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The map label for this gene is gnd [H]

Identifier: 37679791

GI number: 37679791

Start: 1652820

End: 1654268

Strand: Direct

Name: gnd [H]

Synonym: VV1607

Alternate gene names: 37679791

Gene position: 1652820-1654268 (Clockwise)

Preceding gene: 37679790

Following gene: 37679793

Centisome position: 49.27

GC content: 50.24

Gene sequence:

>1449_bases
ATGAAAGGTGATATCGGTGTAATTGGCCTAGCAGTAATGGGTCAAAACCTTATCCTGAACATGAACGACCACGGCTTTAA
AGTGGTGGCTCACAACCGTACTGCGGCGAAAGTAGATGAGTTTCTAGAAGGCCCAGCGAAAGGCACTAACATCATTGGCG
CATACTCACTTGAGGAACTGGTTGAGAAACTGGAAACACCACGCAAAGTGATGTTGATGGTTCGTGCTGGCGCGGTAGTG
GACCAGTTTATTGATGCACTTGTACCGCTTCTTGATAAAGGCGACATCATCATTGACGGTGGTAACACGAACTACCCAGA
CACCAACCGTCGTGTAGCGGCGCTGCGTGAAAAAGGCATCCACTTCATCGGTACTGGTGTCTCTGGTGGTGAAGAAGGCG
CACGTTTCGGCCCTTCTATTATGCCTGGCGGTGCTCCTGAAGCATGGGAAGCGGTTAAGCCTATCTTCCAAGGTATCTCT
GCAAAAACTGACGCTGGCGAGCCTTGCTGTGACTGGGTTGGTAACGATGGTGCAGGTCACTTCGTTAAAATGGTACACAA
CGGCATCGAATACGGCGACATGCAGCTGATCACCGAAGCGTACCAGTTCATGAAAGATGGCCTTGGTATGTCTGCAGACG
AGATGCAAGCCGTTTTCGCTGATTGGAACAAGACTGAGCTAGACAGCTACCTAGTCGAAATCACCGCTGACATCCTTGGC
TACAAAGACGAAGATGGCGAGCCACTAGTAGAAAAGATCCTCGATACGGCTGGCCAAAAAGGCACAGGTAAATGGACAGG
TATCAACGCACTAGACCTAGGCATTCCACTAACGCTTATCTCTGAGTCTGTCTTCTCTCGTTGCCTATCGGCACTAAAAG
ATCAACGTGTTGAAGCTGAGAAATTGTTTGGTAAGACCATCACGCCAGTAGAAGGTGACAAGCAAGAGTGGGTTGACGCA
CTTCGCCAAGCGCTTCTAGCATCTAAGATTATCTCTTACGCTCAAGGCTTTATGCTGATGCGTGAAGCGTCTAATGAAAA
TGGTTGGGATCTCAACTACGGCAACGTGGCACTGATGTGGCGCGGTGGTTGTATCATTCGTTCTGCATTCCTAGGTAACA
TCCGTGATGCCTACGAAGCGAACCCAGATCTTGCGTTCCTAGGCTCTGATGACTACTTCAAAGGCATCCTACAAAACAGC
CTAGTGGCATGGCGTAAAGTGGCGGCGAAGTCGCTAGAAGCGGGCATTCCAATGCCATGTACAACGTCTGCACTGACGTT
CCTAGACGGTTACACAACCGCGCGTCTACCTGCAAACCTACTGCAAGCACAACGTGACTACTTCGGTGCTCACACTTATG
AGCGTATCGACCGTGAGCGTGGTGAGTTCTTCCACACCAACTGGACAGGTACCGGCGGCAACACAGCGTCGACGACTTAC
GACGTTTAA

Upstream 100 bases:

>100_bases
AATTCATGCGAAAGCAGGGCTGACGGAATGGTATTTAGATTTAGACGCAGCAGCGAAAATCGCTTAACCGTCGCAGAAAG
AAATATATTGGAGAGAAACA

Downstream 100 bases:

>100_bases
TAGATCGTTAGTAACCCAATAAAACGCAAAAGGATGTCCAAGTGACATCCTTTTTTCTTGAATGACGTTTAAAGCTAATG
AACAAGATTACGCACGCTTT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MKGDIGVIGLAVMGQNLILNMNDHGFKVVAHNRTAAKVDEFLEGPAKGTNIIGAYSLEELVEKLETPRKVMLMVRAGAVV
DQFIDALVPLLDKGDIIIDGGNTNYPDTNRRVAALREKGIHFIGTGVSGGEEGARFGPSIMPGGAPEAWEAVKPIFQGIS
AKTDAGEPCCDWVGNDGAGHFVKMVHNGIEYGDMQLITEAYQFMKDGLGMSADEMQAVFADWNKTELDSYLVEITADILG
YKDEDGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISESVFSRCLSALKDQRVEAEKLFGKTITPVEGDKQEWVDA
LRQALLASKIISYAQGFMLMREASNENGWDLNYGNVALMWRGGCIIRSAFLGNIRDAYEANPDLAFLGSDDYFKGILQNS
LVAWRKVAAKSLEAGIPMPCTTSALTFLDGYTTARLPANLLQAQRDYFGAHTYERIDRERGEFFHTNWTGTGGNTASTTY
DV

Sequences:

>Translated_482_residues
MKGDIGVIGLAVMGQNLILNMNDHGFKVVAHNRTAAKVDEFLEGPAKGTNIIGAYSLEELVEKLETPRKVMLMVRAGAVV
DQFIDALVPLLDKGDIIIDGGNTNYPDTNRRVAALREKGIHFIGTGVSGGEEGARFGPSIMPGGAPEAWEAVKPIFQGIS
AKTDAGEPCCDWVGNDGAGHFVKMVHNGIEYGDMQLITEAYQFMKDGLGMSADEMQAVFADWNKTELDSYLVEITADILG
YKDEDGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISESVFSRCLSALKDQRVEAEKLFGKTITPVEGDKQEWVDA
LRQALLASKIISYAQGFMLMREASNENGWDLNYGNVALMWRGGCIIRSAFLGNIRDAYEANPDLAFLGSDDYFKGILQNS
LVAWRKVAAKSLEAGIPMPCTTSALTFLDGYTTARLPANLLQAQRDYFGAHTYERIDRERGEFFHTNWTGTGGNTASTTY
DV
>Mature_482_residues
MKGDIGVIGLAVMGQNLILNMNDHGFKVVAHNRTAAKVDEFLEGPAKGTNIIGAYSLEELVEKLETPRKVMLMVRAGAVV
DQFIDALVPLLDKGDIIIDGGNTNYPDTNRRVAALREKGIHFIGTGVSGGEEGARFGPSIMPGGAPEAWEAVKPIFQGIS
AKTDAGEPCCDWVGNDGAGHFVKMVHNGIEYGDMQLITEAYQFMKDGLGMSADEMQAVFADWNKTELDSYLVEITADILG
YKDEDGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISESVFSRCLSALKDQRVEAEKLFGKTITPVEGDKQEWVDA
LRQALLASKIISYAQGFMLMREASNENGWDLNYGNVALMWRGGCIIRSAFLGNIRDAYEANPDLAFLGSDDYFKGILQNS
LVAWRKVAAKSLEAGIPMPCTTSALTFLDGYTTARLPANLLQAQRDYFGAHTYERIDRERGEFFHTNWTGTGGNTASTTY
DV

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=481, Percent_Identity=63.6174636174636, Blast_Score=633, Evalue=0.0,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=55.3418803418803, Blast_Score=517, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17542558, Length=483, Percent_Identity=60.2484472049689, Blast_Score=606, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6321695, Length=487, Percent_Identity=60.3696098562628, Blast_Score=592, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6321977, Length=488, Percent_Identity=61.0655737704918, Blast_Score=582, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24639279, Length=480, Percent_Identity=62.5, Blast_Score=596, Evalue=1e-170,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 52506; Mature: 52506

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGDIGVIGLAVMGQNLILNMNDHGFKVVAHNRTAAKVDEFLEGPAKGTNIIGAYSLEEL
CCCCCEEEEHEECCCCEEEEECCCCEEEEECCCHHHHHHHHHCCCCCCCCEEEHHHHHHH
VEKLETPRKVMLMVRAGAVVDQFIDALVPLLDKGDIIIDGGNTNYPDTNRRVAALREKGI
HHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHCCC
HFIGTGVSGGEEGARFGPSIMPGGAPEAWEAVKPIFQGISAKTDAGEPCCDWVGNDGAGH
EEEECCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHH
FVKMVHNGIEYGDMQLITEAYQFMKDGLGMSADEMQAVFADWNKTELDSYLVEITADILG
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
YKDEDGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISESVFSRCLSALKDQRVEAE
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHHHH
KLFGKTITPVEGDKQEWVDALRQALLASKIISYAQGFMLMREASNENGWDLNYGNVALMW
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEE
RGGCIIRSAFLGNIRDAYEANPDLAFLGSDDYFKGILQNSLVAWRKVAAKSLEAGIPMPC
ECCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TTSALTFLDGYTTARLPANLLQAQRDYFGAHTYERIDRERGEFFHTNWTGTGGNTASTTY
CHHHHHHHCCCCHHHCCHHHHHHHHHHHCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCC
DV
CC
>Mature Secondary Structure
MKGDIGVIGLAVMGQNLILNMNDHGFKVVAHNRTAAKVDEFLEGPAKGTNIIGAYSLEEL
CCCCCEEEEHEECCCCEEEEECCCCEEEEECCCHHHHHHHHHCCCCCCCCEEEHHHHHHH
VEKLETPRKVMLMVRAGAVVDQFIDALVPLLDKGDIIIDGGNTNYPDTNRRVAALREKGI
HHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHCCC
HFIGTGVSGGEEGARFGPSIMPGGAPEAWEAVKPIFQGISAKTDAGEPCCDWVGNDGAGH
EEEECCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCHH
FVKMVHNGIEYGDMQLITEAYQFMKDGLGMSADEMQAVFADWNKTELDSYLVEITADILG
HHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
YKDEDGEPLVEKILDTAGQKGTGKWTGINALDLGIPLTLISESVFSRCLSALKDQRVEAE
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHCCHHHH
KLFGKTITPVEGDKQEWVDALRQALLASKIISYAQGFMLMREASNENGWDLNYGNVALMW
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEE
RGGCIIRSAFLGNIRDAYEANPDLAFLGSDDYFKGILQNSLVAWRKVAAKSLEAGIPMPC
ECCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TTSALTFLDGYTTARLPANLLQAQRDYFGAHTYERIDRERGEFFHTNWTGTGGNTASTTY
CHHHHHHHCCCCHHHCCHHHHHHHHHHHCHHHHHHHHHHCCCEEECCCCCCCCCCCCCCC
DV
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]