Click here to switch to the map view.

The map label for this gene is cysM [H]

Identifier: 42523238

GI number: 42523238

Start: 1678942

End: 1679931

Strand: Direct

Name: cysM [H]

Synonym: Bd1744

Alternate gene names: 42523238

Gene position: 1678942-1679931 (Clockwise)

Preceding gene: 42523237

Following gene: 42523239

Centisome position: 44.38

GC content: 52.12

Gene sequence:

>990_bases
ATGCAGGCCGGTTCCGTTTCAGACGTTGTGGGTCACACACCGTTAATCAAACTTCAATCTCTTTCAAAAATCACCGGATG
TGAGATCTTTGCCAAAGCCGAATATCTGAATCCAGGTGGCAGCGTGAAAGATCGCACAGCGCTGGGAATCATTCAAAGCG
CCGAAAAACAAGGTCTGCTGAAGCCCGGGGACACGATTGTGGAAGGCACCGCAGGGAATACGGGGATTGGTCTTGCCACG
CTGGCGGCGCAGCGGGGGTACCACTGTGTGATCGTGATGCCGGACAACCAGTCCAAAGAAAAATACCATGCGCTCGAAGC
CCTGGGTGTGGAGCTTGTGAAGGTCGCTCCCTGTCCCTTTGCCAATCCCAACCACTTCTACCACACAGCACGCGCCCTGG
CTGAATCTCGCCCCAATTCCTTTTGGGCCAACCAGTTTGAGAACACCGCCAATTTCGAGATTCACTACAAGACGACCGGC
CCTGAGATCTGGGAGCAGATGGGTCAAAGGGTGGACGCCTTTGTTTCCTCTGTCGGAACCGGAGGAACGCTGGCGGGAGT
GTCGGCCTATTTAAAAGAACAAGATCCCAAGGTATTCACGCTTCTGGCGGACCCCATGGGCTCGGGTCTTTATTCGTTTG
TAAAAAGTGGAAAGTTCGAAGCGCAGGGCAGCTCGATCACTGAGGGGATCGGGATCATGCGCCTGACCGAAAACTTTAAA
AAGGCCCGTGTTGATGAGGCCGTTCAAATCCACGACGAACAAATGCTTTCGATGCTTTATTACCTGGCTCAGCATGAAGG
ATTGCTGGTGGGGACATCGGCGGCCTTGAACATCTTTGCCTCATACCAGTATGCCTTGCAAAACCAGGGAAAGGGATTGC
GGATTGCGACTGTGATGGGAGACTCGGCCCTTCGCTATCAATCCAAGGTGTTTAATCCACAGTTCCTGAATGAAAAGAAC
CTGAAAATTATGCCTTTGATTCATAGTTAA

Upstream 100 bases:

>100_bases
ATAGGCCCCCGACATTCAAAATTCTTAACGAAAGCCAGGTTTCAGGACCTGGCTTTTTTGTTTTTCATTGCTATAGTTCT
GAATGGATTGCGAGGTGCTT

Downstream 100 bases:

>100_bases
CGGTGGATAAGAGTCCGGATTGTGATAGGTGTTTACTTATGAAGTACAAGATCCGCGATATCGAAAATTTTATCCATACC
AGCACCTGCTCCACGATCAT

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MQAGSVSDVVGHTPLIKLQSLSKITGCEIFAKAEYLNPGGSVKDRTALGIIQSAEKQGLLKPGDTIVEGTAGNTGIGLAT
LAAQRGYHCVIVMPDNQSKEKYHALEALGVELVKVAPCPFANPNHFYHTARALAESRPNSFWANQFENTANFEIHYKTTG
PEIWEQMGQRVDAFVSSVGTGGTLAGVSAYLKEQDPKVFTLLADPMGSGLYSFVKSGKFEAQGSSITEGIGIMRLTENFK
KARVDEAVQIHDEQMLSMLYYLAQHEGLLVGTSAALNIFASYQYALQNQGKGLRIATVMGDSALRYQSKVFNPQFLNEKN
LKIMPLIHS

Sequences:

>Translated_329_residues
MQAGSVSDVVGHTPLIKLQSLSKITGCEIFAKAEYLNPGGSVKDRTALGIIQSAEKQGLLKPGDTIVEGTAGNTGIGLAT
LAAQRGYHCVIVMPDNQSKEKYHALEALGVELVKVAPCPFANPNHFYHTARALAESRPNSFWANQFENTANFEIHYKTTG
PEIWEQMGQRVDAFVSSVGTGGTLAGVSAYLKEQDPKVFTLLADPMGSGLYSFVKSGKFEAQGSSITEGIGIMRLTENFK
KARVDEAVQIHDEQMLSMLYYLAQHEGLLVGTSAALNIFASYQYALQNQGKGLRIATVMGDSALRYQSKVFNPQFLNEKN
LKIMPLIHS
>Mature_329_residues
MQAGSVSDVVGHTPLIKLQSLSKITGCEIFAKAEYLNPGGSVKDRTALGIIQSAEKQGLLKPGDTIVEGTAGNTGIGLAT
LAAQRGYHCVIVMPDNQSKEKYHALEALGVELVKVAPCPFANPNHFYHTARALAESRPNSFWANQFENTANFEIHYKTTG
PEIWEQMGQRVDAFVSSVGTGGTLAGVSAYLKEQDPKVFTLLADPMGSGLYSFVKSGKFEAQGSSITEGIGIMRLTENFK
KARVDEAVQIHDEQMLSMLYYLAQHEGLLVGTSAALNIFASYQYALQNQGKGLRIATVMGDSALRYQSKVFNPQFLNEKN
LKIMPLIHS

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=313, Percent_Identity=38.9776357827476, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI295821200, Length=313, Percent_Identity=38.9776357827476, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI4557415, Length=313, Percent_Identity=38.9776357827476, Blast_Score=213, Evalue=3e-55,
Organism=Escherichia coli, GI2367138, Length=312, Percent_Identity=37.5, Blast_Score=184, Evalue=5e-48,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=36.3636363636364, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17535051, Length=324, Percent_Identity=36.4197530864198, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17562970, Length=312, Percent_Identity=36.5384615384615, Blast_Score=191, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI32566674, Length=300, Percent_Identity=37, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI115535073, Length=306, Percent_Identity=36.6013071895425, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17561720, Length=312, Percent_Identity=34.6153846153846, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=330, Percent_Identity=33.6363636363636, Blast_Score=148, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17534315, Length=326, Percent_Identity=33.4355828220859, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32566672, Length=226, Percent_Identity=31.858407079646, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17539800, Length=349, Percent_Identity=27.2206303724928, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71996324, Length=346, Percent_Identity=25.1445086705202, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17539640, Length=345, Percent_Identity=24.9275362318841, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321449, Length=328, Percent_Identity=39.9390243902439, Blast_Score=217, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6321594, Length=328, Percent_Identity=34.4512195121951, Blast_Score=173, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24643623, Length=321, Percent_Identity=38.006230529595, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI20129101, Length=321, Percent_Identity=38.006230529595, Blast_Score=201, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 35737; Mature: 35737

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAGSVSDVVGHTPLIKLQSLSKITGCEIFAKAEYLNPGGSVKDRTALGIIQSAEKQGLL
CCCCCCCHHHCCCCEEEEHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCC
KPGDTIVEGTAGNTGIGLATLAAQRGYHCVIVMPDNQSKEKYHALEALGVELVKVAPCPF
CCCCEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCEEEEEECCCCC
ANPNHFYHTARALAESRPNSFWANQFENTANFEIHYKTTGPEIWEQMGQRVDAFVSSVGT
CCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCC
GGTLAGVSAYLKEQDPKVFTLLADPMGSGLYSFVKSGKFEAQGSSITEGIGIMRLTENFK
CCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHH
KARVDEAVQIHDEQMLSMLYYLAQHEGLLVGTSAALNIFASYQYALQNQGKGLRIATVMG
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCCEEEEEEEC
DSALRYQSKVFNPQFLNEKNLKIMPLIHS
CHHHHHHHHCCCCHHCCCCCCEEEEEECC
>Mature Secondary Structure
MQAGSVSDVVGHTPLIKLQSLSKITGCEIFAKAEYLNPGGSVKDRTALGIIQSAEKQGLL
CCCCCCCHHHCCCCEEEEHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCC
KPGDTIVEGTAGNTGIGLATLAAQRGYHCVIVMPDNQSKEKYHALEALGVELVKVAPCPF
CCCCEEEECCCCCCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHCEEEEEECCCCC
ANPNHFYHTARALAESRPNSFWANQFENTANFEIHYKTTGPEIWEQMGQRVDAFVSSVGT
CCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCC
GGTLAGVSAYLKEQDPKVFTLLADPMGSGLYSFVKSGKFEAQGSSITEGIGIMRLTENFK
CCHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHH
KARVDEAVQIHDEQMLSMLYYLAQHEGLLVGTSAALNIFASYQYALQNQGKGLRIATVMG
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCCEEEEEEEC
DSALRYQSKVFNPQFLNEKNLKIMPLIHS
CHHHHHHHHCCCCHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA