA
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
GEKLNFESASEIFDEMAKVIPQYAGMSFERLGIDGLQWPCKTPEDPGTPILHKEKFLRPN
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCC
GLGKFTPVEHKDADELIDEEYPLILTTGRIIFHYNSGTMTRRCDSITNEIDENFIEINTE
CCCCCCCCCCCCHHHHHCCCCCEEEEECEEEEEECCCCHHHHHHHHHHHHCCCEEEECCC
DAKELGIKPGEKVRVSSRRGTVNADARVTENVIKGVVYMSFHFLEEATNKLTNSAYDPVS
HHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KTAELKICAVKVEKI
CCCCEEEEEEEEECC
>Mature Secondary Structure 
TEFKVVHTICPYCGTGCGIDLVVKDGKVVDSHPFKRHPVNEGKVCIKGNYCYEFVHSED
CCEEHHHHHHHHCCCCCCEEEEEECCEEECCCCCCCCCCCCCCEEEECCEEEEEECCCH
RLTKPLIKKNGEFIEATWDEALDLIAGKLKQYSPDEVAFFSCARGTNEESYALQKFARTV
HHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
LKTNNVDHCARIHAPTVVGLGECFGSGAMTNSITDLAQADVLLIYGSNTFEAHPLIARSI
HHCCCCHHHHHHCCCCEEEHHHHHCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHH
VKAKENGTKIIAIDPRTTHTAKMADLHLKLIPGSNIDLINTITNIIIQEGMADEEFIKNR
HHHHCCCCEEEEECCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHH
TEGYDELKDVVSKYTLEKTAELSGIPAETILEAARMYGSAENASIMYCLGVTEYTFGVDN
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCHHHCCHHH
VKSCCNLAMVTGNLGRPGTGVNPLRGQNNVQGACDMGALPNVFPGYQKVGEAYERLENLW
HHHHHCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ETADLNREIGLTSPEVLHKAGEQVKFLHIVGEDPMVADADINHVEKALKSLDFFVVQDIF
HHHCCCCCCCCCCHHHHHHCCCCEEEEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHH
LTETAKLADVVLPAACWAEKDGTFTNSERRVQRIRKAVDAPGDALPDWLIVRKLAEKMGA
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
GEKLNFESASEIFDEMAKVIPQYAGMSFERLGIDGLQWPCKTPEDPGTPILHKEKFLRPN
CCCCCCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCC
GLGKFTPVEHKDADELIDEEYPLILTTGRIIFHYNSGTMTRRCDSITNEIDENFIEINTE
CCCCCCCCCCCCHHHHHCCCCCEEEEECEEEEEECCCCHHHHHHHHHHHHCCCEEEECCC
DAKELGIKPGEKVRVSSRRGTVNADARVTENVIKGVVYMSFHFLEEATNKLTNSAYDPVS
HHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
KTAELKICAVKVEKI
CCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]