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The map label for this gene is hit

Identifier: 42522624

GI number: 42522624

Start: 1015384

End: 1015878

Strand: Direct

Name: hit

Synonym: Bd1069

Alternate gene names: NA

Gene position: 1015384-1015878 (Clockwise)

Preceding gene: 42522623

Following gene: 42522625

Centisome position: 26.84

GC content: 48.69

Gene sequence:

>495_bases
ATGGAGCGAGATGTTTTGTTCCGTCCGGACCGCATGAAATATGTGCGCAAACTGATCAAACCCGATGGCTGTGTTTTTTG
CCGGGCCTCTGAGGAAAAAGTCAGCTTTGAAACCTTGTGCGTGTTTAAATCCAAGCATTCGATGGTGGTTCTGAACAAGT
TCCCTTACAACAGCGGGCACCTTTTGGTATTGCCAAAGCGCCACTGTGGGGACCTGTTGAAGCTTTCCGATGATGAATAT
CATGACCTGCAAAATGTCATTCGTCTGACCATGCAGGCCTTGAATGAGCTTTACCAGCCGGGCGGCATTAATGTGGGTTT
GAACCACGGGGCTGTGGCGGGGGCGGGGATTCCTGAACATCTTCACTACCATGTGATTCCCCGATGGACCGGGGACCTTA
ATTTCTTCCCGTTGATTGCTGAGACCAAGGTCTTGGTTGAAAGTCTTGAGCAGACCTACGAGAAGGTATGGAGTATTTTA
AGAAAATATGAATAG

Upstream 100 bases:

>100_bases
AAAGACATCCGCGAAAAAGACACCCGCAAAAAGAAAAGCGCCAATCAAGGCCCCTGCGGCCGCTCACGGCAAAATCCAGA
TCGGCAAGGATGTCTGGCCG

Downstream 100 bases:

>100_bases
AGGCGTGACTTTCCAAACAGCTCCCATGACCCCTGTGGTGAAGTGGCTGCTGATCATCAATGTGGCTATCTGGTTCGTGT
TCCAAGTGATCATGGAAGGC

Product: hit family hydrolase

Products: NA

Alternate protein names: ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MERDVLFRPDRMKYVRKLIKPDGCVFCRASEEKVSFETLCVFKSKHSMVVLNKFPYNSGHLLVLPKRHCGDLLKLSDDEY
HDLQNVIRLTMQALNELYQPGGINVGLNHGAVAGAGIPEHLHYHVIPRWTGDLNFFPLIAETKVLVESLEQTYEKVWSIL
RKYE

Sequences:

>Translated_164_residues
MERDVLFRPDRMKYVRKLIKPDGCVFCRASEEKVSFETLCVFKSKHSMVVLNKFPYNSGHLLVLPKRHCGDLLKLSDDEY
HDLQNVIRLTMQALNELYQPGGINVGLNHGAVAGAGIPEHLHYHVIPRWTGDLNFFPLIAETKVLVESLEQTYEKVWSIL
RKYE
>Mature_164_residues
MERDVLFRPDRMKYVRKLIKPDGCVFCRASEEKVSFETLCVFKSKHSMVVLNKFPYNSGHLLVLPKRHCGDLLKLSDDEY
HDLQNVIRLTMQALNELYQPGGINVGLNHGAVAGAGIPEHLHYHVIPRWTGDLNFFPLIAETKVLVESLEQTYEKVWSIL
RKYE

Specific function: Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues [H]

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: =2.7.7.53 [H]

Molecular weight: Translated: 18954; Mature: 18954

Theoretical pI: Translated: 8.00; Mature: 8.00

Prosite motif: PS00133 CARBOXYPEPT_ZN_2 ; PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERDVLFRPDRMKYVRKLIKPDGCVFCRASEEKVSFETLCVFKSKHSMVVLNKFPYNSGH
CCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHEEEEECCCCEEEEEECCCCCCC
LLVLPKRHCGDLLKLSDDEYHDLQNVIRLTMQALNELYQPGGINVGLNHGAVAGAGIPEH
EEEECCHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEECCCCCCC
LHYHVIPRWTGDLNFFPLIAETKVLVESLEQTYEKVWSILRKYE
CEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MERDVLFRPDRMKYVRKLIKPDGCVFCRASEEKVSFETLCVFKSKHSMVVLNKFPYNSGH
CCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCHHHEEEEECCCCEEEEEECCCCCCC
LLVLPKRHCGDLLKLSDDEYHDLQNVIRLTMQALNELYQPGGINVGLNHGAVAGAGIPEH
EEEECCHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCEECCCCCCC
LHYHVIPRWTGDLNFFPLIAETKVLVESLEQTYEKVWSILRKYE
CEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036 [H]