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The map label for this gene is pcm

Identifier: 45357665

GI number: 45357665

Start: 111064

End: 111702

Strand: Direct

Name: pcm

Synonym: MMP0102

Alternate gene names: 45357665

Gene position: 111064-111702 (Clockwise)

Preceding gene: 45357662

Following gene: 45357666

Centisome position: 6.69

GC content: 36.46

Gene sequence:

>639_bases
ATGCCTTTAAATGAAATTATTCCTGTTATTGAAAACCTGATTTCAAGAGGTTATATTAAAAAACAAAGTGTAATCGATGC
AATTTTAAGTGTTCCAAGGCACAAATTTATTTCAAAGAGCATGGAAAGTTACGCGTATGTTGATAGCCCTTTAGAGATAG
GATACGGGCAGACTATTTCTGCGATACACATGGTTGGAATAATGTGCGAAGAACTTGATTTAGATGAAGGCCAGAATGTA
CTTGAGGTTGGAACTGGTTCAGGCTACCATGCAGCAGTAGTTTCAAAAATCGTTGGCGAATCTGGAAAAGTTACAACTAT
CGAGAGAATACCCGAACTTTTTGAAAATTCAAAGAAAACACTCTCAGAACTTGGATACAATAACGTTGAAGTGGTTTTGG
GAGATGGTACAAAAGGATATTTAGAAAATGCTCCATACGACAGGATATATGTTACTGCATCGGGACCAGACGTTCCAAAA
GCTCTTTTTAAACAATTAAATGATGGCGGAATATTACTTGCACCCGTTGGGGCCCATTTTCAAACTTTAATGAGATACAC
GAAAATAAACGGTAGTATATCAGAAGAAAAACTTTTAGAGGTTGCATTCGTTCCATTAATTGGTGAGAATGGCTTTTAA

Upstream 100 bases:

>100_bases
AAGATTTTCCATATGTTCACCAAAGAGTTTAGAGCCGAATTATATATCTTTTTGAACATATAAATATTAAACAATTTTTT
TAACAGGGGGTGGTGGGTAC

Downstream 100 bases:

>100_bases
TATTAATTATCTTTTTTAAATTAAAATATTAAAAAATCAACATACTTTTTTATATTTGAAAACAAAATTAATTTTGAAAC
GCGTAGTATATGGAACGTAT

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT

Number of amino acids: Translated: 212; Mature: 211

Protein sequence:

>212_residues
MPLNEIIPVIENLISRGYIKKQSVIDAILSVPRHKFISKSMESYAYVDSPLEIGYGQTISAIHMVGIMCEELDLDEGQNV
LEVGTGSGYHAAVVSKIVGESGKVTTIERIPELFENSKKTLSELGYNNVEVVLGDGTKGYLENAPYDRIYVTASGPDVPK
ALFKQLNDGGILLAPVGAHFQTLMRYTKINGSISEEKLLEVAFVPLIGENGF

Sequences:

>Translated_212_residues
MPLNEIIPVIENLISRGYIKKQSVIDAILSVPRHKFISKSMESYAYVDSPLEIGYGQTISAIHMVGIMCEELDLDEGQNV
LEVGTGSGYHAAVVSKIVGESGKVTTIERIPELFENSKKTLSELGYNNVEVVLGDGTKGYLENAPYDRIYVTASGPDVPK
ALFKQLNDGGILLAPVGAHFQTLMRYTKINGSISEEKLLEVAFVPLIGENGF
>Mature_211_residues
PLNEIIPVIENLISRGYIKKQSVIDAILSVPRHKFISKSMESYAYVDSPLEIGYGQTISAIHMVGIMCEELDLDEGQNVL
EVGTGSGYHAAVVSKIVGESGKVTTIERIPELFENSKKTLSELGYNNVEVVLGDGTKGYLENAPYDRIYVTASGPDVPKA
LFKQLNDGGILLAPVGAHFQTLMRYTKINGSISEEKLLEVAFVPLIGENGF

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family

Homologues:

Organism=Homo sapiens, GI226530908, Length=208, Percent_Identity=40.8653846153846, Blast_Score=128, Evalue=3e-30,
Organism=Escherichia coli, GI1789100, Length=199, Percent_Identity=39.6984924623116, Blast_Score=147, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI71983477, Length=207, Percent_Identity=37.6811594202899, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI193207222, Length=205, Percent_Identity=36.0975609756098, Blast_Score=113, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17981723, Length=213, Percent_Identity=36.150234741784, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PIMT_METMP (Q6M116)

Other databases:

- EMBL:   BX950229
- RefSeq:   NP_987222.1
- ProteinModelPortal:   Q6M116
- SMR:   Q6M116
- GeneID:   2762127
- GenomeReviews:   BX950229_GR
- KEGG:   mmp:MMP0102
- NMPDR:   fig|267377.1.peg.102
- HOGENOM:   HBG699907
- OMA:   GYHAAVV
- ProtClustDB:   PRK13942
- BioCyc:   MMAR267377:MMP0102-MONOMER
- BRENDA:   2.1.1.77
- GO:   GO:0005737
- HAMAP:   MF_00090
- InterPro:   IPR000682
- PANTHER:   PTHR11579
- TIGRFAMs:   TIGR00080

Pfam domain/function: PF01135 PCMT

EC number: =2.1.1.77

Molecular weight: Translated: 23108; Mature: 22977

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS01279 PCMT

Important sites: ACT_SITE 60-60

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNEIIPVIENLISRGYIKKQSVIDAILSVPRHKFISKSMESYAYVDSPLEIGYGQTIS
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
AIHMVGIMCEELDLDEGQNVLEVGTGSGYHAAVVSKIVGESGKVTTIERIPELFENSKKT
HHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHH
LSELGYNNVEVVLGDGTKGYLENAPYDRIYVTASGPDVPKALFKQLNDGGILLAPVGAHF
HHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEEECCHHH
QTLMRYTKINGSISEEKLLEVAFVPLIGENGF
HHHHHHHHCCCCCCHHHHHHHHEEEEECCCCC
>Mature Secondary Structure 
PLNEIIPVIENLISRGYIKKQSVIDAILSVPRHKFISKSMESYAYVDSPLEIGYGQTIS
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
AIHMVGIMCEELDLDEGQNVLEVGTGSGYHAAVVSKIVGESGKVTTIERIPELFENSKKT
HHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHH
LSELGYNNVEVVLGDGTKGYLENAPYDRIYVTASGPDVPKALFKQLNDGGILLAPVGAHF
HHHCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEEECCHHH
QTLMRYTKINGSISEEKLLEVAFVPLIGENGF
HHHHHHHHCCCCCCHHHHHHHHEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA