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The map label for this gene is panB

Identifier: 37680947

GI number: 37680947

Start: 2816344

End: 2817138

Strand: Direct

Name: panB

Synonym: VV2763

Alternate gene names: 37680947

Gene position: 2816344-2817138 (Clockwise)

Preceding gene: 37680946

Following gene: 37680948

Centisome position: 83.96

GC content: 48.3

Gene sequence:

>795_bases
ATGAAAAAAATCACCATTAATGACCTGATTAAGTGGAAGCAGGAAGGTCGTAAATTTGCGACTTCAACAGCATACGATGC
AAGTTTTGCGCAACTTTTTGAGAGCCAAGAAATGCCAGTGTTACTGGTCGGCGACTCTCTTGGTATGGTGTTGCAAGGCA
AAAATGACACGCTTCCAGTGACTGTTGAAGACATTGCTTACCACACACGCTGTGTTCGTGCGGGTAGCCCAAATTGCCTA
TTGATGGCGGATATGCCATTTATGAGTTACGCCACACCAGAGCAAGCCTGTGAAAACGCGGCGCAATTAATGCGAGCGGG
CGCCAACATGGTCAAAATCGAAGGTGGCGATTGGCTGGTTGATACGGTAAAAATGCTCACAGAGCGTGCGGTTCCAGTGT
GTGCCCACCTCGGTTTAACACCACAATCCGTTAATATTTTTGGTGGTTACAAAGTGCAAGGCCGCGATCAGGAAAAAGCC
GATCGCATGGTCAAAGATGCACTGGCGTTGCAAGCGGCAGGCGCACAAATCGTTCTACTTGAGTGTGTACCTGCTGAGCT
AGCAGCACGAATTACTCAAGTGCTGGATGTACCCGTGATTGGTATTGGCGCTGGAAATGTCACCGATGGCCAAATCCTCG
TGATGCACGATATGTTTGGTATTTCAGCCAATTACATGCCAAAATTCTCGAAAAATTTCCTGGCAGAAACAGGAGATATG
CGCAAAGCCGTGGCGCTGTACATGGAACAAGTACAAGCAGGCACCTTCCCTGATGAAGCGCACACCATTGCTTAG

Upstream 100 bases:

>100_bases
CCCTCCCTGATGGGACCGAGCTATCTCAACTTCTCACAATAGTGGATAAGAATGGCCTCGGCATTTGGCATTCATAGCCA
AATCCTGGTAAGGAAAAATC

Downstream 100 bases:

>100_bases
AGGATAATGTAGATGCAAACCTTTGCCGAAATTTCAGCCCTTCGTGAACAGATCAAAACGTTCAAACGCGAAGGACGTCG
AATTGCTTTTGTTCCAACCA

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MKKITINDLIKWKQEGRKFATSTAYDASFAQLFESQEMPVLLVGDSLGMVLQGKNDTLPVTVEDIAYHTRCVRAGSPNCL
LMADMPFMSYATPEQACENAAQLMRAGANMVKIEGGDWLVDTVKMLTERAVPVCAHLGLTPQSVNIFGGYKVQGRDQEKA
DRMVKDALALQAAGAQIVLLECVPAELAARITQVLDVPVIGIGAGNVTDGQILVMHDMFGISANYMPKFSKNFLAETGDM
RKAVALYMEQVQAGTFPDEAHTIA

Sequences:

>Translated_264_residues
MKKITINDLIKWKQEGRKFATSTAYDASFAQLFESQEMPVLLVGDSLGMVLQGKNDTLPVTVEDIAYHTRCVRAGSPNCL
LMADMPFMSYATPEQACENAAQLMRAGANMVKIEGGDWLVDTVKMLTERAVPVCAHLGLTPQSVNIFGGYKVQGRDQEKA
DRMVKDALALQAAGAQIVLLECVPAELAARITQVLDVPVIGIGAGNVTDGQILVMHDMFGISANYMPKFSKNFLAETGDM
RKAVALYMEQVQAGTFPDEAHTIA
>Mature_264_residues
MKKITINDLIKWKQEGRKFATSTAYDASFAQLFESQEMPVLLVGDSLGMVLQGKNDTLPVTVEDIAYHTRCVRAGSPNCL
LMADMPFMSYATPEQACENAAQLMRAGANMVKIEGGDWLVDTVKMLTERAVPVCAHLGLTPQSVNIFGGYKVQGRDQEKA
DRMVKDALALQAAGAQIVLLECVPAELAARITQVLDVPVIGIGAGNVTDGQILVMHDMFGISANYMPKFSKNFLAETGDM
RKAVALYMEQVQAGTFPDEAHTIA

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=263, Percent_Identity=70.3422053231939, Blast_Score=397, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6319653, Length=273, Percent_Identity=35.1648351648352, Blast_Score=158, Evalue=9e-40,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28663; Mature: 28663

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKITINDLIKWKQEGRKFATSTAYDASFAQLFESQEMPVLLVGDSLGMVLQGKNDTLPV
CCEEEHHHHHHHHHHCCHHHCCCCCCHHHHHHHCCCCCCEEEEECCCCEEEECCCCCCCE
TVEDIAYHTRCVRAGSPNCLLMADMPFMSYATPEQACENAAQLMRAGANMVKIEGGDWLV
EHHHHHHHHHHEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHH
DTVKMLTERAVPVCAHLGLTPQSVNIFGGYKVQGRDQEKADRMVKDALALQAAGAQIVLL
HHHHHHHHHCCHHHHHCCCCCCCEEEEECEEECCCCHHHHHHHHHHHHHHHHCCCEEEEE
ECVPAELAARITQVLDVPVIGIGAGNVTDGQILVMHDMFGISANYMPKFSKNFLAETGDM
EECCHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCHH
RKAVALYMEQVQAGTFPDEAHTIA
HHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKKITINDLIKWKQEGRKFATSTAYDASFAQLFESQEMPVLLVGDSLGMVLQGKNDTLPV
CCEEEHHHHHHHHHHCCHHHCCCCCCHHHHHHHCCCCCCEEEEECCCCEEEECCCCCCCE
TVEDIAYHTRCVRAGSPNCLLMADMPFMSYATPEQACENAAQLMRAGANMVKIEGGDWLV
EHHHHHHHHHHEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHH
DTVKMLTERAVPVCAHLGLTPQSVNIFGGYKVQGRDQEKADRMVKDALALQAAGAQIVLL
HHHHHHHHHCCHHHHHCCCCCCCEEEEECEEECCCCHHHHHHHHHHHHHHHHCCCEEEEE
ECVPAELAARITQVLDVPVIGIGAGNVTDGQILVMHDMFGISANYMPKFSKNFLAETGDM
EECCHHHHHHHHHHHCCCEEEECCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHCCCHH
RKAVALYMEQVQAGTFPDEAHTIA
HHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA