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The map label for this gene is 45357569

Identifier: 45357569

GI number: 45357569

Start: 15336

End: 16421

Strand: Direct

Name: 45357569

Synonym: MMP0006

Alternate gene names: NA

Gene position: 15336-16421 (Clockwise)

Preceding gene: 45357565

Following gene: 45357570

Centisome position: 0.92

GC content: 35.08

Gene sequence:

>1086_bases
ATGAAATTTGGATGGATAAAAACAACAGGAAATGACCTTGAAGAGAGAATGGAATCGGTAAAAGATGCTCTTGAGAGTTC
AATTCCCGGAATCATTGCAGAAAAGGAAGAAATAAGTTCTGTAAGAGAACTTGGAAATATAAAAATTGTTTCTGATAATC
TCGATGCAGATGTCGTTTTAATTAATAAAGGGGAAGATTTAGAAATTTTAAAATCTGCAAAACTCTCTGGAAAAGAAACC
GGTGTTTACGTTGTAATAAACACTAAAGAAGATGAAGTATACGCTACAGACGTAAGCAAACTCGATTTTGTCGATTACGT
TGTTTTAGAAGGAAGCGACTGGACAATTATTCCTCTTGAAAACATCATTGCAGATTTATTCAGCGAAGAAATAAAAATTG
TTTCAGTTGTAACAAACGTAAAAGACGCGGAAGCCGCATACGAAATTTTAGAAAAAGGAGTTGACGGTGTAGTTTTAATT
CCTAAAGATATTAACGAAGTAAAAGACTTCTCAAAATTAATTGAAAGAATGAACTCTGAAAGCGTAAAACTCGACTACGC
AACAGTTACAAAAATTGAACCTGTTGGAAGTGGCGATCGGGTCTGTATTGACACATGTTCCATGATGGAAATGGGAGAAG
GAATGTTAATTGGATCCTACTCACGAGGGATGTTTTTAGTTCATTCAGAAACTGTTGAAAACCCGTATGTCGCTACAAGA
CCATTTAGGGTAAATGCCGGACCTGTACATGCCTATATCTTGTGCCCTGAAAACAAAACTAAATATTTAAGCGATTTAAA
AGCAGGCGATAAAGTTTTAGTTGTTAATAAAAACGGTGAAACGAGAGAAGCTATTATCGGACGCGTGAAAATCGAAAAAA
GACCATTATTCCTTGTTGAAGCAGAATATAACGGGGAAAATTTAAGAACAATCCTCCAAAACGCAGAAACTATCCGATTA
GTTGGAGAAGATGGAAAACCAGTTTCAGTTGTTGATTTAAAAGTTGGAACCAAAGTATTGATAAAACCAGATGAAAACGC
GAGACACTTTGGAATGGCGATTAAAGAAACAATTATAGAAAAATAA

Upstream 100 bases:

>100_bases
ATATGTTAATTAATTATAAATAAAAATATATAGATTAAATACATATCAATTCAAGAATCAATTCGGCATATTTGGTTCAA
AATATAGGCATGGTGAATAT

Downstream 100 bases:

>100_bases
TTTTTATTTTTACTTTTTTTAATTTAAAAAAATAATAAACAAGAAAATGATTGTTATCGATTTTTAAAGTTTTATAAATC
TTTTAAGGTAAATTTTGTAA

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: DHQ synthase [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MKFGWIKTTGNDLEERMESVKDALESSIPGIIAEKEEISSVRELGNIKIVSDNLDADVVLINKGEDLEILKSAKLSGKET
GVYVVINTKEDEVYATDVSKLDFVDYVVLEGSDWTIIPLENIIADLFSEEIKIVSVVTNVKDAEAAYEILEKGVDGVVLI
PKDINEVKDFSKLIERMNSESVKLDYATVTKIEPVGSGDRVCIDTCSMMEMGEGMLIGSYSRGMFLVHSETVENPYVATR
PFRVNAGPVHAYILCPENKTKYLSDLKAGDKVLVVNKNGETREAIIGRVKIEKRPLFLVEAEYNGENLRTILQNAETIRL
VGEDGKPVSVVDLKVGTKVLIKPDENARHFGMAIKETIIEK

Sequences:

>Translated_361_residues
MKFGWIKTTGNDLEERMESVKDALESSIPGIIAEKEEISSVRELGNIKIVSDNLDADVVLINKGEDLEILKSAKLSGKET
GVYVVINTKEDEVYATDVSKLDFVDYVVLEGSDWTIIPLENIIADLFSEEIKIVSVVTNVKDAEAAYEILEKGVDGVVLI
PKDINEVKDFSKLIERMNSESVKLDYATVTKIEPVGSGDRVCIDTCSMMEMGEGMLIGSYSRGMFLVHSETVENPYVATR
PFRVNAGPVHAYILCPENKTKYLSDLKAGDKVLVVNKNGETREAIIGRVKIEKRPLFLVEAEYNGENLRTILQNAETIRL
VGEDGKPVSVVDLKVGTKVLIKPDENARHFGMAIKETIIEK
>Mature_361_residues
MKFGWIKTTGNDLEERMESVKDALESSIPGIIAEKEEISSVRELGNIKIVSDNLDADVVLINKGEDLEILKSAKLSGKET
GVYVVINTKEDEVYATDVSKLDFVDYVVLEGSDWTIIPLENIIADLFSEEIKIVSVVTNVKDAEAAYEILEKGVDGVVLI
PKDINEVKDFSKLIERMNSESVKLDYATVTKIEPVGSGDRVCIDTCSMMEMGEGMLIGSYSRGMFLVHSETVENPYVATR
PFRVNAGPVHAYILCPENKTKYLSDLKAGDKVLVVNKNGETREAIIGRVKIEKRPLFLVEAEYNGENLRTILQNAETIRL
VGEDGKPVSVVDLKVGTKVLIKPDENARHFGMAIKETIIEK

Specific function: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis [H]

COG id: COG1465

COG function: function code E; Predicted alternative 3-dehydroquinate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal-type DHQ synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002812
- ProDom:   PD017907 [H]

Pfam domain/function: PF01959 DHQS [H]

EC number: NA

Molecular weight: Translated: 40003; Mature: 40003

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFGWIKTTGNDLEERMESVKDALESSIPGIIAEKEEISSVRELGNIKIVSDNLDADVVL
CCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCEEEEECCCCCCEEE
INKGEDLEILKSAKLSGKETGVYVVINTKEDEVYATDVSKLDFVDYVVLEGSDWTIIPLE
EECCCCHHHHHHCCCCCCCCCEEEEEECCCCCEEEECCCCCCEEEEEEEECCCEEEEEHH
NIIADLFSEEIKIVSVVTNVKDAEAAYEILEKGVDGVVLIPKDINEVKDFSKLIERMNSE
HHHHHHHHCCEEEEEEEECCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCC
SVKLDYATVTKIEPVGSGDRVCIDTCSMMEMGEGMLIGSYSRGMFLVHSETVENPYVATR
CEEEEEEEEEEEEECCCCCEEEEEEHHHHHCCCCEEEEECCCCEEEEEECCCCCCEEEEC
PFRVNAGPVHAYILCPENKTKYLSDLKAGDKVLVVNKNGETREAIIGRVKIEKRPLFLVE
CEEECCCCEEEEEEECCCCHHHHHHHCCCCEEEEECCCCCHHHHEEEEEEEECCCEEEEE
AEYNGENLRTILQNAETIRLVGEDGKPVSVVDLKVGTKVLIKPDENARHFGMAIKETIIE
ECCCCCHHHHHHCCCCEEEEECCCCCEEEEEEEEECCEEEEECCCCCHHHHHHHHHHHHC
K
C
>Mature Secondary Structure
MKFGWIKTTGNDLEERMESVKDALESSIPGIIAEKEEISSVRELGNIKIVSDNLDADVVL
CCEEEEECCCHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHCCCEEEEECCCCCCEEE
INKGEDLEILKSAKLSGKETGVYVVINTKEDEVYATDVSKLDFVDYVVLEGSDWTIIPLE
EECCCCHHHHHHCCCCCCCCCEEEEEECCCCCEEEECCCCCCEEEEEEEECCCEEEEEHH
NIIADLFSEEIKIVSVVTNVKDAEAAYEILEKGVDGVVLIPKDINEVKDFSKLIERMNSE
HHHHHHHHCCEEEEEEEECCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCC
SVKLDYATVTKIEPVGSGDRVCIDTCSMMEMGEGMLIGSYSRGMFLVHSETVENPYVATR
CEEEEEEEEEEEEECCCCCEEEEEEHHHHHCCCCEEEEECCCCEEEEEECCCCCCEEEEC
PFRVNAGPVHAYILCPENKTKYLSDLKAGDKVLVVNKNGETREAIIGRVKIEKRPLFLVE
CEEECCCCEEEEEEECCCCHHHHHHHCCCCEEEEECCCCCHHHHEEEEEEEECCCEEEEE
AEYNGENLRTILQNAETIRLVGEDGKPVSVVDLKVGTKVLIKPDENARHFGMAIKETIIE
ECCCCCHHHHHHCCCCEEEEECCCCCEEEEEEEEECCEEEEECCCCCHHHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA