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The map label for this gene is nadC [H]

Identifier: 37680961

GI number: 37680961

Start: 2832463

End: 2833386

Strand: Direct

Name: nadC [H]

Synonym: VV2777

Alternate gene names: 37680961

Gene position: 2832463-2833386 (Clockwise)

Preceding gene: 37680954

Following gene: 37680962

Centisome position: 84.44

GC content: 50.54

Gene sequence:

>924_bases
ATGCGTTGCAATTCCCCTTTCAAGATAAGATTTGCGATGAAGAACACACATAACAGCCAAGAACGCCTTGATTATTTGAA
GCAACAACTCCCTATCGAAATCACCCGAGCGGTTGCCGATACGCTGAAAGAAGACTTGGGTGGTACGCTAAACGCTGACA
ATGATGTGACGGCCGCGCTTATCCCAGCAGAGGCTATGAATACAGCGACCATCATCACTCGCGAACACGGCGTATTTTGC
GGCCAAGCATGGGCAGATGAAGTGTTCAAACAGCTCGGCGGCAAAGTGACCATTGAGTGGCACGTGAAAGATGGCGACAA
AGTCGAACCGAACCAAACGCTTTGCACACTCACTGGCCCTGCCCGTGATTTGCTGACGGGTGAGCGCAACGCGATGAACT
TTATTCAAACCCTTTCTGGTTGCGCGACCATCACCGCACAATACGCAGCAAAAATTGCGCATACCGAGTGTCGCTTATTA
GATACGCGCAAAACCATCCCTGGCCTACGCAGCGCCTTAAAATACGCAGTGGCCTGTGGCGGCGGCTACAACCACCGAAT
TGGCGTGTTTGACGCTTACCTGATTAAAGAAAACCACATCATTGCCTGCGGTGGCATCACTCAAGCAATCACCAAAGCAA
AAGAGCTGCAACCAGGAAAGCCCGTGGAAGTAGAAACCGAGAACCTCGATGAACTGCGTGAAGCCATTCACGCAGGTGCT
GATATCATTATGCTCGACAACTTCACCACCGAGATGATGCGCCAAGCGGTGGAAATTAACGCAGGCCGCGCAGCACTGGA
AAACTCAGGCAACGTGACATTAGAAACCATTGCAGAATATGCGGAAACAGGCGTGGATTACATTTCGGTTGGCGCCCTGA
CCAAGCATGTAAAAGCGATGGATTTATCGATGCGTTTCAAATAG

Upstream 100 bases:

>100_bases
CGCTTAACGCCCTCCAACCATCCTTGCGTGATCACAGCTTGCATATCATCTCCATGGGTTTGTCAATTAACTGCTGAAAT
TATTACCTACGCAGAGTATC

Downstream 100 bases:

>100_bases
ATACCGACCAGATCACAAAACGGGAGCCCCAGGCTCCCGTTTTTATTTGAGCTGCGAAATTTTGGGTCAGCATCGCATCT
TGTAAGTAACCAGATGTAAA

Product: quinolinate phosphoribosyltransferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MRCNSPFKIRFAMKNTHNSQERLDYLKQQLPIEITRAVADTLKEDLGGTLNADNDVTAALIPAEAMNTATIITREHGVFC
GQAWADEVFKQLGGKVTIEWHVKDGDKVEPNQTLCTLTGPARDLLTGERNAMNFIQTLSGCATITAQYAAKIAHTECRLL
DTRKTIPGLRSALKYAVACGGGYNHRIGVFDAYLIKENHIIACGGITQAITKAKELQPGKPVEVETENLDELREAIHAGA
DIIMLDNFTTEMMRQAVEINAGRAALENSGNVTLETIAEYAETGVDYISVGALTKHVKAMDLSMRFK

Sequences:

>Translated_307_residues
MRCNSPFKIRFAMKNTHNSQERLDYLKQQLPIEITRAVADTLKEDLGGTLNADNDVTAALIPAEAMNTATIITREHGVFC
GQAWADEVFKQLGGKVTIEWHVKDGDKVEPNQTLCTLTGPARDLLTGERNAMNFIQTLSGCATITAQYAAKIAHTECRLL
DTRKTIPGLRSALKYAVACGGGYNHRIGVFDAYLIKENHIIACGGITQAITKAKELQPGKPVEVETENLDELREAIHAGA
DIIMLDNFTTEMMRQAVEINAGRAALENSGNVTLETIAEYAETGVDYISVGALTKHVKAMDLSMRFK
>Mature_307_residues
MRCNSPFKIRFAMKNTHNSQERLDYLKQQLPIEITRAVADTLKEDLGGTLNADNDVTAALIPAEAMNTATIITREHGVFC
GQAWADEVFKQLGGKVTIEWHVKDGDKVEPNQTLCTLTGPARDLLTGERNAMNFIQTLSGCATITAQYAAKIAHTECRLL
DTRKTIPGLRSALKYAVACGGGYNHRIGVFDAYLIKENHIIACGGITQAITKAKELQPGKPVEVETENLDELREAIHAGA
DIIMLDNFTTEMMRQAVEINAGRAALENSGNVTLETIAEYAETGVDYISVGALTKHVKAMDLSMRFK

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=285, Percent_Identity=32.6315789473684, Blast_Score=142, Evalue=4e-34,
Organism=Escherichia coli, GI1786299, Length=292, Percent_Identity=61.6438356164384, Blast_Score=345, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6321162, Length=257, Percent_Identity=32.6848249027237, Blast_Score=133, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 33626; Mature: 33626

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCNSPFKIRFAMKNTHNSQERLDYLKQQLPIEITRAVADTLKEDLGGTLNADNDVTAAL
CCCCCCEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
IPAEAMNTATIITREHGVFCGQAWADEVFKQLGGKVTIEWHVKDGDKVEPNQTLCTLTGP
ECHHHCCCEEEEEECCCCEECHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCEEEEECCC
ARDLLTGERNAMNFIQTLSGCATITAQYAAKIAHTECRLLDTRKTIPGLRSALKYAVACG
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
GGYNHRIGVFDAYLIKENHIIACGGITQAITKAKELQPGKPVEVETENLDELREAIHAGA
CCCCCCEEEEEEEEEECCCEEEECCHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHCCC
DIIMLDNFTTEMMRQAVEINAGRAALENSGNVTLETIAEYAETGVDYISVGALTKHVKAM
CEEEECCHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHH
DLSMRFK
CEEECCC
>Mature Secondary Structure
MRCNSPFKIRFAMKNTHNSQERLDYLKQQLPIEITRAVADTLKEDLGGTLNADNDVTAAL
CCCCCCEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEE
IPAEAMNTATIITREHGVFCGQAWADEVFKQLGGKVTIEWHVKDGDKVEPNQTLCTLTGP
ECHHHCCCEEEEEECCCCEECHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCEEEEECCC
ARDLLTGERNAMNFIQTLSGCATITAQYAAKIAHTECRLLDTRKTIPGLRSALKYAVACG
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
GGYNHRIGVFDAYLIKENHIIACGGITQAITKAKELQPGKPVEVETENLDELREAIHAGA
CCCCCCEEEEEEEEEECCCEEEECCHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHCCC
DIIMLDNFTTEMMRQAVEINAGRAALENSGNVTLETIAEYAETGVDYISVGALTKHVKAM
CEEEECCHHHHHHHHHHHCCCCHHHHCCCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHH
DLSMRFK
CEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8419294; 11677609; 9016724 [H]