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The map label for this gene is recQ [H]

Identifier: 42522549

GI number: 42522549

Start: 932638

End: 934074

Strand: Direct

Name: recQ [H]

Synonym: Bd0988

Alternate gene names: 42522549

Gene position: 932638-934074 (Clockwise)

Preceding gene: 42522545

Following gene: 42522550

Centisome position: 24.65

GC content: 52.75

Gene sequence:

>1437_bases
ATGACCGATCTTCTTCAGCTTTTAAAAGCGAACTTTCCTTTTACTTCTTTCCGGGGCGAGCAGGAGCAAGTCCTGCATAA
AGTTTGGGCAAATCAGAACCTACTGGCTTTAATGCCCACGGGAATGGGAAAAAGCCTCTGCTTTCAGTTTCCAGCAAAGA
CCCGCGAGGGCCTGGTGGTCGTCATATCGCCGCTGATCGCTTTGATGCAGGATCAGGTTTTCAAGGCCCAGGAGCTGGGG
ATCAGTGCCACGTTCTTAAGTTCCACTTTGAGCCGGGACGAACGCGAGTCCCGCCAGAACCGCCTGGCCAAAGGCGACTT
CAAGCTGATCTATGTGACCCCGGAACGCTTCCGTAAACCTGAGTTTCTTCAGGCTATTGAAAAACGGGCCATTCAACTTT
TGGCCGTGGACGAGGCTCACTGTATTTCCCAATGGGGGCATGACTTCCGCCCGGATTATTCCCGGGTCGGAGAGTTCCGC
GCCCTTTTGGGCAATCCGCCGACTTTGGCGCTGACGGCCACGGCGACGCCCGAGGTTCAAAAAGACATCCTGAAAAAACT
GAATATGGAAGACGCCCTGATCATTTCCGCGGGGATTGAGCGCCCGAACCTGGCCCTGAATGTTCACGACATCTATGGAA
TCGATGAAAAGATCCGGGCCATCGTGGGGCTTCGTCATCTGACACCAGGAACGGCGATCATTTATTGCTCTTTGATTCAG
ACGCTGAAGAAAGTTTCGTCTGCGTTGAACCGACTGGGCATGGCGCATCTGGTGTATCACGGCGATTTGCCGCCGCAGGA
TCGCAAGCGCAATCAGAAAGCCTTCCAGACTGAAGAAGCTCCGCTGATGATCGCGACGCCCGCTTTCGGGTTGGGCATCG
ATAAAAGCAACGTGCGCCTGTTGATTCATGCCGAAACCCCGAACTCTTTGGAATCCTATTTTCAGGAGGTCGGTCGTGCC
GGTCGAGACGGGGCCGAGTCATCTTGTCATCTGCTGTATGACCAGGACGATGTCAGCATTCAGATGGAGTTTTTGAAATG
GTCTCACCCCGAGCCTGATTTCATCCGCAAAATCTATCAACTGATAGAAGACAAAAGAATGCAGGTGGATCAGGGTGGAT
TTGACTTCCTTCGTGAACAAATGAATTTTAGAAATCGCCGGGACTTCCGGTCCGAAGCCGCAGTCAGTATTCTGGAACGC
TGGGGATGTCTGCAAAAGTCCGACGATCCGTTTCCCTTTGCTTGCGTGCAGGCACCAACGGACGAGCAGTTCCTGGCGGA
AAACGACGAAGCTATTTTGCGCGCTCAGAACACCAAACTTTTGCAGATGGTGCAGTGGGCGAATCAGGACAGCGAGTGCC
GCATGAATCGCATCTATGCTTACTTTGGGCATGAACACACTGAACCGTGTGGGAAATGCGATATCTGCAAACGATAG

Upstream 100 bases:

>100_bases
TAAGTGCAAAAAAAGATTCTAGGCCAGAATCCCAACGCACCGCATCCTCGAGGGGCCTGGCTGACGGGCCCCCTCTGAGT
AGCGTAGACTGATCGGCACT

Downstream 100 bases:

>100_bases
AACTGAGGAGGTTGTTATGAGAGCTGGTTTGGTATTTCTTGGATCGCTTTTGATTTCGCTTTCTGCGGGGGCGAAGCAAC
TTCCTTTGGAAAAGCTGAAA

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MTDLLQLLKANFPFTSFRGEQEQVLHKVWANQNLLALMPTGMGKSLCFQFPAKTREGLVVVISPLIALMQDQVFKAQELG
ISATFLSSTLSRDERESRQNRLAKGDFKLIYVTPERFRKPEFLQAIEKRAIQLLAVDEAHCISQWGHDFRPDYSRVGEFR
ALLGNPPTLALTATATPEVQKDILKKLNMEDALIISAGIERPNLALNVHDIYGIDEKIRAIVGLRHLTPGTAIIYCSLIQ
TLKKVSSALNRLGMAHLVYHGDLPPQDRKRNQKAFQTEEAPLMIATPAFGLGIDKSNVRLLIHAETPNSLESYFQEVGRA
GRDGAESSCHLLYDQDDVSIQMEFLKWSHPEPDFIRKIYQLIEDKRMQVDQGGFDFLREQMNFRNRRDFRSEAAVSILER
WGCLQKSDDPFPFACVQAPTDEQFLAENDEAILRAQNTKLLQMVQWANQDSECRMNRIYAYFGHEHTEPCGKCDICKR

Sequences:

>Translated_478_residues
MTDLLQLLKANFPFTSFRGEQEQVLHKVWANQNLLALMPTGMGKSLCFQFPAKTREGLVVVISPLIALMQDQVFKAQELG
ISATFLSSTLSRDERESRQNRLAKGDFKLIYVTPERFRKPEFLQAIEKRAIQLLAVDEAHCISQWGHDFRPDYSRVGEFR
ALLGNPPTLALTATATPEVQKDILKKLNMEDALIISAGIERPNLALNVHDIYGIDEKIRAIVGLRHLTPGTAIIYCSLIQ
TLKKVSSALNRLGMAHLVYHGDLPPQDRKRNQKAFQTEEAPLMIATPAFGLGIDKSNVRLLIHAETPNSLESYFQEVGRA
GRDGAESSCHLLYDQDDVSIQMEFLKWSHPEPDFIRKIYQLIEDKRMQVDQGGFDFLREQMNFRNRRDFRSEAAVSILER
WGCLQKSDDPFPFACVQAPTDEQFLAENDEAILRAQNTKLLQMVQWANQDSECRMNRIYAYFGHEHTEPCGKCDICKR
>Mature_477_residues
TDLLQLLKANFPFTSFRGEQEQVLHKVWANQNLLALMPTGMGKSLCFQFPAKTREGLVVVISPLIALMQDQVFKAQELGI
SATFLSSTLSRDERESRQNRLAKGDFKLIYVTPERFRKPEFLQAIEKRAIQLLAVDEAHCISQWGHDFRPDYSRVGEFRA
LLGNPPTLALTATATPEVQKDILKKLNMEDALIISAGIERPNLALNVHDIYGIDEKIRAIVGLRHLTPGTAIIYCSLIQT
LKKVSSALNRLGMAHLVYHGDLPPQDRKRNQKAFQTEEAPLMIATPAFGLGIDKSNVRLLIHAETPNSLESYFQEVGRAG
RDGAESSCHLLYDQDDVSIQMEFLKWSHPEPDFIRKIYQLIEDKRMQVDQGGFDFLREQMNFRNRRDFRSEAAVSILERW
GCLQKSDDPFPFACVQAPTDEQFLAENDEAILRAQNTKLLQMVQWANQDSECRMNRIYAYFGHEHTEPCGKCDICKR

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI14591902, Length=343, Percent_Identity=37.6093294460641, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI14591904, Length=343, Percent_Identity=37.6093294460641, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI51242947, Length=381, Percent_Identity=37.5328083989501, Blast_Score=235, Evalue=5e-62,
Organism=Homo sapiens, GI110735439, Length=345, Percent_Identity=39.1304347826087, Blast_Score=235, Evalue=9e-62,
Organism=Homo sapiens, GI51242943, Length=381, Percent_Identity=37.5328083989501, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI169218196, Length=345, Percent_Identity=39.1304347826087, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI148612816, Length=381, Percent_Identity=37.5328083989501, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI4557365, Length=379, Percent_Identity=36.6754617414248, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI284005309, Length=339, Percent_Identity=33.0383480825959, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI4758138, Length=429, Percent_Identity=22.1445221445221, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI48994977, Length=335, Percent_Identity=39.4029850746269, Blast_Score=256, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI71987997, Length=367, Percent_Identity=35.9673024523161, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71987993, Length=367, Percent_Identity=35.9673024523161, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI25145561, Length=349, Percent_Identity=37.5358166189112, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI32564293, Length=344, Percent_Identity=37.5, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17552866, Length=322, Percent_Identity=37.5776397515528, Blast_Score=214, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI115533224, Length=342, Percent_Identity=23.3918128654971, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71995724, Length=374, Percent_Identity=23.7967914438503, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17507121, Length=374, Percent_Identity=23.7967914438503, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=345, Percent_Identity=36.8115942028986, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6321360, Length=335, Percent_Identity=23.8805970149254, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320224, Length=332, Percent_Identity=21.9879518072289, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324217, Length=317, Percent_Identity=21.7665615141956, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324778, Length=291, Percent_Identity=23.7113402061856, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24646066, Length=354, Percent_Identity=38.9830508474576, Blast_Score=227, Evalue=2e-59,
Organism=Drosophila melanogaster, GI62472181, Length=357, Percent_Identity=35.2941176470588, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24664230, Length=357, Percent_Identity=35.2941176470588, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24664226, Length=357, Percent_Identity=35.5742296918768, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI21358123, Length=354, Percent_Identity=32.7683615819209, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24666101, Length=343, Percent_Identity=24.198250728863, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 54487; Mature: 54356

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLLQLLKANFPFTSFRGEQEQVLHKVWANQNLLALMPTGMGKSLCFQFPAKTREGLVV
CHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHEECCCCCCCCEEE
VISPLIALMQDQVFKAQELGISATFLSSTLSRDERESRQNRLAKGDFKLIYVTPERFRKP
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHCCC
EFLQAIEKRAIQLLAVDEAHCISQWGHDFRPDYSRVGEFRALLGNPPTLALTATATPEVQ
HHHHHHHHHHHEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHH
KDILKKLNMEDALIISAGIERPNLALNVHDIYGIDEKIRAIVGLRHLTPGTAIIYCSLIQ
HHHHHHCCCCCEEEEEECCCCCCEEEEEHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHH
TLKKVSSALNRLGMAHLVYHGDLPPQDRKRNQKAFQTEEAPLMIATPAFGLGIDKSNVRL
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEE
LIHAETPNSLESYFQEVGRAGRDGAESSCHLLYDQDDVSIQMEFLKWSHPEPDFIRKIYQ
EEEECCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEEHHCCCCCHHHHHHHHH
LIEDKRMQVDQGGFDFLREQMNFRNRRDFRSEAAVSILERWGCLQKSDDPFPFACVQAPT
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCC
DEQFLAENDEAILRAQNTKLLQMVQWANQDSECRMNRIYAYFGHEHTEPCGKCDICKR
CHHHHHCCCCCEEEECCHHHHHHHHHCCCCCCHHHHHEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDLLQLLKANFPFTSFRGEQEQVLHKVWANQNLLALMPTGMGKSLCFQFPAKTREGLVV
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHEECCCCCCCCEEE
VISPLIALMQDQVFKAQELGISATFLSSTLSRDERESRQNRLAKGDFKLIYVTPERFRKP
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHCCC
EFLQAIEKRAIQLLAVDEAHCISQWGHDFRPDYSRVGEFRALLGNPPTLALTATATPEVQ
HHHHHHHHHHHEEEECCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCHHH
KDILKKLNMEDALIISAGIERPNLALNVHDIYGIDEKIRAIVGLRHLTPGTAIIYCSLIQ
HHHHHHCCCCCEEEEEECCCCCCEEEEEHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHH
TLKKVSSALNRLGMAHLVYHGDLPPQDRKRNQKAFQTEEAPLMIATPAFGLGIDKSNVRL
HHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEE
LIHAETPNSLESYFQEVGRAGRDGAESSCHLLYDQDDVSIQMEFLKWSHPEPDFIRKIYQ
EEEECCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCEEEEEEHHCCCCCHHHHHHHHH
LIEDKRMQVDQGGFDFLREQMNFRNRRDFRSEAAVSILERWGCLQKSDDPFPFACVQAPT
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCC
DEQFLAENDEAILRAQNTKLLQMVQWANQDSECRMNRIYAYFGHEHTEPCGKCDICKR
CHHHHHCCCCCEEEECCHHHHHHHHHCCCCCCHHHHHEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]