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The map label for this gene is lolC [H]

Identifier: 42523263

GI number: 42523263

Start: 1705794

End: 1707044

Strand: Direct

Name: lolC [H]

Synonym: Bd1774

Alternate gene names: 42523263

Gene position: 1705794-1707044 (Clockwise)

Preceding gene: 42523262

Following gene: 42523266

Centisome position: 45.09

GC content: 52.6

Gene sequence:

>1251_bases
ATGTTAGTAGGCCACCTTTTCCGTCATTTTATTTTTTCTCCGCGAGCGGGTTCTTTGGTGAAACGCATCGCTTGGTTGTC
CATGATTGGGATCACAATCAGCGTGACGGCATTCCTGGTGGTTTTGTTTGTCATGAACGGTATGAATGCCAGCATTCATA
AGCGTATTCTGGGGCTGGAGCCACATCTGTATGTGCAGGTGGCCGGAGCTGACACCGCGCAAAGCCTGGAATCAAGCCCG
GCGTTCCAACGCCTTCAGGAAGACCCTGCCAATCGGGCCTATGTCTATGAAACCATGGATGTCATCATTCGCAGTCAGGA
TGGGCAGTTCCGTGGTGGTATCGCGCGCGGTGTGACGCGCGAAAGTCTTGAGCACTTCATTGAGCAGCTTCAGCGCATCG
ACCGCAAACCCACGGACCGGGATTCTCAGGTCTATTTCTGGGACCCGCAGGATGTGCCTGGACGGGGGGAAGTCGTTGTT
GGAGTGGATCTGGCTCAGTCCCTCGGAGTTTTTGAGGGTGACTTTCTGACGGTGGTGTCGCCATCGGGATTGTTGTTGCC
TCCAGGGGAAACGCCGAAGTTTGAGCGTGTGCGTATCAAGCGTATTGTCACCACCAGTTTGCCGGATCTGGACGGACAAT
TTATTTTCTATCAGCGTGGTGAGGCCTTGAGTGCATTGGTCAGTGAAGGCCTGGGCAAGAACGGGATCGAAGTGTGGCTG
CCGGATGAGGGGCGCATAGAGTCCGTTAAAGAAGATCTGATGAAATTCGAAGGCGTCAGTGTTGAGACCTGGATGGATCG
AAATTCCGCTTTGCTGTATGCGCTGAAGCTTGAAAAGCTGACCATCGGGATTTTCCTGGGCCTTGCCGGTATGATCGCGG
GAAGCTCCATTCTGACGGTGCTGGCTTTGTTGTTGTCGCAGAAAAAACGCGACATCGCGATCTTGCGCACGATTGGTTTT
TCATCCCGTCAGACGGTTCGCACGTTCACGCAGATTGGCTTTTTCCTGGCCGGAATTGGTGTTGTGGGCGGAGTTGTGCT
GGGTACAGGTTTGAGTCTTTACATTCAGGCCAATCCGATTCAGTTTTTGCCGTCGGATGTTTACTATGATTCTTCCATCC
CGGCTTTGGTCAACTATGGCCTGGTCTTTGGGGTTTTGATTGTCAGTGGATTGATTGCCTTGCTCGGTTCTTATATTCCG
GCGAGGACGGCTGCAGAGGTGCAGCCGTCTGATGCCTTAAGAATGAAATAA

Upstream 100 bases:

>100_bases
GTGCGGATATACGTGGGCGAGCGCCTTGCCGCCATGTTTAAAAGTGGTCCCAAATCCCATTGAGGCTTGAATCCGGGTCC
CCAGGCTCTATGATGGGGGA

Downstream 100 bases:

>100_bases
TACTTAAAAACTAAACGCTCACCTGATGGTCGCGAAGGGCGTCGGTCAGGGAGGTTTTCAAGTCCGTGCTGGCCTTGCGT
TTACCGATGATCAGCGCGCA

Product: lipoprotein releasing system transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MLVGHLFRHFIFSPRAGSLVKRIAWLSMIGITISVTAFLVVLFVMNGMNASIHKRILGLEPHLYVQVAGADTAQSLESSP
AFQRLQEDPANRAYVYETMDVIIRSQDGQFRGGIARGVTRESLEHFIEQLQRIDRKPTDRDSQVYFWDPQDVPGRGEVVV
GVDLAQSLGVFEGDFLTVVSPSGLLLPPGETPKFERVRIKRIVTTSLPDLDGQFIFYQRGEALSALVSEGLGKNGIEVWL
PDEGRIESVKEDLMKFEGVSVETWMDRNSALLYALKLEKLTIGIFLGLAGMIAGSSILTVLALLLSQKKRDIAILRTIGF
SSRQTVRTFTQIGFFLAGIGVVGGVVLGTGLSLYIQANPIQFLPSDVYYDSSIPALVNYGLVFGVLIVSGLIALLGSYIP
ARTAAEVQPSDALRMK

Sequences:

>Translated_416_residues
MLVGHLFRHFIFSPRAGSLVKRIAWLSMIGITISVTAFLVVLFVMNGMNASIHKRILGLEPHLYVQVAGADTAQSLESSP
AFQRLQEDPANRAYVYETMDVIIRSQDGQFRGGIARGVTRESLEHFIEQLQRIDRKPTDRDSQVYFWDPQDVPGRGEVVV
GVDLAQSLGVFEGDFLTVVSPSGLLLPPGETPKFERVRIKRIVTTSLPDLDGQFIFYQRGEALSALVSEGLGKNGIEVWL
PDEGRIESVKEDLMKFEGVSVETWMDRNSALLYALKLEKLTIGIFLGLAGMIAGSSILTVLALLLSQKKRDIAILRTIGF
SSRQTVRTFTQIGFFLAGIGVVGGVVLGTGLSLYIQANPIQFLPSDVYYDSSIPALVNYGLVFGVLIVSGLIALLGSYIP
ARTAAEVQPSDALRMK
>Mature_416_residues
MLVGHLFRHFIFSPRAGSLVKRIAWLSMIGITISVTAFLVVLFVMNGMNASIHKRILGLEPHLYVQVAGADTAQSLESSP
AFQRLQEDPANRAYVYETMDVIIRSQDGQFRGGIARGVTRESLEHFIEQLQRIDRKPTDRDSQVYFWDPQDVPGRGEVVV
GVDLAQSLGVFEGDFLTVVSPSGLLLPPGETPKFERVRIKRIVTTSLPDLDGQFIFYQRGEALSALVSEGLGKNGIEVWL
PDEGRIESVKEDLMKFEGVSVETWMDRNSALLYALKLEKLTIGIFLGLAGMIAGSSILTVLALLLSQKKRDIAILRTIGF
SSRQTVRTFTQIGFFLAGIGVVGGVVLGTGLSLYIQANPIQFLPSDVYYDSSIPALVNYGLVFGVLIVSGLIALLGSYIP
ARTAAEVQPSDALRMK

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787360, Length=396, Percent_Identity=27.2727272727273, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1787362, Length=409, Percent_Identity=24.6943765281174, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45623; Mature: 45623

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVGHLFRHFIFSPRAGSLVKRIAWLSMIGITISVTAFLVVLFVMNGMNASIHKRILGLE
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
PHLYVQVAGADTAQSLESSPAFQRLQEDPANRAYVYETMDVIIRSQDGQFRGGIARGVTR
CEEEEEEECCCHHHHHHCCHHHHHHHHCCCCCEEEEEEEEHHEECCCCCCCCCHHHCCCH
ESLEHFIEQLQRIDRKPTDRDSQVYFWDPQDVPGRGEVVVGVDLAQSLGVFEGDFLTVVS
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEECHHHHCCCCCCCEEEEEC
PSGLLLPPGETPKFERVRIKRIVTTSLPDLDGQFIFYQRGEALSALVSEGLGKNGIEVWL
CCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHCCCCCCCCEEEE
PDEGRIESVKEDLMKFEGVSVETWMDRNSALLYALKLEKLTIGIFLGLAGMIAGSSILTV
CCCCCHHHHHHHHHHHCCCCEEHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCHHHHHH
LALLLSQKKRDIAILRTIGFSSRQTVRTFTQIGFFLAGIGVVGGVVLGTGLSLYIQANPI
HHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCC
QFLPSDVYYDSSIPALVNYGLVFGVLIVSGLIALLGSYIPARTAAEVQPSDALRMK
EECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLVGHLFRHFIFSPRAGSLVKRIAWLSMIGITISVTAFLVVLFVMNGMNASIHKRILGLE
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
PHLYVQVAGADTAQSLESSPAFQRLQEDPANRAYVYETMDVIIRSQDGQFRGGIARGVTR
CEEEEEEECCCHHHHHHCCHHHHHHHHCCCCCEEEEEEEEHHEECCCCCCCCCHHHCCCH
ESLEHFIEQLQRIDRKPTDRDSQVYFWDPQDVPGRGEVVVGVDLAQSLGVFEGDFLTVVS
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEECHHHHCCCCCCCEEEEEC
PSGLLLPPGETPKFERVRIKRIVTTSLPDLDGQFIFYQRGEALSALVSEGLGKNGIEVWL
CCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHCCCCCCCCEEEE
PDEGRIESVKEDLMKFEGVSVETWMDRNSALLYALKLEKLTIGIFLGLAGMIAGSSILTV
CCCCCHHHHHHHHHHHCCCCEEHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHCCHHHHHH
LALLLSQKKRDIAILRTIGFSSRQTVRTFTQIGFFLAGIGVVGGVVLGTGLSLYIQANPI
HHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCC
QFLPSDVYYDSSIPALVNYGLVFGVLIVSGLIALLGSYIPARTAAEVQPSDALRMK
EECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]