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The map label for this gene is pheS

Identifier: 42523139

GI number: 42523139

Start: 1572189

End: 1573214

Strand: Direct

Name: pheS

Synonym: Bd1637

Alternate gene names: 42523139

Gene position: 1572189-1573214 (Clockwise)

Preceding gene: 42523134

Following gene: 42523140

Centisome position: 41.56

GC content: 50.0

Gene sequence:

>1026_bases
ATGTCGACGACCAAACTTGATTCCATCAAAGATAACGCCCTGGCGGCCTTTAAAGCGGCCCCCAGCTCCAAAGACCTCTA
TGATCTGAAAGTTCAGTACCTGGGTAAAAGCGGGTCCCTGACTGAAATCATGAAAGAAATGGCTTCTTTGCCGAAAGAGG
AAAAGCCTCTGTTTGGTAAAAAAGTAAATGAAGTGAAGCAGCTTCTGGAGGCCGCTTACACCGAAGCAGAAGACGCTCTG
AAAAAGAAAGAGATCTCTGCCAAAATGGCGGCGGAGGAAATCGACATGACTCTGCCGGCGTTCTCCCAGCCAAAGGGGAC
CGCGCACCCGGTGAATATCGTAGTGGAAGAAATCTTCACCGTGATGTCCCGTCTGGGTTACAGCATCCGCACAGGTCCGA
TGATCGAGAAGGATTATTATAACTTTGAAGCCCTGAACATTCCGGCGGATCACCCCGCACGTGACATGGCCGACACCTTC
TTCGTCGACAAAACCCACGTTTTAAGAACACACACGTCTCCGATTCAAATCCATTCTTTGGAAAATGAAGAGCTTCCATT
GCGTGTGATCGGGACGGGCCCGGTGTTCCGTTGTGACAGCGATATTTCTCACTTGCCGAACTTCCATCAGATTGAAGCTT
TGTGCGTGGATGAGAAAATCTCCATGGCGGACCTGAAGGGCACCATCAGCTTCTTCGTGCGTGAGTTCTTCGGTCCGGGT
CTGAAAACTCGTTTCCGTCCAAGTTACTTCCCGTTCACCGAGCCTTCTGCGGAAGTGGATTGCTCGTGCCCGATCTGTAA
AGGCAAAGGCTGTTCTTTGTGCAAACAAAGCGGCTGGATTGAAATCGGCGGTTGCGGTCTGGTGAATCCGAAAGTGTTCC
AGGCGGCAAAAATTGAATATCCTAAGTGGCAGGGCTTTGCCTTCGGATTTGGTGTTGAGCGTATGGCCATCATCAAGTAC
GGCATCGAAGACATCCGCTTGTTCCCTGAAAACGACGTAAGATTCTTAAGGCAGTTTGTAAAATGA

Upstream 100 bases:

>100_bases
GAACATAGGTCTAAAGGCCTTAAACCTCAAGTCTTTTCTGCGCCGTGTGTAAAAGCTAAATGCTTGAAAATACGGGCCTC
CGGAGGGATATTGAGAACCT

Downstream 100 bases:

>100_bases
AGATCAGTTTAAAATGGCTCCATGATTATGTTGATGTGACCGAATTCTTCCAAAAGCCGGAAGTGCTGGCGGAAGCTTTG
ACCCGTGGCGGTTTGGAGGT

Product: phenylalanyl-tRNA synthetase, alpha subunit

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MSTTKLDSIKDNALAAFKAAPSSKDLYDLKVQYLGKSGSLTEIMKEMASLPKEEKPLFGKKVNEVKQLLEAAYTEAEDAL
KKKEISAKMAAEEIDMTLPAFSQPKGTAHPVNIVVEEIFTVMSRLGYSIRTGPMIEKDYYNFEALNIPADHPARDMADTF
FVDKTHVLRTHTSPIQIHSLENEELPLRVIGTGPVFRCDSDISHLPNFHQIEALCVDEKISMADLKGTISFFVREFFGPG
LKTRFRPSYFPFTEPSAEVDCSCPICKGKGCSLCKQSGWIEIGGCGLVNPKVFQAAKIEYPKWQGFAFGFGVERMAIIKY
GIEDIRLFPENDVRFLRQFVK

Sequences:

>Translated_341_residues
MSTTKLDSIKDNALAAFKAAPSSKDLYDLKVQYLGKSGSLTEIMKEMASLPKEEKPLFGKKVNEVKQLLEAAYTEAEDAL
KKKEISAKMAAEEIDMTLPAFSQPKGTAHPVNIVVEEIFTVMSRLGYSIRTGPMIEKDYYNFEALNIPADHPARDMADTF
FVDKTHVLRTHTSPIQIHSLENEELPLRVIGTGPVFRCDSDISHLPNFHQIEALCVDEKISMADLKGTISFFVREFFGPG
LKTRFRPSYFPFTEPSAEVDCSCPICKGKGCSLCKQSGWIEIGGCGLVNPKVFQAAKIEYPKWQGFAFGFGVERMAIIKY
GIEDIRLFPENDVRFLRQFVK
>Mature_340_residues
STTKLDSIKDNALAAFKAAPSSKDLYDLKVQYLGKSGSLTEIMKEMASLPKEEKPLFGKKVNEVKQLLEAAYTEAEDALK
KKEISAKMAAEEIDMTLPAFSQPKGTAHPVNIVVEEIFTVMSRLGYSIRTGPMIEKDYYNFEALNIPADHPARDMADTFF
VDKTHVLRTHTSPIQIHSLENEELPLRVIGTGPVFRCDSDISHLPNFHQIEALCVDEKISMADLKGTISFFVREFFGPGL
KTRFRPSYFPFTEPSAEVDCSCPICKGKGCSLCKQSGWIEIGGCGLVNPKVFQAAKIEYPKWQGFAFGFGVERMAIIKYG
IEDIRLFPENDVRFLRQFVK

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily

Homologues:

Organism=Homo sapiens, GI5729820, Length=237, Percent_Identity=32.9113924050633, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4758340, Length=269, Percent_Identity=29.368029739777, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1788007, Length=336, Percent_Identity=43.75, Blast_Score=301, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI32566635, Length=249, Percent_Identity=31.7269076305221, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17508957, Length=267, Percent_Identity=29.5880149812734, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI32563657, Length=267, Percent_Identity=29.5880149812734, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6321087, Length=267, Percent_Identity=29.5880149812734, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6325304, Length=281, Percent_Identity=27.4021352313167, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI18858079, Length=283, Percent_Identity=29.6819787985866, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI17137424, Length=291, Percent_Identity=27.1477663230241, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYFA_BDEBA (Q6MMJ2)

Other databases:

- EMBL:   BX842650
- RefSeq:   NP_968519.1
- ProteinModelPortal:   Q6MMJ2
- SMR:   Q6MMJ2
- GeneID:   2735390
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd1637
- NMPDR:   fig|264462.1.peg.1489
- HOGENOM:   HBG284353
- OMA:   FRASYFP
- PhylomeDB:   Q6MMJ2
- BioCyc:   BBAC264462:BD1637-MONOMER
- BRENDA:   6.1.1.20
- GO:   GO:0005737
- HAMAP:   MF_00281
- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978
- PANTHER:   PTHR11538
- TIGRFAMs:   TIGR00468

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d; SSF46589 tRNA_binding_arm

EC number: =6.1.1.20

Molecular weight: Translated: 38245; Mature: 38113

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTKLDSIKDNALAAFKAAPSSKDLYDLKVQYLGKSGSLTEIMKEMASLPKEEKPLFGK
CCCCCCCCCCCCHHEEEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCHH
KVNEVKQLLEAAYTEAEDALKKKEISAKMAAEEIDMTLPAFSQPKGTAHPVNIVVEEIFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
VMSRLGYSIRTGPMIEKDYYNFEALNIPADHPARDMADTFFVDKTHVLRTHTSPIQIHSL
HHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHEEEECCCCEEEEEC
ENEELPLRVIGTGPVFRCDSDISHLPNFHQIEALCVDEKISMADLKGTISFFVREFFGPG
CCCCCCEEEEECCCEEEECCHHHHCCCHHHEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
LKTRFRPSYFPFTEPSAEVDCSCPICKGKGCSLCKQSGWIEIGGCGLVNPKVFQAAKIEY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEECCCCCCCHHHHHHHCCCC
PKWQGFAFGFGVERMAIIKYGIEDIRLFPENDVRFLRQFVK
CCCCCEEECCCHHHHHHHHHCHHHEEECCCHHHHHHHHHHC
>Mature Secondary Structure 
STTKLDSIKDNALAAFKAAPSSKDLYDLKVQYLGKSGSLTEIMKEMASLPKEEKPLFGK
CCCCCCCCCCCHHEEEECCCCCCCCEEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCHH
KVNEVKQLLEAAYTEAEDALKKKEISAKMAAEEIDMTLPAFSQPKGTAHPVNIVVEEIFT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
VMSRLGYSIRTGPMIEKDYYNFEALNIPADHPARDMADTFFVDKTHVLRTHTSPIQIHSL
HHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHEEEECCCCEEEEEC
ENEELPLRVIGTGPVFRCDSDISHLPNFHQIEALCVDEKISMADLKGTISFFVREFFGPG
CCCCCCEEEEECCCEEEECCHHHHCCCHHHEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
LKTRFRPSYFPFTEPSAEVDCSCPICKGKGCSLCKQSGWIEIGGCGLVNPKVFQAAKIEY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCEEECCCCCCCHHHHHHHCCCC
PKWQGFAFGFGVERMAIIKYGIEDIRLFPENDVRFLRQFVK
CCCCCEEECCCHHHHHHHHHCHHHEEECCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA