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The map label for this gene is rmlA2 [C]

Identifier: 42523182

GI number: 42523182

Start: 1621680

End: 1622732

Strand: Direct

Name: rmlA2 [C]

Synonym: Bd1685

Alternate gene names: 42523182

Gene position: 1621680-1622732 (Clockwise)

Preceding gene: 42523181

Following gene: 42523183

Centisome position: 42.87

GC content: 40.27

Gene sequence:

>1053_bases
ATGATGGTGAATTCTGATTTTTTCGTTTCTTTGGATGATACTTTAAGGCATGCAATGGAAGTTCTCGAGAGAAATTCTAT
TCAAATCTGCTTTGTCTTGGATGACAACAAAAAGCTAGTAGGTGCACTTACCGATGGGGATATTCGACGAGCCCTCTTAA
AGTGTTCCGATTTGGATCAATTGGTTAAAGGAGTAATGAATAAGAACCCTAAAAGTATATCGGAGGGATTGTCGAGGAAC
GAGATTGTTGCGAAAATGCGCCAATGGAGAGTTAGGCATTTACCTGTGTTAAACAGTGCTGGCTGTGTAGTTCGAATCGA
AGGTACTGATAGTATTCTTGGTTTGTTAAGGCGAGAAAATAAAGTTGTCCTAATGGCTGGTGGCTTTGGGAAGAGGCTGA
GTCCACTAACAGACAGCGTTCCCAAACCACTCTTGAGGGTTGGTGGCCGTCCGATTTTGGAAACAATATTGATGCGTTTC
TGTGAATTGGGGTTCTATAATTTTATTTTTGTTGTTAATTATCGTGCGGAGATGATTAAGGAGTATTTTCAAAACGGTGA
AAAGTGGGGCGCAACGATAGAGTATTTGCATGAGGAGATACCGCTGGGTACATGTGGAGGCCTATCGTTGCTATCCGAAA
AACCGTCATCTCCAATTTTTGTGATGAACGGTGATATTTTAACTAGAGCAAACTTTGCAGAAATGTTGGATTTTCACGCA
TCCAGTATGGCCACGGCCACAATGGTCGTTCGAGAGCATATTATTGAAATTCCTTACGGTGTGGTAAAAGTAAATGGTGA
TGAAATAGTCTCAATTGAGGAGAAACCGAAAGAAAAAACCTTTGTCAATGCTGGGATTTACATATTATCCCCTGAGGCCC
TTGAGTATATTCCTAGAGATCAATTTTATGATATGCCTAGTTTATTTATGTCCCTTAAGGACAAAGAAAAATTGATACAG
AGTTTTAAACTTAAAGATTACTGGGTCGACATCGGTAGGCTGGAAGATTTTCATAAAGCTCAGTCTGATTTTGAAGGGTA
CTTCGGTGGGTAG

Upstream 100 bases:

>100_bases
GGGCTGTCGTTGTTAAAGATGTACCTCCCGATACAATTGTTTTTGGGGTTCCGGCAAGGGAAGTTAAGTCACAAGTGCGG
TCGTCACTTTAGGGTTATTT

Downstream 100 bases:

>100_bases
CTTAGCTATAATACCAGCACGAGCTGGATCGAGAAGATTGCCAGGGAAGAACAAGAGGAATTTTGCTGGAAAACCTTTGG
TTCAATGGACGATAGAAGCG

Product: mannose-1-phosphate guanyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MMVNSDFFVSLDDTLRHAMEVLERNSIQICFVLDDNKKLVGALTDGDIRRALLKCSDLDQLVKGVMNKNPKSISEGLSRN
EIVAKMRQWRVRHLPVLNSAGCVVRIEGTDSILGLLRRENKVVLMAGGFGKRLSPLTDSVPKPLLRVGGRPILETILMRF
CELGFYNFIFVVNYRAEMIKEYFQNGEKWGATIEYLHEEIPLGTCGGLSLLSEKPSSPIFVMNGDILTRANFAEMLDFHA
SSMATATMVVREHIIEIPYGVVKVNGDEIVSIEEKPKEKTFVNAGIYILSPEALEYIPRDQFYDMPSLFMSLKDKEKLIQ
SFKLKDYWVDIGRLEDFHKAQSDFEGYFGG

Sequences:

>Translated_350_residues
MMVNSDFFVSLDDTLRHAMEVLERNSIQICFVLDDNKKLVGALTDGDIRRALLKCSDLDQLVKGVMNKNPKSISEGLSRN
EIVAKMRQWRVRHLPVLNSAGCVVRIEGTDSILGLLRRENKVVLMAGGFGKRLSPLTDSVPKPLLRVGGRPILETILMRF
CELGFYNFIFVVNYRAEMIKEYFQNGEKWGATIEYLHEEIPLGTCGGLSLLSEKPSSPIFVMNGDILTRANFAEMLDFHA
SSMATATMVVREHIIEIPYGVVKVNGDEIVSIEEKPKEKTFVNAGIYILSPEALEYIPRDQFYDMPSLFMSLKDKEKLIQ
SFKLKDYWVDIGRLEDFHKAQSDFEGYFGG
>Mature_350_residues
MMVNSDFFVSLDDTLRHAMEVLERNSIQICFVLDDNKKLVGALTDGDIRRALLKCSDLDQLVKGVMNKNPKSISEGLSRN
EIVAKMRQWRVRHLPVLNSAGCVVRIEGTDSILGLLRRENKVVLMAGGFGKRLSPLTDSVPKPLLRVGGRPILETILMRF
CELGFYNFIFVVNYRAEMIKEYFQNGEKWGATIEYLHEEIPLGTCGGLSLLSEKPSSPIFVMNGDILTRANFAEMLDFHA
SSMATATMVVREHIIEIPYGVVKVNGDEIVSIEEKPKEKTFVNAGIYILSPEALEYIPRDQFYDMPSLFMSLKDKEKLIQ
SFKLKDYWVDIGRLEDFHKAQSDFEGYFGG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=227, Percent_Identity=33.920704845815, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI11761619, Length=227, Percent_Identity=33.920704845815, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI31881779, Length=200, Percent_Identity=29.5, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI45447090, Length=200, Percent_Identity=29.5, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI133931050, Length=233, Percent_Identity=32.618025751073, Blast_Score=113, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320148, Length=226, Percent_Identity=35.3982300884956, Blast_Score=125, Evalue=9e-30,
Organism=Drosophila melanogaster, GI21355443, Length=227, Percent_Identity=34.3612334801762, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24644084, Length=227, Percent_Identity=34.3612334801762, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24653912, Length=221, Percent_Identity=27.6018099547511, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 39665; Mature: 39665

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMVNSDFFVSLDDTLRHAMEVLERNSIQICFVLDDNKKLVGALTDGDIRRALLKCSDLDQ
CEECCCEEEEEHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEECCHHHHHHHHHHCCHHH
LVKGVMNKNPKSISEGLSRNEIVAKMRQWRVRHLPVLNSAGCVVRIEGTDSILGLLRREN
HHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHCCC
KVVLMAGGFGKRLSPLTDSVPKPLLRVGGRPILETILMRFCELGFYNFIFVVNYRAEMIK
EEEEEECCCCCCCCCHHHHCCHHHHHHCCCHHHHHHHHHHHHHCCEEEEEEEECHHHHHH
EYFQNGEKWGATIEYLHEEIPLGTCGGLSLLSEKPSSPIFVMNGDILTRANFAEMLDFHA
HHHHCCHHCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCEEEECCCEEECCCHHHHHHHHH
SSMATATMVVREHIIEIPYGVVKVNGDEIVSIEEKPKEKTFVNAGIYILSPEALEYIPRD
HHHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCEEEECCEEEECCHHHHHCCCH
QFYDMPSLFMSLKDKEKLIQSFKLKDYWVDIGRLEDFHKAQSDFEGYFGG
HCCCCHHHHHHHHHHHHHHHHHCHHHHHEEHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MMVNSDFFVSLDDTLRHAMEVLERNSIQICFVLDDNKKLVGALTDGDIRRALLKCSDLDQ
CEECCCEEEEEHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEECCHHHHHHHHHHCCHHH
LVKGVMNKNPKSISEGLSRNEIVAKMRQWRVRHLPVLNSAGCVVRIEGTDSILGLLRREN
HHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHCCC
KVVLMAGGFGKRLSPLTDSVPKPLLRVGGRPILETILMRFCELGFYNFIFVVNYRAEMIK
EEEEEECCCCCCCCCHHHHCCHHHHHHCCCHHHHHHHHHHHHHCCEEEEEEEECHHHHHH
EYFQNGEKWGATIEYLHEEIPLGTCGGLSLLSEKPSSPIFVMNGDILTRANFAEMLDFHA
HHHHCCHHCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCEEEECCCEEECCCHHHHHHHHH
SSMATATMVVREHIIEIPYGVVKVNGDEIVSIEEKPKEKTFVNAGIYILSPEALEYIPRD
HHHHHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCEEEECCEEEECCHHHHHCCCH
QFYDMPSLFMSLKDKEKLIQSFKLKDYWVDIGRLEDFHKAQSDFEGYFGG
HCCCCHHHHHHHHHHHHHHHHHCHHHHHEEHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA