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The map label for this gene is ilvD [H]

Identifier: 37681427

GI number: 37681427

Start: 3334083

End: 3335924

Strand: Direct

Name: ilvD [H]

Synonym: VV3243

Alternate gene names: 37681427

Gene position: 3334083-3335924 (Clockwise)

Preceding gene: 37681426

Following gene: 37681428

Centisome position: 99.39

GC content: 54.02

Gene sequence:

>1842_bases
ATGCCTAAATACAGATCAGCCACCACCACTCATGGTCGCAATATGGCCGGTGCGCGCGCACTATGGCGTGCTACGGGCGT
AAAAGATGAAGACTTCGGCAAACCGATTATTGCCGTGGTCAACTCCTTTACCCAGTTCGTACCGGGCCACGTGCACCTGA
AAGACCTTGGTCAATTGGTGGCGAGAGAAATTGAAGCAGCAGGCGGCATTGCCAAAGAATTCAACACCATCGCGGTGGAT
GATGGTATCGCCATGGGCCACGGAGGCATGCTTTATTCACTGCCTTCTCGTGAATTGATTGCCGACTCGGTGGAGTACAT
GGTCAACGCGCACTGTGCCGATGCCATGGTGTGTATCTCCAACTGTGACAAAATCACCCCGGGAATGCTGATGGCGTCAA
TGCGCCTTAATATCCCAGTAATCTTTGTCTCGGGTGGACCAATGGAAGCGGGCAAAACCAAGCTTTCGGATCAGATCATC
AAGCTGGATCTGGTCGATGCCATGATCCAAGGCGCGGATCCTAAAGTCTCGGATGAGCAGAGCGAACAGATCGAGCGCAG
TGCTTGCCCTACCTGTGGATCCTGCTCAGGCATGTTCACCGCCAACTCGATGAACTGTCTCACCGAAGCACTTGGCCTTT
CTCAGCCAGGTAACGGCTCTTTGCTCGCAACGCATGCCGATCGTAAACAACTGTTTATCAGTGCAGGCCAACGTATCGTC
GAACTGACCAAGCGTTACTACGAACAAGATGATGAAAGCGCACTGCCACGCAACATTGCGACCAAAGCCGCGTTTGAAAA
CGCCATGGCGCTAGACATCGCCATGGGCGGTTCAACCAACACCGTTTTACACCTCTTAGCTGCAGCGCAAGAAGGTGAGG
TGGATTTTGACATGACAGACATCGATCGCATGTCACGCATGGTGCCTCACCTATGTAAAGTGGCGCCATCAACCCAGAAA
TACCATATGGAAGATGTGCACCGCGCGGGTGGTGTGGTCGGTATTTTGGGCGAACTTAACCGCGCTGGCCTGCTGCACAA
TCAATCGAAAACGGTGCTTGGCCTCACTTGGGAAGAACAGCTTGCCCAATACGACATCATGCTGACCGATTCGGAAGAAG
TGAAACGCTTCTACCGTGCAGGCCCTGCGGGTATTCGTACCACTCAAGCATTCTCGCAAGATTGCCGCTGGGATACCTTG
GATGACGATCGCGCCCAAGGCTGTATTCGCACCAAAGAAAACGCCTTTAGCCAAGATGGTGGCCTCGCGGTCCTCAAAGG
CAATATTGCGCTGGATGGCTGTATTGTTAAGACGGCGGGTGTGGATGAAAGCATTCTAAAATTCACGGGCCCTGCAGTGG
TCTTTGAAAGCCAAGAAGACGCGGTGGAAGGTATCTTGGGTGGCAAAGTCAAAGCGGGCGATGTGGTGGTGATTCGCTAC
GAAGGCCCGAAAGGCGGCCCAGGCATGCAAGAGATGCTCTACCCTACCACGTATTTGAAATCGATGGGTCTAGGCAAAGC
GTGTGCGCTACTGACCGACGGACGTTTCTCTGGCGGCACGTCTGGTCTTTCCATCGGCCACGCCTCACCAGAAGCGGCCA
ACGGCGGCGCGATCGGTTTGGTCAAACAGGGCGACTTGATTGCCATCGACATTCCAAATCGCACGATTTCTCTGCAAGTT
TCCGAGCAAGAAATGGCAGAGCGCCGTGCGGAACAAGACGCGCTTGGCTGGAAACCCGTCTCTCGCCAACGCGAAGTGTC
GTTTGCGCTGAAAGCCTACGCCAGCATGGCAACCAGTGCCGATAAAGGCGCGGTAAGAGACAAGTCAAAGCTTGAGGGCT
AA

Upstream 100 bases:

>100_bases
GGTGCAAGAAGCGTACTTTGGTTTATTCAATGGCACCACCGAAGATAAGTGGGGCTGGTTAGATTACGTGTACCCAGAGA
AGAAGTAGGGAGACAACAGA

Downstream 100 bases:

>100_bases
GCAATGTCATTAACCCAACAAACTGGCGCAGACTACCTGCGCCAGATACTACGCGCTCCAGTGTATGAAGTGGCAACCGT
CACCCCTTTGCAAGAGATGC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MPKYRSATTTHGRNMAGARALWRATGVKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASMRLNIPVIFVSGGPMEAGKTKLSDQII
KLDLVDAMIQGADPKVSDEQSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFISAGQRIV
ELTKRYYEQDDESALPRNIATKAAFENAMALDIAMGGSTNTVLHLLAAAQEGEVDFDMTDIDRMSRMVPHLCKVAPSTQK
YHMEDVHRAGGVVGILGELNRAGLLHNQSKTVLGLTWEEQLAQYDIMLTDSEEVKRFYRAGPAGIRTTQAFSQDCRWDTL
DDDRAQGCIRTKENAFSQDGGLAVLKGNIALDGCIVKTAGVDESILKFTGPAVVFESQEDAVEGILGGKVKAGDVVVIRY
EGPKGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGLSIGHASPEAANGGAIGLVKQGDLIAIDIPNRTISLQV
SEQEMAERRAEQDALGWKPVSRQREVSFALKAYASMATSADKGAVRDKSKLEG

Sequences:

>Translated_613_residues
MPKYRSATTTHGRNMAGARALWRATGVKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGIAKEFNTIAVD
DGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASMRLNIPVIFVSGGPMEAGKTKLSDQII
KLDLVDAMIQGADPKVSDEQSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFISAGQRIV
ELTKRYYEQDDESALPRNIATKAAFENAMALDIAMGGSTNTVLHLLAAAQEGEVDFDMTDIDRMSRMVPHLCKVAPSTQK
YHMEDVHRAGGVVGILGELNRAGLLHNQSKTVLGLTWEEQLAQYDIMLTDSEEVKRFYRAGPAGIRTTQAFSQDCRWDTL
DDDRAQGCIRTKENAFSQDGGLAVLKGNIALDGCIVKTAGVDESILKFTGPAVVFESQEDAVEGILGGKVKAGDVVVIRY
EGPKGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGLSIGHASPEAANGGAIGLVKQGDLIAIDIPNRTISLQV
SEQEMAERRAEQDALGWKPVSRQREVSFALKAYASMATSADKGAVRDKSKLEG
>Mature_612_residues
PKYRSATTTHGRNMAGARALWRATGVKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEAAGGIAKEFNTIAVDD
GIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMASMRLNIPVIFVSGGPMEAGKTKLSDQIIK
LDLVDAMIQGADPKVSDEQSEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFISAGQRIVE
LTKRYYEQDDESALPRNIATKAAFENAMALDIAMGGSTNTVLHLLAAAQEGEVDFDMTDIDRMSRMVPHLCKVAPSTQKY
HMEDVHRAGGVVGILGELNRAGLLHNQSKTVLGLTWEEQLAQYDIMLTDSEEVKRFYRAGPAGIRTTQAFSQDCRWDTLD
DDRAQGCIRTKENAFSQDGGLAVLKGNIALDGCIVKTAGVDESILKFTGPAVVFESQEDAVEGILGGKVKAGDVVVIRYE
GPKGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGLSIGHASPEAANGGAIGLVKQGDLIAIDIPNRTISLQVS
EQEMAERRAEQDALGWKPVSRQREVSFALKAYASMATSADKGAVRDKSKLEG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=616, Percent_Identity=85.2272727272727, Blast_Score=1098, Evalue=0.0,
Organism=Escherichia coli, GI1788157, Length=574, Percent_Identity=28.5714285714286, Blast_Score=184, Evalue=2e-47,
Organism=Escherichia coli, GI2367371, Length=546, Percent_Identity=28.9377289377289, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI1786464, Length=529, Percent_Identity=30.2457466918715, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6322476, Length=612, Percent_Identity=37.9084967320261, Blast_Score=346, Evalue=7e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65607; Mature: 65475

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKYRSATTTHGRNMAGARALWRATGVKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASMRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPKVSDEQ
CCCCCCHHHHHHHEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHH
SEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFISAGQRIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHH
ELTKRYYEQDDESALPRNIATKAAFENAMALDIAMGGSTNTVLHLLAAAQEGEVDFDMTD
HHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHH
IDRMSRMVPHLCKVAPSTQKYHMEDVHRAGGVVGILGELNRAGLLHNQSKTVLGLTWEEQ
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCEECCCCEEEEEEHHHH
LAQYDIMLTDSEEVKRFYRAGPAGIRTTQAFSQDCRWDTLDDDRAQGCIRTKENAFSQDG
HHHEEEEEECHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHCCCHHCHHHCCCCCC
GLAVLKGNIALDGCIVKTAGVDESILKFTGPAVVFESQEDAVEGILGGKVKAGDVVVIRY
CEEEEECCEEEEEEEEEECCCCHHHHHHCCCEEEEECCHHHHHHHHCCCEECCCEEEEEE
EGPKGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGLSIGHASPEAANGGAIGL
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEE
VKQGDLIAIDIPNRTISLQVSEQEMAERRAEQDALGWKPVSRQREVSFALKAYASMATSA
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCC
DKGAVRDKSKLEG
CCCCCCCHHHCCC
>Mature Secondary Structure 
PKYRSATTTHGRNMAGARALWRATGVKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEAAGGIAKEFNTIAVDDGIAMGHGGMLYSLPSRELIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMASMRLNIPVIFVSGGPMEAGKTKLSDQIIKLDLVDAMIQGADPKVSDEQ
CCCCCCHHHHHHHEECCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHH
SEQIERSACPTCGSCSGMFTANSMNCLTEALGLSQPGNGSLLATHADRKQLFISAGQRIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHH
ELTKRYYEQDDESALPRNIATKAAFENAMALDIAMGGSTNTVLHLLAAAQEGEVDFDMTD
HHHHHHHCCCCCCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHH
IDRMSRMVPHLCKVAPSTQKYHMEDVHRAGGVVGILGELNRAGLLHNQSKTVLGLTWEEQ
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCEECCCCEEEEEEHHHH
LAQYDIMLTDSEEVKRFYRAGPAGIRTTQAFSQDCRWDTLDDDRAQGCIRTKENAFSQDG
HHHEEEEEECHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCHHHCCCHHCHHHCCCCCC
GLAVLKGNIALDGCIVKTAGVDESILKFTGPAVVFESQEDAVEGILGGKVKAGDVVVIRY
CEEEEECCEEEEEEEEEECCCCHHHHHHCCCEEEEECCHHHHHHHHCCCEECCCEEEEEE
EGPKGGPGMQEMLYPTTYLKSMGLGKACALLTDGRFSGGTSGLSIGHASPEAANGGAIGL
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEE
VKQGDLIAIDIPNRTISLQVSEQEMAERRAEQDALGWKPVSRQREVSFALKAYASMATSA
EECCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCC
DKGAVRDKSKLEG
CCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]