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The map label for this gene is msrAB [H]

Identifier: 42522884

GI number: 42522884

Start: 1290147

End: 1290674

Strand: Direct

Name: msrAB [H]

Synonym: Bd1365

Alternate gene names: 42522884

Gene position: 1290147-1290674 (Clockwise)

Preceding gene: 42522882

Following gene: 42522886

Centisome position: 34.1

GC content: 45.45

Gene sequence:

>528_bases
ATGAAGCATTGGATTTTTGTGATGGTGTTTGTTTTTTCTGCTGCGATTTCCGCCAAAGAAAAAGAATATGTAAAACCTTC
TGATGCCGAGTTAAAGAAAACCCTGACTCCGATGCAGTATCAGTGCACGCAGCAGTCGGCGACTGAAAAGCCTTTCGACA
ATGCCTATTGGAATAATAAAAGAGAAGGCATCTATGTCGACATTGTCAGTGGCGAGCCATTGTTCAGTTCTACTGACAAA
TATGACTCCGGCACGGGCTGGCCCAGTTTTACCAAGCCCATCGATGACAGTTCTTTGGTGACAAAGCCTGATTATGAAAT
GTCGGTGGAACGCACTGAGCTGCGTTCCAAAAAGGCTGACTCGCACCTGGGTCATTTGTTTGACGATGGCCCTAAGGATA
AGGGCGGCAAACGATACTGCATCAATTCCGCAGCCCTGAAGTTTATTCCGGTTGAGGAAATGCAAGCCAAGGGATACGGA
CAGTATCTGTCGCTGTTCCCGAAATATAAAAAAGAAAAGAAGAAATAG

Upstream 100 bases:

>100_bases
AAAACAGTCTTGCCGCTTCATTTCGACAAAATGTGAAGTCTGGCCTATCTTTGTGTTAAACTTGTTCCGTCAGCGCACTA
AACTTTTCACGGGGGTGTTT

Downstream 100 bases:

>100_bases
ACCTATTCCTGACAGGTGATAGAGATGTTTTCAGTTCCATCAAGTGTCAGCGTTCCCGTCCAATGACGGGCTGTCACCAT
GTCCAAAGTAAGATGGGCGC

Product: methionine sulfoxide reductase B

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MKHWIFVMVFVFSAAISAKEKEYVKPSDAELKKTLTPMQYQCTQQSATEKPFDNAYWNNKREGIYVDIVSGEPLFSSTDK
YDSGTGWPSFTKPIDDSSLVTKPDYEMSVERTELRSKKADSHLGHLFDDGPKDKGGKRYCINSAALKFIPVEEMQAKGYG
QYLSLFPKYKKEKKK

Sequences:

>Translated_175_residues
MKHWIFVMVFVFSAAISAKEKEYVKPSDAELKKTLTPMQYQCTQQSATEKPFDNAYWNNKREGIYVDIVSGEPLFSSTDK
YDSGTGWPSFTKPIDDSSLVTKPDYEMSVERTELRSKKADSHLGHLFDDGPKDKGGKRYCINSAALKFIPVEEMQAKGYG
QYLSLFPKYKKEKKK
>Mature_175_residues
MKHWIFVMVFVFSAAISAKEKEYVKPSDAELKKTLTPMQYQCTQQSATEKPFDNAYWNNKREGIYVDIVSGEPLFSSTDK
YDSGTGWPSFTKPIDDSSLVTKPDYEMSVERTELRSKKADSHLGHLFDDGPKDKGGKRYCINSAALKFIPVEEMQAKGYG
QYLSLFPKYKKEKKK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=138, Percent_Identity=45.6521739130435, Blast_Score=129, Evalue=9e-31,
Organism=Homo sapiens, GI301336162, Length=138, Percent_Identity=45.6521739130435, Blast_Score=129, Evalue=9e-31,
Organism=Homo sapiens, GI73089054, Length=138, Percent_Identity=45.6521739130435, Blast_Score=129, Evalue=9e-31,
Organism=Homo sapiens, GI37620216, Length=126, Percent_Identity=47.6190476190476, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI117606353, Length=131, Percent_Identity=45.0381679389313, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI1788077, Length=124, Percent_Identity=47.5806451612903, Blast_Score=128, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17553450, Length=121, Percent_Identity=38.8429752066116, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI115532676, Length=120, Percent_Identity=39.1666666666667, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6319816, Length=130, Percent_Identity=30.7692307692308, Blast_Score=78, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24645799, Length=137, Percent_Identity=43.7956204379562, Blast_Score=120, Evalue=3e-28,
Organism=Drosophila melanogaster, GI45553335, Length=129, Percent_Identity=44.9612403100775, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21356369, Length=129, Percent_Identity=44.9612403100775, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI221378664, Length=129, Percent_Identity=44.1860465116279, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI221378662, Length=136, Percent_Identity=42.6470588235294, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24645801, Length=148, Percent_Identity=40.5405405405405, Blast_Score=116, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24645804, Length=140, Percent_Identity=41.4285714285714, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 20035; Mature: 20035

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHWIFVMVFVFSAAISAKEKEYVKPSDAELKKTLTPMQYQCTQQSATEKPFDNAYWNNK
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCC
REGIYVDIVSGEPLFSSTDKYDSGTGWPSFTKPIDDSSLVTKPDYEMSVERTELRSKKAD
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHH
SHLGHLFDDGPKDKGGKRYCINSAALKFIPVEEMQAKGYGQYLSLFPKYKKEKKK
HHHHHHCCCCCCCCCCCEEEECCCCEEEECHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKHWIFVMVFVFSAAISAKEKEYVKPSDAELKKTLTPMQYQCTQQSATEKPFDNAYWNNK
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCC
REGIYVDIVSGEPLFSSTDKYDSGTGWPSFTKPIDDSSLVTKPDYEMSVERTELRSKKAD
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHH
SHLGHLFDDGPKDKGGKRYCINSAALKFIPVEEMQAKGYGQYLSLFPKYKKEKKK
HHHHHHCCCCCCCCCCCEEEECCCCEEEECHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]