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The map label for this gene is rfbB [C]

Identifier: 42523176

GI number: 42523176

Start: 1615053

End: 1616036

Strand: Direct

Name: rfbB [C]

Synonym: Bd1678

Alternate gene names: 42523176

Gene position: 1615053-1616036 (Clockwise)

Preceding gene: 42523175

Following gene: 42523177

Centisome position: 42.69

GC content: 41.77

Gene sequence:

>984_bases
TTGTCGAAAAAAGTTCTTGTTACTGGCGCTGACGGATTTATTGGGTCTCATTTAACGGAGTTATTGGTTAGTGAAGGGTA
CAGTGTTAGGGCTCTTGTTAACTATAATTCGTTTAATTCCTGGGGCTGGCTGGATTCATCGGCGGTGAGAAGCGATATTG
AGGTCGTATCCGGAGACATTCGTGATCCGTTTTTGTGTCGAGATATTACGAAAGGTATGGATGCGATTTTTCATTTGGCT
GCCTTGATAGCGATTCCTTACTCATACGTTGCCCCACAGAGTTACGTTGAGACAAATGTCACGGGTACTTTAAATATTTG
CAAAGCTGCCTTGGACAATGGGGTTGCCAAAGTTGTGCATACTTCTACGAGTGAAGTATACGGAACTGCGCAGTATGTTC
CAATAGATGAGAAGCATCCTTTGCAACCACAGTCCCCGTATAGTGCATCCAAGATAGCCTCTGATGCTATGGCAATGAGT
TTCTTCAATTCATTTGGATTGCCGTTGACTATAGCGCGTCCATTCAACACGTACGGTCCTCGCCAATCCGCTAGGGCAGT
GATTCCTACAATCATCGCTCAAATTGCTTCGGGAAAAAAAGAAATTAGCATAGGGGATATGACACCCACTAGGGATTTCA
ATTACGTTACCGACACATGTAGGGGATTTTTGGCTTTGGCGGCTAACTCCAATTGTATTGGAAAGACAGTGAACATTGGA
TCGAATTATGAAATTTCCATCAAGGATACATTGGAGTTAATTAAGGGGATCATGGGATCAAATATCTCGATTCAATATGA
TAGCCATAGAGTTAGACCTAAAAATTCCGAAGTTCATAGATTATGGTGTGATAATACTTTGATTAATTCTCTTACTGGAT
TTAGCCCATTAGTTAACATCGAGCAGGGACTGAGAATGACGGTGGATTGGTTTAGTCAACGAGAGAATCTGGCAAAATAT
AAGGCAGATGTCTATAATGTTTAG

Upstream 100 bases:

>100_bases
TCCTACGCTAATGTGTTTTTTTTGCTTTAAGTCAAATCTGCTTTGGATAGACTCGTTTATTCATGGGGGATACTATCTTG
CGCTTAAGTAGGAGTGTCCC

Downstream 100 bases:

>100_bases
TGATGTAATCGCTTTTATTCAGGATCTGTACGGTAGTAAGAGTTTTATTCCCTTACATGCTCCTATTTTTACGGGGAATG
AAAAAAAATATGTAATTGAA

Product: UDP-glucose 4-epimerase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MSKKVLVTGADGFIGSHLTELLVSEGYSVRALVNYNSFNSWGWLDSSAVRSDIEVVSGDIRDPFLCRDITKGMDAIFHLA
ALIAIPYSYVAPQSYVETNVTGTLNICKAALDNGVAKVVHTSTSEVYGTAQYVPIDEKHPLQPQSPYSASKIASDAMAMS
FFNSFGLPLTIARPFNTYGPRQSARAVIPTIIAQIASGKKEISIGDMTPTRDFNYVTDTCRGFLALAANSNCIGKTVNIG
SNYEISIKDTLELIKGIMGSNISIQYDSHRVRPKNSEVHRLWCDNTLINSLTGFSPLVNIEQGLRMTVDWFSQRENLAKY
KADVYNV

Sequences:

>Translated_327_residues
MSKKVLVTGADGFIGSHLTELLVSEGYSVRALVNYNSFNSWGWLDSSAVRSDIEVVSGDIRDPFLCRDITKGMDAIFHLA
ALIAIPYSYVAPQSYVETNVTGTLNICKAALDNGVAKVVHTSTSEVYGTAQYVPIDEKHPLQPQSPYSASKIASDAMAMS
FFNSFGLPLTIARPFNTYGPRQSARAVIPTIIAQIASGKKEISIGDMTPTRDFNYVTDTCRGFLALAANSNCIGKTVNIG
SNYEISIKDTLELIKGIMGSNISIQYDSHRVRPKNSEVHRLWCDNTLINSLTGFSPLVNIEQGLRMTVDWFSQRENLAKY
KADVYNV
>Mature_326_residues
SKKVLVTGADGFIGSHLTELLVSEGYSVRALVNYNSFNSWGWLDSSAVRSDIEVVSGDIRDPFLCRDITKGMDAIFHLAA
LIAIPYSYVAPQSYVETNVTGTLNICKAALDNGVAKVVHTSTSEVYGTAQYVPIDEKHPLQPQSPYSASKIASDAMAMSF
FNSFGLPLTIARPFNTYGPRQSARAVIPTIIAQIASGKKEISIGDMTPTRDFNYVTDTCRGFLALAANSNCIGKTVNIGS
NYEISIKDTLELIKGIMGSNISIQYDSHRVRPKNSEVHRLWCDNTLINSLTGFSPLVNIEQGLRMTVDWFSQRENLAKYK
ADVYNV

Specific function: DTDP-L-RHAMNOSE BIOSYNTHESIS WITHIN THE O ANTIGEN BIOSYNTHESIS PATHWAY OF LIPOPOLYSACCHARIDE BIOSYNTHESIS. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=331, Percent_Identity=31.7220543806647, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI42516563, Length=321, Percent_Identity=30.2180685358255, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI56237023, Length=348, Percent_Identity=26.4367816091954, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI56118217, Length=348, Percent_Identity=26.4367816091954, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI189083684, Length=348, Percent_Identity=26.4367816091954, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4504031, Length=335, Percent_Identity=25.3731343283582, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI193211614, Length=257, Percent_Identity=26.0700389105058, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI8393516, Length=257, Percent_Identity=26.0700389105058, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI48994969, Length=345, Percent_Identity=29.5652173913043, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1788353, Length=336, Percent_Identity=30.0595238095238, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788366, Length=343, Percent_Identity=23.9067055393586, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1786974, Length=311, Percent_Identity=27.3311897106109, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788589, Length=282, Percent_Identity=28.0141843971631, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788365, Length=340, Percent_Identity=24.4117647058824, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17539532, Length=326, Percent_Identity=30.6748466257669, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17568069, Length=322, Percent_Identity=26.3975155279503, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71982035, Length=355, Percent_Identity=24.2253521126761, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71982038, Length=355, Percent_Identity=24.2253521126761, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI133901790, Length=232, Percent_Identity=28.448275862069, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17539422, Length=232, Percent_Identity=28.448275862069, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI133901786, Length=232, Percent_Identity=28.448275862069, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI133901788, Length=232, Percent_Identity=28.448275862069, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17539424, Length=232, Percent_Identity=28.448275862069, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI115532424, Length=325, Percent_Identity=26.1538461538462, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17507723, Length=232, Percent_Identity=27.1551724137931, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71987463, Length=189, Percent_Identity=31.2169312169312, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319493, Length=252, Percent_Identity=29.3650793650794, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356223, Length=333, Percent_Identity=29.7297297297297, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI19923002, Length=347, Percent_Identity=26.5129682997118, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24158427, Length=231, Percent_Identity=26.8398268398268, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 35888; Mature: 35757

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKVLVTGADGFIGSHLTELLVSEGYSVRALVNYNSFNSWGWLDSSAVRSDIEVVSGDI
CCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCC
RDPFLCRDITKGMDAIFHLAALIAIPYSYVAPQSYVETNVTGTLNICKAALDNGVAKVVH
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHCCCCCHHHHHHHHHCCCCEEEEE
TSTSEVYGTAQYVPIDEKHPLQPQSPYSASKIASDAMAMSFFNSFGLPLTIARPFNTYGP
CCCHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
RQSARAVIPTIIAQIASGKKEISIGDMTPTRDFNYVTDTCRGFLALAANSNCIGKTVNIG
CHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHEEEEECCCCCCCCEEECC
SNYEISIKDTLELIKGIMGSNISIQYDSHRVRPKNSEVHRLWCDNTLINSLTGFSPLVNI
CCEEEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEECCHHHHHHHCCCCCHHHH
EQGLRMTVDWFSQRENLAKYKADVYNV
HCCCEEHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKKVLVTGADGFIGSHLTELLVSEGYSVRALVNYNSFNSWGWLDSSAVRSDIEVVSGDI
CCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCC
RDPFLCRDITKGMDAIFHLAALIAIPYSYVAPQSYVETNVTGTLNICKAALDNGVAKVVH
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHHCCCCCHHHHHHHHHCCCCEEEEE
TSTSEVYGTAQYVPIDEKHPLQPQSPYSASKIASDAMAMSFFNSFGLPLTIARPFNTYGP
CCCHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
RQSARAVIPTIIAQIASGKKEISIGDMTPTRDFNYVTDTCRGFLALAANSNCIGKTVNIG
CHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHEEEEECCCCCCCCEEECC
SNYEISIKDTLELIKGIMGSNISIQYDSHRVRPKNSEVHRLWCDNTLINSLTGFSPLVNI
CCEEEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEECCHHHHHHHCCCCCHHHH
EQGLRMTVDWFSQRENLAKYKADVYNV
HCCCEEHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]