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The map label for this gene is menA [H]

Identifier: 42522146

GI number: 42522146

Start: 507638

End: 508537

Strand: Direct

Name: menA [H]

Synonym: Bd0546

Alternate gene names: 42522146

Gene position: 507638-508537 (Clockwise)

Preceding gene: 42522143

Following gene: 42522147

Centisome position: 13.42

GC content: 52.0

Gene sequence:

>900_bases
ATGCGATGCAAAATGACCTCTGCGACCCAGATTAAAAGTATTCTTCTCGCTTTTCGCCCCAAAACTTTGACTGCTGCCCT
GGTGCCCTGTGTGGCGGGGACGGCTCTGGTAAAGGCTATCGGTCTTTCCTGGGATGGCTGGGTTTTGTTTTACGCATTGA
TGGCCTCCTTCCTGATTCAGATCGGGACCAATCTGGTGAATGATGCCGTGGACTTTAAAAAGGGTGCGGATACGGAAAAA
CGCATCGGTCCTCAGCGTATCACCCAAGCCGGCATTTTGACGGCCAATCAGGTGATGCTGCTGGGTTCGCTTTGTTTCGC
CTTGGCTGTGATGTGCGGGATCCCGCTGGTGCTGAAAGGCGGCTGGGTGATTGTGGCCATTGGTGTGGCTTCGGTTCTGA
TGGGGTATTCCTACACCGCCGGTCCGTTCCCGTTGGCTTACCTGGGATTGGGCGATCTGTTTGTCATTATCTTTTTTGGT
TTGTTGGCCGTGACGGGGATTGTGTTCCTGAACACCGGTGAGTGGCTGTCCGAGGCGTTTGTATTGGGCCTGCAGATCGG
TTTGCACGCGACAGTGCTGATTGCGATCAACAACTTGCGCGATCATGCCGGTGATCGTCTGGTGAACAAAAAAACCCTGG
CGGTGCGTTTTGGTGTGAAATTCTCTCGCTGGGAAATTGCGGCCTTGGCATTCCTGCCGTTTGTTCTCAATCTGTACTGG
TGGTTTGAAGGTTACAAGATCGCGGCGATTGTCTCGATGTTTGCTTTGCCTTTGGCAGTGAAGATCACAAAAAATGTTTT
CGCCACGGAGCCAAGTCCGGCATACAATAAATTCCTGGGGCAGGCAGCGGGATTGCATCTGCTCTTTGGACTTCTTATTG
CGATTGGATTTGCTTTTTGA

Upstream 100 bases:

>100_bases
ACCCCCTTCATTCGGAAAACCTCCTTCTTTTGCCCTTAGAAATTCTTTTGGTCACGCGAAAAGAATCTGATACAAAGAGG
TTGGATTTTAACCCTTAACA

Downstream 100 bases:

>100_bases
TCAAGATCAGCTACAGCCCCTACACTCTGAAACCTGTCCAGTCCCTGAATGCCGCTACAGCGGCCACCGCGCGTGAAGGG
GTCTTGCTGAAGGTTGAGTG

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MRCKMTSATQIKSILLAFRPKTLTAALVPCVAGTALVKAIGLSWDGWVLFYALMASFLIQIGTNLVNDAVDFKKGADTEK
RIGPQRITQAGILTANQVMLLGSLCFALAVMCGIPLVLKGGWVIVAIGVASVLMGYSYTAGPFPLAYLGLGDLFVIIFFG
LLAVTGIVFLNTGEWLSEAFVLGLQIGLHATVLIAINNLRDHAGDRLVNKKTLAVRFGVKFSRWEIAALAFLPFVLNLYW
WFEGYKIAAIVSMFALPLAVKITKNVFATEPSPAYNKFLGQAAGLHLLFGLLIAIGFAF

Sequences:

>Translated_299_residues
MRCKMTSATQIKSILLAFRPKTLTAALVPCVAGTALVKAIGLSWDGWVLFYALMASFLIQIGTNLVNDAVDFKKGADTEK
RIGPQRITQAGILTANQVMLLGSLCFALAVMCGIPLVLKGGWVIVAIGVASVLMGYSYTAGPFPLAYLGLGDLFVIIFFG
LLAVTGIVFLNTGEWLSEAFVLGLQIGLHATVLIAINNLRDHAGDRLVNKKTLAVRFGVKFSRWEIAALAFLPFVLNLYW
WFEGYKIAAIVSMFALPLAVKITKNVFATEPSPAYNKFLGQAAGLHLLFGLLIAIGFAF
>Mature_299_residues
MRCKMTSATQIKSILLAFRPKTLTAALVPCVAGTALVKAIGLSWDGWVLFYALMASFLIQIGTNLVNDAVDFKKGADTEK
RIGPQRITQAGILTANQVMLLGSLCFALAVMCGIPLVLKGGWVIVAIGVASVLMGYSYTAGPFPLAYLGLGDLFVIIFFG
LLAVTGIVFLNTGEWLSEAFVLGLQIGLHATVLIAINNLRDHAGDRLVNKKTLAVRFGVKFSRWEIAALAFLPFVLNLYW
WFEGYKIAAIVSMFALPLAVKITKNVFATEPSPAYNKFLGQAAGLHLLFGLLIAIGFAF

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=296, Percent_Identity=29.0540540540541, Blast_Score=85, Evalue=8e-17,
Organism=Escherichia coli, GI1790365, Length=295, Percent_Identity=32.2033898305085, Blast_Score=117, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17737429, Length=316, Percent_Identity=29.1139240506329, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32253; Mature: 32253

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCKMTSATQIKSILLAFRPKTLTAALVPCVAGTALVKAIGLSWDGWVLFYALMASFLIQ
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
IGTNLVNDAVDFKKGADTEKRIGPQRITQAGILTANQVMLLGSLCFALAVMCGIPLVLKG
HHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
GWVIVAIGVASVLMGYSYTAGPFPLAYLGLGDLFVIIFFGLLAVTGIVFLNTGEWLSEAF
CEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHH
VLGLQIGLHATVLIAINNLRDHAGDRLVNKKTLAVRFGVKFSRWEIAALAFLPFVLNLYW
HHHHHHHHHEEEEEEEHHHHHHHCHHHCCCCEEEEEECCEECHHHHHHHHHHHHHHHHHH
WFEGYKIAAIVSMFALPLAVKITKNVFATEPSPAYNKFLGQAAGLHLLFGLLIAIGFAF
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRCKMTSATQIKSILLAFRPKTLTAALVPCVAGTALVKAIGLSWDGWVLFYALMASFLIQ
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
IGTNLVNDAVDFKKGADTEKRIGPQRITQAGILTANQVMLLGSLCFALAVMCGIPLVLKG
HHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEC
GWVIVAIGVASVLMGYSYTAGPFPLAYLGLGDLFVIIFFGLLAVTGIVFLNTGEWLSEAF
CEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHH
VLGLQIGLHATVLIAINNLRDHAGDRLVNKKTLAVRFGVKFSRWEIAALAFLPFVLNLYW
HHHHHHHHHEEEEEEEHHHHHHHCHHHCCCCEEEEEECCEECHHHHHHHHHHHHHHHHHH
WFEGYKIAAIVSMFALPLAVKITKNVFATEPSPAYNKFLGQAAGLHLLFGLLIAIGFAF
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]