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The map label for this gene is kdpD [H]

Identifier: 42523250

GI number: 42523250

Start: 1695762

End: 1696433

Strand: Direct

Name: kdpD [H]

Synonym: Bd1758

Alternate gene names: 42523250

Gene position: 1695762-1696433 (Clockwise)

Preceding gene: 42523249

Following gene: 42523251

Centisome position: 44.83

GC content: 51.34

Gene sequence:

>672_bases
GTGGTCGGAATACGAACTCCGCTGACGGCCATTATTGGCTCGGCATCGGCGGTGCTGGATGAAAAAGTTTCTGCCAATAA
AGAAACCCGTGAGCAACTGGCTCAGGACATTGTGGATTCGTCTTTGCGCCTGAATCAGGTGGTGGAAAATCTTTTGGACA
TGTCCCGGTTGAATTCCGGGGCTTTGCGTTTGAAAAAAGAGTGGGTTGATCTGGAGGATGTTCTTTCCGGCCTGCCGGGT
AAGCTGGGCCGTCTGGTGGCACGCCACAAGCTGTCAGTGGTGAACTATCTGGGGTCTTGTTATGCCCAGATTGATGAAAA
GCTGTTTGAACACGTGCTGTTGAATCTTTTGAGCAATGCTGTTCGTTATGCGCCTGAAGGTACTGAAATCACATTACGCC
TTGAAATGGAAAATCGCCGCATTCTTTTGCGGATATTGGATCAAGGGCCGGGGATTCCACAGGACAACCTGAAAAATATC
TTTGAAGCCTTCTATCGCGTTCCTGGCAGTGCCACGGGCGGTGTTGGGTTGGGGCTGGCAATTGTGAAAGCTTTGATTGA
AGCCCATGGCGGCAGGGTCTATGCTCAGAATCGCAAGGATAGGTCCGGAGCGGAGTTCGTCGTGGAACTTCCCTACGAGA
GTCCTCCTGCGGATTTAGAGGACGGAAGATGA

Upstream 100 bases:

>100_bases
GCACGTATGTATTTGGTGTGATGGTGGGATCAAAAAGACAGGGTTGGGGCTTGTTTGCCGCTATGATGTCTATGCTGGTG
GTGATGCTCGCTCTGTCGTT

Downstream 100 bases:

>100_bases
AAGAGAACTTGAAGAAAGTTTTGGTGATTGATGATGAAGCCTCCATCCGTAAGCTTTTGCGGGTGAGTCTGGAAGCCAAC
GCCTATCAGGTGGAAGAGGC

Product: two-component sensor KdpD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MVGIRTPLTAIIGSASAVLDEKVSANKETREQLAQDIVDSSLRLNQVVENLLDMSRLNSGALRLKKEWVDLEDVLSGLPG
KLGRLVARHKLSVVNYLGSCYAQIDEKLFEHVLLNLLSNAVRYAPEGTEITLRLEMENRRILLRILDQGPGIPQDNLKNI
FEAFYRVPGSATGGVGLGLAIVKALIEAHGGRVYAQNRKDRSGAEFVVELPYESPPADLEDGR

Sequences:

>Translated_223_residues
MVGIRTPLTAIIGSASAVLDEKVSANKETREQLAQDIVDSSLRLNQVVENLLDMSRLNSGALRLKKEWVDLEDVLSGLPG
KLGRLVARHKLSVVNYLGSCYAQIDEKLFEHVLLNLLSNAVRYAPEGTEITLRLEMENRRILLRILDQGPGIPQDNLKNI
FEAFYRVPGSATGGVGLGLAIVKALIEAHGGRVYAQNRKDRSGAEFVVELPYESPPADLEDGR
>Mature_223_residues
MVGIRTPLTAIIGSASAVLDEKVSANKETREQLAQDIVDSSLRLNQVVENLLDMSRLNSGALRLKKEWVDLEDVLSGLPG
KLGRLVARHKLSVVNYLGSCYAQIDEKLFEHVLLNLLSNAVRYAPEGTEITLRLEMENRRILLRILDQGPGIPQDNLKNI
FEAFYRVPGSATGGVGLGLAIVKALIEAHGGRVYAQNRKDRSGAEFVVELPYESPPADLEDGR

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=215, Percent_Identity=39.5348837209302, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1788393, Length=214, Percent_Identity=31.7757009345794, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1786783, Length=214, Percent_Identity=30.3738317757009, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI48994928, Length=228, Percent_Identity=28.0701754385965, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787894, Length=172, Percent_Identity=34.8837209302326, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1786600, Length=219, Percent_Identity=28.310502283105, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788713, Length=221, Percent_Identity=28.5067873303167, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87081816, Length=214, Percent_Identity=31.7757009345794, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1790551, Length=116, Percent_Identity=36.2068965517241, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790861, Length=199, Percent_Identity=30.1507537688442, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=222, Percent_Identity=26.1261261261261, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790346, Length=217, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI87082128, Length=226, Percent_Identity=30.9734513274336, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=27.9279279279279, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789403, Length=194, Percent_Identity=32.9896907216495, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788279, Length=191, Percent_Identity=28.2722513089005, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 24514; Mature: 24514

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGIRTPLTAIIGSASAVLDEKVSANKETREQLAQDIVDSSLRLNQVVENLLDMSRLNSG
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ALRLKKEWVDLEDVLSGLPGKLGRLVARHKLSVVNYLGSCYAQIDEKLFEHVLLNLLSNA
HHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRYAPEGTEITLRLEMENRRILLRILDQGPGIPQDNLKNIFEAFYRVPGSATGGVGLGLA
HHCCCCCCEEEEEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
IVKALIEAHGGRVYAQNRKDRSGAEFVVELPYESPPADLEDGR
HHHHHHHHCCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MVGIRTPLTAIIGSASAVLDEKVSANKETREQLAQDIVDSSLRLNQVVENLLDMSRLNSG
CCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ALRLKKEWVDLEDVLSGLPGKLGRLVARHKLSVVNYLGSCYAQIDEKLFEHVLLNLLSNA
HHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRYAPEGTEITLRLEMENRRILLRILDQGPGIPQDNLKNIFEAFYRVPGSATGGVGLGLA
HHCCCCCCEEEEEEEECCCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHH
IVKALIEAHGGRVYAQNRKDRSGAEFVVELPYESPPADLEDGR
HHHHHHHHCCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1532388; 8905232; 9278503; 7499326 [H]