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The map label for this gene is ahcY [H]

Identifier: 42522859

GI number: 42522859

Start: 1265722

End: 1267137

Strand: Direct

Name: ahcY [H]

Synonym: Bd1339

Alternate gene names: 42522859

Gene position: 1265722-1267137 (Clockwise)

Preceding gene: 42522858

Following gene: 42522860

Centisome position: 33.46

GC content: 48.23

Gene sequence:

>1416_bases
ATGTCATTGACTACGACGAACGGAAAAACCGCTATGAAGAAAAATGCTAAAATGAAAGCTCCTACAGCAACTAAAACTGC
TGCTAAAACTCCAGTTGTTGACTACCGAGTCAGCAAAGAAGCAATGGAAAACCCAGAGGTTTTCGCAAAGCTTGCTAAAT
GGGGTCGTGAAGAAATCAAGATTGCTGAAACTGAAATGCCAGGTTTGATGGCTCTTCGTAAAGAGTACAAAAAACAGCAG
CCTTTGAAAGGCGCTCGTATCGCTGGTTGCCTTCACATGACTATCCAGACAGCGGTTCTGATCGAAACGCTAGTTGAGCT
GGGTGCGGAAATCCGCTGGTCTTCTTGCAACATCTTCTCCACTCAGGATCACGCCGCAGCGGCTATCGCGGCAGCGGGCA
TTCCGGTATTTGCATGGAAAGGTCTGACTGAGCAGGAATTCAACTGGTGTATCGAACAAACTATCGTGGGTTGGGGCAAA
GAAGGCTTCAACATGATCCTGGACGACGGTGGTGATTTGACGAACATGATGCACGAGCCTCGTTTCGCCAAAGAAATGAA
GAAAATCATCGGTATCTCTGAAGAGACAACCACCGGTGTCCACAACCTGGAAGTCCTTGTAAAACAGGGTAAACTGAAAG
TTCCAGCGATCAACATCAATGACTCTGTTACCAAATCCAAGTTCGACAATCTGTACGGTTGCCGCGAATCTTTGGCTGAC
GGTATCAAACGTGCAACGGACGTGATGGTTGCCGGTAAGATCTGCGTTGTTGCGGGTTACGGCGATGTGGGTAAAGGTTC
TGCGCACTCTTTGCGTGGACTGGGCGCCCGCGTTCTTGTGACTGAAATCGATCCAATCTGCGCGCTTCAGGCGGCAATGG
AAGGTTTCGAAGTGACAACGATGGAAGATGCAGCTCCATTGGGTGACATCTTCGTAACAGCGACTGGCTGCTGCGACATC
ATCACTGACAAGCACTTCATGAAAATGAAAAACAACGCGATCGTGTGCAACATCGGTCACTTCGATATCGAAATCGACAT
GGCTTGGTTGAACAAGAATTCCAAAATGCGTGAAGTGAAGCCACAAGTGGACATCCACACTTTGAAAAACGGCAAACAAG
TCATCATCCTGGCTAAAGGCCGTTTGGTGAATCTGGGTTGTGCTACGGGCCACCCAAGCTTCGTTATGTCCAACTCCTTC
ACCAATCAGGTGTTGGCGCAAATGGAACTTTTCAACAACCGTGACAAGTACCAGGACATCGCTGTTTACCGCTTGCCTAA
GCATTTGGACGAAAAAGTGGCGGCATTGCACTTGGATAAATTGGGCGTGAAGTTGACTAAACTTTCTTCCAAACAAGCCA
AGTACCTGCACATGAGTCCTCAAGGCCCGTTCAAGCCTGAGCACTACCGTTACTAA

Upstream 100 bases:

>100_bases
GTCCGCACAATTTGAACATACAGTTCTTGTGACGGATACTGGATATGAAATCTTAACTTTACCATAATTTTTAAAAACCT
AAGACAAGGACTTCAATCAA

Downstream 100 bases:

>100_bases
TCAACCCGCAAGGGAAGAGGGGCTGCAGAGAGCGTGAAACTCTCGGACAGTCCTCGCGCAAGGGAGCCTTCGTGGCTCCC
TTTTTTTTTGCCGTTGGACG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MSLTTTNGKTAMKKNAKMKAPTATKTAAKTPVVDYRVSKEAMENPEVFAKLAKWGREEIKIAETEMPGLMALRKEYKKQQ
PLKGARIAGCLHMTIQTAVLIETLVELGAEIRWSSCNIFSTQDHAAAAIAAAGIPVFAWKGLTEQEFNWCIEQTIVGWGK
EGFNMILDDGGDLTNMMHEPRFAKEMKKIIGISEETTTGVHNLEVLVKQGKLKVPAININDSVTKSKFDNLYGCRESLAD
GIKRATDVMVAGKICVVAGYGDVGKGSAHSLRGLGARVLVTEIDPICALQAAMEGFEVTTMEDAAPLGDIFVTATGCCDI
ITDKHFMKMKNNAIVCNIGHFDIEIDMAWLNKNSKMREVKPQVDIHTLKNGKQVIILAKGRLVNLGCATGHPSFVMSNSF
TNQVLAQMELFNNRDKYQDIAVYRLPKHLDEKVAALHLDKLGVKLTKLSSKQAKYLHMSPQGPFKPEHYRY

Sequences:

>Translated_471_residues
MSLTTTNGKTAMKKNAKMKAPTATKTAAKTPVVDYRVSKEAMENPEVFAKLAKWGREEIKIAETEMPGLMALRKEYKKQQ
PLKGARIAGCLHMTIQTAVLIETLVELGAEIRWSSCNIFSTQDHAAAAIAAAGIPVFAWKGLTEQEFNWCIEQTIVGWGK
EGFNMILDDGGDLTNMMHEPRFAKEMKKIIGISEETTTGVHNLEVLVKQGKLKVPAININDSVTKSKFDNLYGCRESLAD
GIKRATDVMVAGKICVVAGYGDVGKGSAHSLRGLGARVLVTEIDPICALQAAMEGFEVTTMEDAAPLGDIFVTATGCCDI
ITDKHFMKMKNNAIVCNIGHFDIEIDMAWLNKNSKMREVKPQVDIHTLKNGKQVIILAKGRLVNLGCATGHPSFVMSNSF
TNQVLAQMELFNNRDKYQDIAVYRLPKHLDEKVAALHLDKLGVKLTKLSSKQAKYLHMSPQGPFKPEHYRY
>Mature_470_residues
SLTTTNGKTAMKKNAKMKAPTATKTAAKTPVVDYRVSKEAMENPEVFAKLAKWGREEIKIAETEMPGLMALRKEYKKQQP
LKGARIAGCLHMTIQTAVLIETLVELGAEIRWSSCNIFSTQDHAAAAIAAAGIPVFAWKGLTEQEFNWCIEQTIVGWGKE
GFNMILDDGGDLTNMMHEPRFAKEMKKIIGISEETTTGVHNLEVLVKQGKLKVPAININDSVTKSKFDNLYGCRESLADG
IKRATDVMVAGKICVVAGYGDVGKGSAHSLRGLGARVLVTEIDPICALQAAMEGFEVTTMEDAAPLGDIFVTATGCCDII
TDKHFMKMKNNAIVCNIGHFDIEIDMAWLNKNSKMREVKPQVDIHTLKNGKQVIILAKGRLVNLGCATGHPSFVMSNSFT
NQVLAQMELFNNRDKYQDIAVYRLPKHLDEKVAALHLDKLGVKLTKLSSKQAKYLHMSPQGPFKPEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=423, Percent_Identity=69.9763593380615, Blast_Score=598, Evalue=1e-171,
Organism=Homo sapiens, GI239937451, Length=408, Percent_Identity=70.343137254902, Blast_Score=580, Evalue=1e-165,
Organism=Homo sapiens, GI24308043, Length=425, Percent_Identity=52.7058823529412, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI195539337, Length=425, Percent_Identity=52.7058823529412, Blast_Score=442, Evalue=1e-124,
Organism=Homo sapiens, GI298286489, Length=425, Percent_Identity=52.7058823529412, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI195539349, Length=425, Percent_Identity=52.7058823529412, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI21361647, Length=425, Percent_Identity=52.9411764705882, Blast_Score=425, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17506425, Length=426, Percent_Identity=69.4835680751174, Blast_Score=613, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6320882, Length=436, Percent_Identity=66.9724770642202, Blast_Score=579, Evalue=1e-166,
Organism=Drosophila melanogaster, GI24642172, Length=422, Percent_Identity=70.8530805687204, Blast_Score=613, Evalue=1e-176,
Organism=Drosophila melanogaster, GI24656245, Length=421, Percent_Identity=52.7315914489311, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI45553387, Length=423, Percent_Identity=52.2458628841608, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI45553385, Length=422, Percent_Identity=52.132701421801, Blast_Score=417, Evalue=1e-116,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51960; Mature: 51829

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTTTNGKTAMKKNAKMKAPTATKTAAKTPVVDYRVSKEAMENPEVFAKLAKWGREEIK
CCEECCCCCHHHHCCCCCCCCCCCCHHCCCCCEEEEECHHHHCCHHHHHHHHHCCHHHEE
IAETEMPGLMALRKEYKKQQPLKGARIAGCLHMTIQTAVLIETLVELGAEIRWSSCNIFS
EECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEC
TQDHAAAAIAAAGIPVFAWKGLTEQEFNWCIEQTIVGWGKEGFNMILDDGGDLTNMMHEP
CCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHCCC
RFAKEMKKIIGISEETTTGVHNLEVLVKQGKLKVPAININDSVTKSKFDNLYGCRESLAD
HHHHHHHHHHCCCCCCCCCHHHHHEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
GIKRATDVMVAGKICVVAGYGDVGKGSAHSLRGLGARVLVTEIDPICALQAAMEGFEVTT
HHHHHHHHEEECCEEEEECCCCCCCCCCHHHHCCCCEEEEEECCHHHHHHHHHCCCEEEE
MEDAAPLGDIFVTATGCCDIITDKHFMKMKNNAIVCNIGHFDIEIDMAWLNKNSKMREVK
ECCCCCCCCEEEEECCCHHHHCCHHHHEECCCEEEEEECCEEEEEEEEEECCCCCHHHCC
PQVDIHTLKNGKQVIILAKGRLVNLGCATGHPSFVMSNSFTNQVLAQMELFNNRDKYQDI
CCCEEEEECCCCEEEEEECCEEEEEEECCCCCCEEECCCHHHHHHHHHHHHCCCCHHHHH
AVYRLPKHLDEKVAALHLDKLGVKLTKLSSKQAKYLHMSPQGPFKPEHYRY
HEECCHHHHHHHHHHHHHHHHCEEEEECCCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SLTTTNGKTAMKKNAKMKAPTATKTAAKTPVVDYRVSKEAMENPEVFAKLAKWGREEIK
CEECCCCCHHHHCCCCCCCCCCCCHHCCCCCEEEEECHHHHCCHHHHHHHHHCCHHHEE
IAETEMPGLMALRKEYKKQQPLKGARIAGCLHMTIQTAVLIETLVELGAEIRWSSCNIFS
EECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEC
TQDHAAAAIAAAGIPVFAWKGLTEQEFNWCIEQTIVGWGKEGFNMILDDGGDLTNMMHEP
CCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHCCC
RFAKEMKKIIGISEETTTGVHNLEVLVKQGKLKVPAININDSVTKSKFDNLYGCRESLAD
HHHHHHHHHHCCCCCCCCCHHHHHEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
GIKRATDVMVAGKICVVAGYGDVGKGSAHSLRGLGARVLVTEIDPICALQAAMEGFEVTT
HHHHHHHHEEECCEEEEECCCCCCCCCCHHHHCCCCEEEEEECCHHHHHHHHHCCCEEEE
MEDAAPLGDIFVTATGCCDIITDKHFMKMKNNAIVCNIGHFDIEIDMAWLNKNSKMREVK
ECCCCCCCCEEEEECCCHHHHCCHHHHEECCCEEEEEECCEEEEEEEEEECCCCCHHHCC
PQVDIHTLKNGKQVIILAKGRLVNLGCATGHPSFVMSNSFTNQVLAQMELFNNRDKYQDI
CCCEEEEECCCCEEEEEECCEEEEEEECCCCCCEEECCCHHHHHHHHHHHHCCCCHHHHH
AVYRLPKHLDEKVAALHLDKLGVKLTKLSSKQAKYLHMSPQGPFKPEHYRY
HEECCHHHHHHHHHHHHHHHHCEEEEECCCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA