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The map label for this gene is dtd

Identifier: 42523123

GI number: 42523123

Start: 1550437

End: 1550874

Strand: Direct

Name: dtd

Synonym: Bd1619

Alternate gene names: 42523123

Gene position: 1550437-1550874 (Clockwise)

Preceding gene: 42523122

Following gene: 42523127

Centisome position: 40.98

GC content: 51.14

Gene sequence:

>438_bases
ATGAAAGCCGTAGTGCAAAGAGTTCAGAATGCCTCCGTTGTTGTGGATGGAAAGTTGGTTTCCTCCATCGATAAAGGCTA
TTTGACGTTGTTGGGGGTTGCCAAGGGCGACAGTGAAGAACAACTGCAAAAGCTGATGACCAAGATCCTTGCTTTAAGAA
TATTCCCGGATGAAACCGGGAAGATGAACCTGTCCCTGAAAGACGTGGGCGGGCAGCACCTGATCGTGTCGCAGTTCACT
TTGCTGGGGGATGCCTCCAAAGGCAATCGTCCCAGCTTCATCGGAGCAGAACTTCCGGATCGCGCCAAAGAACTTTATGA
AAAGGCTCTGGTGCTCAGCGAATCTCAAGGCGTAAAAACCCAAGGCGGTATATTCGGGGCCGACATGAAGGTCAGTCTGC
TGAATGACGGCCCGGTGACGTTGTTGCTGGAAGTATAG

Upstream 100 bases:

>100_bases
CGCTGCGTCGAACCAGTAAGCTGATACAATTTGTTCAATAAAACCCACGTTGAAGAATGTGGGTTTTGTTTTTTTAGAAT
CTGATTTATCAGGAGCCCCT

Downstream 100 bases:

>100_bases
TTTATTTCATGCTGCCTGTGTCCTGCAGCTTCTGATGCCAGGACAGGGCTTTGCTTAGCACGTGAGGGGTCTGACCGCCA
CGAGCCAGGGCTTCTTGATA

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MKAVVQRVQNASVVVDGKLVSSIDKGYLTLLGVAKGDSEEQLQKLMTKILALRIFPDETGKMNLSLKDVGGQHLIVSQFT
LLGDASKGNRPSFIGAELPDRAKELYEKALVLSESQGVKTQGGIFGADMKVSLLNDGPVTLLLEV

Sequences:

>Translated_145_residues
MKAVVQRVQNASVVVDGKLVSSIDKGYLTLLGVAKGDSEEQLQKLMTKILALRIFPDETGKMNLSLKDVGGQHLIVSQFT
LLGDASKGNRPSFIGAELPDRAKELYEKALVLSESQGVKTQGGIFGADMKVSLLNDGPVTLLLEV
>Mature_145_residues
MKAVVQRVQNASVVVDGKLVSSIDKGYLTLLGVAKGDSEEQLQKLMTKILALRIFPDETGKMNLSLKDVGGQHLIVSQFT
LLGDASKGNRPSFIGAELPDRAKELYEKALVLSESQGVKTQGGIFGADMKVSLLNDGPVTLLLEV

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=151, Percent_Identity=43.7086092715232, Blast_Score=98, Evalue=3e-21,
Organism=Escherichia coli, GI1790320, Length=145, Percent_Identity=48.9655172413793, Blast_Score=142, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI115533292, Length=147, Percent_Identity=40.1360544217687, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319982, Length=147, Percent_Identity=46.2585034013605, Blast_Score=117, Evalue=6e-28,
Organism=Drosophila melanogaster, GI281361569, Length=146, Percent_Identity=44.5205479452055, Blast_Score=105, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_BDEBA (Q6MMK8)

Other databases:

- EMBL:   BX842650
- RefSeq:   NP_968503.1
- ProteinModelPortal:   Q6MMK8
- SMR:   Q6MMK8
- GeneID:   2735372
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd1619
- NMPDR:   fig|264462.1.peg.1473
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- PhylomeDB:   Q6MMK8
- ProtClustDB:   PRK05273
- BioCyc:   BBAC264462:BD1619-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 15540; Mature: 15540

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVQRVQNASVVVDGKLVSSIDKGYLTLLGVAKGDSEEQLQKLMTKILALRIFPDETG
CHHHHHHHCCCEEEECCHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHEEECCCCCC
KMNLSLKDVGGQHLIVSQFTLLGDASKGNRPSFIGAELPDRAKELYEKALVLSESQGVKT
EEEEEEECCCCCEEEEEEEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCC
QGGIFGADMKVSLLNDGPVTLLLEV
CCCEEECCEEEEEECCCCEEEEEEC
>Mature Secondary Structure
MKAVVQRVQNASVVVDGKLVSSIDKGYLTLLGVAKGDSEEQLQKLMTKILALRIFPDETG
CHHHHHHHCCCEEEECCHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHEEECCCCCC
KMNLSLKDVGGQHLIVSQFTLLGDASKGNRPSFIGAELPDRAKELYEKALVLSESQGVKT
EEEEEEECCCCCEEEEEEEEEEECCCCCCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCC
QGGIFGADMKVSLLNDGPVTLLLEV
CCCEEECCEEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA