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The map label for this gene is dys [H]

Identifier: 45357700

GI number: 45357700

Start: 143395

End: 144411

Strand: Direct

Name: dys [H]

Synonym: MMP0137

Alternate gene names: 45357700

Gene position: 143395-144411 (Clockwise)

Preceding gene: 45357699

Following gene: 45357701

Centisome position: 8.63

GC content: 35.0

Gene sequence:

>1017_bases
GTGATTTTTATGTCAGATCCAAAAAATGTAGTTTTTAAGGAAAGTGAGGAATTAAACGGTGTTTTTATCGAGGGGCCCGA
TTTTGATGAAACTATCGATTTAAAAGACGTTTTAACAGATTATTATGAAAAAATAGGTTTTCAGGCAACACACCTTGGAA
AAGCCGTTAAAATTTGGAAACAAATCGAAGAAGTTAGAAAAAACGAAGAAGTAGTTGTTTTTATGGGCTATACTTCAAAC
ATGGTTTCATCAGGTCTTAGGGAAATTATATCCTACCTTGTAAAACACAAAAAAGTCGATGTACTGGTTACTACTGCGGG
TGGAATCGAAGAAGATTTTATAAAATGCATAAAACCGTTTGTTCTTGGAGAATGGGACATGGCAGGATCAGATCTTCGAG
AAAAAGGAATAAACAGGATTGGAAATGTATATGTTCCAAATGATAGGTACATAGAATTTGAGACTTACATGACTAAATTT
TTTGAAACGCTTTTGAAAAAACAGCAGGATGAAAATAAAATAATAAGTGCGAGCGAGTTTTGTTTTGAACTTGGAAGATT
CATGGATGAAAATTTAGGGCAAGAAAAAGAAAAATCCATTATTTACTGGGCCTATGTGAATAAAATACCAATATTCTGCC
CCGCAATTACTGATGGTTCAATTGGAGATATGCTCTACTTCTTTAAAAAGAATGAAAAAGGAACTGATTTAAAAATAGAT
GTTGCAAGCGATATTGTAAGACTAAATGACATGGCAATTGATGCAAATAAAACAGCATGCATCGTTTTAGGAGGATCCCT
TCCAAAACACAGCATAATAAATGCAAATCTCTTCAGGGAAGGAACAGATTATGCGATATACATTACAACAGCAGTTCCCT
GGGATGGGTCATTAAGCGGTGCCCCTCCAGAAGAAGGTGTTTCATGGGGTAAAATTCAAGAAAAAGCAGATTTCGTCGAG
ATCTGGGCTGACGCAACGATTGTATTTCCAATGCTCGTTTATGGAGTATTTAAATAA

Upstream 100 bases:

>100_bases
TAAACAATGGCGGATTAATGCCACACTTGAAGAAAAAGATTTCAAAAGCTTAAATTTTTTTATTTAGTTTTTATTTTATT
ATTTTTTACATTATTTTTCG

Downstream 100 bases:

>100_bases
CAATCACAAAATACAATTTTTAAAATTTTTTGAAAAAAGCTCTTTTAAAGGATATAAAGAAAAGATATTTCTTGATATCT
CTCTATTGTTGGGACAAATA

Product: putative deoxyhypusine synthase

Products: NA

Alternate protein names: DHS [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MIFMSDPKNVVFKESEELNGVFIEGPDFDETIDLKDVLTDYYEKIGFQATHLGKAVKIWKQIEEVRKNEEVVVFMGYTSN
MVSSGLREIISYLVKHKKVDVLVTTAGGIEEDFIKCIKPFVLGEWDMAGSDLREKGINRIGNVYVPNDRYIEFETYMTKF
FETLLKKQQDENKIISASEFCFELGRFMDENLGQEKEKSIIYWAYVNKIPIFCPAITDGSIGDMLYFFKKNEKGTDLKID
VASDIVRLNDMAIDANKTACIVLGGSLPKHSIINANLFREGTDYAIYITTAVPWDGSLSGAPPEEGVSWGKIQEKADFVE
IWADATIVFPMLVYGVFK

Sequences:

>Translated_338_residues
MIFMSDPKNVVFKESEELNGVFIEGPDFDETIDLKDVLTDYYEKIGFQATHLGKAVKIWKQIEEVRKNEEVVVFMGYTSN
MVSSGLREIISYLVKHKKVDVLVTTAGGIEEDFIKCIKPFVLGEWDMAGSDLREKGINRIGNVYVPNDRYIEFETYMTKF
FETLLKKQQDENKIISASEFCFELGRFMDENLGQEKEKSIIYWAYVNKIPIFCPAITDGSIGDMLYFFKKNEKGTDLKID
VASDIVRLNDMAIDANKTACIVLGGSLPKHSIINANLFREGTDYAIYITTAVPWDGSLSGAPPEEGVSWGKIQEKADFVE
IWADATIVFPMLVYGVFK
>Mature_338_residues
MIFMSDPKNVVFKESEELNGVFIEGPDFDETIDLKDVLTDYYEKIGFQATHLGKAVKIWKQIEEVRKNEEVVVFMGYTSN
MVSSGLREIISYLVKHKKVDVLVTTAGGIEEDFIKCIKPFVLGEWDMAGSDLREKGINRIGNVYVPNDRYIEFETYMTKF
FETLLKKQQDENKIISASEFCFELGRFMDENLGQEKEKSIIYWAYVNKIPIFCPAITDGSIGDMLYFFKKNEKGTDLKID
VASDIVRLNDMAIDANKTACIVLGGSLPKHSIINANLFREGTDYAIYITTAVPWDGSLSGAPPEEGVSWGKIQEKADFVE
IWADATIVFPMLVYGVFK

Specific function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine

COG id: COG1899

COG function: function code O; Deoxyhypusine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoxyhypusine synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503325, Length=349, Percent_Identity=42.9799426934097, Blast_Score=282, Evalue=3e-76,
Organism=Homo sapiens, GI7108338, Length=349, Percent_Identity=36.3896848137536, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI7108340, Length=349, Percent_Identity=34.0974212034384, Blast_Score=194, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17536927, Length=334, Percent_Identity=43.4131736526946, Blast_Score=280, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6321859, Length=351, Percent_Identity=41.8803418803419, Blast_Score=279, Evalue=5e-76,
Organism=Drosophila melanogaster, GI45550569, Length=351, Percent_Identity=43.8746438746439, Blast_Score=303, Evalue=9e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002773
- InterPro:   IPR022899 [H]

Pfam domain/function: PF01916 DS [H]

EC number: =2.5.1.46 [H]

Molecular weight: Translated: 38353; Mature: 38353

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFMSDPKNVVFKESEELNGVFIEGPDFDETIDLKDVLTDYYEKIGFQATHLGKAVKIWK
CEEECCCCCEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
QIEEVRKNEEVVVFMGYTSNMVSSGLREIISYLVKHKKVDVLVTTAGGIEEDFIKCIKPF
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHH
VLGEWDMAGSDLREKGINRIGNVYVPNDRYIEFETYMTKFFETLLKKQQDENKIISASEF
HCCCCCCCCHHHHHHHHHHHCCEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCEEHHHHH
CFELGRFMDENLGQEKEKSIIYWAYVNKIPIFCPAITDGSIGDMLYFFKKNEKGTDLKID
HHHHHHHHHHHCCCHHHCCEEEEEEECCCCEEEECCCCCCHHHEEEEEECCCCCCEEEEE
VASDIVRLNDMAIDANKTACIVLGGSLPKHSIINANLFREGTDYAIYITTAVPWDGSLSG
HHHHHHHHHCEEEECCCEEEEEECCCCCCCCEEECHHEECCCCEEEEEEEECCCCCCCCC
APPEEGVSWGKIQEKADFVEIWADATIVFPMLVYGVFK
CCCHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCC
>Mature Secondary Structure
MIFMSDPKNVVFKESEELNGVFIEGPDFDETIDLKDVLTDYYEKIGFQATHLGKAVKIWK
CEEECCCCCEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHH
QIEEVRKNEEVVVFMGYTSNMVSSGLREIISYLVKHKKVDVLVTTAGGIEEDFIKCIKPF
HHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHH
VLGEWDMAGSDLREKGINRIGNVYVPNDRYIEFETYMTKFFETLLKKQQDENKIISASEF
HCCCCCCCCHHHHHHHHHHHCCEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCEEHHHHH
CFELGRFMDENLGQEKEKSIIYWAYVNKIPIFCPAITDGSIGDMLYFFKKNEKGTDLKID
HHHHHHHHHHHCCCHHHCCEEEEEEECCCCEEEECCCCCCHHHEEEEEECCCCCCEEEEE
VASDIVRLNDMAIDANKTACIVLGGSLPKHSIINANLFREGTDYAIYITTAVPWDGSLSG
HHHHHHHHHCEEEECCCEEEEEECCCCCCCCEEECHHEECCCCEEEEEEEECCCCCCCCC
APPEEGVSWGKIQEKADFVEIWADATIVFPMLVYGVFK
CCCHHCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA