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The map label for this gene is rsmA

Identifier: 42522227

GI number: 42522227

Start: 593573

End: 594397

Strand: Direct

Name: rsmA

Synonym: Bd0637

Alternate gene names: 42522227

Gene position: 593573-594397 (Clockwise)

Preceding gene: 42522226

Following gene: 42522228

Centisome position: 15.69

GC content: 51.27

Gene sequence:

>825_bases
ATGAGTTATTCACGCGAACGTCTGCAGCGCGCGCAAGAAGCCATGGGCATTGCCGCGAAAAAATCTTTGGGCCAGAACTT
TCTGGTCAGCGACACGGTCATCAATCGTATCATCGATCAGGTGAAGGCCTTTGCGCCGGAAGAACTGGTCGAAGTGGGCC
CCGGCCCGGGGGCATTGACGGATCTGTTGTTAGAGCTGAATCTGCCGCTGCAGCTGATTGAGCTGGACTCTGCCATTGCG
GCTTACTGGCGCGAAAAAGGTTTGACAGTGATTGAGCAAGACGCCCTTCGCTTGGACTGGAAGCAGTTCTATACCGGCAA
GCGTGTGGTCTTTGTCAGCAATCTGCCGTATCAGATTTCATCCAGCATCGTGATTGAGCGTTCGTTGGAAAATGAAGGTG
TGGCAGCGATGGTGCTGATGTTCCAAAAGGAAGTCGCCCAGAAAATCCGCGGCACTGTGGACAGTGATCTGTACGGTCTT
TTAAGTGTCTATGCACAAGCTTTCTGGAAGATTGAAACCGTGACGGATGCCGGTCCAAGGGATTTCCAGCCGCCTCCAAA
GGTGGCCAGCCGGGTGCTTTCTTTCGAACGTATTGAGTCTGAGGTCAAAAACCGCAAGGCTTTCCTGACATTTGTAAAGT
GCGCCTTCGCGCAAAGACGCAAGCTTTTGAAGAAAAATTTGTCTGGTCTTTTAAGTCAAAAGAAGCTAACTGAAGAGCAA
ATGGTCGGCTGGTTGGCCGAGCTGGGCTTTAAAGAAACGGCCCGTGCTGAGGAGCTTTCTCCGAAGCAGTTTGTGGCCCT
GTATAAGCATTTTGGATTTGAGTAA

Upstream 100 bases:

>100_bases
CCGCGATGATCGGTTACGTCGGTGCTTTGCGCATGGCTCGCGGTGAAGTGTCGGCTTTGGATCTGGGACCGTCCCCTCAA
GCTCTTGCATCGGATTTTAA

Downstream 100 bases:

>100_bases
ATGAGCGAAAACATCCTGATTGTTCATGAGAACAAAAAAGCACGCTTTGACTACACGATCGTGGAAACCTACGAGGCGGG
TCTGCAGCTTATGGGCAGCG

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MSYSRERLQRAQEAMGIAAKKSLGQNFLVSDTVINRIIDQVKAFAPEELVEVGPGPGALTDLLLELNLPLQLIELDSAIA
AYWREKGLTVIEQDALRLDWKQFYTGKRVVFVSNLPYQISSSIVIERSLENEGVAAMVLMFQKEVAQKIRGTVDSDLYGL
LSVYAQAFWKIETVTDAGPRDFQPPPKVASRVLSFERIESEVKNRKAFLTFVKCAFAQRRKLLKKNLSGLLSQKKLTEEQ
MVGWLAELGFKETARAEELSPKQFVALYKHFGFE

Sequences:

>Translated_274_residues
MSYSRERLQRAQEAMGIAAKKSLGQNFLVSDTVINRIIDQVKAFAPEELVEVGPGPGALTDLLLELNLPLQLIELDSAIA
AYWREKGLTVIEQDALRLDWKQFYTGKRVVFVSNLPYQISSSIVIERSLENEGVAAMVLMFQKEVAQKIRGTVDSDLYGL
LSVYAQAFWKIETVTDAGPRDFQPPPKVASRVLSFERIESEVKNRKAFLTFVKCAFAQRRKLLKKNLSGLLSQKKLTEEQ
MVGWLAELGFKETARAEELSPKQFVALYKHFGFE
>Mature_273_residues
SYSRERLQRAQEAMGIAAKKSLGQNFLVSDTVINRIIDQVKAFAPEELVEVGPGPGALTDLLLELNLPLQLIELDSAIAA
YWREKGLTVIEQDALRLDWKQFYTGKRVVFVSNLPYQISSSIVIERSLENEGVAAMVLMFQKEVAQKIRGTVDSDLYGLL
SVYAQAFWKIETVTDAGPRDFQPPPKVASRVLSFERIESEVKNRKAFLTFVKCAFAQRRKLLKKNLSGLLSQKKLTEEQM
VGWLAELGFKETARAEELSPKQFVALYKHFGFE

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily

Homologues:

Organism=Homo sapiens, GI7657198, Length=227, Percent_Identity=33.920704845815, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1786236, Length=267, Percent_Identity=31.0861423220974, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI25146882, Length=211, Percent_Identity=32.7014218009479, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI25141369, Length=282, Percent_Identity=24.822695035461, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324989, Length=183, Percent_Identity=30.0546448087432, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21358017, Length=195, Percent_Identity=28.7179487179487, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357273, Length=280, Percent_Identity=27.5, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RSMA_BDEBA (Q6MQ47)

Other databases:

- EMBL:   BX842647
- RefSeq:   NP_967607.1
- ProteinModelPortal:   Q6MQ47
- SMR:   Q6MQ47
- GeneID:   2733592
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd0637
- NMPDR:   fig|264462.1.peg.577
- HOGENOM:   HBG319664
- OMA:   TPIIMKL
- BioCyc:   BBAC264462:BD0637-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00607
- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530
- Gene3D:   G3DSA:1.10.8.100
- PANTHER:   PTHR11727
- SMART:   SM00650
- TIGRFAMs:   TIGR00755

Pfam domain/function: PF00398 RrnaAD

EC number: =2.1.1.182

Molecular weight: Translated: 30980; Mature: 30849

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: BINDING 26-26 BINDING 28-28 BINDING 53-53 BINDING 74-74 BINDING 94-94 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYSRERLQRAQEAMGIAAKKSLGQNFLVSDTVINRIIDQVKAFAPEELVEVGPGPGALT
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCCHHHH
DLLLELNLPLQLIELDSAIAAYWREKGLTVIEQDALRLDWKQFYTGKRVVFVSNLPYQIS
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCEEEEEECCCHHHC
SSIVIERSLENEGVAAMVLMFQKEVAQKIRGTVDSDLYGLLSVYAQAFWKIETVTDAGPR
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHECCCCCCC
DFQPPPKVASRVLSFERIESEVKNRKAFLTFVKCAFAQRRKLLKKNLSGLLSQKKLTEEQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVGWLAELGFKETARAEELSPKQFVALYKHFGFE
HHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SYSRERLQRAQEAMGIAAKKSLGQNFLVSDTVINRIIDQVKAFAPEELVEVGPGPGALT
CCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCCHHHH
DLLLELNLPLQLIELDSAIAAYWREKGLTVIEQDALRLDWKQFYTGKRVVFVSNLPYQIS
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHCCCEEEEEECCCHHHC
SSIVIERSLENEGVAAMVLMFQKEVAQKIRGTVDSDLYGLLSVYAQAFWKIETVTDAGPR
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHECCCCCCC
DFQPPPKVASRVLSFERIESEVKNRKAFLTFVKCAFAQRRKLLKKNLSGLLSQKKLTEEQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVGWLAELGFKETARAEELSPKQFVALYKHFGFE
HHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA