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The map label for this gene is pgl [H]

Identifier: 37679790

GI number: 37679790

Start: 1652004

End: 1652786

Strand: Direct

Name: pgl [H]

Synonym: VV1606

Alternate gene names: 37679790

Gene position: 1652004-1652786 (Clockwise)

Preceding gene: 37679789

Following gene: 37679791

Centisome position: 49.25

GC content: 47.51

Gene sequence:

>783_bases
GTGGCGTTTCCCATGCAAAAACCTAACAGATACGGACTACTGCGAACTATGATCAATCACAAGATCTACCAAACAGCAGA
GCAGGTAGTAGAAAGCCTAGCAAACGACATGAAAGCGTTTAGCGAAATGGGCCGACCTGTTCATATCTCACTTTCTGGTG
GCAGCACGCCTAAAATGCTGTTTAAGCTTTTGGCATCAGAAACGTACGCAACCTCCATTCAGTGGCAAAATCTTCATTTT
TGGTGGGGTGATGAACGTTGCGTGGCACCAGACGATGCTGAGAGCAACTACGGTGAAGCGAATGCTCTTTTGTTCTCAAA
ACTAAGAGAATTGAGCCAAGTGAGCATTCCTGCGGAAAACATTCACCGCATCCGTGGTGAAGAGCAACCAGAAGTGGAAG
CGGCACGTTTCGCAAAAGAAATGGCAGACGTGATTCCAACCGATAACGGCACACCTGTGTTCGATTGGATTTTGCTTGGT
GTTGGCGCAGATGGTCACACGGCGTCGCTTTTCCCAGGTCAAACGAATTATGACGATGAGAACCTGTCAGTATTGGCTTC
TCATCCGGAATCTGGACAAATTCGCGTTTCGAAAACGGCACGTGTACTGGAAGCGGCTAAACGCATTAGCTACTTAGTAC
TGGGTGCAGGTAAAGCGGACATTGTTGAAGAGATCAACAGCAATCCAGCGGAAGAACTTCCTTACCCGGCAGCAAAAATT
CATGCGAAAGCAGGGCTGACGGAATGGTATTTAGATTTAGACGCAGCAGCGAAAATCGCTTAA

Upstream 100 bases:

>100_bases
TCCTCGATTTCAAACAAGATCCACAAGCACTCTTTGGTTATGCCTGCGGCACTTGGGGGCCAAAAGAGTCAGACGATTTG
CTGCAGCGTGACGATCGCGC

Downstream 100 bases:

>100_bases
CCGTCGCAGAAAGAAATATATTGGAGAGAAACAATGAAAGGTGATATCGGTGTAATTGGCCTAGCAGTAATGGGTCAAAA
CCTTATCCTGAACATGAACG

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MAFPMQKPNRYGLLRTMINHKIYQTAEQVVESLANDMKAFSEMGRPVHISLSGGSTPKMLFKLLASETYATSIQWQNLHF
WWGDERCVAPDDAESNYGEANALLFSKLRELSQVSIPAENIHRIRGEEQPEVEAARFAKEMADVIPTDNGTPVFDWILLG
VGADGHTASLFPGQTNYDDENLSVLASHPESGQIRVSKTARVLEAAKRISYLVLGAGKADIVEEINSNPAEELPYPAAKI
HAKAGLTEWYLDLDAAAKIA

Sequences:

>Translated_260_residues
MAFPMQKPNRYGLLRTMINHKIYQTAEQVVESLANDMKAFSEMGRPVHISLSGGSTPKMLFKLLASETYATSIQWQNLHF
WWGDERCVAPDDAESNYGEANALLFSKLRELSQVSIPAENIHRIRGEEQPEVEAARFAKEMADVIPTDNGTPVFDWILLG
VGADGHTASLFPGQTNYDDENLSVLASHPESGQIRVSKTARVLEAAKRISYLVLGAGKADIVEEINSNPAEELPYPAAKI
HAKAGLTEWYLDLDAAAKIA
>Mature_259_residues
AFPMQKPNRYGLLRTMINHKIYQTAEQVVESLANDMKAFSEMGRPVHISLSGGSTPKMLFKLLASETYATSIQWQNLHFW
WGDERCVAPDDAESNYGEANALLFSKLRELSQVSIPAENIHRIRGEEQPEVEAARFAKEMADVIPTDNGTPVFDWILLGV
GADGHTASLFPGQTNYDDENLSVLASHPESGQIRVSKTARVLEAAKRISYLVLGAGKADIVEEINSNPAEELPYPAAKIH
AKAGLTEWYLDLDAAAKIA

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=268, Percent_Identity=33.955223880597, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI6912586, Length=216, Percent_Identity=33.7962962962963, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI115533058, Length=219, Percent_Identity=31.0502283105023, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI115533060, Length=219, Percent_Identity=31.0502283105023, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321957, Length=218, Percent_Identity=30.2752293577982, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321687, Length=263, Percent_Identity=28.5171102661597, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324362, Length=214, Percent_Identity=30.8411214953271, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319918, Length=221, Percent_Identity=28.9592760180996, Blast_Score=76, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24641119, Length=240, Percent_Identity=27.9166666666667, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 28685; Mature: 28553

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFPMQKPNRYGLLRTMINHKIYQTAEQVVESLANDMKAFSEMGRPVHISLSGGSTPKML
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHH
FKLLASETYATSIQWQNLHFWWGDERCVAPDDAESNYGEANALLFSKLRELSQVSIPAEN
HHHHHHHHHHCEEEECCEEEEECCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
IHRIRGEEQPEVEAARFAKEMADVIPTDNGTPVFDWILLGVGADGHTASLFPGQTNYDDE
HHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHEEECCCCCCEEEECCCCCCCCCC
NLSVLASHPESGQIRVSKTARVLEAAKRISYLVLGAGKADIVEEINSNPAEELPYPAAKI
CCEEEECCCCCCCEEEHHHHHHHHHHHHHEEEEEECCHHHHHHHHCCCCHHHCCCCHHHH
HAKAGLTEWYLDLDAAAKIA
HHHCCCHHHHEEHHHHHCCC
>Mature Secondary Structure 
AFPMQKPNRYGLLRTMINHKIYQTAEQVVESLANDMKAFSEMGRPVHISLSGGSTPKML
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHH
FKLLASETYATSIQWQNLHFWWGDERCVAPDDAESNYGEANALLFSKLRELSQVSIPAEN
HHHHHHHHHHCEEEECCEEEEECCCEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHH
IHRIRGEEQPEVEAARFAKEMADVIPTDNGTPVFDWILLGVGADGHTASLFPGQTNYDDE
HHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHEEECCCCCCEEEECCCCCCCCCC
NLSVLASHPESGQIRVSKTARVLEAAKRISYLVLGAGKADIVEEINSNPAEELPYPAAKI
CCEEEECCCCCCCEEEHHHHHHHHHHHHHEEEEEECCHHHHHHHHCCCCHHHCCCCHHHH
HAKAGLTEWYLDLDAAAKIA
HHHCCCHHHHEEHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9020051 [H]