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The map label for this gene is acs

Identifier: 42522828

GI number: 42522828

Start: 1234410

End: 1236347

Strand: Direct

Name: acs

Synonym: Bd1306

Alternate gene names: 42522828

Gene position: 1234410-1236347 (Clockwise)

Preceding gene: 42522827

Following gene: 42522829

Centisome position: 32.63

GC content: 53.1

Gene sequence:

>1938_bases
ATGCACAAAGAACTTTATCCCGTGAATTCCGAGGTGGCGAAAAAAGCCTGGATTGATGAAGCCAAATACAAAGCCATGTA
TGAGCGCTCCATTCAAGACAACGAAGCCTTTTGGGCCGAGCAAGCCGAGCGCCTGGACTGGATCAAAAAGTGGGATAAGG
TCAAAGAAGTCAGTTTCAAGAAACCCGTTAGCATCAAATGGTACTTGGGTGGAAAAATGAATGTGTCCTACAATTGCGTG
GACCGTCATTTAAAAACCCGCGGCGACAAAACAGCCCTGCTGTGGGAAGCCGACAATCCATCCACACCTTCACGCAAAAT
CACTTACAAAGAACTGCATCTGGAAGTGTGCCGCTTCGCCAATGTCCTGAAAAAAATGGGCGTGAAAAAAGGCGATGTGG
TGACGATCTATATGCCGATGATTCCGGATACAGCCGTGGCGATGCTGGCCTGTGCGCGCATCGGGGCGGTTCATTCGGTG
GTGTTTGCCGGTTTTTCTCCGGATTCCATCTCAGATCGTATTTTGGACGGGCAGTGCCGGTTTGTGATCACCGGTGATGC
CGGCTTCCGCGGCAGCAAAGTGGTGGCGTTAAAAGAAAATATCGATAAAGCACTTGTGAAAACTCCGGACGTGCAAAAAG
TTCTGGTGGTGAAATATGCGGGCACGACGGTGGACATGAAGCCGGGCCGTGATCTTTGGTATCACGAAGAAGTCAAAACC
GTCAGCGACCAGTGTGAACCAGAACCCATGGACGCGGAAGATCCTTTGTTTATTCTTTACACTTCCGGTTCCACAGGAAA
ACCCAAAGGGGTGATGCACACCACGGGGGGATATCTGGTGTATGCCAGCATGACCCACCAGTATGTCTTTGATTATCACG
AAGATGATATCTACTGGTGTTCTGCTGACGTGGGTTGGGTGACCGGCCATAGCTATATCGTGTATGGCCCGCTGGCGAAT
GGGGCGACAAGTTTGTTCTTTGAAGGGGTGCCGAACTATCCAACTCCAAGCCGTTTCTGGGAAGTGGTCGACAAACACAA
AGTCACAATATTCTATACCTCACCAACGGCGATTCGTTCTTTGATGCGCGAAGGGGACGCGGCGGTGAAAACCACCTCGC
GAAAAACCCTGCGCCTGCTGGGGTCCGTCGGGGAGCCGATCAATCCGGAAGCCTGGGCATGGTATCACGATGTGGTCGGT
GAAGGACGCTGCCCGGTTGTCGATACATGGTGGCAGACAGAAACCGGTGGCATTCTGATCACGCCACTGCCGGGGGCGAT
TGCGCAAAAGCCGGGGTCTGCAACTTTACCGTTCTTTGGGGTGCAACCGAAACTTTTGACCAACGAAGGACAAGAGATCC
ATGGACCGGGCGAAGGGGTGCTGGTGATTGCGGATTCCTGGCCGGGCCAGATGCGCACGGTGTATCGCAATCACGAACGT
TTTGAAGACACGTATTTCTCGAACTATCCCGGGTACTATTTCACAGGCGACGGCTGTCGTCGCGATCAGGACGGGTATTA
CTGGATCACGGGACGGGTGGATGACGTGATCAACGTTTCCGGTCACCGCCTGGGGACGGCTGAAATTGAATCAGCGCTTG
TGGCCCATCACAAAGTGGCTGAAGCCGCCGTGGTTGGATATCCACATGATATCAAAGGGCAGGGGATTTATGCCTTTGTC
ACCTTGAAGTCCGGTGAAACGGCCAGTGAAGAGCTGCGTAAAGAGCTGATTCAGACCGTGCGTAAAGAGATCGGGCCGAT
TGCGACTCCGGATCTGATTCAGTGGGCTCCACGTCTGCCGAAGACCCGTTCTGGCAAGATTATGCGCCGAATCCTGCGTA
AAATCGCCGAGAACCACCCGGATCAACTGGGGGATACGACAACCTTGTCAGAGCCTGCGGTGGTCCAAGAACTGGTGGAC
AATCGCATGAACCGGTGA

Upstream 100 bases:

>100_bases
TATTGTGCAACAGGCGCTTAATTAACACTTTTAAATACTTTCCTGGGCGTTAACGTTTGACCTCATTCTCAGTTGATTTA
CGATTGAGAATGAGGTGACT

Downstream 100 bases:

>100_bases
TAGCTTGCGCGTCATGAACACACGTATGATGACCCTGATTTTGATGGTGCTTGTTGCGGCTTTCAGCCGTTTGATCCCTC
ATCCTTGGAACTTCACCGCG

Product: acetyl coenzyme A synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme

Number of amino acids: Translated: 645; Mature: 645

Protein sequence:

>645_residues
MHKELYPVNSEVAKKAWIDEAKYKAMYERSIQDNEAFWAEQAERLDWIKKWDKVKEVSFKKPVSIKWYLGGKMNVSYNCV
DRHLKTRGDKTALLWEADNPSTPSRKITYKELHLEVCRFANVLKKMGVKKGDVVTIYMPMIPDTAVAMLACARIGAVHSV
VFAGFSPDSISDRILDGQCRFVITGDAGFRGSKVVALKENIDKALVKTPDVQKVLVVKYAGTTVDMKPGRDLWYHEEVKT
VSDQCEPEPMDAEDPLFILYTSGSTGKPKGVMHTTGGYLVYASMTHQYVFDYHEDDIYWCSADVGWVTGHSYIVYGPLAN
GATSLFFEGVPNYPTPSRFWEVVDKHKVTIFYTSPTAIRSLMREGDAAVKTTSRKTLRLLGSVGEPINPEAWAWYHDVVG
EGRCPVVDTWWQTETGGILITPLPGAIAQKPGSATLPFFGVQPKLLTNEGQEIHGPGEGVLVIADSWPGQMRTVYRNHER
FEDTYFSNYPGYYFTGDGCRRDQDGYYWITGRVDDVINVSGHRLGTAEIESALVAHHKVAEAAVVGYPHDIKGQGIYAFV
TLKSGETASEELRKELIQTVRKEIGPIATPDLIQWAPRLPKTRSGKIMRRILRKIAENHPDQLGDTTTLSEPAVVQELVD
NRMNR

Sequences:

>Translated_645_residues
MHKELYPVNSEVAKKAWIDEAKYKAMYERSIQDNEAFWAEQAERLDWIKKWDKVKEVSFKKPVSIKWYLGGKMNVSYNCV
DRHLKTRGDKTALLWEADNPSTPSRKITYKELHLEVCRFANVLKKMGVKKGDVVTIYMPMIPDTAVAMLACARIGAVHSV
VFAGFSPDSISDRILDGQCRFVITGDAGFRGSKVVALKENIDKALVKTPDVQKVLVVKYAGTTVDMKPGRDLWYHEEVKT
VSDQCEPEPMDAEDPLFILYTSGSTGKPKGVMHTTGGYLVYASMTHQYVFDYHEDDIYWCSADVGWVTGHSYIVYGPLAN
GATSLFFEGVPNYPTPSRFWEVVDKHKVTIFYTSPTAIRSLMREGDAAVKTTSRKTLRLLGSVGEPINPEAWAWYHDVVG
EGRCPVVDTWWQTETGGILITPLPGAIAQKPGSATLPFFGVQPKLLTNEGQEIHGPGEGVLVIADSWPGQMRTVYRNHER
FEDTYFSNYPGYYFTGDGCRRDQDGYYWITGRVDDVINVSGHRLGTAEIESALVAHHKVAEAAVVGYPHDIKGQGIYAFV
TLKSGETASEELRKELIQTVRKEIGPIATPDLIQWAPRLPKTRSGKIMRRILRKIAENHPDQLGDTTTLSEPAVVQELVD
NRMNR
>Mature_645_residues
MHKELYPVNSEVAKKAWIDEAKYKAMYERSIQDNEAFWAEQAERLDWIKKWDKVKEVSFKKPVSIKWYLGGKMNVSYNCV
DRHLKTRGDKTALLWEADNPSTPSRKITYKELHLEVCRFANVLKKMGVKKGDVVTIYMPMIPDTAVAMLACARIGAVHSV
VFAGFSPDSISDRILDGQCRFVITGDAGFRGSKVVALKENIDKALVKTPDVQKVLVVKYAGTTVDMKPGRDLWYHEEVKT
VSDQCEPEPMDAEDPLFILYTSGSTGKPKGVMHTTGGYLVYASMTHQYVFDYHEDDIYWCSADVGWVTGHSYIVYGPLAN
GATSLFFEGVPNYPTPSRFWEVVDKHKVTIFYTSPTAIRSLMREGDAAVKTTSRKTLRLLGSVGEPINPEAWAWYHDVVG
EGRCPVVDTWWQTETGGILITPLPGAIAQKPGSATLPFFGVQPKLLTNEGQEIHGPGEGVLVIADSWPGQMRTVYRNHER
FEDTYFSNYPGYYFTGDGCRRDQDGYYWITGRVDDVINVSGHRLGTAEIESALVAHHKVAEAAVVGYPHDIKGQGIYAFV
TLKSGETASEELRKELIQTVRKEIGPIATPDLIQWAPRLPKTRSGKIMRRILRKIAENHPDQLGDTTTLSEPAVVQELVD
NRMNR

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

Homologues:

Organism=Homo sapiens, GI8923896, Length=665, Percent_Identity=55.187969924812, Blast_Score=738, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=678, Percent_Identity=54.1297935103245, Blast_Score=733, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=621, Percent_Identity=51.207729468599, Blast_Score=646, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=637, Percent_Identity=38.1475667189953, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI31982927, Length=609, Percent_Identity=26.4367816091954, Blast_Score=206, Evalue=5e-53,
Organism=Homo sapiens, GI42544132, Length=516, Percent_Identity=28.8759689922481, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI38505220, Length=516, Percent_Identity=29.4573643410853, Blast_Score=182, Evalue=8e-46,
Organism=Homo sapiens, GI122937307, Length=517, Percent_Identity=28.4332688588008, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI115511026, Length=536, Percent_Identity=27.2388059701493, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI58082049, Length=516, Percent_Identity=26.5503875968992, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI157311624, Length=516, Percent_Identity=25.968992248062, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI157311622, Length=516, Percent_Identity=25.968992248062, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI187761345, Length=401, Percent_Identity=27.431421446384, Blast_Score=110, Evalue=6e-24,
Organism=Homo sapiens, GI187761343, Length=401, Percent_Identity=27.431421446384, Blast_Score=110, Evalue=6e-24,
Organism=Homo sapiens, GI42544134, Length=349, Percent_Identity=24.6418338108883, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI195947378, Length=402, Percent_Identity=25.1243781094527, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI156151445, Length=600, Percent_Identity=22.8333333333333, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1790505, Length=646, Percent_Identity=63.4674922600619, Blast_Score=860, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=630, Percent_Identity=35.7142857142857, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI221142682, Length=541, Percent_Identity=23.1053604436229, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1788107, Length=569, Percent_Identity=24.780316344464, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI145693145, Length=507, Percent_Identity=22.4852071005917, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1786810, Length=527, Percent_Identity=21.6318785578748, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71983001, Length=641, Percent_Identity=52.7301092043682, Blast_Score=660, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71982997, Length=641, Percent_Identity=52.7301092043682, Blast_Score=660, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=636, Percent_Identity=22.9559748427673, Blast_Score=148, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17558820, Length=512, Percent_Identity=23.6328125, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI32563687, Length=516, Percent_Identity=23.6434108527132, Blast_Score=103, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17557194, Length=551, Percent_Identity=24.3194192377495, Blast_Score=99, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17538037, Length=146, Percent_Identity=32.8767123287671, Blast_Score=80, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71985884, Length=392, Percent_Identity=23.469387755102, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323182, Length=653, Percent_Identity=49.9234303215926, Blast_Score=644, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319264, Length=639, Percent_Identity=49.9217527386541, Blast_Score=634, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319699, Length=367, Percent_Identity=25.6130790190736, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24667955, Length=662, Percent_Identity=53.6253776435045, Blast_Score=725, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=57.8291814946619, Blast_Score=671, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=57.8846153846154, Blast_Score=622, Evalue=1e-178,
Organism=Drosophila melanogaster, GI21355225, Length=631, Percent_Identity=36.608557844691, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI18859661, Length=535, Percent_Identity=25.2336448598131, Blast_Score=110, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21355181, Length=550, Percent_Identity=23.2727272727273, Blast_Score=102, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24648260, Length=529, Percent_Identity=25.1417769376182, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24656500, Length=364, Percent_Identity=21.7032967032967, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACSA_BDEBA (Q6MNF1)

Other databases:

- EMBL:   BX842649
- RefSeq:   NP_968208.1
- HSSP:   Q8ZKF6
- ProteinModelPortal:   Q6MNF1
- SMR:   Q6MNF1
- GeneID:   2734497
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd1306
- NMPDR:   fig|264462.1.peg.1178
- HOGENOM:   HBG547964
- OMA:   ATYLEWY
- PhylomeDB:   Q6MNF1
- BioCyc:   BBAC264462:BD1306-MONOMER
- BRENDA:   6.2.1.1
- HAMAP:   MF_01123
- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873
- TIGRFAMs:   TIGR02188

Pfam domain/function: PF00501 AMP-binding

EC number: =6.2.1.1

Molecular weight: Translated: 72415; Mature: 72415

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00455 AMP_BINDING

Important sites: ACT_SITE 514-514

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKELYPVNSEVAKKAWIDEAKYKAMYERSIQDNEAFWAEQAERLDWIKKWDKVKEVSFK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
KPVSIKWYLGGKMNVSYNCVDRHLKTRGDKTALLWEADNPSTPSRKITYKELHLEVCRFA
CCCEEEEEECCEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHH
NVLKKMGVKKGDVVTIYMPMIPDTAVAMLACARIGAVHSVVFAGFSPDSISDRILDGQCR
HHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCEECCCEE
FVITGDAGFRGSKVVALKENIDKALVKTPDVQKVLVVKYAGTTVDMKPGRDLWYHEEVKT
EEEECCCCCCCCEEEEEHHCCHHHHHCCCCCCEEEEEEEECCEEECCCCCCCCCHHHHHH
VSDQCEPEPMDAEDPLFILYTSGSTGKPKGVMHTTGGYLVYASMTHQYVFDYHEDDIYWC
HHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCEEEEEEECCCCEEEE
SADVGWVTGHSYIVYGPLANGATSLFFEGVPNYPTPSRFWEVVDKHKVTIFYTSPTAIRS
ECCCCEEECCCEEEEECCCCCCHHHEECCCCCCCCHHHHHHHHHCCEEEEEEECHHHHHH
LMREGDAAVKTTSRKTLRLLGSVGEPINPEAWAWYHDVVGEGRCPVVDTWWQTETGGILI
HHHCCCCCEEECCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEECCCCCCCCCEEE
TPLPGAIAQKPGSATLPFFGVQPKLLTNEGQEIHGPGEGVLVIADSWPGQMRTVYRNHER
ECCCCHHHCCCCCCCCCEECCCCCEECCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHH
FEDTYFSNYPGYYFTGDGCRRDQDGYYWITGRVDDVINVSGHRLGTAEIESALVAHHKVA
HHHHHHCCCCCEEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHH
EAAVVGYPHDIKGQGIYAFVTLKSGETASEELRKELIQTVRKEIGPIATPDLIQWAPRLP
HHHEECCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCC
KTRSGKIMRRILRKIAENHPDQLGDTTTLSEPAVVQELVDNRMNR
CCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MHKELYPVNSEVAKKAWIDEAKYKAMYERSIQDNEAFWAEQAERLDWIKKWDKVKEVSFK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
KPVSIKWYLGGKMNVSYNCVDRHLKTRGDKTALLWEADNPSTPSRKITYKELHLEVCRFA
CCCEEEEEECCEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHH
NVLKKMGVKKGDVVTIYMPMIPDTAVAMLACARIGAVHSVVFAGFSPDSISDRILDGQCR
HHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCEECCCEE
FVITGDAGFRGSKVVALKENIDKALVKTPDVQKVLVVKYAGTTVDMKPGRDLWYHEEVKT
EEEECCCCCCCCEEEEEHHCCHHHHHCCCCCCEEEEEEEECCEEECCCCCCCCCHHHHHH
VSDQCEPEPMDAEDPLFILYTSGSTGKPKGVMHTTGGYLVYASMTHQYVFDYHEDDIYWC
HHHCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEECCEEEEEEECCCCEEEE
SADVGWVTGHSYIVYGPLANGATSLFFEGVPNYPTPSRFWEVVDKHKVTIFYTSPTAIRS
ECCCCEEECCCEEEEECCCCCCHHHEECCCCCCCCHHHHHHHHHCCEEEEEEECHHHHHH
LMREGDAAVKTTSRKTLRLLGSVGEPINPEAWAWYHDVVGEGRCPVVDTWWQTETGGILI
HHHCCCCCEEECCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCEEECCCCCCCCCEEE
TPLPGAIAQKPGSATLPFFGVQPKLLTNEGQEIHGPGEGVLVIADSWPGQMRTVYRNHER
ECCCCHHHCCCCCCCCCEECCCCCEECCCCCEECCCCCEEEEEECCCCCHHHHHHHHHHH
FEDTYFSNYPGYYFTGDGCRRDQDGYYWITGRVDDVINVSGHRLGTAEIESALVAHHKVA
HHHHHHCCCCCEEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHH
EAAVVGYPHDIKGQGIYAFVTLKSGETASEELRKELIQTVRKEIGPIATPDLIQWAPRLP
HHHEECCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCC
KTRSGKIMRRILRKIAENHPDQLGDTTTLSEPAVVQELVDNRMNR
CCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA