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The map label for this gene is pepA [H]

Identifier: 37681091

GI number: 37681091

Start: 2966834

End: 2968342

Strand: Direct

Name: pepA [H]

Synonym: VV2907

Alternate gene names: 37681091

Gene position: 2966834-2968342 (Clockwise)

Preceding gene: 37681087

Following gene: 37681093

Centisome position: 88.44

GC content: 48.71

Gene sequence:

>1509_bases
ATGGAGTTCAGTGTAAAAAGTGGCAGTCCAGAGAAACAACGTAGCGCATGTATCGTTGTTGGTGTGTTTGAACCACGTCG
CCTTTCTCCAGTAGCCGAACAGCTCGATAAAATCAGTGACGGTTACATCAGTTCACTACTTCGCCGTGGTGATCTAGAAG
GTAAACCAGGTCAGATGCTACTGCTGCATCAAGTTCCAGGTGTGCTTTCTGAACGTGTTCTTTTGGTTGGTTGCGGTAAA
GAGCGTGAGCTTGGTGAGCGCCAATATAAAGAGATCATTCAGAAAACCATCAATACACTTAACGAAACAGGCTCTATGGA
AGCGGTGTGCTTCCTAACTGAACTGCACGTTAAAGGCCGTGACACGTACTGGAAAGTGCGCCAAGCGGTTGAAGCAACGA
AAGATGGCCTGTATACCTTTGATCAATTCAAGAGCGTGAAGCCAGAAACACGTCGCCCACTACGTAAGCTTGTCTTCAAC
GTACCAACACGTCGTGAACTGAACCTTGGCGAGAAAGCCATCACTCACGGTTTGGCGATTGCTTCAGGTGTGAAAGCCTG
TAAAGACCTTGGCAACATGCCACCAAACATCGCAAACCCAGCTTACCTCGCCTCTCAAGCGCGTCGTCTGGCAGATGACT
ACGAAACCATCACCACCAAAATCATCGGTGAGCAAGAGATGGAAAAACTGGGTATGTCTTCTTACCTAGCGGTCGGTCGC
GGTTCAAAAAATGAATCGATGATGTCTATCATCGAATACAAAGGCCATCCAGATTCAGAAGCCAAACCGATTGTTCTTGT
CGGTAAAGGTCTAACATTCGATTCAGGCGGTATTTCACTGAAACCAGGCGAAGGCATGGATGAAATGAAATACGACATGT
GTGGTGCAGCCTCCGTATTCGGCACGATGAAAGCGCTGGCAAAACTGAACCTACCAGTCAACGTGATTGGCGTACTTGCT
GGTTGTGAAAACATGCCAGGCAGCAACGCTTACCGTCCAGGTGATATCCTAACGACTATGTCAGGTCAAACCGTAGAAGT
ACTCAATACCGATGCAGAAGGTCGTTTGGTACTGTGTGATGCACTGACTTACGTTGAGCGTTTTGAACCAGACTGCGTGG
TTGACGTTGCGACGCTCACTGGCGCTTGTGTTATTGCACTGGGTCACCACATTACTGGTGTTCTGTCTAACCACAACCCT
CTTGCTCATGAGCTCGTCAATGCTTCTGAACAATCTAGCGATCGTGCTTGGCGCCTACCAATGGCGGATGAATACCATGA
ACAGCTAAAGAGCCCATTTGCCGACATGGCAAACATTGGCGGCCGTCCTGGTGGTACCATCACAGCAGCATGCTTCTTGT
CTAAATTTGCTAAGAAATACAACTGGGCACACCTAGACATCGCAGGCACAGCATGGAAGTCTGGCGCAGCCAAAGGGTCG
ACAGGTCGTCCTGTCTCTATGCTGGTCCAATTCCTGCTAAATCGCAGTGGCCAAGAGACTGAAGAATAA

Upstream 100 bases:

>100_bases
TAATCTGTAACTTACAGAGTAGACCGAGAATAGAATTCAACAAGTAAGCGGTCATTATCTAACATTTAGAACTATTTGTC
TTCAGGATGTAGGAGTACGC

Downstream 100 bases:

>100_bases
TTCAAGTCAATGTAAAAAGGGCCGCAAGGCCCTTTTTTTCATCGCCAGAGAGACGAACAAGCTATGCAAAGAGCCACGTT
TTACATTGTCCGAGAACACA

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPVAEQLDKISDGYISSLLRRGDLEGKPGQMLLLHQVPGVLSERVLLVGCGK
ERELGERQYKEIIQKTINTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVEATKDGLYTFDQFKSVKPETRRPLRKLVFN
VPTRRELNLGEKAITHGLAIASGVKACKDLGNMPPNIANPAYLASQARRLADDYETITTKIIGEQEMEKLGMSSYLAVGR
GSKNESMMSIIEYKGHPDSEAKPIVLVGKGLTFDSGGISLKPGEGMDEMKYDMCGAASVFGTMKALAKLNLPVNVIGVLA
GCENMPGSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERFEPDCVVDVATLTGACVIALGHHITGVLSNHNP
LAHELVNASEQSSDRAWRLPMADEYHEQLKSPFADMANIGGRPGGTITAACFLSKFAKKYNWAHLDIAGTAWKSGAAKGS
TGRPVSMLVQFLLNRSGQETEE

Sequences:

>Translated_502_residues
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPVAEQLDKISDGYISSLLRRGDLEGKPGQMLLLHQVPGVLSERVLLVGCGK
ERELGERQYKEIIQKTINTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVEATKDGLYTFDQFKSVKPETRRPLRKLVFN
VPTRRELNLGEKAITHGLAIASGVKACKDLGNMPPNIANPAYLASQARRLADDYETITTKIIGEQEMEKLGMSSYLAVGR
GSKNESMMSIIEYKGHPDSEAKPIVLVGKGLTFDSGGISLKPGEGMDEMKYDMCGAASVFGTMKALAKLNLPVNVIGVLA
GCENMPGSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERFEPDCVVDVATLTGACVIALGHHITGVLSNHNP
LAHELVNASEQSSDRAWRLPMADEYHEQLKSPFADMANIGGRPGGTITAACFLSKFAKKYNWAHLDIAGTAWKSGAAKGS
TGRPVSMLVQFLLNRSGQETEE
>Mature_502_residues
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPVAEQLDKISDGYISSLLRRGDLEGKPGQMLLLHQVPGVLSERVLLVGCGK
ERELGERQYKEIIQKTINTLNETGSMEAVCFLTELHVKGRDTYWKVRQAVEATKDGLYTFDQFKSVKPETRRPLRKLVFN
VPTRRELNLGEKAITHGLAIASGVKACKDLGNMPPNIANPAYLASQARRLADDYETITTKIIGEQEMEKLGMSSYLAVGR
GSKNESMMSIIEYKGHPDSEAKPIVLVGKGLTFDSGGISLKPGEGMDEMKYDMCGAASVFGTMKALAKLNLPVNVIGVLA
GCENMPGSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERFEPDCVVDVATLTGACVIALGHHITGVLSNHNP
LAHELVNASEQSSDRAWRLPMADEYHEQLKSPFADMANIGGRPGGTITAACFLSKFAKKYNWAHLDIAGTAWKSGAAKGS
TGRPVSMLVQFLLNRSGQETEE

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=377, Percent_Identity=39.2572944297082, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI47155554, Length=324, Percent_Identity=32.7160493827161, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI1790710, Length=503, Percent_Identity=79.9204771371769, Blast_Score=849, Evalue=0.0,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=37.1875, Blast_Score=185, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI17556903, Length=324, Percent_Identity=31.7901234567901, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17565172, Length=214, Percent_Identity=30.8411214953271, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355725, Length=518, Percent_Identity=29.9227799227799, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI24661038, Length=332, Percent_Identity=35.2409638554217, Blast_Score=198, Evalue=9e-51,
Organism=Drosophila melanogaster, GI20129969, Length=520, Percent_Identity=28.8461538461538, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24662227, Length=505, Percent_Identity=29.9009900990099, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI21355645, Length=494, Percent_Identity=28.7449392712551, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24662223, Length=494, Percent_Identity=28.7449392712551, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI161077148, Length=492, Percent_Identity=28.0487804878049, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI20130057, Length=492, Percent_Identity=28.0487804878049, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI19922386, Length=494, Percent_Identity=29.3522267206478, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI20129963, Length=504, Percent_Identity=28.7698412698413, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21357381, Length=308, Percent_Identity=32.4675324675325, Blast_Score=135, Evalue=8e-32,
Organism=Drosophila melanogaster, GI221379063, Length=308, Percent_Identity=32.4675324675325, Blast_Score=135, Evalue=9e-32,
Organism=Drosophila melanogaster, GI221379062, Length=308, Percent_Identity=32.4675324675325, Blast_Score=135, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24646701, Length=360, Percent_Identity=26.3888888888889, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24646703, Length=360, Percent_Identity=26.3888888888889, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI21358201, Length=360, Percent_Identity=26.3888888888889, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 54629; Mature: 54629

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPVAEQLDKISDGYISSLLRRGDLEGKPGQML
CCCCCCCCCCHHHCCCEEEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEE
LLHQVPGVLSERVLLVGCGKERELGERQYKEIIQKTINTLNETGSMEAVCFLTELHVKGR
EEECCCCHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCC
DTYWKVRQAVEATKDGLYTFDQFKSVKPETRRPLRKLVFNVPTRRELNLGEKAITHGLAI
CHHHHHHHHHHHHHCCCEEHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ASGVKACKDLGNMPPNIANPAYLASQARRLADDYETITTKIIGEQEMEKLGMSSYLAVGR
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHCC
GSKNESMMSIIEYKGHPDSEAKPIVLVGKGLTFDSGGISLKPGEGMDEMKYDMCGAASVF
CCCCHHHHHHHHHCCCCCCCCCCEEEEECCCEECCCCEEECCCCCHHHHHHHHHHHHHHH
GTMKALAKLNLPVNVIGVLAGCENMPGSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCD
HHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEH
ALTYVERFEPDCVVDVATLTGACVIALGHHITGVLSNHNPLAHELVNASEQSSDRAWRLP
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEECC
MADEYHEQLKSPFADMANIGGRPGGTITAACFLSKFAKKYNWAHLDIAGTAWKSGAAKGS
CCHHHHHHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
TGRPVSMLVQFLLNRSGQETEE
CCCCHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPVAEQLDKISDGYISSLLRRGDLEGKPGQML
CCCCCCCCCCHHHCCCEEEEECCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEE
LLHQVPGVLSERVLLVGCGKERELGERQYKEIIQKTINTLNETGSMEAVCFLTELHVKGR
EEECCCCHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHCCC
DTYWKVRQAVEATKDGLYTFDQFKSVKPETRRPLRKLVFNVPTRRELNLGEKAITHGLAI
CHHHHHHHHHHHHHCCCEEHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
ASGVKACKDLGNMPPNIANPAYLASQARRLADDYETITTKIIGEQEMEKLGMSSYLAVGR
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCHHHHHHCC
GSKNESMMSIIEYKGHPDSEAKPIVLVGKGLTFDSGGISLKPGEGMDEMKYDMCGAASVF
CCCCHHHHHHHHHCCCCCCCCCCEEEEECCCEECCCCEEECCCCCHHHHHHHHHHHHHHH
GTMKALAKLNLPVNVIGVLAGCENMPGSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCD
HHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEEEH
ALTYVERFEPDCVVDVATLTGACVIALGHHITGVLSNHNPLAHELVNASEQSSDRAWRLP
HHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEECC
MADEYHEQLKSPFADMANIGGRPGGTITAACFLSKFAKKYNWAHLDIAGTAWKSGAAKGS
CCHHHHHHHHCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCC
TGRPVSMLVQFLLNRSGQETEE
CCCCHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA