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The map label for this gene is hisC

Identifier: 42522616

GI number: 42522616

Start: 1006897

End: 1008015

Strand: Direct

Name: hisC

Synonym: Bd1061

Alternate gene names: 42522616

Gene position: 1006897-1008015 (Clockwise)

Preceding gene: 42522611

Following gene: 42522617

Centisome position: 26.62

GC content: 48.7

Gene sequence:

>1119_bases
GTGAAGATTTCTCCCGAAATTTTGAATCTGGTGCCCTACAAACCTGGAAAGCCGATTTCCGAGACCCAACGTGAGTACGG
GCTCACAACGGTCTACAAACTCGCAAGTAACGAGAATCCTTTGGGTCCCAGCCCGAAAGCCATGGCGGCAGTGAAGCAGG
CTTTGGATCATCAGCACCTGTATCCGGATCCATCCCACTATGAGCTTTTGCAGACTTTGTCGAAAGAATGGGGCTTCCCG
ACAAAACAACTTGCTATTGGTAACGGCAGCGACGAGCTGATTGATCTGTTGTGCCGTATCTACTGTGAGCACCATGACGG
CGTTTTGACATCTGCGGCAGCGTTTAATGCTTATGAAGTCAGCGCTCCGGCCAACCGTGCGGTGATCCACAAAGTTCCCA
TGGCTGAAGGCTATCGTTTCGATCTGCCAGCCATTGCGGATTATTTCCTGAAACACCCGGAAAAAAACATCCGTTTGATT
TTTGTCTCTAATCCCAACAATCCTACCGGTACTTACGCGACCAAAGCGGAAGTGGAGGCTTTCCTTCAGAAAGTCGGTAA
CCGCGACGATGTGATGATTATTTTTGATGAAGCCTATAACGAATTTGTGCGTGCCAAAGACTATGCTTCCGCACAAGGGT
ACATGGGGCAGTATAAGAACCTGATTGTTCTTCGCACTTTCTCCAAAATCTATGGCCTGGCGGGTTTCCGCCTGGGTGCG
ATGATCGCGCCGCCCGAGGTTGTGGAAGTCTTTAACCGTGTGCGCAAACCATTTAATGTCAACGATTTAGCGCAAGTGGC
TGCAAATGCGGCTCTGCAAGATAAAGAATTTATTGAGCGATCGCAGCAGATTTGCTGGAAAGGGCTTGATTACTTCTACA
AGAAGTTAGAAGAATTAGGCCTGCCTTACATTCCATCTCAGGGAAATTTTGTCATGTTTGACACCCTCCGTGACGCCGCC
AAGGTGAACGAAGCGTTGTTACGTCGCGGAATTATTATGAGACCTCTATTGAACTATGGGTTCAAGACGCATCTGCGTTT
GAGTGTAGGGCGCGATCATGAAAATGAGGCAGCAATGGTTGCCTTGGCGGAAGTTCTAAAAGAAATCACTCCGCTGTAG

Upstream 100 bases:

>100_bases
TGCATTTTCGAACGCTCTCTATTGAATTTGCTCTGGAATGTTGTTAAGTCTTAGTCGGACAGGTATAGCAAAGTATTCTC
TCTAAGAAAAGGATTCTAAA

Downstream 100 bases:

>100_bases
TTTTGGAGAATTATGGGAATGGTAATTACGATTGATGGCCCTGCGGCCTCCGGAAAATCTTCAGTAAGTCGTGAGCTGGC
TCGTCGTTTGGGCTGGCAGT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKISPEILNLVPYKPGKPISETQREYGLTTVYKLASNENPLGPSPKAMAAVKQALDHQHLYPDPSHYELLQTLSKEWGFP
TKQLAIGNGSDELIDLLCRIYCEHHDGVLTSAAAFNAYEVSAPANRAVIHKVPMAEGYRFDLPAIADYFLKHPEKNIRLI
FVSNPNNPTGTYATKAEVEAFLQKVGNRDDVMIIFDEAYNEFVRAKDYASAQGYMGQYKNLIVLRTFSKIYGLAGFRLGA
MIAPPEVVEVFNRVRKPFNVNDLAQVAANAALQDKEFIERSQQICWKGLDYFYKKLEELGLPYIPSQGNFVMFDTLRDAA
KVNEALLRRGIIMRPLLNYGFKTHLRLSVGRDHENEAAMVALAEVLKEITPL

Sequences:

>Translated_372_residues
MKISPEILNLVPYKPGKPISETQREYGLTTVYKLASNENPLGPSPKAMAAVKQALDHQHLYPDPSHYELLQTLSKEWGFP
TKQLAIGNGSDELIDLLCRIYCEHHDGVLTSAAAFNAYEVSAPANRAVIHKVPMAEGYRFDLPAIADYFLKHPEKNIRLI
FVSNPNNPTGTYATKAEVEAFLQKVGNRDDVMIIFDEAYNEFVRAKDYASAQGYMGQYKNLIVLRTFSKIYGLAGFRLGA
MIAPPEVVEVFNRVRKPFNVNDLAQVAANAALQDKEFIERSQQICWKGLDYFYKKLEELGLPYIPSQGNFVMFDTLRDAA
KVNEALLRRGIIMRPLLNYGFKTHLRLSVGRDHENEAAMVALAEVLKEITPL
>Mature_372_residues
MKISPEILNLVPYKPGKPISETQREYGLTTVYKLASNENPLGPSPKAMAAVKQALDHQHLYPDPSHYELLQTLSKEWGFP
TKQLAIGNGSDELIDLLCRIYCEHHDGVLTSAAAFNAYEVSAPANRAVIHKVPMAEGYRFDLPAIADYFLKHPEKNIRLI
FVSNPNNPTGTYATKAEVEAFLQKVGNRDDVMIIFDEAYNEFVRAKDYASAQGYMGQYKNLIVLRTFSKIYGLAGFRLGA
MIAPPEVVEVFNRVRKPFNVNDLAQVAANAALQDKEFIERSQQICWKGLDYFYKKLEELGLPYIPSQGNFVMFDTLRDAA
KVNEALLRRGIIMRPLLNYGFKTHLRLSVGRDHENEAAMVALAEVLKEITPL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=366, Percent_Identity=27.8688524590164, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322075, Length=395, Percent_Identity=27.8481012658228, Blast_Score=122, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_BDEBA (P60998)

Other databases:

- EMBL:   BX842648
- RefSeq:   NP_967996.1
- ProteinModelPortal:   P60998
- SMR:   P60998
- GeneID:   2734881
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd1061
- NMPDR:   fig|264462.1.peg.966
- HOGENOM:   HBG646350
- OMA:   ASNESHY
- PhylomeDB:   P60998
- BioCyc:   BBAC264462:BD1061-MONOMER
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PRINTS:   PR00753
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 41903; Mature: 41903

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISPEILNLVPYKPGKPISETQREYGLTTVYKLASNENPLGPSPKAMAAVKQALDHQHL
CCCCHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
YPDPSHYELLQTLSKEWGFPTKQLAIGNGSDELIDLLCRIYCEHHDGVLTSAAAFNAYEV
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCEEE
SAPANRAVIHKVPMAEGYRFDLPAIADYFLKHPEKNIRLIFVSNPNNPTGTYATKAEVEA
CCCCCCCEEEECCCCCCCEECCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHH
FLQKVGNRDDVMIIFDEAYNEFVRAKDYASAQGYMGQYKNLIVLRTFSKIYGLAGFRLGA
HHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHCC
MIAPPEVVEVFNRVRKPFNVNDLAQVAANAALQDKEFIERSQQICWKGLDYFYKKLEELG
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPYIPSQGNFVMFDTLRDAAKVNEALLRRGIIMRPLLNYGFKTHLRLSVGRDHENEAAMV
CCCCCCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHH
ALAEVLKEITPL
HHHHHHHHHCCC
>Mature Secondary Structure
MKISPEILNLVPYKPGKPISETQREYGLTTVYKLASNENPLGPSPKAMAAVKQALDHQHL
CCCCHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCC
YPDPSHYELLQTLSKEWGFPTKQLAIGNGSDELIDLLCRIYCEHHDGVLTSAAAFNAYEV
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCEEE
SAPANRAVIHKVPMAEGYRFDLPAIADYFLKHPEKNIRLIFVSNPNNPTGTYATKAEVEA
CCCCCCCEEEECCCCCCCEECCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHH
FLQKVGNRDDVMIIFDEAYNEFVRAKDYASAQGYMGQYKNLIVLRTFSKIYGLAGFRLGA
HHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHCC
MIAPPEVVEVFNRVRKPFNVNDLAQVAANAALQDKEFIERSQQICWKGLDYFYKKLEELG
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPYIPSQGNFVMFDTLRDAAKVNEALLRRGIIMRPLLNYGFKTHLRLSVGRDHENEAAMV
CCCCCCCCCEEEEHHHHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEEECCCCCCHHHHH
ALAEVLKEITPL
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA