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The map label for this gene is idsA [H]

Identifier: 45357608

GI number: 45357608

Start: 62928

End: 63881

Strand: Direct

Name: idsA [H]

Synonym: MMP0045

Alternate gene names: 45357608

Gene position: 62928-63881 (Clockwise)

Preceding gene: 45357607

Following gene: 45357609

Centisome position: 3.79

GC content: 33.65

Gene sequence:

>954_bases
ATGGTGTTTGATAGGGAAATATTGTCAAAAATCGATTCTGAACTCAAAAAATACATGGAAAAAGATACTAAACTTTACGG
TGCATCAAAACACCTATTACTTGCAGGCGGTAAAAGAGTAAGACCTTATCTTTCAATTTTAACATATCTCTTAAAGAAAG
ATGAGCTTACTGAAATAATGGCACCAGCACTTTCTGTTGAATTGATTCATAATTATACATTAGTTCATGACGATATAATG
GATAATGATGATCAGAGAAGGGGAATCCCTACAGTTCACACCGTTTATGGTGAACCAATCGCAATTTTGGCTGGAGATTT
ATTATATGCAAAGGCTTTCGAAGCTCTTTCAAATATTGAAGATAGTAACAAGGCTCACGAAGTTTTAAAGGTTTTATCTA
AAGCATGTGTCGAAGTCTGCGAAGGACAGACTGAAGATATGGAATTTGAAGAAAGATTCCCGACTTTAGACGAATACCTT
GAAATGATTTCCAAAAAAACAGGTGCTTTAATTGTAGCTCCTGTAGAAATTGGAGCAGTTATGGCAGACTGTACTCCTGA
AGAAAGAGAAGCACTCTGTAATTATGCAAAAAGAATTGGAATGACTTTCCAGATTCAAGACGATGTTTTAGATTTAATTG
GGGATCAAAAAACAATCGGAAAGCCTGTGGGTAGTGACATTGTTGAAGGTAAAAAGACAATGATGGTAATTCACGCAATG
GAAAACCTTTCTGAAGATAAAAAAGAAAGATTATTGCAGATTTTAGGAAATCAAGATGCAAATCAACAAGAAGTTGCAGA
AGCAATTGAACTTTTAGCAGATTCTATTAATTATGCAAAAGATACAATGAAAAACGCAACAGAAGAAGCTAAAGATTACT
TAAAAATATTCGATGCAGAAAAAAGAAAAAATCTCGAAAACATTGCAGATTTTATCATCGAAAGAATTCACTAA

Upstream 100 bases:

>100_bases
TTAGCAGAAGAAGAAGGATTCAGACTCGGTGAAGATGTACACTTACTCAGAAACGGTCAAAGCTTGAAATTTGAAAGAGT
AATTTAATTGAGGTGCTAAA

Downstream 100 bases:

>100_bases
TTACATTTAACTAGCTATTTTAACTTTTTTTAAAATTTAAAGGTGTTTTAATGAAAATTCCTAAAATTTACGTTGAAGGA
GAATTAAACGACGGCGATCG

Product: bifunctional short chain isoprenyl diphosphate synthase

Products: NA

Alternate protein names: (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyl pyrophosphate synthase; FPP synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MVFDREILSKIDSELKKYMEKDTKLYGASKHLLLAGGKRVRPYLSILTYLLKKDELTEIMAPALSVELIHNYTLVHDDIM
DNDDQRRGIPTVHTVYGEPIAILAGDLLYAKAFEALSNIEDSNKAHEVLKVLSKACVEVCEGQTEDMEFEERFPTLDEYL
EMISKKTGALIVAPVEIGAVMADCTPEEREALCNYAKRIGMTFQIQDDVLDLIGDQKTIGKPVGSDIVEGKKTMMVIHAM
ENLSEDKKERLLQILGNQDANQQEVAEAIELLADSINYAKDTMKNATEEAKDYLKIFDAEKRKNLENIADFIIERIH

Sequences:

>Translated_317_residues
MVFDREILSKIDSELKKYMEKDTKLYGASKHLLLAGGKRVRPYLSILTYLLKKDELTEIMAPALSVELIHNYTLVHDDIM
DNDDQRRGIPTVHTVYGEPIAILAGDLLYAKAFEALSNIEDSNKAHEVLKVLSKACVEVCEGQTEDMEFEERFPTLDEYL
EMISKKTGALIVAPVEIGAVMADCTPEEREALCNYAKRIGMTFQIQDDVLDLIGDQKTIGKPVGSDIVEGKKTMMVIHAM
ENLSEDKKERLLQILGNQDANQQEVAEAIELLADSINYAKDTMKNATEEAKDYLKIFDAEKRKNLENIADFIIERIH
>Mature_317_residues
MVFDREILSKIDSELKKYMEKDTKLYGASKHLLLAGGKRVRPYLSILTYLLKKDELTEIMAPALSVELIHNYTLVHDDIM
DNDDQRRGIPTVHTVYGEPIAILAGDLLYAKAFEALSNIEDSNKAHEVLKVLSKACVEVCEGQTEDMEFEERFPTLDEYL
EMISKKTGALIVAPVEIGAVMADCTPEEREALCNYAKRIGMTFQIQDDVLDLIGDQKTIGKPVGSDIVEGKKTMMVIHAM
ENLSEDKKERLLQILGNQDANQQEVAEAIELLADSINYAKDTMKNATEEAKDYLKIFDAEKRKNLENIADFIIERIH

Specific function: Supplies Octaprenyl Diphosphate, The Precursor For The Side Chain Of The Isoprenoid Quinones Ubiquinone And Menaquinone. [C]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=260, Percent_Identity=30.7692307692308, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4758430, Length=274, Percent_Identity=30.2919708029197, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI83700220, Length=274, Percent_Identity=30.2919708029197, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1789578, Length=313, Percent_Identity=28.1150159744409, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1786623, Length=271, Percent_Identity=37.6383763837638, Blast_Score=135, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17505681, Length=241, Percent_Identity=28.6307053941909, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508563, Length=302, Percent_Identity=27.4834437086093, Blast_Score=73, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325188, Length=230, Percent_Identity=28.695652173913, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24651612, Length=295, Percent_Identity=27.4576271186441, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281365769, Length=230, Percent_Identity=27.8260869565217, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24660002, Length=230, Percent_Identity=27.8260869565217, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.10 [H]

Molecular weight: Translated: 35803; Mature: 35803

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFDREILSKIDSELKKYMEKDTKLYGASKHLLLAGGKRVRPYLSILTYLLKKDELTEIM
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
APALSVELIHNYTLVHDDIMDNDDQRRGIPTVHTVYGEPIAILAGDLLYAKAFEALSNIE
HHHHHHHHHHHHHHEEHHHCCCCCCCCCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHCCC
DSNKAHEVLKVLSKACVEVCEGQTEDMEFEERFPTLDEYLEMISKKTGALIVAPVEIGAV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHCCCCEEEEEHHHHHH
MADCTPEEREALCNYAKRIGMTFQIQDDVLDLIGDQKTIGKPVGSDIVEGKKTMMVIHAM
HHCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCHHHCCCCCHHHHCCHHHHHHHHHH
ENLSEDKKERLLQILGNQDANQQEVAEAIELLADSINYAKDTMKNATEEAKDYLKIFDAE
HHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRKNLENIADFIIERIH
HHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MVFDREILSKIDSELKKYMEKDTKLYGASKHLLLAGGKRVRPYLSILTYLLKKDELTEIM
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
APALSVELIHNYTLVHDDIMDNDDQRRGIPTVHTVYGEPIAILAGDLLYAKAFEALSNIE
HHHHHHHHHHHHHHEEHHHCCCCCCCCCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHCCC
DSNKAHEVLKVLSKACVEVCEGQTEDMEFEERFPTLDEYLEMISKKTGALIVAPVEIGAV
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHCCCCEEEEEHHHHHH
MADCTPEEREALCNYAKRIGMTFQIQDDVLDLIGDQKTIGKPVGSDIVEGKKTMMVIHAM
HHCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHCCCHHHCCCCCHHHHCCHHHHHHHHHH
ENLSEDKKERLLQILGNQDANQQEVAEAIELLADSINYAKDTMKNATEEAKDYLKIFDAE
HHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KRKNLENIADFIIERIH
HHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]