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The map label for this gene is gcp

Identifier: 42522226

GI number: 42522226

Start: 592539

End: 593576

Strand: Direct

Name: gcp

Synonym: Bd0636

Alternate gene names: 42522226

Gene position: 592539-593576 (Clockwise)

Preceding gene: 42522225

Following gene: 42522227

Centisome position: 15.66

GC content: 53.66

Gene sequence:

>1038_bases
GTGATTGAAAGAGTTCTCGCCATTGAAACCAGCTGTGATGACACCTCTGTCGCGATCGTTGATCGTACCGGCTGGGTTCA
CTCTGTGGTGGCGGCCTCTCAGGATCTGGATCACGAAATCTATGGCGGCATCGTCCCTGAAATTGCCGCCCGCAACCATT
CCATCGCTTTAATTCCATTAATCGAAGAAGCCTTTAAGAAAGCCAACATGAATTGGTCTGACGTGCAGGGTATTGCCGTC
ACCAATCGTCCGGGTTTGATCGGCGCTTTGATTGTGGGGCTGGTGACTGCGAAGTCCTTGTCTCAGGCAAAACATTTGCC
TTTCTTGGGTGTGAACCACCTGGAAGGGCATTTGCTGGCGCCGTTTTTGCGCGATGATAAATATGCTCCACCGGAAGATT
TTGGTTACCCATATGTGGGTTTGGCGATCAGCGGGGGGCACACAAGTTTGTATCAAATTAAAGGACTGGGCGATTATCGT
ATCTTGGGTGCTACCAAGGATGATGCGGCCGGGGAGTGTTTCGATAAATTTGCAAAGATGGCAGGCCTGGGGTTCCCGGG
TGGAGTGCGCGTCGATCAAATGGCCAAGGCGGGGAATCCGCAGGCTTTCGAATTCCCCCGCAGCATGATCCATGATGACA
CTTTCGACATGAGCTTCTCGGGATTAAAATCTTCCGGCCAGCGCATGCTTGAACAACTGGGACCAGAACTTGTGCAGGAG
CGTCTGCCGGATCTGTGCGCCTCGTTCCAGGAAGCCATCGTGGATGTCCTGATCGCGAAGCTGGATCGGGCGGCGAAAGT
CTTCCGCTCCAAGCGTGTGATTCTGACCGGCGGGGTCAGCGCGAATTCGCGTCTTCGTCAGCGGGCTCAGGAATGGGCCG
ACAAAAAAGGTTATACTTTGGTGATCCCACCTCTGCGTTACTGTACTGATAACGCCGCGATGATCGGTTACGTCGGTGCT
TTGCGCATGGCTCGCGGTGAAGTGTCGGCTTTGGATCTGGGACCGTCCCCTCAAGCTCTTGCATCGGATTTTAAATGA

Upstream 100 bases:

>100_bases
GAGGCAAAAACCTTCTATGACGAGGTGGTCAGCAAGTTTCCGAAGTCAGAAGAGGCTCGTCGTGCTAAGATCCGTTTGAA
GGGTTTAAAAAAGTAATACT

Downstream 100 bases:

>100_bases
GTTATTCACGCGAACGTCTGCAGCGCGCGCAAGAAGCCATGGGCATTGCCGCGAAAAAATCTTTGGGCCAGAACTTTCTG
GTCAGCGACACGGTCATCAA

Product: O-sialoglycoprotein endopeptidase

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MIERVLAIETSCDDTSVAIVDRTGWVHSVVAASQDLDHEIYGGIVPEIAARNHSIALIPLIEEAFKKANMNWSDVQGIAV
TNRPGLIGALIVGLVTAKSLSQAKHLPFLGVNHLEGHLLAPFLRDDKYAPPEDFGYPYVGLAISGGHTSLYQIKGLGDYR
ILGATKDDAAGECFDKFAKMAGLGFPGGVRVDQMAKAGNPQAFEFPRSMIHDDTFDMSFSGLKSSGQRMLEQLGPELVQE
RLPDLCASFQEAIVDVLIAKLDRAAKVFRSKRVILTGGVSANSRLRQRAQEWADKKGYTLVIPPLRYCTDNAAMIGYVGA
LRMARGEVSALDLGPSPQALASDFK

Sequences:

>Translated_345_residues
MIERVLAIETSCDDTSVAIVDRTGWVHSVVAASQDLDHEIYGGIVPEIAARNHSIALIPLIEEAFKKANMNWSDVQGIAV
TNRPGLIGALIVGLVTAKSLSQAKHLPFLGVNHLEGHLLAPFLRDDKYAPPEDFGYPYVGLAISGGHTSLYQIKGLGDYR
ILGATKDDAAGECFDKFAKMAGLGFPGGVRVDQMAKAGNPQAFEFPRSMIHDDTFDMSFSGLKSSGQRMLEQLGPELVQE
RLPDLCASFQEAIVDVLIAKLDRAAKVFRSKRVILTGGVSANSRLRQRAQEWADKKGYTLVIPPLRYCTDNAAMIGYVGA
LRMARGEVSALDLGPSPQALASDFK
>Mature_345_residues
MIERVLAIETSCDDTSVAIVDRTGWVHSVVAASQDLDHEIYGGIVPEIAARNHSIALIPLIEEAFKKANMNWSDVQGIAV
TNRPGLIGALIVGLVTAKSLSQAKHLPFLGVNHLEGHLLAPFLRDDKYAPPEDFGYPYVGLAISGGHTSLYQIKGLGDYR
ILGATKDDAAGECFDKFAKMAGLGFPGGVRVDQMAKAGNPQAFEFPRSMIHDDTFDMSFSGLKSSGQRMLEQLGPELVQE
RLPDLCASFQEAIVDVLIAKLDRAAKVFRSKRVILTGGVSANSRLRQRAQEWADKKGYTLVIPPLRYCTDNAAMIGYVGA
LRMARGEVSALDLGPSPQALASDFK

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=344, Percent_Identity=31.6860465116279, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI8923380, Length=285, Percent_Identity=31.2280701754386, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1789445, Length=335, Percent_Identity=41.4925373134328, Blast_Score=255, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17557464, Length=333, Percent_Identity=30.3303303303303, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71995670, Length=334, Percent_Identity=33.8323353293413, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320099, Length=375, Percent_Identity=33.0666666666667, Blast_Score=155, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6322891, Length=310, Percent_Identity=29.3548387096774, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI20129063, Length=339, Percent_Identity=33.0383480825959, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21357207, Length=290, Percent_Identity=32.4137931034483, Blast_Score=135, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_BDEBA (Q6MQ48)

Other databases:

- EMBL:   BX842647
- RefSeq:   NP_967606.1
- ProteinModelPortal:   Q6MQ48
- SMR:   Q6MQ48
- MEROPS:   M22.001
- GeneID:   2733591
- GenomeReviews:   BX842601_GR
- KEGG:   bba:Bd0636
- NMPDR:   fig|264462.1.peg.576
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- PhylomeDB:   Q6MQ48
- BioCyc:   BBAC264462:BD0636-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 37342; Mature: 37342

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIERVLAIETSCDDTSVAIVDRTGWVHSVVAASQDLDHEIYGGIVPEIAARNHSIALIPL
CCCCEEEEECCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHCCCHHHHHCCCCCEEEEHH
IEEAFKKANMNWSDVQGIAVTNRPGLIGALIVGLVTAKSLSQAKHLPFLGVNHLEGHLLA
HHHHHHHCCCCHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEC
PFLRDDKYAPPEDFGYPYVGLAISGGHTSLYQIKGLGDYRILGATKDDAAGECFDKFAKM
HHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHH
AGLGFPGGVRVDQMAKAGNPQAFEFPRSMIHDDTFDMSFSGLKSSGQRMLEQLGPELVQE
HCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHH
RLPDLCASFQEAIVDVLIAKLDRAAKVFRSKRVILTGGVSANSRLRQRAQEWADKKGYTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCCEE
VIPPLRYCTDNAAMIGYVGALRMARGEVSALDLGPSPQALASDFK
EECCHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCCC
>Mature Secondary Structure
MIERVLAIETSCDDTSVAIVDRTGWVHSVVAASQDLDHEIYGGIVPEIAARNHSIALIPL
CCCCEEEEECCCCCCEEEEEECCCHHHHHHHHHCCCCHHHHCCCHHHHHCCCCCEEEEHH
IEEAFKKANMNWSDVQGIAVTNRPGLIGALIVGLVTAKSLSQAKHLPFLGVNHLEGHLLA
HHHHHHHCCCCHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEC
PFLRDDKYAPPEDFGYPYVGLAISGGHTSLYQIKGLGDYRILGATKDDAAGECFDKFAKM
HHHCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHH
AGLGFPGGVRVDQMAKAGNPQAFEFPRSMIHDDTFDMSFSGLKSSGQRMLEQLGPELVQE
HCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCHHHHHH
RLPDLCASFQEAIVDVLIAKLDRAAKVFRSKRVILTGGVSANSRLRQRAQEWADKKGYTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCCEE
VIPPLRYCTDNAAMIGYVGALRMARGEVSALDLGPSPQALASDFK
EECCHHHHCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA