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The map label for this gene is holC [H]

Identifier: 37681093

GI number: 37681093

Start: 2968406

End: 2968855

Strand: Direct

Name: holC [H]

Synonym: VV2908

Alternate gene names: 37681093

Gene position: 2968406-2968855 (Clockwise)

Preceding gene: 37681091

Following gene: 37681094

Centisome position: 88.49

GC content: 46.44

Gene sequence:

>450_bases
ATGCAAAGAGCCACGTTTTACATTGTCCGAGAACACACCCCACAAGCAACGCCAGAAGGTTTTGCTCACTACGTAGTGTT
CCTTGCCCACCATTTTGCCAAGCAAGGGGCGAAGGTGTATCTCAATGGAGAAAGTAAACGTCACGCAGAGCAAATTGCAG
AGTACTTTTGGCAAGTTGAGCCCGCTCAGTTTGTTGCGCATAATTTGGTCGGTGAAGGTCCAAAATACGCCACCAACATT
GAGATAGGTCACGAAGGTGTCAAGCCAAGCTGGAACCGCCAACTGGTAATAAATTTGGCGAAAAATGAGACAACCTTTGC
GAACAAGTTTGCTGAGGTGGTAGACTTCGTCCCTTGCGAAGAAAAAGCTAAACAGCTCGCGCGAGAAAGGTATAAAATCT
ACCGTCAAGCAGGTTACCAACTGCAAACAATCGAAATTGAACACAACTAG

Upstream 100 bases:

>100_bases
CCTGCTAAATCGCAGTGGCCAAGAGACTGAAGAATAATTCAAGTCAATGTAAAAAGGGCCGCAAGGCCCTTTTTTTCATC
GCCAGAGAGACGAACAAGCT

Downstream 100 bases:

>100_bases
CGGTCAATCCTTATAGTTAAGCTCTCCCAATAGAGAGTTCACTTATAAAGATTGACCTAGATTAACTTAACCAGATTAAG
CTCCCATGGAAAAAACATAC

Product: DNA polymerase III subunit chi

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MQRATFYIVREHTPQATPEGFAHYVVFLAHHFAKQGAKVYLNGESKRHAEQIAEYFWQVEPAQFVAHNLVGEGPKYATNI
EIGHEGVKPSWNRQLVINLAKNETTFANKFAEVVDFVPCEEKAKQLARERYKIYRQAGYQLQTIEIEHN

Sequences:

>Translated_149_residues
MQRATFYIVREHTPQATPEGFAHYVVFLAHHFAKQGAKVYLNGESKRHAEQIAEYFWQVEPAQFVAHNLVGEGPKYATNI
EIGHEGVKPSWNRQLVINLAKNETTFANKFAEVVDFVPCEEKAKQLARERYKIYRQAGYQLQTIEIEHN
>Mature_149_residues
MQRATFYIVREHTPQATPEGFAHYVVFLAHHFAKQGAKVYLNGESKRHAEQIAEYFWQVEPAQFVAHNLVGEGPKYATNI
EIGHEGVKPSWNRQLVINLAKNETTFANKFAEVVDFVPCEEKAKQLARERYKIYRQAGYQLQTIEIEHN

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2927

COG function: function code L; DNA polymerase III, chi subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790709, Length=143, Percent_Identity=38.4615384615385, Blast_Score=103, Evalue=6e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007459 [H]

Pfam domain/function: PF04364 DNA_pol3_chi [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 17247; Mature: 17247

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRATFYIVREHTPQATPEGFAHYVVFLAHHFAKQGAKVYLNGESKRHAEQIAEYFWQVE
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCC
PAQFVAHNLVGEGPKYATNIEIGHEGVKPSWNRQLVINLAKNETTFANKFAEVVDFVPCE
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCH
EKAKQLARERYKIYRQAGYQLQTIEIEHN
HHHHHHHHHHHHHHHHCCCEEEEEEEECC
>Mature Secondary Structure
MQRATFYIVREHTPQATPEGFAHYVVFLAHHFAKQGAKVYLNGESKRHAEQIAEYFWQVE
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCC
PAQFVAHNLVGEGPKYATNIEIGHEGVKPSWNRQLVINLAKNETTFANKFAEVVDFVPCE
HHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCH
EKAKQLARERYKIYRQAGYQLQTIEIEHN
HHHHHHHHHHHHHHHHCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8389364; 8246893; 7610040; 9278503; 2670557; 8505305; 1575709 [H]