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The map label for this gene is aspA [H]

Identifier: 42521990

GI number: 42521990

Start: 350642

End: 352339

Strand: Direct

Name: aspA [H]

Synonym: Bd0376

Alternate gene names: 42521990

Gene position: 350642-352339 (Clockwise)

Preceding gene: 42521989

Following gene: 42521995

Centisome position: 9.27

GC content: 53.71

Gene sequence:

>1698_bases
ATGCTGGCGGGCCTTGCAGTGATAGCCACTATCACGGGGACTTTATTTACCAACTGTGCGAAGAACAGTTTCACCGCCGT
TGGTGAAGAGCTGGTGGGCACCGGGGCGGATCCGCTGTTGGGTTATGCCTGGCATATCAATAACACCGGACAAAAGGTTT
TCGCCACCGATGCCGGAACCGCGGGTGTTGATCTGAATCTGTTGCAGTCGTGGACCGGGGGACTGACCGGAAGTGGAATC
AAGATTGTGATTTCCGATGACGGGGTTCAGGATGCCCATCCGGATTTGAAGGACAACTTCCTTTATGGGGTGTCCAAGAA
CTATCATACTTCAGGTACGAACAATGCTCCTCCGAACTCTGCGGATGACAATCACGGGACTGCGGTTGCGGGTCTGGCGG
CGGCTGTCGGGGATAACGGTGTGGGCAGCAAGGGTGTTGCTTACAAAGCCAAACTGCTGGCCTATAACTTCCTGTCTACA
GGAGTTTCGCAAACCTTCAGCCGAATGGCCGAGCAGCTGAGCGGTGGGTATGATGTTTACAACATGAGCTGGGGGAACTC
GCAGAACTATCTGCCGGATCCTGTGGCCGCCTGGGAAACAGCTTTGCTGAACGGGGTGCTCAATGGTCGCAGTGGCAAAG
GCTCCATTTATGTAAAGTCTGCCGGTAATGACTTCCTGGTGGAATGCAAAGGCTCCACCGACACCTACTGCATCGGCAAC
TCCAATTTGGACCCGGACAACAGCACGCCTTACACAATTCTGGTGACGGCATTAAATTCCACCGGTGACGCGGCTTCGTA
TTCGTCTGTGGGTTCGAATGTCTGGATTTCGTCCTTTGGGGGAGAGTCCGGCGATGATTCTCCGGCGATGGTGACCACCG
ATCGCACCGGTTGTACGGCGGGCTATGCTCAGACCAGCATTTCCGGCAAAGTGGAGTTCGAACGAGGCAACAACGGAAAC
AGCAATTGCAATTACACGACGACATTTAACGGGACTTCTTCGGCGGCTCCGGTTCTGACCGGGGCGATTGCGCTTCTGCT
GGAAGCCAATCCGAATCTCAACTGGCGTGATGTGAAATACATTCTGGCGAAGACGGCGGTGCAGGTTCGTCCTAACTCGG
GGGCCATCAGTAACCATCCACTTAGAAATTATCCAGGGAATTCGTCCAAGAACGTGATTCTGCCGACAGGGGCGGTCTGG
GAAAATGCCTGGGTGACCAACAGTGCCGGATTCAAATTCCACAACTGGTATGGCTTTGGTCGTGTGGATGTGGATGCGGC
GGTGGCGATGGCAAAAAACTACACTTCGACGTTTACGGCCGGTCTTTCTGGTACAAGTTGGATTGAGAACACAACAAGGG
TGGCCATTCCTGATTACAGTGCGACGGGTGTCAGCAACACCGTGACAGTGACAGACAATCTGCGCATCGAAGGGGTTCGT
ATCCGGTTGAAAGTGGATCATGACCGCGTGGGGGATCTGGGTGTGGAACTGACGTCTCCGTCAGGCACCAAGAGCATGAT
TTTGAATATGCGAAATTCGTTGTTGGGTCAGGTGGACTATGACAACGAAGTCTTCCTGAGCAATGCTTTCTTCCAGGAGC
GCTCCAATGGCACCTGGACAATCAAAGTCATTGATGGTGGTTCAACCTTCAATGGGGATCTGGTCAGCTGGGGGCTGCAG
ATCATCGGAACACCTTAG

Upstream 100 bases:

>100_bases
TCCTCTTTGAAAGAACGTTTAAGCAGCGAACCTGGCGTCAGTCAGACCCAGCTGGAGATTTTGAGCAGGAAGTATGAAAA
GTTTTAGTCCCAAAGCCAAA

Downstream 100 bases:

>100_bases
TCCGCAATAAACATCGATGATATACAGCGGGTTTCAAGGTTTCCGCTGTAATAGGACGTTGAACCCACACGGGAGAATGT
CTTTGTGGTGCTGTCATAGC

Product: putative extracellular serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MLAGLAVIATITGTLFTNCAKNSFTAVGEELVGTGADPLLGYAWHINNTGQKVFATDAGTAGVDLNLLQSWTGGLTGSGI
KIVISDDGVQDAHPDLKDNFLYGVSKNYHTSGTNNAPPNSADDNHGTAVAGLAAAVGDNGVGSKGVAYKAKLLAYNFLST
GVSQTFSRMAEQLSGGYDVYNMSWGNSQNYLPDPVAAWETALLNGVLNGRSGKGSIYVKSAGNDFLVECKGSTDTYCIGN
SNLDPDNSTPYTILVTALNSTGDAASYSSVGSNVWISSFGGESGDDSPAMVTTDRTGCTAGYAQTSISGKVEFERGNNGN
SNCNYTTTFNGTSSAAPVLTGAIALLLEANPNLNWRDVKYILAKTAVQVRPNSGAISNHPLRNYPGNSSKNVILPTGAVW
ENAWVTNSAGFKFHNWYGFGRVDVDAAVAMAKNYTSTFTAGLSGTSWIENTTRVAIPDYSATGVSNTVTVTDNLRIEGVR
IRLKVDHDRVGDLGVELTSPSGTKSMILNMRNSLLGQVDYDNEVFLSNAFFQERSNGTWTIKVIDGGSTFNGDLVSWGLQ
IIGTP

Sequences:

>Translated_565_residues
MLAGLAVIATITGTLFTNCAKNSFTAVGEELVGTGADPLLGYAWHINNTGQKVFATDAGTAGVDLNLLQSWTGGLTGSGI
KIVISDDGVQDAHPDLKDNFLYGVSKNYHTSGTNNAPPNSADDNHGTAVAGLAAAVGDNGVGSKGVAYKAKLLAYNFLST
GVSQTFSRMAEQLSGGYDVYNMSWGNSQNYLPDPVAAWETALLNGVLNGRSGKGSIYVKSAGNDFLVECKGSTDTYCIGN
SNLDPDNSTPYTILVTALNSTGDAASYSSVGSNVWISSFGGESGDDSPAMVTTDRTGCTAGYAQTSISGKVEFERGNNGN
SNCNYTTTFNGTSSAAPVLTGAIALLLEANPNLNWRDVKYILAKTAVQVRPNSGAISNHPLRNYPGNSSKNVILPTGAVW
ENAWVTNSAGFKFHNWYGFGRVDVDAAVAMAKNYTSTFTAGLSGTSWIENTTRVAIPDYSATGVSNTVTVTDNLRIEGVR
IRLKVDHDRVGDLGVELTSPSGTKSMILNMRNSLLGQVDYDNEVFLSNAFFQERSNGTWTIKVIDGGSTFNGDLVSWGLQ
IIGTP
>Mature_565_residues
MLAGLAVIATITGTLFTNCAKNSFTAVGEELVGTGADPLLGYAWHINNTGQKVFATDAGTAGVDLNLLQSWTGGLTGSGI
KIVISDDGVQDAHPDLKDNFLYGVSKNYHTSGTNNAPPNSADDNHGTAVAGLAAAVGDNGVGSKGVAYKAKLLAYNFLST
GVSQTFSRMAEQLSGGYDVYNMSWGNSQNYLPDPVAAWETALLNGVLNGRSGKGSIYVKSAGNDFLVECKGSTDTYCIGN
SNLDPDNSTPYTILVTALNSTGDAASYSSVGSNVWISSFGGESGDDSPAMVTTDRTGCTAGYAQTSISGKVEFERGNNGN
SNCNYTTTFNGTSSAAPVLTGAIALLLEANPNLNWRDVKYILAKTAVQVRPNSGAISNHPLRNYPGNSSKNVILPTGAVW
ENAWVTNSAGFKFHNWYGFGRVDVDAAVAMAKNYTSTFTAGLSGTSWIENTTRVAIPDYSATGVSNTVTVTDNLRIEGVR
IRLKVDHDRVGDLGVELTSPSGTKSMILNMRNSLLGQVDYDNEVFLSNAFFQERSNGTWTIKVIDGGSTFNGDLVSWGLQ
IIGTP

Specific function: Agent of furonculosis [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI299523015, Length=529, Percent_Identity=29.4896030245747, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI20336246, Length=523, Percent_Identity=29.0630975143403, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI4505579, Length=540, Percent_Identity=26.8518518518519, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI76443679, Length=536, Percent_Identity=26.6791044776119, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI20336244, Length=550, Percent_Identity=29.0909090909091, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI20336180, Length=544, Percent_Identity=27.2058823529412, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI4505577, Length=544, Percent_Identity=27.2058823529412, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI20336182, Length=517, Percent_Identity=27.6595744680851, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI20336184, Length=517, Percent_Identity=27.4661508704062, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI27894285, Length=520, Percent_Identity=26.9230769230769, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI20336190, Length=520, Percent_Identity=26.9230769230769, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI20336188, Length=520, Percent_Identity=26.9230769230769, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI295424143, Length=552, Percent_Identity=25.9057971014493, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI20336242, Length=552, Percent_Identity=25.9057971014493, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI20336248, Length=550, Percent_Identity=27.0909090909091, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI20336186, Length=310, Percent_Identity=28.3870967741935, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI295424145, Length=252, Percent_Identity=28.1746031746032, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71987206, Length=560, Percent_Identity=29.2857142857143, Blast_Score=165, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71988312, Length=550, Percent_Identity=27.6363636363636, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71988321, Length=551, Percent_Identity=27.7676950998185, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71988315, Length=551, Percent_Identity=27.7676950998185, Blast_Score=162, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71988297, Length=551, Percent_Identity=27.7676950998185, Blast_Score=162, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71988308, Length=551, Percent_Identity=27.7676950998185, Blast_Score=162, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71988301, Length=551, Percent_Identity=27.7676950998185, Blast_Score=162, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI25141268, Length=543, Percent_Identity=26.1510128913444, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71983555, Length=403, Percent_Identity=26.302729528536, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17505240, Length=485, Percent_Identity=27.2164948453608, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71987215, Length=473, Percent_Identity=27.2727272727273, Blast_Score=110, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324091, Length=541, Percent_Identity=28.6506469500924, Blast_Score=169, Evalue=9e-43,
Organism=Drosophila melanogaster, GI281360987, Length=543, Percent_Identity=28.9134438305709, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24642494, Length=543, Percent_Identity=28.9134438305709, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24642490, Length=543, Percent_Identity=28.9134438305709, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI45555723, Length=543, Percent_Identity=28.9134438305709, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24642492, Length=543, Percent_Identity=28.9134438305709, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24642488, Length=543, Percent_Identity=28.9134438305709, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24642484, Length=543, Percent_Identity=28.9134438305709, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24642486, Length=543, Percent_Identity=28.9134438305709, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI17136192, Length=546, Percent_Identity=29.3040293040293, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24650056, Length=512, Percent_Identity=24.0234375, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24650058, Length=512, Percent_Identity=24.0234375, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24650060, Length=512, Percent_Identity=24.0234375, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45553513, Length=512, Percent_Identity=24.0234375, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45553515, Length=512, Percent_Identity=24.0234375, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17864552, Length=513, Percent_Identity=24.3664717348928, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI281360985, Length=192, Percent_Identity=33.8541666666667, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008979
- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR002884 [H]

Pfam domain/function: PF01483 P_proprotein; PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 59452; Mature: 59452

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAGLAVIATITGTLFTNCAKNSFTAVGEELVGTGADPLLGYAWHINNTGQKVFATDAGT
CCCHHEEHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEECCCC
AGVDLNLLQSWTGGLTGSGIKIVISDDGVQDAHPDLKDNFLYGVSKNYHTSGTNNAPPNS
CCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCC
ADDNHGTAVAGLAAAVGDNGVGSKGVAYKAKLLAYNFLSTGVSQTFSRMAEQLSGGYDVY
CCCCCCCCHHHHHHHHCCCCCCCCCCEEEEHHEEHHHHHHHHHHHHHHHHHHHCCCEEEE
NMSWGNSQNYLPDPVAAWETALLNGVLNGRSGKGSIYVKSAGNDFLVECKGSTDTYCIGN
EECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECCCCCEEEECC
SNLDPDNSTPYTILVTALNSTGDAASYSSVGSNVWISSFGGESGDDSPAMVTTDRTGCTA
CCCCCCCCCCEEEEEEEECCCCCCCCHHHCCCCEEEEECCCCCCCCCCEEEEECCCCCCC
GYAQTSISGKVEFERGNNGNSNCNYTTTFNGTSSAAPVLTGAIALLLEANPNLNWRDVKY
CCEECCCCCEEEEECCCCCCCCCCEEEEECCCCCCCHHHHEEEEEEEECCCCCCHHHHHH
ILAKTAVQVRPNSGAISNHPLRNYPGNSSKNVILPTGAVWENAWVTNSAGFKFHNWYGFG
EEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEECCCCEEEEEEEECC
RVDVDAAVAMAKNYTSTFTAGLSGTSWIENTTRVAIPDYSATGVSNTVTVTDNLRIEGVR
EEEHHHHHHHHHCCCCEEECCCCCCCHHCCCEEEEECCCCCCCCCCEEEEECCEEEEEEE
IRLKVDHDRVGDLGVELTSPSGTKSMILNMRNSLLGQVDYDNEVFLSNAFFQERSNGTWT
EEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHCEECCCCCEEEEEEHHHHHCCCCEEE
IKVIDGGSTFNGDLVSWGLQIIGTP
EEEEECCCCCCCCCEEECEEEEECC
>Mature Secondary Structure
MLAGLAVIATITGTLFTNCAKNSFTAVGEELVGTGADPLLGYAWHINNTGQKVFATDAGT
CCCHHEEHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEECCCC
AGVDLNLLQSWTGGLTGSGIKIVISDDGVQDAHPDLKDNFLYGVSKNYHTSGTNNAPPNS
CCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCC
ADDNHGTAVAGLAAAVGDNGVGSKGVAYKAKLLAYNFLSTGVSQTFSRMAEQLSGGYDVY
CCCCCCCCHHHHHHHHCCCCCCCCCCEEEEHHEEHHHHHHHHHHHHHHHHHHHCCCEEEE
NMSWGNSQNYLPDPVAAWETALLNGVLNGRSGKGSIYVKSAGNDFLVECKGSTDTYCIGN
EECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEEEEECCCCCEEEECC
SNLDPDNSTPYTILVTALNSTGDAASYSSVGSNVWISSFGGESGDDSPAMVTTDRTGCTA
CCCCCCCCCCEEEEEEEECCCCCCCCHHHCCCCEEEEECCCCCCCCCCEEEEECCCCCCC
GYAQTSISGKVEFERGNNGNSNCNYTTTFNGTSSAAPVLTGAIALLLEANPNLNWRDVKY
CCEECCCCCEEEEECCCCCCCCCCEEEEECCCCCCCHHHHEEEEEEEECCCCCCHHHHHH
ILAKTAVQVRPNSGAISNHPLRNYPGNSSKNVILPTGAVWENAWVTNSAGFKFHNWYGFG
EEEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCEEECCCCEEEEEEEECC
RVDVDAAVAMAKNYTSTFTAGLSGTSWIENTTRVAIPDYSATGVSNTVTVTDNLRIEGVR
EEEHHHHHHHHHCCCCEEECCCCCCCHHCCCEEEEECCCCCCCCCCEEEEECCEEEEEEE
IRLKVDHDRVGDLGVELTSPSGTKSMILNMRNSLLGQVDYDNEVFLSNAFFQERSNGTWT
EEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHCEECCCCCEEEEEEHHHHHCCCCEEE
IKVIDGGSTFNGDLVSWGLQIIGTP
EEEEECCCCCCCCCEEECEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1468618 [H]