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The map label for this gene is fmt

Identifier: 37681410

GI number: 37681410

Start: 3316013

End: 3316960

Strand: Direct

Name: fmt

Synonym: VV3226

Alternate gene names: 37681410

Gene position: 3316013-3316960 (Clockwise)

Preceding gene: 37681409

Following gene: 37681411

Centisome position: 98.85

GC content: 51.58

Gene sequence:

>948_bases
TTGAGCAAGCCTTTACGTATTGTATTTGCAGGTACTCCGGACTTCGCCGCCCAACATTTGGCGGCGTTGTTGTCTTCGGA
GCATGAAGTCATTGCAGTTTACACCCAACCTGATCGCCCAGCCGGTCGCGGGAAAAAACTCACGGCAAGCCCTGTCAAAA
CCATTGCTTTGGAACACAACATTCCGGTTTATCAACCAGAAAACTTTAAGTCTGACGAAGCCAAGCAAGCCCTCGCGGAT
CTCAATGCTGACATCATGGTCGTGGTCGCTTATGGCTTGTTATTACCACAAGCGGTGTTAGATACACCGAAATTGGGTTG
TATCAATGTCCACGGCTCGATTCTGCCTCGCTGGCGTGGCGCAGCACCGATTCAGCGCTCTATTTGGGCGGGTGATGCTG
AAACGGGCGTGACCATCATGCAAATGGACATCGGCCTAGATACCGGCGACATGCTGAAAATTGCCACGCTGCCGATCGAC
GCAAGCGATACCAGCGCCACCATGTACGATAAATTGGCCAAACTTGGCCCTGTGGCACTGGTTGAGTGTTTGGCAGATAT
CGCCGCTGGCACAGCCATCGCAATTAAGCAAGATGACGAGCGAGCAAACTACGCCAAGAAACTCAGCAAGGAAGAAGCAC
GCATCAATTGGCAAGACGATGCAGAACACATCGAACGTTGTGTTCGTGCTTTCAATCCATGGCCAATGAGCCATTTCGAA
GTGGCAGAAAACAGCATTAAAGTGTGGCAAAGCCGCGTCGAAGCCAGCAGTCATGACGCACCCGCGGGGACCATCCTCAA
AGCGGATAAAAGCGGCATTTATATCGCCACTGGCCATGGCTGCCTAGTATTGGAGCAGATCCAAATTCCAGGCAAAAAAG
CGATGCCAGTACAAGATGTTCTCAACGCTCGCGCCGCTTGGTTTGAAGTTGGCAGTGTACTGAGTTAA

Upstream 100 bases:

>100_bases
CCGCTAAAGCGCAAGCGTATCCAAGACAAGCTAGCCAAAATCAAACGCTTTAACGAGAAACAGCGCTAAATCGCGCTGAT
ACCATAAGAAGGAAGGTACC

Downstream 100 bases:

>100_bases
CCTGCCAAGCAATCGGGCATTTTTGCCCAGTTTAAGAACTTTACGAGGGCAGAGACGCCCTCTTTAACTTTAAGGTACTC
ATCATGAATGTTCGCGCTGC

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSKPLRIVFAGTPDFAAQHLAALLSSEHEVIAVYTQPDRPAGRGKKLTASPVKTIALEHNIPVYQPENFKSDEAKQALAD
LNADIMVVVAYGLLLPQAVLDTPKLGCINVHGSILPRWRGAAPIQRSIWAGDAETGVTIMQMDIGLDTGDMLKIATLPID
ASDTSATMYDKLAKLGPVALVECLADIAAGTAIAIKQDDERANYAKKLSKEEARINWQDDAEHIERCVRAFNPWPMSHFE
VAENSIKVWQSRVEASSHDAPAGTILKADKSGIYIATGHGCLVLEQIQIPGKKAMPVQDVLNARAAWFEVGSVLS

Sequences:

>Translated_315_residues
MSKPLRIVFAGTPDFAAQHLAALLSSEHEVIAVYTQPDRPAGRGKKLTASPVKTIALEHNIPVYQPENFKSDEAKQALAD
LNADIMVVVAYGLLLPQAVLDTPKLGCINVHGSILPRWRGAAPIQRSIWAGDAETGVTIMQMDIGLDTGDMLKIATLPID
ASDTSATMYDKLAKLGPVALVECLADIAAGTAIAIKQDDERANYAKKLSKEEARINWQDDAEHIERCVRAFNPWPMSHFE
VAENSIKVWQSRVEASSHDAPAGTILKADKSGIYIATGHGCLVLEQIQIPGKKAMPVQDVLNARAAWFEVGSVLS
>Mature_314_residues
SKPLRIVFAGTPDFAAQHLAALLSSEHEVIAVYTQPDRPAGRGKKLTASPVKTIALEHNIPVYQPENFKSDEAKQALADL
NADIMVVVAYGLLLPQAVLDTPKLGCINVHGSILPRWRGAAPIQRSIWAGDAETGVTIMQMDIGLDTGDMLKIATLPIDA
SDTSATMYDKLAKLGPVALVECLADIAAGTAIAIKQDDERANYAKKLSKEEARINWQDDAEHIERCVRAFNPWPMSHFEV
AENSIKVWQSRVEASSHDAPAGTILKADKSGIYIATGHGCLVLEQIQIPGKKAMPVQDVLNARAAWFEVGSVLS

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI164663775, Length=255, Percent_Identity=34.5098039215686, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI21614513, Length=261, Percent_Identity=29.8850574712644, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI238814322, Length=283, Percent_Identity=28.9752650176678, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1789683, Length=314, Percent_Identity=62.1019108280255, Blast_Score=406, Evalue=1e-115,
Organism=Escherichia coli, GI1788589, Length=277, Percent_Identity=29.6028880866426, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI133930964, Length=317, Percent_Identity=25.2365930599369, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45550868, Length=305, Percent_Identity=28.5245901639344, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28571984, Length=225, Percent_Identity=30.2222222222222, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24585660, Length=243, Percent_Identity=32.5102880658436, Blast_Score=95, Evalue=5e-20,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 34065; Mature: 33934

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPLRIVFAGTPDFAAQHLAALLSSEHEVIAVYTQPDRPAGRGKKLTASPVKTIALEHN
CCCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCEEEEEECC
IPVYQPENFKSDEAKQALADLNADIMVVVAYGLLLPQAVLDTPKLGCINVHGSILPRWRG
CCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCC
AAPIQRSIWAGDAETGVTIMQMDIGLDTGDMLKIATLPIDASDTSATMYDKLAKLGPVAL
CCCHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCHHHH
VECLADIAAGTAIAIKQDDERANYAKKLSKEEARINWQDDAEHIERCVRAFNPWPMSHFE
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHH
VAENSIKVWQSRVEASSHDAPAGTILKADKSGIYIATGHGCLVLEQIQIPGKKAMPVQDV
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCEEEEEEECCCCCCCCCHHHH
LNARAAWFEVGSVLS
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKPLRIVFAGTPDFAAQHLAALLSSEHEVIAVYTQPDRPAGRGKKLTASPVKTIALEHN
CCCEEEEEECCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCEEEEEECC
IPVYQPENFKSDEAKQALADLNADIMVVVAYGLLLPQAVLDTPKLGCINVHGSILPRWRG
CCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCC
AAPIQRSIWAGDAETGVTIMQMDIGLDTGDMLKIATLPIDASDTSATMYDKLAKLGPVAL
CCCHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCHHHH
VECLADIAAGTAIAIKQDDERANYAKKLSKEEARINWQDDAEHIERCVRAFNPWPMSHFE
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHH
VAENSIKVWQSRVEASSHDAPAGTILKADKSGIYIATGHGCLVLEQIQIPGKKAMPVQDV
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEECCCEEEEEEECCCCCCCCCHHHH
LNARAAWFEVGSVLS
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA