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The map label for this gene is ilvA [H]

Identifier: 42522611

GI number: 42522611

Start: 1001306

End: 1002517

Strand: Direct

Name: ilvA [H]

Synonym: Bd1056

Alternate gene names: 42522611

Gene position: 1001306-1002517 (Clockwise)

Preceding gene: 42522607

Following gene: 42522616

Centisome position: 26.47

GC content: 52.81

Gene sequence:

>1212_bases
ATGAAAGTCAGCTTTGCAGACATCCAAAAAGCCCGTGAACTTCTGAAAGACATCATCTGTCCAACCGAGATGAGTCATTC
CATCAGCGCCAGCAACCTGCTTAAAAGCGAAGTGTACCTGAAGTTTGAAAACACTCAGCGCACGGGAAGTTTTAAATTCC
GCGGGGCCTATAACAAAATCTCCAATCTGACAGCCGACGAAAAAGCCCGCGGTGTGGTCGCCAGCTCTGCCGGAAATCAC
GCGCAAGGTGTCGCCCTGTCAGCGAAACTGGCCGGAGTCAAATCCACCATCGTGATGCCGGAGACAGCCTCGATCAGCAA
AGCTTCCGCGACCCGTGATTACGGCGCCAACGTCGTGCTTAAAGGCGAGATCTACGACGAGGCTTTCGAACATGCCCAGA
AACTGGAAAAAGAACACGGCTACACCTTCGTGCACCCTTATCAGGACCCTTATGTGATCGCTGGCCAGGGAACCATCGGG
ATCGAGATCCTGGAAAAGGTTCCAGACCTGGATACGGTGATTGTGCCCATCGGGGGTGGCGGTCTGATCAGTGGTGTGGC
GTTGGCGGTGAAGGCCATCAATCCAAAGATCCGCGTGATCGGTGTGCAAAGCGACCGCTCTCCGGGAATGGCGCATCTTT
ATAACAAACAGCCTTTGTCCCAGATCAAACGTGCCGCCACGATTGCTGACGGCATTGCGATCAAAAACCCTTCCCAGGTG
ATGCTGGACAGTTTCATTTCCAAGTATGTCGATCAGGTGGTGACAGTCAGTGATGACGAGATCGCTGAAGCGATTGTGTT
CCTGATGGAAAGAGCCAAAACCGTAGCTGAAGGCTCTGGCGCAGCGGCGATGGCAGCTGCGATGTCCCGCGGACTGGATC
TGGGTAAAAAGACCTGTGTGATTATCAGCGGTGGAAATATCGATCTGAACATCGTTTCAAAGATCATCGACCGTGGTCAG
ATTCTGCGCGGACGCCTGTGTGAGTTGTCCGTGATTGTGGATGACCTTCCGGGGAATTTGAGCCGTTTGACTCAGGCAAT
TGCCTCTCAAAAAGCCAACATCCTGGAAGTGCGTCACGACCGTGTGTCGAAGGGGCTTTCACTGCGTGAAACCCGCATCG
ACTTCGTTCTAGAGACTACGAGCATTGAACATGTTGAACGGATTAAGCGGGCTCTTGAGGAAACTGGAGCCAAGGTTATC
CAAAGCACCTAA

Upstream 100 bases:

>100_bases
TTACTCCAGCCTTGGAGTGAGGGTTTCGTCCGAGCTTTTGCCTCATAAAGAGTATCCTCCGGTGTGGGGATTAACTGTGT
ATTGGGAGCCCTGATCCAAA

Downstream 100 bases:

>100_bases
AGAAATCCCTGAAGGCTGCTCCCAGTCCTTTAGATTGTACTTCATAAGAATCCGCTGCAGCTCTCCGCTGCGGCGAAGCT
CCTCGACCCCGCGACTGAGA

Product: threonine ammonia-lyase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MKVSFADIQKARELLKDIICPTEMSHSISASNLLKSEVYLKFENTQRTGSFKFRGAYNKISNLTADEKARGVVASSAGNH
AQGVALSAKLAGVKSTIVMPETASISKASATRDYGANVVLKGEIYDEAFEHAQKLEKEHGYTFVHPYQDPYVIAGQGTIG
IEILEKVPDLDTVIVPIGGGGLISGVALAVKAINPKIRVIGVQSDRSPGMAHLYNKQPLSQIKRAATIADGIAIKNPSQV
MLDSFISKYVDQVVTVSDDEIAEAIVFLMERAKTVAEGSGAAAMAAAMSRGLDLGKKTCVIISGGNIDLNIVSKIIDRGQ
ILRGRLCELSVIVDDLPGNLSRLTQAIASQKANILEVRHDRVSKGLSLRETRIDFVLETTSIEHVERIKRALEETGAKVI
QST

Sequences:

>Translated_403_residues
MKVSFADIQKARELLKDIICPTEMSHSISASNLLKSEVYLKFENTQRTGSFKFRGAYNKISNLTADEKARGVVASSAGNH
AQGVALSAKLAGVKSTIVMPETASISKASATRDYGANVVLKGEIYDEAFEHAQKLEKEHGYTFVHPYQDPYVIAGQGTIG
IEILEKVPDLDTVIVPIGGGGLISGVALAVKAINPKIRVIGVQSDRSPGMAHLYNKQPLSQIKRAATIADGIAIKNPSQV
MLDSFISKYVDQVVTVSDDEIAEAIVFLMERAKTVAEGSGAAAMAAAMSRGLDLGKKTCVIISGGNIDLNIVSKIIDRGQ
ILRGRLCELSVIVDDLPGNLSRLTQAIASQKANILEVRHDRVSKGLSLRETRIDFVLETTSIEHVERIKRALEETGAKVI
QST
>Mature_403_residues
MKVSFADIQKARELLKDIICPTEMSHSISASNLLKSEVYLKFENTQRTGSFKFRGAYNKISNLTADEKARGVVASSAGNH
AQGVALSAKLAGVKSTIVMPETASISKASATRDYGANVVLKGEIYDEAFEHAQKLEKEHGYTFVHPYQDPYVIAGQGTIG
IEILEKVPDLDTVIVPIGGGGLISGVALAVKAINPKIRVIGVQSDRSPGMAHLYNKQPLSQIKRAATIADGIAIKNPSQV
MLDSFISKYVDQVVTVSDDEIAEAIVFLMERAKTVAEGSGAAAMAAAMSRGLDLGKKTCVIISGGNIDLNIVSKIIDRGQ
ILRGRLCELSVIVDDLPGNLSRLTQAIASQKANILEVRHDRVSKGLSLRETRIDFVLETTSIEHVERIKRALEETGAKVI
QST

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=319, Percent_Identity=36.9905956112853, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI19923959, Length=142, Percent_Identity=34.5070422535211, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI33469958, Length=145, Percent_Identity=35.1724137931034, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789505, Length=318, Percent_Identity=48.7421383647799, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1790207, Length=356, Percent_Identity=35.3932584269663, Blast_Score=183, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71991565, Length=401, Percent_Identity=37.6558603491272, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17537387, Length=395, Percent_Identity=37.7215189873418, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17508781, Length=282, Percent_Identity=35.1063829787234, Blast_Score=146, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322631, Length=314, Percent_Identity=38.2165605095541, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320930, Length=362, Percent_Identity=33.9779005524862, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6319788, Length=274, Percent_Identity=24.8175182481752, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355833, Length=407, Percent_Identity=37.1007371007371, Blast_Score=200, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24645328, Length=310, Percent_Identity=37.0967741935484, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24643623, Length=322, Percent_Identity=27.639751552795, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI20129101, Length=322, Percent_Identity=27.639751552795, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43368; Mature: 43368

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVSFADIQKARELLKDIICPTEMSHSISASNLLKSEVYLKFENTQRTGSFKFRGAYNKI
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHEEEEEEECCCCCCCCEEEEEHHHHH
SNLTADEKARGVVASSAGNHAQGVALSAKLAGVKSTIVMPETASISKASATRDYGANVVL
HCCCCCHHHCCEEECCCCCCCCCEEEEEECCCCCEEEECCCCCCCCHHHCCCCCCCCEEE
KGEIYDEAFEHAQKLEKEHGYTFVHPYQDPYVIAGQGTIGIEILEKVPDLDTVIVPIGGG
ECCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCHHHHHHHCCCCCEEEEEECCC
GLISGVALAVKAINPKIRVIGVQSDRSPGMAHLYNKQPLSQIKRAATIADGIAIKNPSQV
HHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHCCCEECCCHHH
MLDSFISKYVDQVVTVSDDEIAEAIVFLMERAKTVAEGSGAAAMAAAMSRGLDLGKKTCV
HHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEE
IISGGNIDLNIVSKIIDRGQILRGRLCELSVIVDDLPGNLSRLTQAIASQKANILEVRHD
EEECCCCCHHHHHHHHCCCHHHHCCCEEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHH
RVSKGLSLRETRIDFVLETTSIEHVERIKRALEETGAKVIQST
HHHCCCCCEEEHEEEEEECCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKVSFADIQKARELLKDIICPTEMSHSISASNLLKSEVYLKFENTQRTGSFKFRGAYNKI
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHEEEEEEECCCCCCCCEEEEEHHHHH
SNLTADEKARGVVASSAGNHAQGVALSAKLAGVKSTIVMPETASISKASATRDYGANVVL
HCCCCCHHHCCEEECCCCCCCCCEEEEEECCCCCEEEECCCCCCCCHHHCCCCCCCCEEE
KGEIYDEAFEHAQKLEKEHGYTFVHPYQDPYVIAGQGTIGIEILEKVPDLDTVIVPIGGG
ECCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCHHHHHHHCCCCCEEEEEECCC
GLISGVALAVKAINPKIRVIGVQSDRSPGMAHLYNKQPLSQIKRAATIADGIAIKNPSQV
HHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHCCCCHHHHHHHHHHHHCCCEECCCHHH
MLDSFISKYVDQVVTVSDDEIAEAIVFLMERAKTVAEGSGAAAMAAAMSRGLDLGKKTCV
HHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEE
IISGGNIDLNIVSKIIDRGQILRGRLCELSVIVDDLPGNLSRLTQAIASQKANILEVRHD
EEECCCCCHHHHHHHHCCCHHHHCCCEEEEEEEECCCCCHHHHHHHHHHCCCHHHHHHHH
RVSKGLSLRETRIDFVLETTSIEHVERIKRALEETGAKVIQST
HHHCCCCCEEEHEEEEEECCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA