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The map label for this gene is serA [H]

Identifier: 37681036

GI number: 37681036

Start: 2908021

End: 2909250

Strand: Direct

Name: serA [H]

Synonym: VV2851

Alternate gene names: 37681036

Gene position: 2908021-2909250 (Clockwise)

Preceding gene: 37681034

Following gene: 37681039

Centisome position: 86.69

GC content: 46.5

Gene sequence:

>1230_bases
ATGGCCAAAGTTTCACTGGAAAAAGAGAAAATAAAAATCTTACTTCTTGAAGGCCTCCACCCTTCTTCGGTAGAAGTGCT
ACAAGCGGCAGGTTACACCAATATCGAGTACCACAAGGGTTCCTTGTCGGATGCGGATCTTCTAGAAGCGGTTAAAGATG
CGCACTTCATCGGTATTCGCTCTCGCACCAACTTAACCGAAGAAGTCATTAACGCAGCGCAAAAACTGGTTGCGATTGGT
TGCTTCTGTATTGGTACCAACCAAGTGGATCTAAATGCAGCGGCAAAACGTGGGATTCCCGTGTTTAATGCCCCATTCTC
TAACACGCGTAGCGTAGCGGAATTAGTCTTGGGTCAAATCCTGCTGTTACTTCGTGGTATTCCAGAAAAAAATGCCTTGG
CACACCGTGGTATTTGGAAAAAGAGTGCAGACAATTCTTACGAAGCTCGTGGTAAGCGTCTTGGTATTATTGGTTACGGC
CATATCGGTACTCAGCTCGGTATTATTGCTGAAAACTTGGGTATGCGTGTTTACTTCTACGATATCGAGAATAAGCTCTC
GCTAGGTAATGCAACTCAAATCCCAACCATGAGCGAATTGCTCAACAAATGTGATGTGATTTCTCTACACGTACCAGAAA
CGCCAGACACGAAAAACATGATGGGTGCAGAAGAGTTTGCTCGTATGAAGCCTGGTGCTATTTTCATCAACGCAGCTCGT
GGCACTGTGGTCGATATTGAAGCGCTATGCCATTCACTCGAATCAGGTCATATTGCTGGCGCAGCGATTGACGTTTTCCC
GGTTGAACCTGCAACCAACGCAGATCCTTTCGAGTCGCCATTGCAAAAATTCGACAACGTGATTCTTACTCCACACGTTG
GCGGCTCAACTCAAGAAGCACAAGAGAACATTGGTGTTGAAGTCGCAGGCAAATTAGCGAAGTATTCAGACAACGGCTCA
ACGCTGTCTAGCGTTAACTTCCCTGAAGTGTCACTGCCAGAACATCGCAGTTGTTCACGCTTGCTGCACATTCACCAAAA
CCGCCCGGGCATTCTGACGCAAATCAACACCATTTTTGCTGAAGAAGGCATCAACATCGCCGGTCAATACCTGCAGACCT
CAGCTGATATTGGTTATGTGGTGATTGACGTAGAAACCGAGCGCTCTGAAGAAGCACTGGTCAAACTTAAAGAGATCGAA
GGCACAATTCGAGCTCGAATCCTTCACTAA

Upstream 100 bases:

>100_bases
AACGTTTGTCCTCCGCCAAAACTGTTAATTTCACTGCTCTTAACGATTTTGTTTAACGTGCGCCAAATTAGCCCACCTTT
CCATTTTAAGGACGAAAACA

Downstream 100 bases:

>100_bases
TAAAAACAGCAAAGGGCAGGTTATCCTGCCCTTTATTTTATTCATCATTTTACTAAAACTTAATCAAGCTTATACGTCAC
GTCGACTTGATCACGAATGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MAKVSLEKEKIKILLLEGLHPSSVEVLQAAGYTNIEYHKGSLSDADLLEAVKDAHFIGIRSRTNLTEEVINAAQKLVAIG
CFCIGTNQVDLNAAAKRGIPVFNAPFSNTRSVAELVLGQILLLLRGIPEKNALAHRGIWKKSADNSYEARGKRLGIIGYG
HIGTQLGIIAENLGMRVYFYDIENKLSLGNATQIPTMSELLNKCDVISLHVPETPDTKNMMGAEEFARMKPGAIFINAAR
GTVVDIEALCHSLESGHIAGAAIDVFPVEPATNADPFESPLQKFDNVILTPHVGGSTQEAQENIGVEVAGKLAKYSDNGS
TLSSVNFPEVSLPEHRSCSRLLHIHQNRPGILTQINTIFAEEGINIAGQYLQTSADIGYVVIDVETERSEEALVKLKEIE
GTIRARILH

Sequences:

>Translated_409_residues
MAKVSLEKEKIKILLLEGLHPSSVEVLQAAGYTNIEYHKGSLSDADLLEAVKDAHFIGIRSRTNLTEEVINAAQKLVAIG
CFCIGTNQVDLNAAAKRGIPVFNAPFSNTRSVAELVLGQILLLLRGIPEKNALAHRGIWKKSADNSYEARGKRLGIIGYG
HIGTQLGIIAENLGMRVYFYDIENKLSLGNATQIPTMSELLNKCDVISLHVPETPDTKNMMGAEEFARMKPGAIFINAAR
GTVVDIEALCHSLESGHIAGAAIDVFPVEPATNADPFESPLQKFDNVILTPHVGGSTQEAQENIGVEVAGKLAKYSDNGS
TLSSVNFPEVSLPEHRSCSRLLHIHQNRPGILTQINTIFAEEGINIAGQYLQTSADIGYVVIDVETERSEEALVKLKEIE
GTIRARILH
>Mature_408_residues
AKVSLEKEKIKILLLEGLHPSSVEVLQAAGYTNIEYHKGSLSDADLLEAVKDAHFIGIRSRTNLTEEVINAAQKLVAIGC
FCIGTNQVDLNAAAKRGIPVFNAPFSNTRSVAELVLGQILLLLRGIPEKNALAHRGIWKKSADNSYEARGKRLGIIGYGH
IGTQLGIIAENLGMRVYFYDIENKLSLGNATQIPTMSELLNKCDVISLHVPETPDTKNMMGAEEFARMKPGAIFINAARG
TVVDIEALCHSLESGHIAGAAIDVFPVEPATNADPFESPLQKFDNVILTPHVGGSTQEAQENIGVEVAGKLAKYSDNGST
LSSVNFPEVSLPEHRSCSRLLHIHQNRPGILTQINTIFAEEGINIAGQYLQTSADIGYVVIDVETERSEEALVKLKEIEG
TIRARILH

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=37.2239747634069, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI145580578, Length=253, Percent_Identity=30.8300395256917, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4557499, Length=253, Percent_Identity=30.8300395256917, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI61743967, Length=260, Percent_Identity=29.6153846153846, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI4557497, Length=260, Percent_Identity=29.6153846153846, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI145580575, Length=254, Percent_Identity=30.7086614173228, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI6912396, Length=274, Percent_Identity=28.1021897810219, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1789279, Length=411, Percent_Identity=74.2092457420924, Blast_Score=630, Evalue=0.0,
Organism=Escherichia coli, GI87082289, Length=251, Percent_Identity=31.4741035856574, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1787645, Length=251, Percent_Identity=29.8804780876494, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788660, Length=267, Percent_Identity=26.5917602996255, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87081824, Length=192, Percent_Identity=26.0416666666667, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=323, Percent_Identity=32.1981424148607, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=251, Percent_Identity=27.8884462151394, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=47.1014492753623, Blast_Score=394, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=46.8599033816425, Blast_Score=389, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6324964, Length=257, Percent_Identity=28.0155642023346, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=236, Percent_Identity=27.5423728813559, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324980, Length=194, Percent_Identity=24.7422680412371, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321253, Length=162, Percent_Identity=25.9259259259259, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=34.21926910299, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI28571528, Length=293, Percent_Identity=29.3515358361775, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28574286, Length=265, Percent_Identity=29.0566037735849, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646446, Length=258, Percent_Identity=31.0077519379845, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646448, Length=258, Percent_Identity=31.0077519379845, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646452, Length=258, Percent_Identity=31.0077519379845, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24646450, Length=258, Percent_Identity=31.0077519379845, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI62472511, Length=258, Percent_Identity=31.0077519379845, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24585514, Length=276, Percent_Identity=25.7246376811594, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28574282, Length=276, Percent_Identity=25.7246376811594, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI28574284, Length=279, Percent_Identity=25.4480286738351, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI45551003, Length=279, Percent_Identity=25.4480286738351, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45552429, Length=279, Percent_Identity=25.4480286738351, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24585516, Length=303, Percent_Identity=25.0825082508251, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44389; Mature: 44258

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVSLEKEKIKILLLEGLHPSSVEVLQAAGYTNIEYHKGSLSDADLLEAVKDAHFIGIR
CCCCCCCCCEEEEEEEECCCCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHEEEEC
SRTNLTEEVINAAQKLVAIGCFCIGTNQVDLNAAAKRGIPVFNAPFSNTRSVAELVLGQI
CCCCHHHHHHHHHHHHHHHEEEEEECCEEECCHHHHCCCCEEECCCCCHHHHHHHHHHHH
LLLLRGIPEKNALAHRGIWKKSADNSYEARGKRLGIIGYGHIGTQLGIIAENLGMRVYFY
HHHHCCCCCCCCHHHCCCCCCCCCCCHHCCCCEEEEEEECCHHHHHHHHHHCCCCEEEEE
DIENKLSLGNATQIPTMSELLNKCDVISLHVPETPDTKNMMGAEEFARMKPGAIFINAAR
ECCCCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHCCCCEEEEECCC
GTVVDIEALCHSLESGHIAGAAIDVFPVEPATNADPFESPLQKFDNVILTPHVGGSTQEA
CCEEEHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHCCEEEECCCCCCHHHH
QENIGVEVAGKLAKYSDNGSTLSSVNFPEVSLPEHRSCSRLLHIHQNRPGILTQINTIFA
HHHCCEEEECHHHEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHH
EEGINIAGQYLQTSADIGYVVIDVETERSEEALVKLKEIEGTIRARILH
HCCCCHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEEEECC
>Mature Secondary Structure 
AKVSLEKEKIKILLLEGLHPSSVEVLQAAGYTNIEYHKGSLSDADLLEAVKDAHFIGIR
CCCCCCCCEEEEEEEECCCCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHEEEEC
SRTNLTEEVINAAQKLVAIGCFCIGTNQVDLNAAAKRGIPVFNAPFSNTRSVAELVLGQI
CCCCHHHHHHHHHHHHHHHEEEEEECCEEECCHHHHCCCCEEECCCCCHHHHHHHHHHHH
LLLLRGIPEKNALAHRGIWKKSADNSYEARGKRLGIIGYGHIGTQLGIIAENLGMRVYFY
HHHHCCCCCCCCHHHCCCCCCCCCCCHHCCCCEEEEEEECCHHHHHHHHHHCCCCEEEEE
DIENKLSLGNATQIPTMSELLNKCDVISLHVPETPDTKNMMGAEEFARMKPGAIFINAAR
ECCCCCCCCCCCCCCCHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHCCCCEEEEECCC
GTVVDIEALCHSLESGHIAGAAIDVFPVEPATNADPFESPLQKFDNVILTPHVGGSTQEA
CCEEEHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHCCEEEECCCCCCHHHH
QENIGVEVAGKLAKYSDNGSTLSSVNFPEVSLPEHRSCSRLLHIHQNRPGILTQINTIFA
HHHCCEEEECHHHEECCCCCEEEECCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHH
EEGINIAGQYLQTSADIGYVVIDVETERSEEALVKLKEIEGTIRARILH
HCCCCHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]