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The map label for this gene is lysA [H]

Identifier: 42523266

GI number: 42523266

Start: 1708581

End: 1709756

Strand: Direct

Name: lysA [H]

Synonym: Bd1777

Alternate gene names: 42523266

Gene position: 1708581-1709756 (Clockwise)

Preceding gene: 42523263

Following gene: 42523270

Centisome position: 45.17

GC content: 49.49

Gene sequence:

>1176_bases
GTGGAATACATCAATAATGAATTGTGTCTTGGTCCGTTAAAAAAACCACTTTTGCCCCTGGTGGCCAATTACATGCGCCC
CATTTATGTCTACGATCTTGATTCTGTCGCGCAAAGGTATCAGGCGATGTCTCAGGCTTTGAAGGGGACTCGTCTTTTTT
TCGCGGTGAAATCCAATCCCAATCCTGGTGTTCTGCAAAAACTTAAAAGCCTCGGCGCCGGGGCCGATGTGGTTTCTTTG
GGCGAGATCAAACGCGCCCTGGAATGCGGCTTTTCTCCGCAGGACATTGTCTATAGCGGCGTGGGGAAAACCAAATTTGA
ACTGGCCGAGGCACTGAAGCTCGGCATTTATCAGATCAATGTGGAAAGTTTGCCGGAGCTTGAGCGGATTGGTGTGCTGG
CTCGTGAATTAAATAAAAAAGCCCAGGTGGCTTTGCGCTTGAACCCGGATGTGGATATTAATACGCATCCCTATATTGCC
ACGGGTTTGAAGGACAATAAATTCGGTATGGAACGCTCGATGGTTCCGGCTTTGGTGAAATGTCTTAAAAGCTATTCGGA
TTCCATCGATCTGGTGGGCGTCAGTTTGCATCTGGGGTCCCAAATGCTGGAGTTCTCCGGTTACGATGAAGCGCTAAAAA
GGCTTAAGACCGTGTATCTGGAGCTGCAGGCCCAGTTCCCGACATTGAAAAAGTTCGACTTTGGCGGGGGTCTGGGGATT
TTCTATGATCGTGTTGACCTTCAATTGGAAGAATCCCTGCTGCAGAAGTACGCGCAAATCACTTTGGAAAACCTGTCGGA
TCTTAACTGTGAACTGCAGGCAGAACCCGGCCGCTGGCTGGTGGCGCATTGCGGGGCTTTGATCACGCAAGTGCAGTACA
TCAAAGAAACCAGTGCAAAAACATTTGTGATCGTCGATGCAGGTATGAATCACCTGATTCGTCCTTCGTTGTATGAGGCC
ACACACCGTATCGAGCCGCTGAAAAGAAAAGACGCGGCCTTTGTAGTGGATGTTGTGGGGCCGATCTGTGAGTCTTCGGA
TTTCTTCGCGAAAGAAATCTCTCTGACGAAGGTGCAAGAAGGCGACTTTGTGGCGATCATGGATTCCGGGGCCTATGGGT
ATTCCATGGCCAGCGTCTATAACCTGCAGGAACTGCCTTTGGAGATTTGCATCTAA

Upstream 100 bases:

>100_bases
TGCCAGGCCGGTACCGGCAAACCTTTGGAAGTGTAAGTAAAAATAGAAGTTTTCATGACAAATCATCCTTCATGGGCCAT
CATACTAGCACGAGGTTTTC

Downstream 100 bases:

>100_bases
ACGTCGACGACCGCGTACTGATCGGCTTTGGCGGGTTTTAAAATCCGCTGGGCCATTTCAGTGAAGTGCGCGGAGGAATC
CGTCGTCATGATGTCAATGC

Product: hypothetical protein

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MEYINNELCLGPLKKPLLPLVANYMRPIYVYDLDSVAQRYQAMSQALKGTRLFFAVKSNPNPGVLQKLKSLGAGADVVSL
GEIKRALECGFSPQDIVYSGVGKTKFELAEALKLGIYQINVESLPELERIGVLARELNKKAQVALRLNPDVDINTHPYIA
TGLKDNKFGMERSMVPALVKCLKSYSDSIDLVGVSLHLGSQMLEFSGYDEALKRLKTVYLELQAQFPTLKKFDFGGGLGI
FYDRVDLQLEESLLQKYAQITLENLSDLNCELQAEPGRWLVAHCGALITQVQYIKETSAKTFVIVDAGMNHLIRPSLYEA
THRIEPLKRKDAAFVVDVVGPICESSDFFAKEISLTKVQEGDFVAIMDSGAYGYSMASVYNLQELPLEICI

Sequences:

>Translated_391_residues
MEYINNELCLGPLKKPLLPLVANYMRPIYVYDLDSVAQRYQAMSQALKGTRLFFAVKSNPNPGVLQKLKSLGAGADVVSL
GEIKRALECGFSPQDIVYSGVGKTKFELAEALKLGIYQINVESLPELERIGVLARELNKKAQVALRLNPDVDINTHPYIA
TGLKDNKFGMERSMVPALVKCLKSYSDSIDLVGVSLHLGSQMLEFSGYDEALKRLKTVYLELQAQFPTLKKFDFGGGLGI
FYDRVDLQLEESLLQKYAQITLENLSDLNCELQAEPGRWLVAHCGALITQVQYIKETSAKTFVIVDAGMNHLIRPSLYEA
THRIEPLKRKDAAFVVDVVGPICESSDFFAKEISLTKVQEGDFVAIMDSGAYGYSMASVYNLQELPLEICI
>Mature_391_residues
MEYINNELCLGPLKKPLLPLVANYMRPIYVYDLDSVAQRYQAMSQALKGTRLFFAVKSNPNPGVLQKLKSLGAGADVVSL
GEIKRALECGFSPQDIVYSGVGKTKFELAEALKLGIYQINVESLPELERIGVLARELNKKAQVALRLNPDVDINTHPYIA
TGLKDNKFGMERSMVPALVKCLKSYSDSIDLVGVSLHLGSQMLEFSGYDEALKRLKTVYLELQAQFPTLKKFDFGGGLGI
FYDRVDLQLEESLLQKYAQITLENLSDLNCELQAEPGRWLVAHCGALITQVQYIKETSAKTFVIVDAGMNHLIRPSLYEA
THRIEPLKRKDAAFVVDVVGPICESSDFFAKEISLTKVQEGDFVAIMDSGAYGYSMASVYNLQELPLEICI

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=385, Percent_Identity=26.2337662337662, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI22538418, Length=380, Percent_Identity=22.8947368421053, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI21361583, Length=380, Percent_Identity=22.8947368421053, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI16506287, Length=372, Percent_Identity=22.0430107526882, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789203, Length=396, Percent_Identity=30.5555555555556, Blast_Score=164, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17562780, Length=377, Percent_Identity=26.2599469496021, Blast_Score=104, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6322664, Length=410, Percent_Identity=26.5853658536585, Blast_Score=104, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 43452; Mature: 43452

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYINNELCLGPLKKPLLPLVANYMRPIYVYDLDSVAQRYQAMSQALKGTRLFFAVKSNP
CCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEEEECCC
NPGVLQKLKSLGAGADVVSLGEIKRALECGFSPQDIVYSGVGKTKFELAEALKLGIYQIN
CHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHEEECCCCHHHHHHHHHHHCEEEEE
VESLPELERIGVLARELNKKAQVALRLNPDVDINTHPYIATGLKDNKFGMERSMVPALVK
HHHCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHH
CLKSYSDSIDLVGVSLHLGSQMLEFSGYDEALKRLKTVYLELQAQFPTLKKFDFGGGLGI
HHHHCCCCEEEEEEEEHHCCHHHHCCCHHHHHHHHHHHHHHHEECCCCCEEECCCCCCEE
FYDRVDLQLEESLLQKYAQITLENLSDLNCELQAEPGRWLVAHCGALITQVQYIKETSAK
EEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
TFVIVDAGMNHLIRPSLYEATHRIEPLKRKDAAFVVDVVGPICESSDFFAKEISLTKVQE
EEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEHHHHHCCCCCCHHHHCEEEEECC
GDFVAIMDSGAYGYSMASVYNLQELPLEICI
CCEEEEEECCCCCCHHHHHHHHHHCCHHHCC
>Mature Secondary Structure
MEYINNELCLGPLKKPLLPLVANYMRPIYVYDLDSVAQRYQAMSQALKGTRLFFAVKSNP
CCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCEEEEEEECCC
NPGVLQKLKSLGAGADVVSLGEIKRALECGFSPQDIVYSGVGKTKFELAEALKLGIYQIN
CHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHEEECCCCHHHHHHHHHHHCEEEEE
VESLPELERIGVLARELNKKAQVALRLNPDVDINTHPYIATGLKDNKFGMERSMVPALVK
HHHCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHH
CLKSYSDSIDLVGVSLHLGSQMLEFSGYDEALKRLKTVYLELQAQFPTLKKFDFGGGLGI
HHHHCCCCEEEEEEEEHHCCHHHHCCCHHHHHHHHHHHHHHHEECCCCCEEECCCCCCEE
FYDRVDLQLEESLLQKYAQITLENLSDLNCELQAEPGRWLVAHCGALITQVQYIKETSAK
EEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCC
TFVIVDAGMNHLIRPSLYEATHRIEPLKRKDAAFVVDVVGPICESSDFFAKEISLTKVQE
EEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEHHHHHCCCCCCHHHHCEEEEECC
GDFVAIMDSGAYGYSMASVYNLQELPLEICI
CCEEEEEECCCCCCHHHHHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA