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The map label for this gene is copA [H]

Identifier: 37679860

GI number: 37679860

Start: 1729601

End: 1731970

Strand: Direct

Name: copA [H]

Synonym: VV1676

Alternate gene names: 37679860

Gene position: 1729601-1731970 (Clockwise)

Preceding gene: 37679859

Following gene: 37679861

Centisome position: 51.56

GC content: 45.57

Gene sequence:

>2370_bases
ATGACACAATCCTGTTATCACTGTGGTGAAGATGTACCGGTCAACACGGATTTTAAAGTTGAAATCTTAGGTGAAACTCG
CGAAATGTGTTGCCCAGGTTGTGAGACCGTGGCGCAAACAATCGTGGATAATGGCCTCGTTTCTTATTACCAATATCGAA
CCGCGCCAGCAGAAAAAGTAGAGTTGGTGCCTGAGCAACTCAAGGCCCTCATTCATTACGACAACGAGGAAGTTCAAGCC
GAGTTTGTGCGCAGCAACGACAATTATTGTGAAGTGATGCTTTCTTTAGAGGGCGTTTCTTGTGCGGCGTGCGCGTGGTT
AATTGAAAAACAAGTGAATGGTCAAACGGGTGTGGTGTCAATAAAGGTAAATACCACCACGAATCGAGCACTGCTCTCTT
GGGATAAATCCAAAACAAAACTGAGTGAGCTTCTTTCCGGCATTCATGCTCTAGGCTACAAAGCCGCCCCTTTTGAAGCG
GATAAACAAGAGGCCTCATATCATGCGACGATGAAGCAGTATCTTTATCGGCTCGGCATAGCGGGACTGGCGACAATGCA
AGTGATGATGCTGGCCGTTGCATTGTATTTGGAAGTCTTTGGCGATCTTGAACCAGAGTTTAAGAATTACTTTCGTTGGG
TGAGTTTGATTTTTGCAACACCAGTGTTGCTTTACTCTGCCCTACCATTTTACCTAAATGCTTGGCGCAGTATTAAAGGA
CGAACCTTGGGGATGGATGTGCCTGTATCCATTGCCTTGATTTTTGCATATTGTGCGAGCTTAGTGGCAACCGTCACAGA
ACAAGGGGAAGTGTTTTTTGAGTCCATCTCAATGTTCACTTTTTTCTTGTTAGTTGGGCGCTTTTTAGAAATGCGAGCTC
GTCGAAAAGCGGCGGCTGCAAGTGGTAATTTGCTTAAACTGATCCCTGCTATCGCCACAACGTTGGATGGCAAGCAAGTG
CCGGTAAAGAGCCTAAAAATTGGTGATCAAGTCCGAGTTTTACCAGGTGAGCATATACCCGCCGATGGTTTTGTTGTTGA
AGGACGAATCCATATTGACGAATCAATGCTAACTGGAGAATCGGTACATGTCGTCAAGCGCGCTGGTGACGCGGTTTTTG
CTGGAACCCTCAATGGCGATGAGTCGTTTGTTTTGCAGGTAACGAGCTCGAAGGCGGATTCGGTGATTTCCAATATCGTT
CGGCTTCAAGATGAAGCGCAACACTCTAAGCCCAAAATTGCAGAAGTGGCAGATGTAGTGGCACGTTATTTTGTCGGTGC
TATCTTGCTTATTTCCGCAGCCACTTGGTTTTATTGGCATCAGACAAAACCAGAAGATGCCTTTTGGATCATGCTCTCTG
TTCTTGTGGCGACTTGCCCATGCGCGCTTTCTCTTGCAACACCAACTGCACTAACGTGTGCCACTTCTCGAATGGGTAAC
TTTGGTATCCTATTGCGAAAAGGACATGTATTTGAAACCTTGTGTAAAGTTAACCACTTAGTAATCGATAAAACAGGTAC
GTTGACCAAAGGCGATATTGAAGTTGAAGATACAAAAACCTTCGATGAGTTCAGTAAAGAAACGTGTCTTGCGTTAGCGG
CTAGCCTAGAGAGCCATGCCAATCACCCTATTGCCCGTGCATTCAAACCTTATTTTGATACAGATTTCCAGGTTAGCGAT
GTGGTCAATATCATTGGCTCTGGCATTTCCGGAACTTGGGATAATAAGGCAATAAACATCGGCAGCGCGGCGTTCGTTCT
AGGTAGAGCCGCATTAGAAAAAAATGCGGTTTATATGTCCATTGATGGTAAGCATGTGGCAACATTCTATTATCATGATC
CAATTCGAAAAGAGAGTCATGAGCTCATTGAAAAGTTTGCCCAAGCAGGTATCAAAACCACTTTGTTAACGGGAGACTCG
GCCGCCAATGCTGAGGGTGTCGCAAAGGCTGTTGGAATTGAGCACGTTATCGCGTCAGCGAAACCGGAGGATAAACTAGC
GTATCTCAAAGGATTGGAAGAGAACGATATCACGATGATGGTTGGTGACGGTATCAACGATGCTCCAACACTAGCTGGTG
CGCATTTATCTGTAGCAATGGGCAGTGGTACTGATGTCGCTAAGGCATCTGCTGATATGACGCTGCTTGGGGATCGTTTA
GATAAGCTCCTAGAAGCTCGTGAGTTGGCGTTAAGAACTCGACGAATCATAAAGGAAAATCTCGCTTGGTCATTGGGTTA
TAACCTATTGATTCTACCTCTGGCTGTCGCTGGTTTGGTTGCGCCTTATATTGCGGTTGTAGGAATGTCTGGTAGCTCTA
TAATAGTGGTCTCTAACTCCTTAAGACTGCTCAAAGAGCGTGGAAAGTAA

Upstream 100 bases:

>100_bases
GGGCCTTGGTTTATTGAGCTTCAACCACATGACCAAAAGTGGTTAGTTCAAGGTCGCGTTACTTTCCCTTCTTCCGCAAC
TGTTTTGATGAACTAAGACT

Downstream 100 bases:

>100_bases
ACAATGGAAAGTTTGTATCTTCTTATCCCAATTGCAATCGTGTTGGTTTGTGTTGCTGTAGCGATATTTCTTTGGGCGGT
AAAAAGCGAGCAGTTTGAAG

Product: cation transport ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 789; Mature: 788

Protein sequence:

>789_residues
MTQSCYHCGEDVPVNTDFKVEILGETREMCCPGCETVAQTIVDNGLVSYYQYRTAPAEKVELVPEQLKALIHYDNEEVQA
EFVRSNDNYCEVMLSLEGVSCAACAWLIEKQVNGQTGVVSIKVNTTTNRALLSWDKSKTKLSELLSGIHALGYKAAPFEA
DKQEASYHATMKQYLYRLGIAGLATMQVMMLAVALYLEVFGDLEPEFKNYFRWVSLIFATPVLLYSALPFYLNAWRSIKG
RTLGMDVPVSIALIFAYCASLVATVTEQGEVFFESISMFTFFLLVGRFLEMRARRKAAAASGNLLKLIPAIATTLDGKQV
PVKSLKIGDQVRVLPGEHIPADGFVVEGRIHIDESMLTGESVHVVKRAGDAVFAGTLNGDESFVLQVTSSKADSVISNIV
RLQDEAQHSKPKIAEVADVVARYFVGAILLISAATWFYWHQTKPEDAFWIMLSVLVATCPCALSLATPTALTCATSRMGN
FGILLRKGHVFETLCKVNHLVIDKTGTLTKGDIEVEDTKTFDEFSKETCLALAASLESHANHPIARAFKPYFDTDFQVSD
VVNIIGSGISGTWDNKAINIGSAAFVLGRAALEKNAVYMSIDGKHVATFYYHDPIRKESHELIEKFAQAGIKTTLLTGDS
AANAEGVAKAVGIEHVIASAKPEDKLAYLKGLEENDITMMVGDGINDAPTLAGAHLSVAMGSGTDVAKASADMTLLGDRL
DKLLEARELALRTRRIIKENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSGSSIIVVSNSLRLLKERGK

Sequences:

>Translated_789_residues
MTQSCYHCGEDVPVNTDFKVEILGETREMCCPGCETVAQTIVDNGLVSYYQYRTAPAEKVELVPEQLKALIHYDNEEVQA
EFVRSNDNYCEVMLSLEGVSCAACAWLIEKQVNGQTGVVSIKVNTTTNRALLSWDKSKTKLSELLSGIHALGYKAAPFEA
DKQEASYHATMKQYLYRLGIAGLATMQVMMLAVALYLEVFGDLEPEFKNYFRWVSLIFATPVLLYSALPFYLNAWRSIKG
RTLGMDVPVSIALIFAYCASLVATVTEQGEVFFESISMFTFFLLVGRFLEMRARRKAAAASGNLLKLIPAIATTLDGKQV
PVKSLKIGDQVRVLPGEHIPADGFVVEGRIHIDESMLTGESVHVVKRAGDAVFAGTLNGDESFVLQVTSSKADSVISNIV
RLQDEAQHSKPKIAEVADVVARYFVGAILLISAATWFYWHQTKPEDAFWIMLSVLVATCPCALSLATPTALTCATSRMGN
FGILLRKGHVFETLCKVNHLVIDKTGTLTKGDIEVEDTKTFDEFSKETCLALAASLESHANHPIARAFKPYFDTDFQVSD
VVNIIGSGISGTWDNKAINIGSAAFVLGRAALEKNAVYMSIDGKHVATFYYHDPIRKESHELIEKFAQAGIKTTLLTGDS
AANAEGVAKAVGIEHVIASAKPEDKLAYLKGLEENDITMMVGDGINDAPTLAGAHLSVAMGSGTDVAKASADMTLLGDRL
DKLLEARELALRTRRIIKENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSGSSIIVVSNSLRLLKERGK
>Mature_788_residues
TQSCYHCGEDVPVNTDFKVEILGETREMCCPGCETVAQTIVDNGLVSYYQYRTAPAEKVELVPEQLKALIHYDNEEVQAE
FVRSNDNYCEVMLSLEGVSCAACAWLIEKQVNGQTGVVSIKVNTTTNRALLSWDKSKTKLSELLSGIHALGYKAAPFEAD
KQEASYHATMKQYLYRLGIAGLATMQVMMLAVALYLEVFGDLEPEFKNYFRWVSLIFATPVLLYSALPFYLNAWRSIKGR
TLGMDVPVSIALIFAYCASLVATVTEQGEVFFESISMFTFFLLVGRFLEMRARRKAAAASGNLLKLIPAIATTLDGKQVP
VKSLKIGDQVRVLPGEHIPADGFVVEGRIHIDESMLTGESVHVVKRAGDAVFAGTLNGDESFVLQVTSSKADSVISNIVR
LQDEAQHSKPKIAEVADVVARYFVGAILLISAATWFYWHQTKPEDAFWIMLSVLVATCPCALSLATPTALTCATSRMGNF
GILLRKGHVFETLCKVNHLVIDKTGTLTKGDIEVEDTKTFDEFSKETCLALAASLESHANHPIARAFKPYFDTDFQVSDV
VNIIGSGISGTWDNKAINIGSAAFVLGRAALEKNAVYMSIDGKHVATFYYHDPIRKESHELIEKFAQAGIKTTLLTGDSA
ANAEGVAKAVGIEHVIASAKPEDKLAYLKGLEENDITMMVGDGINDAPTLAGAHLSVAMGSGTDVAKASADMTLLGDRLD
KLLEARELALRTRRIIKENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSGSSIIVVSNSLRLLKERGK

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=823, Percent_Identity=28.1895504252734, Blast_Score=285, Evalue=1e-76,
Organism=Homo sapiens, GI115529486, Length=857, Percent_Identity=28.0046674445741, Blast_Score=269, Evalue=7e-72,
Organism=Homo sapiens, GI55743073, Length=602, Percent_Identity=28.2392026578073, Blast_Score=204, Evalue=3e-52,
Organism=Escherichia coli, GI1786691, Length=848, Percent_Identity=30.188679245283, Blast_Score=330, Evalue=2e-91,
Organism=Escherichia coli, GI1789879, Length=724, Percent_Identity=30.1104972375691, Blast_Score=251, Evalue=1e-67,
Organism=Escherichia coli, GI1786914, Length=446, Percent_Identity=28.0269058295964, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17556548, Length=514, Percent_Identity=28.2101167315175, Blast_Score=187, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320475, Length=738, Percent_Identity=28.7262872628726, Blast_Score=282, Evalue=2e-76,
Organism=Saccharomyces cerevisiae, GI6319772, Length=669, Percent_Identity=28.6995515695067, Blast_Score=245, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6321430, Length=510, Percent_Identity=22.7450980392157, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325221, Length=531, Percent_Identity=22.7871939736347, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321271, Length=148, Percent_Identity=34.4594594594595, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221329854, Length=549, Percent_Identity=28.9617486338798, Blast_Score=195, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24668708, Length=145, Percent_Identity=32.4137931034483, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24668704, Length=145, Percent_Identity=32.4137931034483, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281366617, Length=145, Percent_Identity=32.4137931034483, Blast_Score=69, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161085803, Length=180, Percent_Identity=30, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24668696, Length=145, Percent_Identity=32.4137931034483, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR001366
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 85947; Mature: 85816

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQSCYHCGEDVPVNTDFKVEILGETREMCCPGCETVAQTIVDNGLVSYYQYRTAPAEKV
CCCCCHHCCCCCCCCCCEEEEEECCCHHHCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHH
ELVPEQLKALIHYDNEEVQAEFVRSNDNYCEVMLSLEGVSCAACAWLIEKQVNGQTGVVS
HHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCEEEE
IKVNTTTNRALLSWDKSKTKLSELLSGIHALGYKAAPFEADKQEASYHATMKQYLYRLGI
EEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AGLATMQVMMLAVALYLEVFGDLEPEFKNYFRWVSLIFATPVLLYSALPFYLNAWRSIKG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RTLGMDVPVSIALIFAYCASLVATVTEQGEVFFESISMFTFFLLVGRFLEMRARRKAAAA
CEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGNLLKLIPAIATTLDGKQVPVKSLKIGDQVRVLPGEHIPADGFVVEGRIHIDESMLTGE
CCCHHHHHHHHHHHCCCCCCCHHHCCCCCEEEECCCCCCCCCCEEEEEEEEECHHHHCCC
SVHVVKRAGDAVFAGTLNGDESFVLQVTSSKADSVISNIVRLQDEAQHSKPKIAEVADVV
HHHHHHHCCCEEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ARYFVGAILLISAATWFYWHQTKPEDAFWIMLSVLVATCPCALSLATPTALTCATSRMGN
HHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHCCCC
FGILLRKGHVFETLCKVNHLVIDKTGTLTKGDIEVEDTKTFDEFSKETCLALAASLESHA
CEEEEECCHHHHHHHHHCCEEEECCCCEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHC
NHPIARAFKPYFDTDFQVSDVVNIIGSGISGTWDNKAINIGSAAFVLGRAALEKNAVYMS
CCCHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCEEEE
IDGKHVATFYYHDPIRKESHELIEKFAQAGIKTTLLTGDSAANAEGVAKAVGIEHVIASA
ECCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCC
KPEDKLAYLKGLEENDITMMVGDGINDAPTLAGAHLSVAMGSGTDVAKASADMTLLGDRL
CCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHCCCCHHHHHHHH
DKLLEARELALRTRRIIKENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSGSSIIVVSNS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
LRLLKERGK
HHHHHHCCC
>Mature Secondary Structure 
TQSCYHCGEDVPVNTDFKVEILGETREMCCPGCETVAQTIVDNGLVSYYQYRTAPAEKV
CCCCHHCCCCCCCCCCEEEEEECCCHHHCCCCHHHHHHHHHHCCHHHHHHHCCCCHHHH
ELVPEQLKALIHYDNEEVQAEFVRSNDNYCEVMLSLEGVSCAACAWLIEKQVNGQTGVVS
HHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHCCCCCEEEE
IKVNTTTNRALLSWDKSKTKLSELLSGIHALGYKAAPFEADKQEASYHATMKQYLYRLGI
EEEECCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
AGLATMQVMMLAVALYLEVFGDLEPEFKNYFRWVSLIFATPVLLYSALPFYLNAWRSIKG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RTLGMDVPVSIALIFAYCASLVATVTEQGEVFFESISMFTFFLLVGRFLEMRARRKAAAA
CEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGNLLKLIPAIATTLDGKQVPVKSLKIGDQVRVLPGEHIPADGFVVEGRIHIDESMLTGE
CCCHHHHHHHHHHHCCCCCCCHHHCCCCCEEEECCCCCCCCCCEEEEEEEEECHHHHCCC
SVHVVKRAGDAVFAGTLNGDESFVLQVTSSKADSVISNIVRLQDEAQHSKPKIAEVADVV
HHHHHHHCCCEEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ARYFVGAILLISAATWFYWHQTKPEDAFWIMLSVLVATCPCALSLATPTALTCATSRMGN
HHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHCCCC
FGILLRKGHVFETLCKVNHLVIDKTGTLTKGDIEVEDTKTFDEFSKETCLALAASLESHA
CEEEEECCHHHHHHHHHCCEEEECCCCEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHC
NHPIARAFKPYFDTDFQVSDVVNIIGSGISGTWDNKAINIGSAAFVLGRAALEKNAVYMS
CCCHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCEEEE
IDGKHVATFYYHDPIRKESHELIEKFAQAGIKTTLLTGDSAANAEGVAKAVGIEHVIASA
ECCCEEEEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCC
KPEDKLAYLKGLEENDITMMVGDGINDAPTLAGAHLSVAMGSGTDVAKASADMTLLGDRL
CCCHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHCCCCHHHHHHHH
DKLLEARELALRTRRIIKENLAWSLGYNLLILPLAVAGLVAPYIAVVGMSGSSIIVVSNS
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
LRLLKERGK
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA